57d50aa9_Health_Information_Library__Why
[Used for] 2 Stars Depression and Premenstrual Syndrome Take under medical supervision: 100 to 300 mg daily [Why] 
Several studies indicate that supplementing with vitamin B6 helps alleviate depression, including depression associated with PMS. Oral contraceptives can deplete the body of vitamin B6, a nutrient needed for maintenance of normal mental functioning. Double-blind research shows that women who are depressed and who have become depleted of vitamin B6 while taking oral contraceptives typically respond to vitamin B6 supplementation.71 In one trial, 20 mg of vitamin B6 were taken twice per day. Some evidence suggests that people who are depressed-even when not taking the oral contraceptive-are still more likely to be B6 deficient than people who are not depressed.72 Several clinical trials also indicate that vitamin B6 supplementation helps alleviate depression associated with premenstrual syndrome (PMS),73 although the research remains inconsistent.74 Many doctors suggest that women who have depression associated with PMS take 100-300 mg of vitamin B6 per day-a level of intake that requires supervision by a doctor.
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