0
SPEAKER_02
 This is episode number 1,211 with New York Times bestselling author, Dr. David Perlmutter.
0
SPEAKER_02
Welcome to the School of Greatness.
0
SPEAKER_02
My name is Lewis Howes, a former pro athlete turned lifestyle entrepreneur.
0
SPEAKER_02
And each week we bring you an inspiring person or message to help you discover how to unlock your inner greatness.
0
SPEAKER_02
Thanks for spending some time with me today.
0
SPEAKER_02
Now let the class begin.
0
SPEAKER_02
 Welcome back, my friend.
0
SPEAKER_02
Today's guest is Dr. David Perlmutter, who is a board-certified neurologist and five-time New York Times bestselling author.
0
SPEAKER_02
He received his MD degree from the University of Miami School of Medicine, where he was awarded the Leonard G. Roundtree Research Award.
0
SPEAKER_02
And he currently serves on the board of directors and is a fellow of the American College of Nutrition.
0
SPEAKER_02
He's written a new book called Drop Acid,
0
SPEAKER_02
 The surprising new science of uric acid, the key to losing weight, controlling blood sugar, and achieving extraordinary health.
0
SPEAKER_02
In this episode we dive deep about how your diet can contribute to your behavior, the real reason most people are addicted to sugar, how to reduce the risk of Alzheimer's and other diseases.
0
SPEAKER_02
 The emerging science behind uric acid and everything you need to know about its effects on the body and so much more.
0
SPEAKER_02
I'm excited about this one.
0
SPEAKER_02
I hope you really enjoy it.
0
SPEAKER_02
Make sure to share this with someone that you think would be inspired by this message as well as we are all about helping improve the quality as many people's lives as possible.
0
SPEAKER_02
So please share this message if you find it helpful.
0
SPEAKER_02
 And a quick reminder, if this is your first time here, please subscribe over on Apple Podcasts or Spotify to the School of Greatness to stay up to date.
0
SPEAKER_02
We've got over 1200 episodes from some of the biggest minds in the world, some of the greatest athletes, doctors, nutritionists, scientists, leaders, all about how to improve your life.
0
SPEAKER_02
So make sure to subscribe and stay up to date on this podcast.
0
SPEAKER_02
 And I want to give a shout out to the fan of the week from Rowe who said, Lewis highlights all self-help topics and more in this can't miss podcast.
0
SPEAKER_02
He and his guest experts offer insightful advice and information that is helpful to anyone that listens.
0
SPEAKER_02
So big thank you to Rowe for being a fan of the week and leaving us a review over on Apple podcast and a very excited about this one.
0
SPEAKER_02
So in just a moment, I bring you the one and only Dr. David Perlmutter.
0
SPEAKER_02
 I definitely have my favorite type of workouts, but I think we can all agree that changing them up often makes it easier to stay excited for our fitness goals each day.
0
SPEAKER_02
Of course, it can be hard to always come up with new types of workout routines, which is why I love Peloton.
0
SPEAKER_02
 They are always coming out with new stuff to help switch up your exercises, especially right now to ring in the new year.
0
SPEAKER_02
The Peloton Bike and Bike Plus are releasing new classes, new music and new ways to keep your workouts fun and motivating.
0
SPEAKER_02
And guess what, I'm super pumped about this.
0
SPEAKER_02
Peloton is adding boxing to their workout lineup.
0
SPEAKER_02
No gloves needed.
0
SPEAKER_02
I've recently gotten into boxing and let me tell you, it's an incredible and super fun way to get your exercise in.
0
SPEAKER_02
 Even if you've never boxed before, these classes will have you working up a sweat while working on the fundamentals of form, footwork, and fun combos that will keep you on your toes.
0
SPEAKER_02
For a limited time, try the Peloton app free for two months, then $12.99 per month after.
0
SPEAKER_02
New members only.
0
SPEAKER_02
Visit onepeloton.com slash app to learn more.
0
SPEAKER_02
That's two months free at onepeloton.com.
0
SPEAKER_02
Offer expires January 31st, 2022.
0
SPEAKER_02
Terms apply.
0
SPEAKER_02
 What are those main foods or ingredients that keep us in fear-based brain activity as opposed to the- That's an excellent question.
0
SPEAKER_00
It's really foods that threaten metabolism.
0
SPEAKER_00
In other words, refined carbohydrates, foods to which you may be sensitive as a unique individual, and foods that tend to elevate uric acid.
0
SPEAKER_00
These are the foods of the day.
0
SPEAKER_00
By and large, the biggest issue for us is fructose.
0
SPEAKER_00
 leads to uric acid and turns on inflammation, turns on oxidative stress, does other things that we'll talk about.
0
SPEAKER_00
But beyond that, through the lens of what that's doing to our thinking process and locking us into amygdala-based behavior, it's a big deal.
0
SPEAKER_00
And we're watching it play out around the world.
0
SPEAKER_00
You feel the shift.
0
SPEAKER_00
 Yeah, there was always conflict in the world, but there's never been the polarization like we're seeing now.
0
SPEAKER_00
I know.
0
SPEAKER_00
And the lack of compassion for your fellow human.
0
SPEAKER_00
 Now the Dalai Lama said that, if you want others to be happy, practice compassion.
0
SPEAKER_00
But if you want to be happy, practice compassion.
0
SPEAKER_00
So it works.
0
SPEAKER_00
That's tapping into your prefrontal cortex.
0
SPEAKER_02
It's funny, I was just interviewing a therapist, psychologist, Dr. Ramani Navrasila, who is the leading expert on narcissism and narcissism, personality disorders, and all things narcissists.
0
SPEAKER_02
 And I'm curious if part of narcissism are these fear-based, you know, reactive thoughts and emotions could be diminished by the things people eat and be less narcissistic because most narcissists aren't compassionate.
0
SPEAKER_02
We have two chapters on that exact topic.
0
SPEAKER_00
Really?
0
SPEAKER_00
Oh yeah.
0
SPEAKER_00
In the book?
0
SPEAKER_00
Not in that book.
0
SPEAKER_00
Okay.
0
SPEAKER_00
In the book I'm gonna send you, Brainwash.
0
SPEAKER_00
Wow.
0
SPEAKER_00
But you are correct.
0
SPEAKER_00
 Narcissism is really just the amygdala doing its thing.
0
SPEAKER_00
That it's all about me.
0
SPEAKER_00
It's all about ultimately my fears.
0
SPEAKER_00
 So it's a very fear-based program from which the brain and reality, the brain operates in reality is seen and doesn't really have the door open in any way for other, the feelings of others and how I'm, what I might do to be helpful for that other person.
0
SPEAKER_00
So it, and so as I described, food, because it separates, it segregates the
0
SPEAKER_00
 A prefrontal cortex from the amygdala.
0
SPEAKER_00
The amygdala is the fear-based part of the brain, right?
0
SPEAKER_02
But it dictates behavior.
0
SPEAKER_02
The amygdala dictates behavior.
0
SPEAKER_02
That's right.
0
SPEAKER_02
So if it's turned on and fear-based all the time, it's pretty hard to have a compassionate, calm behavior.
0
SPEAKER_02
You're locked out from that.
0
SPEAKER_02
You're kept out of God's kingdom.
0
SPEAKER_00
Wow.
0
SPEAKER_00
Yeah.
0
SPEAKER_00
 So this prefrontal cortex exercises the control, reins that in and says, hey, I know you want to eat this food now.
0
SPEAKER_00
I know you want to do this.
0
SPEAKER_00
I know you want to be a bully and hit somebody.
0
SPEAKER_00
But we're going to rein that in because there's a better purpose here in life.
0
SPEAKER_00
And that's our gift as humans, the opposable thumb and this prefrontal cortex, right?
0
SPEAKER_00
Yes.
0
SPEAKER_00
 And so that superhighway, that communication that's bidirectional, we really depend upon to get the job done as humans living together on this planet.
0
SPEAKER_00
When that is compromised, for any number of reasons,
0
SPEAKER_00
 We don't have that ability, and we're locked into that other mentality, clearly a mentality that's based on a reptilian brain.
0
SPEAKER_00
That is feasting, it's fear-based, and reproduction, basically that's it.
0
SPEAKER_00
It's all about my needs.
0
SPEAKER_00
What I want.
0
SPEAKER_00
What I want, and right now.
0
SPEAKER_00
 That's the amygdala.
0
SPEAKER_00
Yeah, and what threatens this disconnection, one of the most powerful threats, is the process of inflammation.
0
SPEAKER_00
And that takes us back to your question.
0
SPEAKER_00
The foods we eat which fan the flames of inflammation by disrupting our metabolism,
0
SPEAKER_00
 separate us from the input of the adult in the room, and lock us in.
0
SPEAKER_00
And it's a feed-forward cycle, meaning that the more that you've locked out the prefrontal cortex, the worse decisions you make, as it relates, for example, to the foods you eat.
0
SPEAKER_00
You continue to eat those bad foods, inflammation is augmented.
0
SPEAKER_00
You keep making bad choices in your life.
0
SPEAKER_00
You bet, you're locked in.
0
SPEAKER_00
You're reactive.
0
SPEAKER_00
You spiral down, and now you're in a... So how do you get out of that?
0
SPEAKER_00
 Well, so we offered up, what are the off ramps?
0
SPEAKER_00
A whole program based upon what you can do to choose to meditate for a few minutes a day.
0
SPEAKER_00
We'll expand that with time, getting out in nature, getting enough restorative sleep, perhaps
0
SPEAKER_00
 being a little bit more proactive about following your blood sugar.
0
SPEAKER_00
In that book, we didn't talk about continuous glucose monitoring.
0
SPEAKER_00
We have a whole section in this book about that.
0
SPEAKER_00
But talked about those foods, if you could give us one week, we're gonna help you redirect.
0
SPEAKER_00
So in Brainwash, you have a couple chapters on narcissism specifically?
0
SPEAKER_00
Well, actually, when you really read the book, you're gonna realize that it's throughout the book.
0
SPEAKER_00
It's a commentary about where we are
0
SPEAKER_00
 how we got there and what you can do now to get us away from that.
0
SPEAKER_02
I mean, with social media and using, I think everything's a tool.
0
SPEAKER_02
I think everything's a tool.
0
SPEAKER_02
You can use social media to benefit people or you can use social media to benefit yourself with this selfie culture, right?
0
SPEAKER_02
Of me, me, me, look at me, me, me.
0
SPEAKER_02
And I'm curious how that plays in with
0
SPEAKER_02
 are eating habits and nutrition habits based on, I guess, the psychological seeing yourself all the time and getting attention for how you look all the time on social media from random strangers, as opposed to when you just used to walk out in the street and get attention, but now it's just like, in a moment, you can get this dopamine hit.
0
SPEAKER_00
The original term for that was Snapchat dysmorphia.
0
SPEAKER_00
 where you had to cultivate your social media appearance, not so much your real appearance of what people will experience face-to-face in terms of not just what you look like, but what do you got underneath it, which is truly what matters, right?
0
SPEAKER_00
It's really less about what you look like.
0
SPEAKER_00
It's about what you portray, how you interact,
0
SPEAKER_00
 What is your message?
0
SPEAKER_00
What is the message?
0
SPEAKER_00
What is your contribution?
0
SPEAKER_00
That's what, to me, I think really seems to matter.
0
SPEAKER_00
But, you know, that stuff is so underrated now.
0
SPEAKER_00
It's all about what you look like.
0
SPEAKER_00
And it has to be within the first three or four seconds, and that's end of story.
0
SPEAKER_02
 So in Brainwash, you're talking about social media, narcissism, and all these different things.
0
SPEAKER_02
How are those affecting us in what we choose to eat as well?
0
SPEAKER_02
Is it part of the cycle when we get these dopamine hits for looking good or our social media?
0
SPEAKER_02
Do we then choose to eat certain foods from that?
0
SPEAKER_00
Or what is that?
0
SPEAKER_00
No, I think that's an excellent question.
0
SPEAKER_00
I think that the answer is no, because I think
0
SPEAKER_00
 We either eat what we want to eat, or we eat what we know is good for us.
0
SPEAKER_00
Now, what we want to eat, what's deep in our brains, is sugar.
0
SPEAKER_00
So we are deeply programmed.
0
SPEAKER_00
Every person walking in the plant, you're laughing because you know exactly what I'm talking about.
0
SPEAKER_00
That's my vice.
0
SPEAKER_02
Of course it is.
0
SPEAKER_02
I've never been drunk in my life.
0
SPEAKER_02
I don't drink alcohol.
0
SPEAKER_02
I don't smoke.
0
SPEAKER_02
I don't do drugs.
0
SPEAKER_02
 but sugar is a thing that, when I'm disciplined, I can be completely off of it.
0
SPEAKER_02
When the prefrontal cortex is in the driver's seat, when the adult is in the room.
0
SPEAKER_02
But when I'm not disciplined, I can just be like, oh, let's just eat as much as you want.
0
SPEAKER_02
So it's always been an opportunity for growth for me, let's say, where there's seasons of life where I'm extremely clean and other seasons where it's like, eh, you know, just have as much as you want.
