f6098d8b__and_Use_of_Laboratory_Animals__Comments
[ID] 12 [Entry Date] 03/02/2011 at 01:08:10 PM [Affiliation] Self [Comments] 
Comment 1: On the proposed use of pharmaceutical grade chemicals: this would seem to limit use of compounds that are made and supplied by various NIH institutes (e.g., NIDA, NIMH). This is a valuable Institute service to research that provides unusual, expensive compounds in amounts that adequate to animal studies. In addition, some items that should be considered (e.g., pharmacokinetics) when these compounds are used can only be known after they are given to animals. Comment 2: The prescribed once/week weighing frequency for food-restricted animals is not suitable and may be unnecessary, even risky in some situations. For example, non-human primates (and other larger species) often must be anesthetized (with attendant risks) for weighing. Experience shows that frequent weighing is useful to the point that stable feeding/weight conditions are established. After that point, the frequency of weighing can be decreased
Listing of Public Comments on Proposed Adoption and Implementation of the Eighth Edition of the Guide for the Care and Use of Laboratory Animals