دانلود مقاله و خرید ترجمه:مدل های حیوانی در آسیب های جراحتی نخاعی
مدل های حیوانی در آسیب های جراحتی نخاعی
Animal Models in Traumatic Spinal Cord Injury
Neural Regen Res. 2014 Nov 15; 9(22)
Mahdi Sharif-Alhoseini and Vafa Rahimi-Movaghar
Traumatic spinal cord injury (SCI) causes high mortality, severe disability, expensive cure, extensive rehabilitation, and a high economic burden. There has been no definite treatment for SCI, but numerous studies including experimental modeling are being performed to assist resolving this fundamental problem.
The first reported SCI model was presented by Allen in 1911 where a mass was dropped from a prescribed height onto the dorsal surface of the canine dura. After that, the animal models of SCI from simple lamprey to non-human primates were used to develop pathophysiological knowledge on cell injury and repair process of spinal cord.
Currently, to choose an animal model, some factors are considered depending upon the proposed aim of the study. Transections and contusions of the spinal cord are the most commonly used methods for animal modeling of SCI. While transection models provide an idealized setting for studying spinal cord regeneration across a complete lesion, but transected spinal cords are rarely encountered in human SCI. In other words, most injured spinal cords maintain some tissue continuity across the area of injury. But contusion and compression models are more clinically relevant. These models can create graded injuries and characterized by hemorrhagic necrosis, ischemia, inflammation, and central cavitation. Besides, compression models contribute to simulate the persistent spinal canal occlusion that is common in human SCIs.
The ongoing development of SCI animal models reflects the need to review all types of them and gauge about their advantages or disadvantages. The purpose of this chapter is to review animal models in SCI from studies indexed in Medline.
Animal Models | Spinal Cord Injury | مدل های حیوانی | آسیب نخاعی | دانلود مقاله | دانلود مقاله isi با ترجمه فارسی | دانلود مقاله پزشکی 1 با ترجمه فارسی | سایت دانلود مقاله