0
SPEAKER_02
 And it always affects me.
0
SPEAKER_02
What are the main risks of sugar in the first place?
0
SPEAKER_02
And why should we be aware of it before figuring out how to get it under control?
0
SPEAKER_00
 Well, let me go back to just the notion of your sugar desire.
0
SPEAKER_00
You are like, I would say, seven plus billion people, meaning it's what led us survive, our desire for Sweet.
0
SPEAKER_00
We're deeply programmed.
0
SPEAKER_00
It's not learned.
0
SPEAKER_00
It's not an app that we picked up along the way.
0
SPEAKER_00
It came when you bought that computer.
0
SPEAKER_00
It was built into the hard drive that we will seek out Sweet.
0
SPEAKER_00
Why?
0
SPEAKER_00
Because Sweet,
0
SPEAKER_00
 tells us that a food is safe.
0
SPEAKER_00
It tells us that it is ripe, meaning highest in nutrients.
0
SPEAKER_00
It's good for the fruit because that's when the seeds of that fruit need to be dispersed.
0
SPEAKER_00
So everything works together.
0
SPEAKER_00
But it also tells us that winter's coming.
0
SPEAKER_00
 which means it tells our bodies to shift metabolism and start making and storing fat.
0
SPEAKER_00
And it turns out that the danger signal that winter's coming, the signal that tells your body to make that happen involves uric acid.
0
SPEAKER_00
And this is something that happened to our ancestors around 14 to 17 million years ago when the earth became cool.
0
SPEAKER_00
 And certain primates who developed mutations in the genes that dealt with an enzyme called uric case that breaks down uric acid, they developed mutations that turned that enzyme off.
0
SPEAKER_00
So they couldn't break down uric acid.
0
SPEAKER_00
So uric acid levels would elevate.
0
SPEAKER_00
They survived.
0
SPEAKER_00
 Not that they got fat, but they stored just a little bit more fat, so they might survive, whereas the other primate might not, and then they would pass the genes on.
0
SPEAKER_00
And that comes to us.
0
SPEAKER_00
That's why we make fat when we're exposed, for example, to fructose.
0
SPEAKER_00
It was a powerful survival mechanism, and we carry it today.
0
SPEAKER_00
 The problem is now fructose is everywhere, in every food we eat, so we're suffering from this evolutionary environmental mismatch.
0
SPEAKER_00
I mean, that's the premise of the Paleo movement.
0
SPEAKER_00
Let's try to emulate an environment that our Paleolithic ancestors must have experienced in terms of lifestyle, exercise, activity, and certainly food and sleep.
0
SPEAKER_00
 So, it's not that the gene is necessarily bad, it's the context of today bombarding that gene pathway with the signal that says, you better make fat and make it fast because winter's coming and you need to be ready.
0
SPEAKER_00
You need to lay down some fat.
0
SPEAKER_00
 You need to raise your blood sugar to power your brain because there's not going to be any food.
0
SPEAKER_00
You need your brain so that you can forage and find some food.
0
SPEAKER_00
That's our ace in the hole.
0
SPEAKER_00
That's our high card.
0
SPEAKER_00
So that's why there's all this excitement then about the relationship between fructose, the downstream metabolite, which is uric acid, making more sugar, making more fat, and really a central player in our metabolic mayhem.
0
SPEAKER_00
And how much does sugar affect the brain?
0
SPEAKER_00
 Well, the brain does run on a form of sugar called glucose.
0
SPEAKER_00
There is even some suggestion that the brain can metabolize a small amount of fructose.
0
SPEAKER_00
That's really kind of recent data.
0
SPEAKER_00
But the brain is not tolerant to any significant degree of disruption of our metabolism.
0
SPEAKER_00
This is what I call metabolic mayhem.
0
SPEAKER_00
Because this disturbance of our metabolism sets the stage then for inflammation.
0
SPEAKER_00
 And that is the underlying cornerstone of brain degeneration.
0
SPEAKER_00
Alzheimer's is an inflammatory disease, like coronary artery disease, type 2 diabetes, obesity.
0
SPEAKER_00
These are inflammatory conditions.
0
SPEAKER_00
So Alzheimer's is very much the brain on fire, which is what the word inflammation means, to be on fire.
0
SPEAKER_00
 So we've got to do everything we can to put the fire out as an intervention.
0
SPEAKER_00
And to prevent it as well, so it doesn't get there.
0
SPEAKER_02
Have there been cases, not to go off topic here, but have there been cases of people with... We're deep into the woods, we're good.
0
SPEAKER_02
Have there been cases where people have had Alzheimer's that have reversed it?
0
SPEAKER_02
Is that possible yet?
0
SPEAKER_00
Yes.
0
SPEAKER_02
 Really?
0
SPEAKER_00
There are.
0
SPEAKER_00
There are books written about it.
0
SPEAKER_00
In fact, I wrote the foreword to a book by Dr. Dale Bredesen, who is here in L.A.
0
SPEAKER_00
at UCLA.
0
SPEAKER_00
And he has reversed it now in over 100 patients.
0
SPEAKER_00
Come on.
0
SPEAKER_00
Oh, absolutely.
0
SPEAKER_00
Early stage, or is this like... Early to moderate, yeah.
0
SPEAKER_00
 Wow.
0
SPEAKER_00
Yeah, he's gotten people back to work.
0
SPEAKER_00
So we live in a world, Western medicine, of monotherapy.
0
SPEAKER_00
And we're going to create a magic pill for you that will take your diabetes away, for example.
0
SPEAKER_00
 I was giving a talk in New Jersey to 500 mainstream doctors.
0
SPEAKER_00
Why they chose me, I don't know.
0
SPEAKER_00
But I said, how do you treat diabetes?
0
SPEAKER_00
And people would raise their hands and say, oh, I use such and such a drug.
0
SPEAKER_00
I use this or that.
0
SPEAKER_00
And then I said, well, what happens when you stop using that medication?
0
SPEAKER_00
And they said, well, within a day or two, the blood sugars go up.
0
SPEAKER_00
So I asked the question, did you really treat the diabetes?
0
SPEAKER_00
 And then I presented data from a Dr. Sarah Hallberg where using a ketogenic diet reestablishes insulin sensitivity and people don't need medication.
0
SPEAKER_00
Published research, that's treatment.
0
SPEAKER_00
So again, we're not treating diabetes with the drug and we don't have a drug for Alzheimer's, doesn't exist.
0
SPEAKER_00
I wish there were such a thing.
0
SPEAKER_00
We know what happened with this Adduhelm drug that was put out in February of this past year.
0
SPEAKER_00
 And finally, mainstream neurology said, you know what, this isn't working, and challenges the notion that this accumulation of beta-amyloid is the cause of Alzheimer's.
0
SPEAKER_00
Getting back to Dr. Bredesen, he's identified 36 different inputs that can affect the brain in different ways.
0
SPEAKER_00
 and identifies in each patient what is disrupted.
0
SPEAKER_00
Is it brain energetics, meaning the brain's inability to use glucose as a fuel?
0
SPEAKER_00
Is it inflammation?
0
SPEAKER_00
Is it toxic?
0
SPEAKER_00
Is it infectious?
0
SPEAKER_00
Is it previous trauma?
0
SPEAKER_00
What is going on in the brain?
0
SPEAKER_00
Let's work on that.
0
SPEAKER_00
Rather than one size fits all, you're gonna take this pill and lo and behold, you're gonna get better.
0
SPEAKER_00
 So it's a paradigm shift, and I was, in the intro to his book, or the forward, I said, you know, this is on par with washing your hands before delivering a baby.
0
SPEAKER_00
You know, it's that big of a deal.
0
SPEAKER_02
What would you say, based on all the research you've done, and also with these other doctors you've worked with, would be the three or four or five key things to eliminate or to do to prevent Alzheimer's, or to start reversing it in the early stages?
0
SPEAKER_00
 So, again, I think the most important thing is to realize that it begins a lot earlier than you think.
0
SPEAKER_00
How early?
0
SPEAKER_00
30 years before clinical symptoms, at least.
0
SPEAKER_00
That's what our peer-reviewed literature is telling us.
0
SPEAKER_00
And I'll tell you why.
0
SPEAKER_00
Because a study that appeared in the journal Neurology
0
SPEAKER_00
 looked at, created what's called an inflammatory composite score, and they looked at people, they did blood work, and they created a marker of their level of inflammation, and then they went back and evaluated them 28 years later, and they perfectly correlated who got Alzheimer's with how high their inflammation score was 28 years before.
0
SPEAKER_00
Oh my gosh.
0
SPEAKER_00
Now we've seen the same thing with waist circumference.
0
SPEAKER_00
 Three decades.
0
SPEAKER_00
We've seen the same thing with brain scans that look at glucose utilization are predictive Long before people began to forget their grandchildren's names So the point is when does it begin?
0
SPEAKER_00
Does it begin in the 30s and I would submit it begins a lot earlier that when we see adolescents now that are diabetic that are obese and support significantly overweight and
0
SPEAKER_00
 When we see teenagers in high school experiencing head trauma from contact sports, these are issues that are profound.
0
SPEAKER_00
We know that inflammation, the set point of inflammation, to some degree is determined before a child is even born, based upon the gut bacteria of the mother.
0
SPEAKER_00
 and we know that, for example, how a child is even born, vaginal birth versus cesarean birth plays a huge role in determining that child's level of inflammation, immune function, risk for autoimmunity, and even risk for obesity later in life.
0
SPEAKER_00
Based on how they're delivered.
0
SPEAKER_00
How they're delivered.
0
SPEAKER_00
If a child is born by C-section, doesn't pass through the vaginal birth canal, doesn't get those bacteria that are there
0
SPEAKER_00
 to anoint that child.
0
SPEAKER_00
Passing through the birth canal puts bacteria in the mouth and the nose and the eyes throughout the body of that child that then are the seeds to create that microbiome for that living being.
0
SPEAKER_00
Wow.
0
SPEAKER_00
As opposed to picking up bacteria in the operating room because mom had to have a c-section.
0
SPEAKER_00
 There is a time and a place for a C-section, but a third of American births are C-section right now.
0
SPEAKER_02
So you're saying if there's like, this is an extreme complication, we've got to do a C-section, that's when you say, hey, we want everyone safe.
0
SPEAKER_00
The umbilical cords wrapped around the child's neck, whatever it might be.
0
SPEAKER_00
 as a matter of convenience or not wanting to, whatever.
0
SPEAKER_00
Not dealing with a certain amount of pain or whatever it is, yeah.
0
SPEAKER_00
And I think that the narrative that's given to mother and father to be is, you know, you can either deliver or we'll do a C-section, let's say Thursday at 11 a.m., how does that?
0
SPEAKER_00
 How does that work for your schedule?
0
SPEAKER_00
Yeah, and how big will my scar be?
0
SPEAKER_00
Well, we need to have a discussion that C-section delivery has lifelong implications for your child.
0
SPEAKER_00
Significant increased risk for autoimmune conditions like type 1 diabetes, for autism, for celiac disease, all increased in kids born via C-section.
0
SPEAKER_00
And that's published literature.
0
SPEAKER_02
Is there a way to, let's say there was an extreme complication
0
SPEAKER_02
 There was gonna be an issue if there was not a C-section for whatever reason.
0
SPEAKER_02
Is there a way to get that bacteria into the child, that healthy bacteria?
0
SPEAKER_02
I'm asking, I don't know.
0
SPEAKER_02
Is there a way to do that?
0
SPEAKER_02
Is there a way to, I have no idea.
0
SPEAKER_00
In fact, it's a wonderful question.
0
SPEAKER_00
I like where you're thinking.
0
SPEAKER_00
So if you were a research clinician, you'd fall asleep tonight thinking, what could we do?
0
SPEAKER_00
The child should get this,
0
SPEAKER_00
 a ray of bacteria from passing through the birth canal, but they're bypassing that.
0
SPEAKER_00
What can we do?
0
SPEAKER_00
So... Go ahead.
0
SPEAKER_00
I was thinking, well, let's inject them with something.
0
SPEAKER_00
Close.
0
SPEAKER_00
So here's what the research at NYU has looked at, and that is taking a cotton swab, swabbing the vaginal canal, and then when the baby's born, covering their face with it.
0
SPEAKER_00
So that's already being done.
0
SPEAKER_00
Does that work?
0
SPEAKER_00
 It's in the early stages of, you know, people want to play it out for a few years and see what it does.
0
SPEAKER_00
But that's exactly what's going on.
0
SPEAKER_00
Right, right, yeah.
0
SPEAKER_00
Swab it around and put it on their whole body.
0
SPEAKER_00
You bet.
0
SPEAKER_00
Put it in their mouth a little bit.
0
SPEAKER_00
Exactly.
0
SPEAKER_00
In their ears, in their nose.
0
SPEAKER_02
Yeah, see if it works, I guess.
0
SPEAKER_00
And the reason they're doing this is because, you know, the gut bacteria, and in fact the microbiome in the entire body, not just in the gut,
0
SPEAKER_00
 is really central.
