Akwukwo nke P450 3A4 na-eme ka Powodafinil kwadoro ya ma mechiekwa ụfọdụ subtypes nke ezinụlọ P450 enzyme ezinụlọ cytochrome. Enwere ike inwe mkparịta ụka na ọtụtụ ọgwụ ndị ọzọ, nke na-emechi ma ọ bụ na-eme ka ụdị ihe ọkpụkpụ P450 dị na cytochrome. Ndị a na-agụnye ụfọdụ ọgwụ mgbochi oral, ọgwụ ọjọọ maka ọgwụgwọ ọrịa mgbochi (anticonvulsants), anticoagulants (anticoagulants), antidepressants ma ọ bụ cyclosporine immunosuppressant.