f6098d8b__and_Use_of_Laboratory_Animals__Comments
[ID] 396 [Entry Date] 04/21/2011 at 10:28:36 PM [Affiliation] Self [Comments] 
Comment 1: I have read through much of the guide and was struck by a number of general statements that would be problematic and intrusive in daily research efforts. Many of these statements are vague and appear to make arbitrary distinctions. This sort of guidance is more likely to lead to unnecessary delays and expenses in research. As someone who studies the neural mechanisms of ingestive behavior the statement below concerns me: "In the case of conditioned-response research protocols, use of a highly preferred food or fluid as positive reinforcement, instead of restriction, is recommended." This is something that we routinely do and I can attest that animals do not always acquire tasks when given preferred food. A mild food restriction is often necessary in these studies. Most importantly, what is the basis for making this recommendation? Is there something unhealthy about mild restriction? In fact, the vast majority of research across animal phyla indicate that food restriction improves many health parameters. Even after restriction, our animal models are still heavier than a similar animal in the wild. Comment 2: No, I do think this guide, in its current from should serve as the basis for evaluation in a year. There is a need for more discussion of its implications - both financial and scientific.
Listing of Public Comments on Proposed Adoption and Implementation of the Eighth Edition of the Guide for the Care and Use of Laboratory Animals