0
SPEAKER_00
We have this relationship with these trillions of bacteria that are involved in our mood, in our immune function, in our set point of inflammation in our bodies.
0
SPEAKER_00
It's really quite profound when we humble ourselves and recognize that our day-to-day thought process is highly influenced by the gut bacteria, the bacteria that live within us.
0
SPEAKER_00
 that the array of bacteria living within us change our gene expression moment to moment.
0
SPEAKER_00
They're changing our life code.
0
SPEAKER_00
They're altering which parts of our genes are turned on and which are turned off to suit their needs.
0
SPEAKER_00
And in turn,
0
SPEAKER_00
 They create an environment for us to be healthier or not, depending on how we treat them.
0
SPEAKER_00
When we bombard our gut bacteria with unnecessary medications, with eating the foods that destabilize them, they're not able to do their job.
0
SPEAKER_00
Our guts become leaky, we increase inflammation, and that's, as we've talked about, what we don't want to do.
0
SPEAKER_00
I'll send you a book I wrote called Brain Maker.
0
SPEAKER_00
It's all about the microbiome and the brain.
0
SPEAKER_00
Please.
0
SPEAKER_02
 What would be, this is all fascinating because I was asking about the things that we could do to prevent or start to reverse Alzheimer's and you said, well, it all goes back to actually childbirth and making sure we have the right, I guess, bacteria for the gut and the body and the brain and the immune system to be aligned so we don't have these issues later.
0
SPEAKER_02
 And you were saying it's 30 years before you can you can tell based on the the waist circumference and based on The foods you're eating and things like that.
0
SPEAKER_02
So What would you say are those?
0
SPEAKER_02
Let's talk about the things you should eliminate if you could eliminate three to five things to set yourself up for the best possible of prevention
0
SPEAKER_02
 without having head trauma and all these other things, but food, environment, you know.
0
SPEAKER_00
I wrote an article about this this morning.
0
SPEAKER_00
I got pinged by a national magazine wanting exactly this article, so I got up extra early to write it and fired it off.
0
SPEAKER_00
Crazy.
0
SPEAKER_00
But if we understand that the worst thing for the brain is chronic inflammation, anything we can do to target that is going to help.
0
SPEAKER_00
 So that's where diet comes in, a diet with lower levels of refined carbohydrates, things to add to the diet like good fat.
0
SPEAKER_00
We know that there's some all-stars out there that really are really important for brain health, like the omega-3 DHA, docosahexaenoic acid, generally from fish oil, although there's a vegetarian form of that.
0
SPEAKER_00
But I think the biggest lever that can be pulled
0
SPEAKER_00
 provided a diet is reasonable, would be aerobic exercise.
0
SPEAKER_00
So this is profound.
0
SPEAKER_00
So this is an epigenetic player.
0
SPEAKER_00
This turns on the genes that make something called BDNF, brain-derived neurotrophic factor.
0
SPEAKER_00
 which is fundamental for healing damaged neurons, but also for nurturing them, allowing them to do what they can do and should do, but also stimulates what is called synaptogenesis, where brain cells connect to each other, and even allows the human brain to grow new brain cells.
0
SPEAKER_00
Who knew?
0
SPEAKER_00
When you're doing aerobic exercise.
0
SPEAKER_00
Yes.
0
SPEAKER_02
So even if you have, let's say, not the cleanest diet, and you have some sugar here and there, maybe you have some wine or some alcohol or whatever it is,
0
SPEAKER_02
 You're saying doing consistent aerobic exercise will help defend against all those things as well.
0
SPEAKER_00
Could help.
0
SPEAKER_00
Well again, it's not that your guest today is saying that.
0
SPEAKER_00
That's what the literature shows.
0
SPEAKER_00
It's profound.
0
SPEAKER_00
So the work, the original work is done by Dr. Erickson at University of Pittsburgh.
0
SPEAKER_00
Okay.
0
SPEAKER_00
And fascinating research looking at two groups of individuals, several hundred in each group,
0
SPEAKER_00
 One group got a stretching program and one group got an aerobics program.
0
SPEAKER_00
Now I'm not knocking stretching, I mean that's very important, but the aerobics part, pushing up your heart rate, is what seems to be very important for augmenting this production of this BDNF.
0
SPEAKER_00
How long is the heart rate up for, or how long is the program, like 20, 30 minutes?
0
SPEAKER_00
It was variable, but my recommendation is minimum of 20 minutes.
0
SPEAKER_00
What should that heart rate be depends obviously on the person.
0
SPEAKER_00
I typically say,
0
SPEAKER_00
 180 minus your age as a ballpark.
0
SPEAKER_00
Now that might be too low for some people, too high for some people, but you know, that's where you use a wearable and you see where you're comfortable.
0
SPEAKER_00
I typically say you should be breathing hard, but not hard enough that you can't have a conversation with somebody.
0
SPEAKER_00
I mean, these are kind of, you know.
0
SPEAKER_00
A hard jog.
0
SPEAKER_00
Yeah, depending on what, you know, it may be walking for somebody, it may be,
0
SPEAKER_00
 You know, maybe an elliptical machine at a certain rate, who knows?
0
SPEAKER_00
But once that happens after a period of time, so this BDNF starts to get produced, and what did the study show that I'm quoting?
0
SPEAKER_00
They follow these people for a year.
0
SPEAKER_00
Those who
1
SPEAKER_01
 who did the aerobics had, instead of declining size of their brain's memory center, called the hippocampus, it actually increased during the course of one year.
1
SPEAKER_01
I mean, we expect everything's gonna be on the skids, but here it actually increased and memory function improved.
1
SPEAKER_01
It is a wow.
1
SPEAKER_01
I mean, that's not supposed to happen.
1
SPEAKER_01
Is that daily?
1
SPEAKER_01
Is that three times a week?
1
SPEAKER_01
What is that?
1
SPEAKER_01
This was five days a week.
1
SPEAKER_01
Five days a week.
1
SPEAKER_01
 But interestingly, in 2017, in the journal Neurology, the Green Journal Neurology, which is put out by the American Academy of Neurology, they're the group that says that you're a board-certified neurologist.
1
SPEAKER_01
So it's our most revered neurology journal.
1
SPEAKER_01
 They had a practice guidelines section asking the question, what does science validate us being able to recommend for patients who have what's called MCI, mild cognitive impairment?
1
SPEAKER_01
 That is one step beyond what's called subjective cognitive impairment.
1
SPEAKER_01
Subjective cognitive impairment is, you know, I can't remember the Wi-Fi code or whatever, the gate code, you know, I can't remember where I put my phone.
1
SPEAKER_01
Who does that, right?
1
SPEAKER_01
That's why Apple now makes those things, right?
1
SPEAKER_01
Anyway, that's subjective.
1
SPEAKER_01
 You go to the doctor's office and they administer a test and everything's okay.
1
SPEAKER_01
So you just have subjective issues, senior moments, if you will.
1
SPEAKER_01
Mild cognitive impairment means you've gone to the doctor's office, they test you, and you're already showing some areas that are not dementia-like, but they're not, on the other hand, normal.
1
SPEAKER_01
So you're starting to decline, and that's when
1
SPEAKER_01
 the intervention needs to happen.
1
SPEAKER_01
So the question that was asked in general, what can we recommend?
1
SPEAKER_01
They went through, I think, 14 different interventions.
1
SPEAKER_01
This drug, that drug, you know, the approved drugs for Alzheimer's.
1
SPEAKER_01
They made one recommendation.
1
SPEAKER_01
They said only one thing
1
SPEAKER_01
 This is a mainstream journal.
1
SPEAKER_01
There's only one thing that has any scientific support that you can recommend for your patient, and it's a drug called exercise.
1
SPEAKER_01
They said that's the only thing that stands the test of scrutiny that can actually slow the decline in patients who've established mild cognitive impairment.
1
SPEAKER_01
That's where that new drug, Aduhelm,
1
SPEAKER_01
 was targeting patients with mild cognitive impairment and it failed.
1
SPEAKER_01
So yet how many neurologists will say you've got to exercise?
1
SPEAKER_01
Where's the ad on television saying, you know, I'm glad my dad is taking this drug or that drug because he has Alzheimer's.
1
SPEAKER_01
 But the drugs aren't working.
1
SPEAKER_01
We've got to recommend lifestyle changes.
1
SPEAKER_01
Get enough sleep.
1
SPEAKER_01
Sleep issues are related to profound increased risk for Alzheimer's for a number of reasons, including increasing inflammation, including problems with increasing blood sugar, and dramatically increasing your risk for type 2 diabetes just because you're not sleeping well.
1
SPEAKER_01
If you get type 2 diabetes, you have quadrupled your risk
1
SPEAKER_01
 for becoming an Alzheimer's patient, a disease for which there is no simple treatment.
1
SPEAKER_01
So we've got to focus on metabolism.
1
SPEAKER_01
We've got to keep people from becoming diabetic.
1
SPEAKER_01
We've got to get the willies when we know that the prediction is that by 2030,
1
SPEAKER_01
 50% of American adults will be obese.
1
SPEAKER_01
2030 is eight years from now.
1
SPEAKER_01
You used to think, oh 2030, the glaciers are melting, that's sometime in the distant future, thank you Al Gore.
1
SPEAKER_01
It's eight years from now.
1
SPEAKER_01
Think about that.
1
SPEAKER_00
So they're predicting 50% of the US population will be obese?
1
SPEAKER_00
Adults.
1
SPEAKER_01
It's already one third of American adults that have high blood pressure.
1
SPEAKER_01
It's already 10% of children between the ages of 12 and 18 that have high blood pressure, that require medication.
1
SPEAKER_01
 What was it like 30 years ago?
1
SPEAKER_01
Things were better, but that's just about when things change.
1
SPEAKER_01
And what happened?
1
SPEAKER_01
 What happened was we were all told, not just doctors, but the lay population as well, that fat was the enemy, right?
1
SPEAKER_01
Low fat, everything.
1
SPEAKER_00
Low fat Oreos.
1
SPEAKER_01
Low fat Oreos with that white stuff in the middle that we all loved, right?
1
SPEAKER_01
Who wouldn't?
1
SPEAKER_01
And what happened was because we all went fat free or low fat as best we could, there was far more carbohydrates and simple carbohydrates in the diet.
1
SPEAKER_01
Sugar consumption skyrocketed.
1
SPEAKER_01
 So between 1970 and 1990, fructose consumption went up 1,000%.
1
SPEAKER_01
Now, fructose was looked upon as being a safer sugar than table sugar, per se, or certainly than glucose, because fructose in its metabolism doesn't require insulin, doesn't mess with the insulin issue.
1
SPEAKER_01
So it was looked upon, it was even recommended by the American Diabetes Association.
1
SPEAKER_01
 And yet, fructose consumption directly leads to insulin resistance.
1
SPEAKER_01
That's the harbinger for future diabetes.
1
SPEAKER_01
So, it is about the worst sugar we could be consuming.
1
SPEAKER_01
And yet, we're consuming it left, right, and center these days.
1
SPEAKER_00
 Wait a minute, so the American Diabetes Association, is that what you said?
1
SPEAKER_00
Said fructose.
1
SPEAKER_00
They recommended that fructose was a way to prevent type 2 diabetes?
1
SPEAKER_00
No, that if you needed a sweetener, fructose is a better choice.
1
SPEAKER_01
In other words, high fructose corn syrup, which is 55% fructose and only 42% glucose.
1
SPEAKER_01
 was the problem, right?
1
SPEAKER_01
Your blood glucose goes up with diabetes, so we've got to limit that.
1
SPEAKER_01
Eat more fructose.
1
SPEAKER_01
Bad idea.
1
SPEAKER_01
Bad recommendation.
1
SPEAKER_01
So our government to this day supports the growth of corn to make fructose to the tune of $500 billion a year.
1
SPEAKER_01
And our USDA food nutrition recommendations that are issued every five years have continued to say, when they were just released,
1
SPEAKER_01
 last year that we can get up to 10% of our calories per day from sugar.
1
SPEAKER_01
Despite the fact that over 99% of the scientists who weighed in and gave the USDA information said, that's way too much.
1
SPEAKER_01
So I wrote, along with another doctor, an open letter in Medpage to President Biden saying, look,
1
SPEAKER_01
 That's not what the science is telling us.
1
SPEAKER_01
It's going to break the bank to take care of these people with the obesity, the diabetes, the hypertension, the dyslipidemia, and all the downstream issues, the coronary heart disease, the Alzheimer's, the cancer, and again type 2 diabetes.
1
SPEAKER_01
 are the consequences of these dietary recommendations.
1
SPEAKER_01
We've got to rein in our sugar consumption, and we all have a sweet tooth, and it's good business to sell a lot of sugar.
1
SPEAKER_01
Close to 70% of the prepackaged, the labeled foods, or the ones that carry a barcode,
1
SPEAKER_01
 Of the two million foods sold in America's grocery stores have added sweetener and by and large It's high fructose corn syrup.
1
SPEAKER_01
It's super sweet and it's really cheap.
1
SPEAKER_01
It's good.
