57d50aa9_Health_Information_Library__Why
[Used for] 2 Stars Type 1 Diabetes 1,800 mg daily of of pyridoxine alpha-ketoglutarate or 50 mg daily pyridoxine [Why] 
People with diabetes often have low vitamin B6 levels. Supplementing with the vitamin may restore levels and improve glucose tolerance. Blood levels of vitamin B1 (thiamine) have been found to be low in people with type 1 diabetes.111 A controlled trial in Africa found that supplementing with both vitamin B1 (25 mg per day) and vitamin B6 (50 mg per day) led to significant improvement of symptoms of diabetic nerve damage (neuropathy) after four weeks.112 However, since this was a trial conducted among people in a vitamin B1-deficient developing country, these improvements might not occur in other people with diabetes. Another trial found that combining vitamin B1 (in a special fat-soluble form) and vitamin B6 plus vitamin B12 in high but variable amounts led to improvement in some aspects of diabetic neuropathy in 12 weeks.113 As a result, some doctors recommend that people with diabetic neuropathy supplement with vitamin B1, though the optimal level of intake remains unknown.114 Many people with diabetes have low blood levels of vitamin B6.115 , 116 Levels are even lower in people with diabetes who also have neuropathy.117 In a trial that included people with type 1 diabetes, 1,800 mg per day of a special form of vitamin B6-pyridoxine alpha-ketoglutarate-improved glucose tolerance dramatically.118 Vitamin B6 may also reduce the amount of glycosylation, so taking adequate amounts of this vitamin may be beneficial for all people with diabetes.119
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