0ba0c9c5_t_Red_104___Environment_Canada_Summary_table_Response
[Comment] Cumulative or additive effects of lead and chromium along with other carcinogenic substances should be considered in the screening assessment. [Response] 
The ecological assessments of effects to aquatic organisms are based on experimental toxicity data for Pigment Yellow 34; therefore, they already consider the potential for acute effects to aquatic organisms due to the measured presence of both metals in solution. A cumulative or additive analysis is beyond the scope of the health screening assessment for the two pigments. For most classes of substances, the available data are insufficient to conduct a cumulative risk assessment.
Public comments for C.I. Pigment Red 104 - Environment Canada