1
SPEAKER_01
It's cheap.
1
SPEAKER_01
Yeah, it's great and less filling It's less filling it doesn't which means you keep eating more and more exactly so up so fructose
1
SPEAKER_01
 as a survival mechanism for our ancestors, didn't tell them to stop eating.
1
SPEAKER_01
In fact, it played with this satiety hormone called leptin, and blocked how leptin works in the brain.
1
SPEAKER_01
So we would eat, and then want to eat some more, and then keep eating.
1
SPEAKER_00
Why?
1
SPEAKER_01
You bet, we would survive.
1
SPEAKER_01
But now it's making us sick.
1
SPEAKER_01
It's very much making us sick, and we're supporting it, and
1
SPEAKER_01
 It's, you know, clarion cries from a few of us out there, you know, the Robert Lustigs, the Gary Taubes, you know, those of us who are really recognizing what is going on here at that, you know, the sweetening of our foods and the sense that it's natural.
1
SPEAKER_01
Did you used to eat a lot of sugar yourself?
1
SPEAKER_01
 Growing up or as an adult?
1
SPEAKER_01
I think as a kid, we always had soda.
1
SPEAKER_01
Yeah.
1
SPEAKER_01
We had black cherry soda.
1
SPEAKER_01
And so we drank a lot of that.
1
SPEAKER_01
That would be the primary source.
1
SPEAKER_01
And we did drink a lot of orange juice growing up in Florida.
1
SPEAKER_01
So that's about the worst thing you could do.
1
SPEAKER_01
It's just such a high load quickly of fructose in your system.
1
SPEAKER_01
So I said from that perspective, yes.
1
SPEAKER_00
 But you weren't big on sweets and candy and cakes and cookies.
1
SPEAKER_01
I would say no more than anybody else.
1
SPEAKER_01
Yeah.
1
SPEAKER_01
Do I still want it and desire it?
1
SPEAKER_01
Absolutely.
1
SPEAKER_00
Really?
1
SPEAKER_01
Oh, yeah.
1
SPEAKER_00
How do you manage it?
1
SPEAKER_00
Do you have it some?
1
SPEAKER_00
Do you have it seasonally?
1
SPEAKER_01
I definitely eat some fruit.
1
SPEAKER_01
I can't tell you when I had a glass of juice.
1
SPEAKER_01
It's not even in my memory anymore.
1
SPEAKER_01
I will say that I had some gingerbread.
1
SPEAKER_01
 and loved every bit of it.
1
SPEAKER_01
I don't have much sugar contained recently, but it's generally off the table for me.
1
SPEAKER_01
I mean, I don't want to become diabetic.
1
SPEAKER_01
My father died of Alzheimer's.
1
SPEAKER_01
I have a continuous glucose monitor.
1
SPEAKER_01
I know darn well, moment to moment, what my foods are doing to me, and I'm keeping my blood sugar under control.
1
SPEAKER_00
You have a monitor on your- I'm traveling right now, so I don't have it on.
1
SPEAKER_00
Okay, I got you, but you usually have it on your shoulder.
1
SPEAKER_00
Left shoulder, yeah.
1
SPEAKER_00
I usually have it right here, CGM.
1
SPEAKER_01
 And so you check.
1
SPEAKER_01
Oh, you need to get that.
1
SPEAKER_01
We'll get you set.
1
SPEAKER_00
Really?
1
SPEAKER_00
Oh, absolutely.
1
SPEAKER_00
I know like Asprey and all these other guys have them, and Sergei Young and all these people, and I'm like, ah, do I want this in my body?
1
SPEAKER_00
Do you feel it a lot?
1
SPEAKER_00
No.
1
SPEAKER_00
Is it, it's not painful?
1
SPEAKER_01
So this is not a needle in your body.
1
SPEAKER_00
Oh, okay, what is it?
1
SPEAKER_01
It's measuring it in what's called the interstitial fluid, which is right in the top layer of your skin.
1
SPEAKER_01
Oh, okay.
1
SPEAKER_01
You put the patch on, you don't know.
1
SPEAKER_01
It's not the bulky plastic thing, or is it like a?
1
SPEAKER_01
No, it's a tiny little patch, but then you put a patch over it to keep it there, that way you can get it wet and you can shower.
1
SPEAKER_01
 Wow.
1
SPEAKER_01
In fact, I think I arranged Sergei to get his.
1
SPEAKER_00
Really?
1
SPEAKER_00
Oh, yeah.
1
SPEAKER_00
OK, cool.
1
SPEAKER_00
Yeah, we had Sergei on here as well.
1
SPEAKER_00
So what does that do for you to know?
1
SPEAKER_01
It tells Louis specifically what foods will make you.
1
SPEAKER_01
 And then you have to tell me, not only are you gonna post it, but you'll become a part of the tribe that's monitoring your blood sugar level.
1
SPEAKER_01
And you've mentioned people that you probably respect.
1
SPEAKER_01
They're both close friends of mine, I respect them both.
1
SPEAKER_01
And what's really valuable is they know how important this is.
1
SPEAKER_01
 So there's a Dr. Casey Means, who I'm hoping you get on your program.
1
SPEAKER_01
I'm gonna have dinner with her on Saturday night.
1
SPEAKER_01
And she is the founder of a company called Levels.
1
SPEAKER_01
And Levels is the software for understanding what this CGM, Continuous Glucose Monitor, is telling you.
1
SPEAKER_01
 How important is CGM?
1
SPEAKER_01
It's so important that I put it in the new book, actually.
1
SPEAKER_01
I put a whole chapter.
1
SPEAKER_01
Actually, Casey Means helped create that chapter.
1
SPEAKER_01
It's really important.
1
SPEAKER_01
And, you know, moving forward, there may well be a day when that same patch is going to give you other information, like your uric acid levels, so you can know how the foods you're eating are affecting uric acid, because it's equally valuable.
1
SPEAKER_00
 So, you kind of shifted your identity to just saying like juice and certain sugary foods are off the table.
1
SPEAKER_00
You're not even like tempted.
1
SPEAKER_00
You might be tempted, but you're like, there's no chance I will have this.
1
SPEAKER_01
Professionally and personally, I've seen what Alzheimer's does.
1
SPEAKER_01
 And that's the big threat for me.
1
SPEAKER_01
I mean, I have a family history of it, so I'm at increased risk.
1
SPEAKER_01
Generally, not as much risk it would have been if my mother would have had Alzheimer's.
1
SPEAKER_01
It would have been a much greater risk.
1
SPEAKER_01
And I don't carry one of the risk markers called the APO4 allele.
1
SPEAKER_01
I don't carry that.
1
SPEAKER_01
 But, is to say, that is an allele of predisposition, not determinant.
1
SPEAKER_01
It doesn't mean if you have APOE4 or you have two APOE4s that you're definitely going to get it.
1
SPEAKER_01
Your risk is increased dramatically as much as 12-fold if you have both 4 and 4.
1
SPEAKER_01
 But again, in that situation, you do everything you can to chart your destiny, change your destiny, and say that the APOE4 allele works in concert with other things over which you do have control.
1
SPEAKER_01
You don't have control over your genetic legacy.
1
SPEAKER_01
It's a gift from all of those who came before.
1
SPEAKER_01
And there may be some upside to carrying the APOE4 allele.
1
SPEAKER_01
If there weren't, then why would it persist?
1
SPEAKER_01
If it was always a bad thing,
1
SPEAKER_01
 then why would it still be present in our population?
1
SPEAKER_01
To the extent some populations, 20-30% of the population carries at least one APOE4 allele.
1
SPEAKER_01
It's got to do something positive.
1
SPEAKER_01
Maybe not in today's world, but maybe
1
SPEAKER_01
 you know, in our Paleolithic ancestors, or even more recently, it was protective, maybe because it has a role to play in inflammation, which can be a good thing.
1
SPEAKER_01
Inflammation can be life-saving.
1
SPEAKER_01
But excessive inflammation.
1
SPEAKER_01
Chronic inflammation.
1
SPEAKER_01
Chronic or acute severe inflammation.
1
SPEAKER_01
In COVID, there's something called, you know, this storm, the cytokine storm, where the body is basically on fire from these inflammatory chemicals that destroys tissue, the lungs, the heart, the brain.
1
SPEAKER_01
 But we have to consider a notion of another term, the cytokine drizzle, where you have just a slight uptick of these cytokines floating around your body all the time.
1
SPEAKER_01
The Grand Canyon wasn't formed by one huge flood, cytokine storm, it's that slow river going through it for hundreds of thousands of years, and look what you get.
1
SPEAKER_01
So we've gotta rein in inflammation through our diets, through conscious awareness of the role of our gut bacteria.
1
SPEAKER_01
 keeping in mind the notion of gut permeability or leakiness, how lack of sleep augments inflammation, all of these things.
1
SPEAKER_01
And I don't want this to sound too compelling, right?
1
SPEAKER_01
I mean, you've talked to really wonderful people whose focus has been reining in inflammation, whether it's getting into really cold water, or doing the things Sergei Young talks about, and certainly you've talked a lot about diet and how important that is.
1
SPEAKER_01
 Diet is more than just macro and micronutrients.
1
SPEAKER_01
It's information.
1
SPEAKER_01
The foods that you eat are speaking right now to your DNA, changing your gene expression.
1
SPEAKER_01
That's heady.
1
SPEAKER_01
I mean, when I was in medical school, DNA was locked in a glass case, and it determined everything about you.
1
SPEAKER_01
 what your body would be like, what you'd be allergic to, you know, your destiny was there.
1
SPEAKER_01
And now we know that we interact with our DNA aggressively that, you know, more than 90% of the genes that code for health and longevity are under our control to some degree based upon what we choose to do.
1
SPEAKER_01
I mean the moment you
1
SPEAKER_01
 want to binge watch something and you stay up really late to watch the twelfth episode of Suits or whatever it is, and you didn't get up, you had to get up in the morning, and you're not right, that changes gene expression.
1
SPEAKER_01
Obviously not for the better.
1
SPEAKER_01
It does other things.
1
SPEAKER_01
It increases your body's production of cortisol, a stress hormone.
1
SPEAKER_01
That's toxic to your hippocampal neurons.
1
SPEAKER_01
 You know increasing inflammation decreasing your ability to detoxify So much of what's around us and yet we have the data we can use our prefrontal cortex to say Maybe that wasn't a good idea.
1
SPEAKER_02
Mm-hmm.
1
SPEAKER_01
And no one is perfect.
1
SPEAKER_01
I mean No one can be perfect because no one fully understands the exact pro to a pro program through for them Through what is called personalized medicine.
1
SPEAKER_01
That would be the right thing for you for me, you know, what's right for me
1
SPEAKER_01
 at my age, in my body type, based upon my previous experiences, is clearly gonna be different from what would be best for you.
1
SPEAKER_01
That said, there are the broad strokes, which, you know, we can challenge, and I know 10 years from now, when I come back on your podcast, we may have a different story.
1
SPEAKER_01
And that's a good thing.
1
SPEAKER_01
Oh, yeah.
1
SPEAKER_01
I mean, I was parroting the low-fat narrative 30 years ago.
1
SPEAKER_01
Oh, yeah, absolutely.
1
SPEAKER_00
What do you think will change in 10 years?
1
SPEAKER_00
 based on historical evidence, based on trends, based on the new science and research that's coming out?
1
SPEAKER_01
 You know, the exciting thing for me is something called genetic reprogramming.
1
SPEAKER_01
And I think you mentioned that you've interviewed David Sinclair.
1
SPEAKER_01
Yep, yep, Dr. Jason Fung, Sinclair, and you know, all that.
1
SPEAKER_01
Yeah, so that's what his research is all about.
1
SPEAKER_01
It's the ability that is being developed to revert cells back to a more primitive, less defined phenotype, or how they look.
1
SPEAKER_01
 and then allow them to start over again.
1
SPEAKER_01
And he is demonstrating it in rodents where he has crushed their optic nerve.
1
SPEAKER_01
 and then uses this technique of genetic reprogramming, and they regain their vision.
1
SPEAKER_01
That's crazy.
1
SPEAKER_01
It is crazy.
1
SPEAKER_01
But until that time, I think looking at how we're understanding this epigenetic control that we have, how we can harness that to reduce inflammation,
1
SPEAKER_01
 to increase our detoxification functionality, to allow brain cells to replicate and to connect better.
1
SPEAKER_01
That's something we talked about earlier.
1
SPEAKER_01
This control over the BDNF that I mentioned via exercise is an epigenetic intervention.
1
SPEAKER_01
You're changing the epi over genetic control over that genome, that part of the genome.
1
SPEAKER_01
 that regulates our production of this chemical, brain-derived neurotrophic factor.
1
SPEAKER_01
But important that, yeah, BDNF's a player, but as a trophic hormone in the brain, but so is insulin.
1
SPEAKER_01
And everybody is talking about insulin in terms of, well, we need
1
SPEAKER_01
 Insulin and adequate amounts and functionality to keep our blood sugar in check no argument But insulin does other things in the body just because we learned about its role in blood sugar doesn't mean that's all it does Insulin like BDNF is a trophic hormone for brain neurons.
