Ecole des Science Byimana yashinzwe muri 1952 na abafurere baba Marist . Yakinguye amarembo nkishuri ribanza rya Bukomero ryakiraga abahungu gusa, nyuma iba Ecole des Moniteurs. Kuva rishingwa, umufurere Alvarus, Leon Jozef Backx  yari umuyobozi w'ishuri mu myaka hafi mirongo itanu. Mu 1978, Ngombwa Stanislas, umuyobozi mukuru w'iryo shuri, yari mu cyiciro cya gatandatu cya siyansi. Mu 1987, ishuri ryatangiye kwakira abakobwa. Muri jenoside yo mu Rwanda yo mu 1994, iryo shuri ryatakaje abakozi benshi ndetse n’abanyeshuri. Ishuri ryagize amazina menshi ariko azwi cyane ni Ecole des Science Byimana. Mu 2002, iryo shuri ryijihije isabukuru yimyaka 50 hamwe n’abanyeshuri 800, abahungu, n’abakobwa.