0ba0c9c5_t_Red_104___Environment_Canada_Summary_table_Response
[Comment] Three epidemiological investigations (Davies et al. 1979, 1984; Cooper et al. (EEH) 1983; Kano et al. 1993) indicated that lead chromate pigment production did not show an increased risk of carcinogenicity. [Response] 
Although no significantly increased risk of lung cancer incidence were observed in some of the epidemiological investigations (Davies et al. 1979, 1984; Cooper et al. (EEH) 1983) conducted in the lead chromate pigment production plants, the authors speculated that the numbers of observed and expected deaths were too small in these studies for definitive conclusions. In the Kano et al. study (1993), the authors speculate that exposures may have been reduced due to improved workplace hygiene practices, thereby reducing lung cancer risk among the workers in the production of various chromate pigments, including lead chromate, zinc chromate and strontium chromate pigments. The exposure levels in the Kano et al (1993) study were not quantified. The description of these studies has been refined in the screening assessment and noted in the uncertainties.
Public comments for C.I. Pigment Red 104 - Environment Canada