1
SPEAKER_01
So we need insulin to do its job to be around and we control how our bodies and our brains are
1
SPEAKER_01
 are able to interact with insulin based upon our lifestyle choices.
1
SPEAKER_01
So when we become insulin resistant by eating the wrong foods, not exercising, not getting enough sleep, the brain doesn't like that at all.
1
SPEAKER_01
Because fundamental to brain degeneration is what is called the bioenergetic theory, which means how do brain cells use energy?
1
SPEAKER_01
That is the most predictive measurement of brain degeneration.
1
SPEAKER_01
 We talked about earlier when we should begin thinking about the Alzheimer's Prevention Program.
1
SPEAKER_01
You can do a brain scan using what's called fluorodeoxyglucose, which is a transiently radioactive glucose, inject it into a person and do a brain scan, a PET scan.
1
SPEAKER_01
 and that will show glucose utilization in the brain.
1
SPEAKER_01
And you can see areas in the brain that are not up to speed, the temporoparietal region if you must, that are not using glucose.
1
SPEAKER_01
That predicts brain function decline two decades, three decades in the future.
1
SPEAKER_01
 even more exciting is you can now image the brain in people with ketones and demonstrate that the very same areas that are dysfunctional as it relates to their ability to use glucose, the brain neurons are perfectly fine when they're using ketones as fuel.
1
SPEAKER_01
Meaning that these neurons, it's not that they're not using glucose because they're no longer functional,
1
SPEAKER_01
 they're no longer functional because they're not using glucose.
1
SPEAKER_01
Give me another fuel and I'll come right back into the game.
1
SPEAKER_01
Put me in coach, just give me the right fuel, right?
1
SPEAKER_01
So give them ketones, the brain scan looks great.
1
SPEAKER_01
Those temporal parietal areas are now lit up and that is the reason that there's so much research looking at ketogenic diet as an intervention for Alzheimer's treatment.
1
SPEAKER_01
There's a Matthew Phillips in New Zealand
1
SPEAKER_01
 who has published reports now of improving brain functionality.
1
SPEAKER_01
With a keto diet.
1
SPEAKER_01
Ketogenic diet in Alzheimer's patients who are well along and also Parkinson's patients.
1
SPEAKER_01
Wow.
1
SPEAKER_01
Same kind of thing.
1
SPEAKER_01
That there's improvement putting patients on a keto diet in Alzheimer's patients.
1
SPEAKER_00
Who knew?
1
SPEAKER_00
Is it because of the things that are
1
SPEAKER_00
 are added in a keto diet or the things that are eliminated in a keto diet?
1
SPEAKER_01
I think it's both.
1
SPEAKER_01
But one thing I would say, this is an important point, kind of one of those bullet points, is if you're keto, and therefore you're eliminating carbs, don't eliminate fiber.
1
SPEAKER_01
So that's a huge issue because, you know, plant foods, fiber itself is a carb, right?
1
SPEAKER_01
That's what fiber is, so you don't wanna eliminate that.
1
SPEAKER_01
 So this is, you know, this groundbreaking work done by on keto and the body, keto the brain, people like Dominic D'Agostino, and then this Dr. Matthew Phillips, you know, really groundbreaking.
1
SPEAKER_01
I mean, there's a sense that, you know, in our primate and certainly Paleolithic past, when we didn't have foods, and you know, now we like to fast for a couple days, you know, we want to trigger those things, but
1
SPEAKER_01
 Our ancestors didn't necessarily choose to fast.
1
SPEAKER_00
That was what happened.
1
SPEAKER_01
They were forced to fast.
1
SPEAKER_01
Yeah, when they didn't have a grocery store nearby.
1
SPEAKER_01
And hunting and gathering didn't mean hunting down a convenience store or gathering up the Doritos.
1
SPEAKER_01
So that's what their physiologies allowed them to do, is to shift.
1
SPEAKER_01
They were metabolically flexible, which we can become easily enough.
1
SPEAKER_01
And they could shift over to ketones and power the brain and do those things.
1
SPEAKER_01
 then tap into their fat reserves quite readily and create those ATP molecules with less free radical production and survive.
1
SPEAKER_00
If someone's trying to fast now, will the metabolism change or will they keep the fat because the body's saying, well, you're not eating, so I'm going to keep the fat here and not burn it as quickly?
1
SPEAKER_01
 Actually, they'll burn the fat and they'll burn it readily once glycogen stores have been depleted.
1
SPEAKER_01
How long does that take usually?
1
SPEAKER_01
It depends, but it actually happens fairly quickly.
1
SPEAKER_01
You begin generating those ketones early on within 12 hours.
1
SPEAKER_01
 So it depends, of course, on your level of physical activity.
1
SPEAKER_01
So it's generally said that if you're a runner, around 13 miles is when glycogen stores are depleted.
1
SPEAKER_01
Then you need the sports drink or whatever it is to get more sugar.
1
SPEAKER_01
Or if you're keto adapted and metabolically flexible, then you can begin to tap into a huge resource of calories and energy.
1
SPEAKER_00
We've had a lot of fasting experts on.
1
SPEAKER_00
We just had Dr. Walter Longo on, and he was just saying,
1
SPEAKER_00
 doing a consistent 12 hours a day fast, like consistently every day is what his research suggests is the best approach.
1
SPEAKER_00
There's other people that say the 16 and 8, and there's other people that say go a 24-hour day fast.
1
SPEAKER_00
What have you seen based on
1
SPEAKER_01
 Well, I think his work is really very powerful and you know He's certainly done a lot more than simply talk about what's great for you from a metabolic perspective I mean he is deep into the role of fasting and immune function as it relates to cancer Yes, so doing some breathtaking work.
1
SPEAKER_01
So I would say that the notion of time-restricted eating perhaps more popularized by Dr. Satchin Panda is
1
SPEAKER_01
 would tend to indicate that a little bit longer in terms of the fast, and then compressing the feeding window might be a little bit more appropriate.
1
SPEAKER_01
So like a 16-8, 16 fast.
1
SPEAKER_01
There's really nothing, well I shouldn't say that, I think for some people maybe it would be, but that's more of a behavioral modification.
1
SPEAKER_01
 Because, you know, early on, let's say you do 12 and 12, you'll adapt very quickly, especially as you shift over to more fat and less carbs.
1
SPEAKER_01
Fat is incredibly satisfying in terms of hunger.
1
SPEAKER_01
And, you know, people say, well, you know, mom said breakfast is the most important meal.
1
SPEAKER_01
You shouldn't skip breakfast.
1
SPEAKER_01
I'm fine with that.
1
SPEAKER_01
I think mom was right.
1
SPEAKER_01
 But mom sort of emphasized what you had for breakfast.
1
SPEAKER_00
Yeah, don't eat some sugary cereals and some Pop-Tarts.
1
SPEAKER_01
Yeah, which we love.
1
SPEAKER_01
So maybe there were some more sweets in my youth than I'm talking to.
1
SPEAKER_01
 But it's really not just about what you eat, it's when you eat.
1
SPEAKER_01
And you say, well, I skip breakfast.
1
SPEAKER_01
Well, no you don't.
1
SPEAKER_01
Nobody on the planet skips breakfast, ever.
1
SPEAKER_01
Because we all break fast, eventually.
1
SPEAKER_01
Whether it's 40 days and 40 nights, or it's a two-day fast, or whatever it may be, we all break fast, we all end up having our break fast.
1
SPEAKER_01
 For me, that's usually one or two in the afternoon.
1
SPEAKER_01
That's when you start to eat.
1
SPEAKER_01
Yeah, that works for me.
1
SPEAKER_01
I do have coffee in the morning, so technically, Rhonda Patrick would argue that that might not be necessarily fasting.
1
SPEAKER_01
She's great.
1
SPEAKER_01
I know darn well that I'm producing ketones.
1
SPEAKER_01
I measure.
1
SPEAKER_01
I see what's going on.
1
SPEAKER_01
I check my blood sugar, so I'm getting some benefit.
1
SPEAKER_01
If I didn't have anything but water in the morning,
1
SPEAKER_01
 two things would happen.
1
SPEAKER_01
It would be a more truthful fast, but I'd be not the most pleasant.
1
SPEAKER_01
I'll tell the world I need that lift in the morning.
1
SPEAKER_01
It does great things for me.
1
SPEAKER_01
And knowing that coffee consumption is associated with reduced risk of Alzheimer's I think is a real plus.
1
SPEAKER_01
And also the fact that it lowers uric acid is also something I'm into.
1
SPEAKER_00
Rhonda, I think a week ago talked about
1
SPEAKER_00
 some new research about coffee, the benefits of coffee, which has been researched for a while, but something around, I can't remember specifically what it was based on, but she loves that research as well.
1
SPEAKER_00
And I think she's got the levels, the monitor.
1
SPEAKER_01
Oh, I think she has a level, the patch, but.
1
SPEAKER_00
Yeah, she said, when I interviewed her, she said that, I said, what's one food you would eliminate from a child's diet?
1
SPEAKER_00
 She said grapes and I go, huh interesting she goes because I My kid had like a bag of grapes and then I ate one when I had the monitor on I can remember she had a monitor here here but and she's like it just skyrocketed something her glucose levels or whatever it is and
1
SPEAKER_00
 Well, kids shouldn't be eating grapes anyway, because you'll choke on them.
1
SPEAKER_00
Right, right.
1
SPEAKER_00
But she was like sugar, Bob.
1
SPEAKER_00
So that was her recommendation.
1
SPEAKER_00
But do you think these wearables, for some people listening or watching, might be like, gosh, this is just so much to every day check something and see the levels.
1
SPEAKER_00
Can I just live a natural life and just sensibly, do I need to measure all this?
1
SPEAKER_01
I don't know what that means.
1
SPEAKER_01
Yeah.
1
SPEAKER_01
 It's back to where we started, and that is, what does that mean?
1
SPEAKER_01
More importantly, what does it mean for Louis to eat sensibly?
1
SPEAKER_01
How do you define sensible?
1
SPEAKER_01
Sensible would be a diet that's not spiking your blood sugar, as an example, or doesn't have a dramatic effect on the area under the curve of what your glucose levels are over time, more important.
1
SPEAKER_01
 I don't know what sensible is for you.
1
SPEAKER_01
I know some broad strokes that are pretty likely going to affect your blood sugar I think we all know those but Should you be compulsive about it?
1
SPEAKER_01
Yep, you should be because we you want to prevent it sooner than later Yeah, I mean we live in a world of reactive medicine and I would prefer to be proactive and preventive
1
SPEAKER_01
 Yeah, you know, there's a great quote from John Kennedy.
1
SPEAKER_01
It's that the time to fix the roof is when the sun is shining And for you know, you're in great health right now, and I want to keep it
2
SPEAKER_00
 Now's the time.
2
SPEAKER_00
I want to come back in 10 years and do the show again.
2
SPEAKER_00
Yes.
2
SPEAKER_00
And you'll be healthy still.
2
SPEAKER_00
Yeah.
2
SPEAKER_00
You've done all the right things.
2
SPEAKER_00
But how would you know?
2
SPEAKER_00
Would you know because you went to your doctor and every year she checks your blood sugar and says, well, it's okay.
2
SPEAKER_00
You're not diabetic yet.
2
SPEAKER_00
Or maybe it's trending upward.
2
SPEAKER_00
God, you need a lot more information than that.
2
SPEAKER_00
 Now, there was an op-ed in Journal of the American Medical Association several months ago that said, you know, non-diabetics shouldn't be checking their blood sugars with CGM because they're just going to become compulsive and neurotic and all that.
2
SPEAKER_00
Maybe that's true.
2
SPEAKER_00
 But I would prefer to recommend erring on that side where people have information and at least have the opportunity to choose whether they're going to do something about it or not.
2
SPEAKER_00
Right.
2
SPEAKER_01
And how would you know?
2
SPEAKER_01
The more information, more frequent information, the better.
2
SPEAKER_01
At least you have the knowledge, okay, I'm doing something that's affecting my body, my blood type, everything else, right?
2
SPEAKER_00
 Yeah, I mean even sleep.
2
SPEAKER_00
I wear an Oura ring.
2
SPEAKER_00
And I learned a lot about, generally that's one thing I do pretty well is sleep.
2
SPEAKER_00
Do you usually wear it out throughout the day or just at sleep?
2
SPEAKER_00
No, I use my Apple Watch during the day.
2
SPEAKER_00
Track everything else?
2
SPEAKER_00
Yeah.
2
SPEAKER_00
 Or a ring at night, just because I like it.
2
SPEAKER_00
I've learned that a real benefit for me in terms of the restorative aspect of sleep, because I get a good night's sleep, but the restorative parameters that are measured is walking after dinner.
2
SPEAKER_00
We never did that before.
2
SPEAKER_00
My wife and I, we exercise in the morning pretty aggressively.
2
SPEAKER_00
 And then, but the idea of taking a walk after dinner, it's a great thing.
2
SPEAKER_00
I mean, we see people out walking, their dogs are just walking.
