0ba0c9c5_t_Red_104___Environment_Canada_Summary_table_Response
[Comment] These pigments have not been shown to be carcinogenic or genotoxic in studies specific to lead chromate pigments. As well, they were aware of no credible experimental data developed using actual lead chromate pigments in the form sold in commerce which substantiates this claim. Nor is any such data cited in the screening assessment. [Response] 
It is acknowledged that the database specific to these two pigments is limited. However, as presented in the screening assessment, data specific to the pigments included cytogenicity in mammalian cells and, when solubilized, induction of gene mutation in bacteria. In addition, lead chromate pigment induced tumours were observed in the experimental animals exposed via subcutaneous administration. Bronchial squamous metaplasia and dysplasia were observed in experimental animals after bronchial implantation of lead chromate pigments. As well, increased lung cancer risk was observed among workers involved in chromate pigment production.
Public comments for C.I. Pigment Red 104 - Environment Canada