2
SPEAKER_00
So it's a nice thing to do anyway, but it really helped me with my pulse, heart rate variability, which is a, which is,
2
SPEAKER_00
 tied into how well you recover during sleep.
2
SPEAKER_00
And so my heart rate variability went up quite a bit.
2
SPEAKER_00
Now I think I'm fearful that viewers are thinking, what is all this crap?
2
SPEAKER_00
What are these guys talking about?
2
SPEAKER_00
And I don't want to do any of that.
2
SPEAKER_00
Give me some bullet points.
2
SPEAKER_00
So I would say that it's time to avail yourself of this biotechnology.
2
SPEAKER_00
I think it's really great.
2
SPEAKER_00
But the broad strokes are again back to the simple things that you've gotta exercise.
2
SPEAKER_00
You've got to make,
2
SPEAKER_00
 Every effort to get a good night's sleep.
2
SPEAKER_01
It's so important.
2
SPEAKER_01
Matthew Walker, when we had him on talking about sleep and just how one hour less of sleep can change so much, both focus and attention and memory loss and all these things.
2
SPEAKER_01
And if you couple that every day more and more, it's just gonna hurt you long term.
2
SPEAKER_00
So really try, yeah.
2
SPEAKER_00
And what his research has more recently demonstrated, you know, getting back to the whole notion of brain health,
2
SPEAKER_00
 is lack of sleep and how it increases the presence of beta-amyloid, which is, if you buy into the amyloid hypothesis of Alzheimer's, and I think it plays a role, I don't think it's the end-all, as we talked about.
2
SPEAKER_00
Dr. Bredesen has looked at a lot of different parameters that are influential in terms of brain health and risk for decline.
2
SPEAKER_00
 But, you know, who wants to have a brain load of amyloid?
2
SPEAKER_00
Not me.
2
SPEAKER_00
And therefore, yet another reason.
2
SPEAKER_00
With lack of sleep, increasing your insulin resistance, increasing your blood sugar, increasing your cortisol, threatening your hippocampus, increasing your risk of obesity or at least significant weight gain, increasing your uric acid as a powerful metabolic marker.
2
SPEAKER_00
 So, yeah, and it's important to look at the parameters that you can modify to help you get a better night's sleep, but you may not know.
2
SPEAKER_00
Next morning you wake up, gosh, I went to sleep at 10 o'clock, now I'm waking up and I slept all night.
2
SPEAKER_00
You might not have.
2
SPEAKER_00
 You might have awakened four or five times.
2
SPEAKER_00
You didn't know it.
2
SPEAKER_00
Well, you remember the one time you got up to pee But what about the other four times when you didn't fully awaken, but you dropped out of those restorative levels of sleep?
2
SPEAKER_00
You won't know that you won't know how much time you spent in rem or deep restorative sleep Unless you're using a wearable and it's this ticket.
2
SPEAKER_00
Yeah, so try it out.
2
SPEAKER_00
You know, what what is there to lose you wake up in the morning?
2
SPEAKER_00
 And you download the information into your smartphone or it's already in your phone.
2
SPEAKER_00
You just open the app I have it in my phone right here.
2
SPEAKER_00
I can look and tell you what my sleep is like And uh, did you do well and if you did well you say gee Uh, not that now i'm gonna have a great day or I had a I got a crappy score i'm gonna have a crummy day You know, that's the risk but if you had a crappy score you say to yourself
2
SPEAKER_00
 Maybe it was that glass of wine, or maybe I shouldn't have had dessert, or we ate too late, or I didn't exercise at all.
2
SPEAKER_00
Yeah, the cappuccino at four o'clock in the afternoon.
2
SPEAKER_00
For me, I can do that, and it doesn't seem to affect my sleep, gratefully.
2
SPEAKER_00
 But for others, it may.
2
SPEAKER_00
Kombucha, which I think, you know, I like kombucha, but it's made from tea.
2
SPEAKER_00
So you have kombucha to drink with dinner.
2
SPEAKER_00
Maybe that's a factor.
2
SPEAKER_00
You just don't know.
2
SPEAKER_00
And it's good to be thinking about what your choices are.
2
SPEAKER_00
And lovingly and slowly, you modify things until, you know, you get a solid eight hours and you're killing it on the deep sleep and the REM sleep and the latency, how long it takes you to drop in and you're
2
SPEAKER_00
 other things, your heart rate variability, and then you've got that checked off.
2
SPEAKER_00
And can you become neurotic about it?
2
SPEAKER_00
I guess so, but I'm willing to take that risk.
2
SPEAKER_01
Right, yeah.
2
SPEAKER_01
It's better to be neurotic than to have no information.
2
SPEAKER_00
Yeah, and to do what modern medicine
2
SPEAKER_00
 wants you to do, and that is come to us when you're having a problem, then we'll talk about it.
2
SPEAKER_00
But meanwhile, do whatever you want.
2
SPEAKER_00
Live your life, come what may.
2
SPEAKER_00
Eat whatever the heck you want.
2
SPEAKER_00
You know, you have that big dessert, and then you take your diabetes pill.
2
SPEAKER_00
You know, you didn't cure your diabetes with that pill, as I mentioned earlier.
2
SPEAKER_00
So it's, we've gotta be our own advocates.
2
SPEAKER_00
It's very clear.
2
SPEAKER_00
Mainstream medicine, again, is gonna be there if you need them.
2
SPEAKER_00
 in an accident or have surgery, great.
2
SPEAKER_00
But in terms of keeping you healthy, you've got to be your own advocate.
2
SPEAKER_00
And the only way you can do it is by getting at least a modicum of information.
2
SPEAKER_01
So what would you say are the foods or the liquids that are off limits for you?
2
SPEAKER_01
Or maybe that are like very rare, that you'll consume something, whether it's a gingerbread, I'll drink this.
2
SPEAKER_00
So we were watching Rick Steves on public television,
2
SPEAKER_00
 And it was obviously a couple of years ago because no one was wearing masks.
2
SPEAKER_00
He was in Europe and it was for Christmas and he ate gingerbread.
2
SPEAKER_00
My wife and I looked at him and we went, we've got to get some gingerbread.
2
SPEAKER_00
So I was able to find some.
2
SPEAKER_00
 So from time to time, having something that's sensible, that's not really killing it.
2
SPEAKER_00
But I think it's the high fructose foods and the high sugar foods.
2
SPEAKER_00
Understand that table sugar is 50% fructose.
2
SPEAKER_00
Sucrose, this table sugar that is the ingredient, that two tablespoons of sugar along with the refined flour and some vanilla, and next thing you know, you've got dessert.
2
SPEAKER_00
 And somehow it, you know, it's alchemy.
2
SPEAKER_00
It creates something new, de novo, out of these ingredients.
2
SPEAKER_00
Pizza, the same way.
2
SPEAKER_00
Somehow, well, it's pizza.
2
SPEAKER_00
But no, it's made from flour, highly refined carb flour dough, refined flour, and then you put tomato sauce in the mushrooms.
2
SPEAKER_00
It's now not that anymore.
2
SPEAKER_00
It's a new thing.
2
SPEAKER_00
It's pizza.
2
SPEAKER_00
Therefore, it's good.
2
SPEAKER_00
 What's off-limits for you then?
2
SPEAKER_00
What's like, you don't have... Well, one thing I don't ever eat is liver.
2
SPEAKER_00
I'm not saying it's bad food, I just can't eat it.
2
SPEAKER_00
I hate it.
2
SPEAKER_00
Off-limits are soda, fructose-containing sauces, condiments, fruit juice, that's for sure.
2
SPEAKER_00
Anything that's got a lot of sugar is off the table.
2
SPEAKER_00
Sweets, candy, and all that stuff.
2
SPEAKER_00
No, that's not for me.
2
SPEAKER_00
 You don't eat it?
2
SPEAKER_00
No.
2
SPEAKER_00
It's completely out of your... No, I won't say completely.
2
SPEAKER_00
I might have a mint.
2
SPEAKER_00
You might have...okay.
2
SPEAKER_00
In fact, there was a...so I remember them.
2
SPEAKER_00
I had a mint that was in our rental car that Hertz put there for me.
2
SPEAKER_00
I ate that.
2
SPEAKER_00
But generally, that's not who I am.
2
SPEAKER_00
I don't eat...I don't need it.
2
SPEAKER_00
 Do I feel guilty afterwards?
2
SPEAKER_00
Probably not.
2
SPEAKER_00
Maybe I could feel more guilty.
2
SPEAKER_01
After eating a mint, you mean, or what?
2
SPEAKER_00
No, I don't.
2
SPEAKER_00
I don't feel guilty, I mean.
2
SPEAKER_00
Well, because you have it once a year or something.
2
SPEAKER_00
I know, I mean.
2
SPEAKER_00
You remember the last.
2
SPEAKER_00
So I don't, you know, I don't obsess that I had a mint, or that I tasted somebody's key lime pie.
2
SPEAKER_00
Right.
2
SPEAKER_00
But sodas are gone, that's for sure, and sugar in the coffee and all that.
2
SPEAKER_00
I will say that I had a post on Instagram recently, and, you know,
2
SPEAKER_00
 It was, honey, I'm sorry, will you forgive me?
2
SPEAKER_00
Oh, you can't have honey?
2
SPEAKER_00
Well, here's the thing.
2
SPEAKER_00
Oh, no.
2
SPEAKER_00
People thought I had messed up with my wife, and I was asking for her forgiveness.
2
SPEAKER_00
That's funny.
2
SPEAKER_00
And it was the biggest Instagram post I think I've ever had.
2
SPEAKER_00
And I'm not taking credit for it.
2
SPEAKER_00
One of our team members, Jonathan Jacobs, if you're watching this, he created it.
2
SPEAKER_00
And it was because there is evidence that honey actually can help lower uric acid.
2
SPEAKER_00
 But beyond that, it may, more importantly, be not a huge metabolic threat, though it contains fructose.
2
SPEAKER_00
It doesn't mean that agave is on the table.
2
SPEAKER_00
It is not.
2
SPEAKER_00
Agave is something I would never touch.
2
SPEAKER_00
I would never go near agave.
2
SPEAKER_00
 No, and I also would not be ever consuming artificial sweeteners like aspartame, for example, because of the threat for gut bacteria.
2
SPEAKER_00
The other thing that I'm super careful about would be any medication that might be prescribed for me, like an antibiotic.
2
SPEAKER_00
I really go through a lot of cogitation if I'm injured, you know, and
2
SPEAKER_00
 or had an operation, for example, and there's a need for an antibiotic.
2
SPEAKER_00
I break the doctor's orders generally.
2
SPEAKER_00
Now, I don't want your viewers to say, oh, I'm never taking antibiotics.
2
SPEAKER_00
But these are weapons of mass microbial destruction in your gut.
2
SPEAKER_00
 And every time a child has a sniffle, goes to a pediatrician, they prescribe the liquid, whatever it is, antibiotic.
2
SPEAKER_00
That's just inappropriate, in my opinion.
2
SPEAKER_00
Really?
2
SPEAKER_00
Yeah, it really is.
2
SPEAKER_00
Ear infections can oftentimes get what's called tincture of time, meaning waited out.
2
SPEAKER_00
Now, there's got to be a disclaimer here.
2
SPEAKER_00
People make their own decisions.
2
SPEAKER_00
 Talk to your health care provider, but that's one of the biggest issues of our time the effects of medications on the gut bacteria like proton pump inhibitors taken by 14 million Americans Profoundly disrupt the gut bacteria and are associated in the journal stroke with an increased risk of dementia and a dramatic increased risk of stroke well
2
SPEAKER_00
 by taking these acid-blocking drugs.
2
SPEAKER_00
They also raise uric acid, and they are over-the-counter.
2
SPEAKER_00
You think you ate something you shouldn't have, you go into a store and you buy this acid-blocking drug.
2
SPEAKER_00
You take it all the time because you just think you need it.
2
SPEAKER_00
I'd say change your diet, first of all, if you're not tolerating certain foods.
2
SPEAKER_01
Right, and this surprising new science of uric acid.
2
SPEAKER_01
 We haven't talked about that.
2
SPEAKER_00
I think we're gonna do a virtual and need to talk about it later.
2
SPEAKER_00
But I wanna say one other thing as it relates to foods that are really important to be aware of, and it's fat.
2
SPEAKER_00
And therein lies an important discussion because the good fats are a blessing.
2
SPEAKER_00
Eat all the extra virgin olive oil you can put your hands on, organic fats like good sources of omega-3s.
2
SPEAKER_00
 But by all means, you really want to avoid the processed vegetable oils, canola, corn oil, soybean oil, soy especially.
2
SPEAKER_00
These need to be avoided.
2
SPEAKER_00
These are used structurally in your body to create cell membranes that
2
SPEAKER_00
 It's where all the action is in terms of how cells work, even brain cells, importantly, how they are able to transmit information from one brain cell to the next.
2
SPEAKER_00
Those receivers and transmitters are built by the fats that they have access to, which are the fats that you consume.
2
SPEAKER_00
They don't come from the air.
2
SPEAKER_00
So being really careful about the fats you consume, I think, is fundamentally important.
2
SPEAKER_00
What are the good oils then?
2
SPEAKER_00
 Well, there are a lot.
2
SPEAKER_00
I think coconut oil to some degree, extra virgin olive oil.
2
SPEAKER_00
Strange as it may sound, we travel with a bottle of extra virgin olive oil.
2
SPEAKER_01
Extra virgin olive oil based on... Organic.
2
SPEAKER_01
Which is different than what other type of olive oil?
2
SPEAKER_00
 Well, there are olive oils that aren't necessarily extra virgin, so are heated in the processing.
2
SPEAKER_00
And if you ask for olive oil in a restaurant, oftentimes they're allowed to call it olive oil if it's 51% olive oil.
2
SPEAKER_00
What is the other 49?
2
SPEAKER_00
Is it canola?
2
SPEAKER_00
What is it?
2
SPEAKER_00
You don't know.
2
SPEAKER_00
I can taste the canola oil now.
2
SPEAKER_00
Interesting, Italy is the largest importer of olive oil.
2
SPEAKER_00
 So they import olive oil and then they manufacture what passes as olive oil by this 51% rule.
2
SPEAKER_00
So you really wanna be super careful where you're getting your olive oil and making sure that it's treated appropriately, that it's not been heated, that you keep it closed in a cool, dark place if you can.
2
SPEAKER_00
That sounds a little bit compulsive, but we did.
2
SPEAKER_00
So we live in Florida, here we are in California, right?
2
SPEAKER_00
First thing, went to a health food store, bought a bottle of olive oil, we take it to the restaurant when we go to dinner.
2
SPEAKER_00
 Nobody seems to care, I mean, and if they did care, that would be interesting.
2
SPEAKER_00
I wouldn't bother me in the least.
2
SPEAKER_00
We have a bottle of olive oil.
2
SPEAKER_00
I mean, it's not, they don't charge you a corking fee like they would charge if you bought a bottle of wine, right?
2
SPEAKER_00
So, and that's a really, and just pour it on.
2
SPEAKER_00
 You know, I try to have a liter of olive oil myself a week.
2
SPEAKER_00
Really?
2
SPEAKER_01
Yeah.
2
SPEAKER_01
Dr. Gundry talks about that too.
2
SPEAKER_01
He says have a liter a week of olive oil for the gut bacteria, the microbiome.
2
SPEAKER_00
Well, he's talking about it, you know, he too focuses a lot on inflammation.
2
SPEAKER_00
His idea that lectins are a powerful cause of inflammation because of, through the mechanism of disrupting the gut lining and other, even to some degree, blood brain barrier.
2
SPEAKER_00
 But his call for EVOO, extra virgin olive oil, again, deals with its role in helping tamp down inflammation, but also helping allow our bodies to build parts of the body that are made from fat, like cell membranes, from good things, so supplying raw materials.
2
SPEAKER_00
What are you pouring it on, if you're not pouring it on the breads and the, you know?
2
SPEAKER_00
I pour it on everything.
2
SPEAKER_00
I mean, I have it on, I do it on my eggs, which I have most days.
2
SPEAKER_00
I often have salad for breakfast,
2
SPEAKER_00
 Or I'll have avocados and have extra virgin olive oil.
2
SPEAKER_00
Just pour it all there?
2
SPEAKER_00
Yeah, I mean if I'm... And that's usually like around noon or one so you can get away with having salads.
2
SPEAKER_00
No one's gonna say, well you're having that for breakfast?
2
SPEAKER_00
Who does that, right?
2
SPEAKER_00
I do it at the restaurant.
2
SPEAKER_00
I mean at the hotel.
2
SPEAKER_00
That's what I want for breakfast.
2
SPEAKER_00
They have it.
2
SPEAKER_00
 Well, it's not on the menu, but you'll manage.
2
SPEAKER_00
I know you will.
2
SPEAKER_00
You can get some lettuce out there, yeah.
2
SPEAKER_00
Yeah.
2
SPEAKER_00
I mean, sometimes if I'm busy, I'll have an avocado, take the seed out, and fill that little reservoir with olive oil.
2
SPEAKER_00
Problem solved.
2
SPEAKER_00
There you go.
2
SPEAKER_00
Wow.
2
SPEAKER_00
And maybe use a plate, but that's about as aggressive as I get sometimes.
2
SPEAKER_01
 I want to go over this a little bit.
2
SPEAKER_01
Oh, that's why we're here today.
2
SPEAKER_01
Yes.
2
SPEAKER_01
Because a lot of people, since a third of Americans are obese, and it sounds like in 10 years, half is the predictions.
2
SPEAKER_01
Most people today want to learn how to lose weight, but they don't want to do the work.
2
SPEAKER_01
They don't want to give up the things that they really enjoy, and they don't want to work out as much as they probably should.
2
SPEAKER_01
And they probably don't want to go to bed earlier to sleep so that they can burn more fat when they're sleeping, all these different things.
2
SPEAKER_01
 So what is this surprising new science of uric acid?
2
SPEAKER_01
What is uric acid?
2
SPEAKER_01
What do we need to know about it?
2
SPEAKER_01
And how do we use it to lose weight?
2
SPEAKER_00
Uric acid is the downstream end metabolite of fructose.
2
SPEAKER_00
What does that mean?
2
SPEAKER_00
So it means when you eat fructose, it goes into your body, it's absorbed through your testicle lining,
2
SPEAKER_00
 It undergoes a series of changes until it reaches uric acid, at which point that uric acid, some of it stays in the bloodstream, some of it is excreted.
2
SPEAKER_00
So sugar turns into uric acid at some point.
2
SPEAKER_00
Fructose turns into uric acid.
2
SPEAKER_00
Fructose.
2
SPEAKER_00
Okay, so not sugar.
2
SPEAKER_00
Right.
2
SPEAKER_00
Well, fructose is sugar, but this is unique.
2
SPEAKER_00
Fructose and glucose are
2
SPEAKER_00
 Totally different.
2
SPEAKER_00
I would say apples and oranges, that's confusing.
2
SPEAKER_01
Apples and candy bars, yeah.
2
SPEAKER_01
So where's fructose and where's glucose for those that aren't sure?
2
SPEAKER_00
That's right.
2
SPEAKER_00
So fructose, the name comes from fruit sugar, fructose.
2
SPEAKER_00
Ose in biochemistry means, or in chemistry means sugar.
2
SPEAKER_00
And this is what is found in fruit and this was what allowed some of our ancestors to survive.
2
SPEAKER_00
Okay.
2
SPEAKER_00
 who could eat fruit in the late summer, early fall, and had a little advantage that they would make more fat, such that when food was unavailable, they would survive, and those who didn't make that little bit more fat would perish.
2
SPEAKER_00
We didn't get their genes.
2
SPEAKER_00
We got the genes from the ones who survived.
2
SPEAKER_00
Who could produce a little more fat.
2
SPEAKER_00
A little bit more fat, and became a little bit more insulin resistant, so that their blood sugar would go up just a little bit,
2
SPEAKER_00
 Allowing their brains to help them avoid the two things that were their biggest threats starvation and predation starvation not having a food Predation getting eaten.
2
SPEAKER_00
Mm-hmm, you know not both of which are not really threats to most of us these days, right?
2
SPEAKER_00
It's not like we're gonna be walking on the street and lions gonna come now eat you know in which case you'd want to have a smart be smart so you could do what you need to do to get away from the lion and then and then glucose comes from
2
SPEAKER_00
 Glucose is also found in foods and certainly table sugar.
2
SPEAKER_00
Glucose and fructose bound together is what is called sucrose.
2
SPEAKER_00
That is table sugar in a 50-50 ratio.
2
SPEAKER_00
I'm not going to say
2
SPEAKER_00
 That is the natural way, but I would like to say it in the context of this unnatural combination where the fructose is unnaturally increased to create what's called high fructose corn syrup, which is incredibly pervasive in our world today.
2
SPEAKER_00
That's 55% fructose.
2
SPEAKER_00
That 5% makes a big difference.
2
SPEAKER_00
So we as Americans are consuming 17 teaspoons of sugar a day.
2
SPEAKER_00
How many should we have?
2
SPEAKER_00
 I don't know, we don't need sugar.
2
SPEAKER_00
We don't need sugar.
2
SPEAKER_00
We need zero.
2
SPEAKER_00
Zero sugar.
2
SPEAKER_00
The human requirement is zero.
2
SPEAKER_00
So how much sugar do you have a day?
2
SPEAKER_00
Hard to say, not very much.
2
SPEAKER_00
Where is there sugar?
2
SPEAKER_00
 I don't know.
2
SPEAKER_00
I have very little.
2
SPEAKER_00
You don't eat fruit.
2
SPEAKER_00
Oh, I do eat fruit.
2
SPEAKER_00
So there's going to be some sugar in fruit.
2
SPEAKER_00
And there is a modicum of sugar in my kombucha, but I dilute it down, usually with about two parts water and then one part kombucha.
2
SPEAKER_00
I don't use sweeteners, except occasionally I've been trying a little bit of allulose.
2
SPEAKER_00
 As of late, allulose is a new sweetener that actually has been demonstrated to improve your blood sugar.
2
SPEAKER_00
So it has positive metabolic activities.
2
SPEAKER_00
And if somebody is making something for me that's using monk fruit, I will think that's acceptable.
2
SPEAKER_00
But there's sugar in vegetables.
2
SPEAKER_00
So there is definitely gonna be sugar in my diet.
2
SPEAKER_00
 not 71 grams per day, which is what the typical American gets.
2
SPEAKER_00
And this is a relatively recent phenomenon.
2
SPEAKER_01
So you can eliminate, I mean, you'll have minimal doses of sugar, but very little.
2
SPEAKER_00
In the 1920s, we would consume about 15 grams of fructose a day.
2
SPEAKER_00
Now it's 55.
2
SPEAKER_01
 So what does that do to burning fat if we're having that much sugar?
2
SPEAKER_00
Fructose says don't burn fat.
2
SPEAKER_00
Fructose tells your body winter's coming.
2
SPEAKER_00
Get ready.
2
SPEAKER_00
 make fat, store fat, lock it up.
2
SPEAKER_00
That's the signaling mechanism.
2
SPEAKER_00
So when we look at this metabolism, we have to look at it through the eyes of our evolution.
2
SPEAKER_00
And again, we never had fructose like we have now.
2
SPEAKER_00
We had it in small amounts, or if we would gorge on the
2
SPEAKER_00
 blueberries, whatever we found, which we should have done, only in a small window of the air when we would make enough fat that would allow us to get through.
2
SPEAKER_00
Animals that hibernate just gorge on fruit.
2
SPEAKER_00
I mean, what does a hummingbird consume prior to flying across North America?
2
SPEAKER_00
 nectar, sugar water.
2
SPEAKER_00
If you want to have a hummingbird in your backyard, you put out sugar water, they will hone in on that like nobody's business.
2
SPEAKER_00
And the hummingbird might be one of the fattest animals on the planet.
2
SPEAKER_00
 When they are storing fat for their long journey, 40% of their body weight can be fat.
2
SPEAKER_00
We think of whales as having a lot of fat, and of course they do, obviously.
2
SPEAKER_00
But whales use body fat, a little off topic, sure for energy,
2
SPEAKER_00
 but also as their source of fresh water.
2
SPEAKER_00
So when you metabolize fat, you're creating gram for gram water.
2
SPEAKER_00
When you metabolize one gram of fat, you make one gram of water.
2
SPEAKER_00
So for our ancestors, what a powerful tool
2
SPEAKER_00
 to survive not just in food scarcity, but water scarcity as well.
2
SPEAKER_00
To keep from becoming dehydrated, that little bit of body fat would help them make water as it was metabolized, they could survive.
2
SPEAKER_01
So what does uric acid tell us then, as the key to losing weight?
2
SPEAKER_01
What is, is it, because it's a link to sugar.
2
SPEAKER_00
Yeah, so this person that you described who's not gonna exercise, gonna not get enough sleep, gonna eat
2
SPEAKER_00
 sugar, all that stuff, keeping their uric acid level under control.
2
SPEAKER_00
First of all, it's not really going to be possible because a high level of fructose is going to keep your uric acid level elevated, number one.
2
SPEAKER_00
Number two,
2
SPEAKER_00
 they have overridden all the benefits of uric acid.
2
SPEAKER_00
We're targeting people who are trying and not really hitting the mark.
2
SPEAKER_00
They're doing their best to eat right, they are getting some exercise, and they're still not losing the weight they wanna lose.
2
SPEAKER_00
Blood pressure's still a little bit elevated, still blood sugar might be a little elevated.
2
SPEAKER_00
This is another tool, a brand new tool, a powerful tool in the toolbox.
2
SPEAKER_00
Know your uric acid level.
2
SPEAKER_00
How do you know it?
2
SPEAKER_00
 you go to the doctor and get it checked, or you get a monitor.
2
SPEAKER_00
Is this a blood draw?
2
SPEAKER_00
It's a finger stick.
2
SPEAKER_00
A finger stick.
2
SPEAKER_00
At the doctor's office, it's a blood draw, but for you, and the monitor I will send you, it's a finger stick.
2
SPEAKER_00
The levels monitor or a different monitor?
2
SPEAKER_00
It's like a blood sugar monitor, like a glucose monitor.
2
SPEAKER_01
Okay, gotcha.
2
SPEAKER_01
 So you prick it, and then it tells you your uric acid levels, is that right?
2
SPEAKER_01
That's right.
2
SPEAKER_01
And so do we, what does that information do for us?
2
SPEAKER_01
Or how do we optimize it?
2
SPEAKER_00
Much like you optimize it by going on a specific diet to help lower your uric values, L-U-V, the Love Diet.
2
SPEAKER_00
Ooh, I like the Love Diet.
2
SPEAKER_00
The Love Diet, it's right on the cover.
2
SPEAKER_00
And that is a diet specifically designed to help you accomplish the task.
2
SPEAKER_00
 lowering uric values.
2
SPEAKER_00
You will take quercetin 500 milligrams a day which targets an enzyme that's involved in uric acid production.
2
SPEAKER_00
You'll pay attention to your sleep.
2
SPEAKER_00
You will reduce fructose and be conscious of other two inputs to uric acid which are alcohol and purines.
2
SPEAKER_00
Purines are found
2
SPEAKER_00
 a lot in organ meat, for example, in small fish like sardines and anchovies.
2
SPEAKER_00
Doesn't mean you can't have them, but you're now gonna start to see how they affect your uric acid level.
2
SPEAKER_00
And you wanna get your uric acid level below 5.5.
2
SPEAKER_00
 And you're going to have this next week, and you'll text me.
2
SPEAKER_01
I will.
2
SPEAKER_01
Get it below.
2
SPEAKER_01
What's high level then?
2
SPEAKER_00
Above 5.5.
2
SPEAKER_00
That's high.
2
SPEAKER_00
So when you go to the doctor and you ask what's normal, they're going to tell you 7.
2
SPEAKER_00
 But that's a uric acid value that relates to something called gout, which is really the context that they look at uric acid.
2
SPEAKER_00
Oh my gosh.
2
SPEAKER_00
Yeah, it's only looked at by mainstream medicine in terms of gout.
2
SPEAKER_00
There is 20 years of robust medical research, we have 400 references in this book, looking at uric acid as the central player in metabolic dysfunction.
2
SPEAKER_01
 So if you get it below 5.5, that tells you what?
2
SPEAKER_01
That this person has the ability to burn more fat, to lose more weight.
2
SPEAKER_00
You're gonna shift more towards burning and less storing of fat.
2
SPEAKER_00
It can help you get your blood sugar under control.
2
SPEAKER_00
 It will very likely help you rein in your blood pressure.
2
SPEAKER_00
It may even help you with your lipids, your HDL, LDL, triglycerides as well.
2
SPEAKER_00
So these things are all influenced by having an elevated uric acid.
2
SPEAKER_00
So is it the end all?
2
SPEAKER_00
No, but is it yet another powerful arrow in your quiver?
2
SPEAKER_00
You bet.
2
SPEAKER_00
And these days, when you think you're working out however many times a week,
2
SPEAKER_00
 You're eating the best you can.
2
SPEAKER_00
No one's perfect.
2
SPEAKER_00
And this is just another piece to that puzzle, but it's a powerful piece.
2
SPEAKER_00
And the science is taking off.
2
SPEAKER_00
This is not the last time you're gonna hear about uric acid.
2
SPEAKER_00
Really?
2
SPEAKER_01
Oh my gosh.
2
SPEAKER_01
And this is what?
2
SPEAKER_01
To check this, you prick your finger once every week or once a month or you do this?
2
SPEAKER_00
Well, it depends.
2
SPEAKER_00
For me, it's every couple of weeks, two to three weeks.
2
SPEAKER_00
I run around 4.5, 4.6.
2
SPEAKER_00
Can you be too low?
2
SPEAKER_00
 Probably not.
2
SPEAKER_00
We do see very low values in elderly people with very little muscle mass because they're not breaking down any more muscle.
2
SPEAKER_00
They don't have muscle to break down, therefore they don't liberate what are called purines.
2
SPEAKER_00
 There is some discussion that uric acid may have some antioxidant properties, but I think that we're moving past that.
2
SPEAKER_00
It's not really setting up for scrutiny.
2
SPEAKER_00
I think keeping it below 5.5 should be the goal.
2
SPEAKER_00
 You know, a doctor may say, hey, below seven is what we're looking for because of gout, but I would say that's a situation to be kind of people being down on what they're not up on.
2
SPEAKER_01
Right.
2
SPEAKER_01
Well, I know a lot of people want to have extraordinary health, and so I'm so grateful that you decided to create the book on this and create a process with a plan, the diet, everything in here, the love diet, which I think is really cool.
2
SPEAKER_01
 We'll have to do another episode sometime in the future.
2
SPEAKER_01
Yeah, we didn't really get to the book, but that's okay, because we were into some good areas.
2
SPEAKER_01
I think it's beautiful, yeah.
2
SPEAKER_01
I have a couple final questions for you.
2
SPEAKER_01
This is called The Three Truths.
2
SPEAKER_01
I ask everyone this question at the end of the interview, and it's a hypothetical scenario.
2
SPEAKER_01
So imagine it's many years away, but it's your last day, last day on Earth.
2
SPEAKER_01
And you get to choose the day, you get to live as long as you want, but eventually you gotta turn the lights off for this world.
2
SPEAKER_01
And you have accomplished every dream you could think of.
3
SPEAKER_00
 You've lived the life that you want to, you have the relationships, you have the accomplishments, the impact, it's all there.
3
SPEAKER_00
But for whatever reason, every piece of work or piece of content you've put out into the world has to go with you or go to another place.
3
SPEAKER_00
We don't have access to this information anymore.
3
SPEAKER_00
So this book, everything you've created, for whatever reason, it's gone.
3
SPEAKER_00
Again, hypothetical world.
3
SPEAKER_00
 But you have a piece of paper and a pen and you get to write down three things you know to be true about life, about your experiences, about what you've learned that you would want to share with the world, and this is all we would have to be reminded by your message.
3
SPEAKER_00
What would you say are those three truths for you?
3
SPEAKER_01
Number one, and I'm not going to rank them, but number one that comes to mind is there is nothing constant except change.
3
SPEAKER_01
 Number two is the golden rule.
3
SPEAKER_01
Do unto others as you would have them do unto you.
3
SPEAKER_01
And number three would be don't sweat the small stuff.
3
SPEAKER_01
I remember who said that to me the very first time.
3
SPEAKER_01
It was a freshman in college.
3
SPEAKER_01
And oddly enough, his name was John Kennedy.
3
SPEAKER_01
Not John Kennedy, but that was his name.
3
SPEAKER_01
 And it was very meaningful.
3
SPEAKER_01
I didn't get it at first.
3
SPEAKER_00
I said, don't swear the small stuff.
3
SPEAKER_00
But over the years, I've gotten it.
3
SPEAKER_00
Isn't the book, Don't Swear the Small Stuff, and it's all small stuff?
3
SPEAKER_00
Isn't that the tagline?
3
SPEAKER_01
It's not worth it.
3
SPEAKER_00
It isn't worth it.
3
SPEAKER_00
What do you wish you'd have learned?
3
SPEAKER_01
 Implemented 30 years ago for yourself that maybe you didn't implement yet, but now you know From a practical point of view I would have said Don't get as much Sun really.
3
SPEAKER_01
Oh, man.
3
SPEAKER_01
I really overdid and paying the price now number two floss more regularly Yeah, number three.
3
SPEAKER_01
I would say don't sweat the small stuff.
3
SPEAKER_01
I
3
SPEAKER_01
 Because it took a while to learn that.
3
SPEAKER_01
Obsessing over every little thing that was like... I know I'm a driven individual.
3
SPEAKER_01
I know that.
3
SPEAKER_01
It's just who I am.
3
SPEAKER_01
And when that starts to bleed out into relationships and other things... Sleep and health.
3
SPEAKER_01
Everything.
3
SPEAKER_01
So it's about focusing on what really matters.
3
SPEAKER_01
And the older you get,
3
SPEAKER_01
 the more you realize, A, what really matters, and why did you invest so much into things that... Meaningless things, whatever.
3
SPEAKER_01
What really matters to you now?
3
SPEAKER_01
I have a gift, and I'm not trying to be bombastic with that.
3
SPEAKER_01
And my gift is to be able to have the ability to take complex information and present it to many people who may not have the ability to access that information.
3
SPEAKER_00
 By virtue of its complexity, right like everything in the back of the book.
3
SPEAKER_00
That's just you know, yeah actions of research papers I'm never gonna read this.
3
SPEAKER_01
Yeah, I mean everybody has a gift.
3
SPEAKER_01
I feel very fortunate that I'm able to identify mine and Exploit the heck out of me because the word doctor doesn't mean healer it means teacher and
3
SPEAKER_01
 And that's, at this stage in my life, what I'm doing, and that is getting out information that I think is going to be helpful.
3
SPEAKER_01
Because there's a lot of misinformation out there.
3
SPEAKER_01
We've talked about a lot of that today.
3
SPEAKER_01
About, you know, that you can eat sugar and fat is the end.
3
SPEAKER_01
All the things that we've been told.
3
SPEAKER_01
 And I think it's important for people to hear the other side, the science-validated, scientific-validated truths for us, that may change, things may change, rule number one.
3
SPEAKER_01
So that's the mission, and I think it's very comforting to be on mission, for me, day to day.
3
SPEAKER_00
Yeah.
3
SPEAKER_00
So, you wish you would've flossed more, and you wish you would've got less sun.
3
SPEAKER_01
 I mean, I'm not saying getting some sun is a bad thing, but... Sun's good, but it's not... Oh my gosh.
3
SPEAKER_00
Did you have just some skin issues or challenges?
3
SPEAKER_00
Oh, yeah.
3
SPEAKER_00
I mean... Really?
3
SPEAKER_00
Well, being in Florida every day, too, I guess, growing up is... Yeah.
3
SPEAKER_01
I mean, in my last year of high school and then early in college, I built houses in Florida Keys.
3
SPEAKER_01
Oh, man.
3
SPEAKER_01
 You know, the whole thing, no shirt.
3
SPEAKER_01
I'm a Mr. Tough Guy.
3
SPEAKER_01
I think getting some sun is a good thing, but you gotta be careful.
3
SPEAKER_01
Nowadays, I'm being much more careful, of course, making sure my vitamin D level's where it needs to be, but as a general rule, if you don't wanna have your face acid washed, which was no fun, yes, because of all the skin things, be careful in the sun.
3
SPEAKER_00
 Your book is coming out, Drop Acid, The Surprising New Science of Uric Acid, The Key to Losing Weight, Controlling Blood Sugar, and Achieving Extraordinary Health, which I believe is something a lot of people want, extraordinary health.
3
SPEAKER_00
So I highly recommend you guys all get a copy of this book.
3
SPEAKER_00
It's going to give you some powerful tools.
3
SPEAKER_00
And for me, I love that you say that you make the complex simple.
3
SPEAKER_00
 are at least simple to understand.
3
SPEAKER_00
Maybe some of these things are challenging changes to make for people, but easy to understand, so you are at least...
3
SPEAKER_00
 with the right wisdom and the knowledge to take action in an easier way, hopefully.
3
SPEAKER_00
People can get this everywhere.
3
SPEAKER_00
Where else can we go to support you?
3
SPEAKER_00
Social media, website?
3
SPEAKER_01
Well, I think the clearinghouse is drpromutter.com, drpromutter.com, and that's sort of the launchpad for everything else that I do.
3
SPEAKER_01
I mean, the book has a dedicated URL, drop us a book, but I think drpromutter.com is
3
SPEAKER_00
 Homebase.
3
SPEAKER_00
Yes, Homebase.
3
SPEAKER_00
It's got all the links to everything.
3
SPEAKER_00
All your other previous books, which I got to check out.
3
SPEAKER_00
Brainwash.
3
SPEAKER_00
I think that one's going to be fascinating for me as well.
3
SPEAKER_00
I'll get you a copy.
3
SPEAKER_00
Brainwash.
3
SPEAKER_00
Now, the more people that have these wearables on, I'm going to have to start getting this stuff, I'm sure, now.
3
SPEAKER_00
So, I'll talk to Dr... What's her name again?
3
SPEAKER_00
 KC means with levels you recommend that we'll talk to her later today.
3
SPEAKER_00
Okay, you'll connect me I'll get the text intro before we go to the Final question I would acknowledge you David for for showing up vulnerably for showing up and being true authentic honest and I think it's it's beautiful to see someone who is as intelligent and accomplished as you and
3
SPEAKER_00
 still connected to your heart and caring about people so deeply and so compassionate about helping people and serving people at a high level to not have to experience the type of pains and Sadness and challenges that that you went through and that so many of your clients went through for many years and a lot of people are going through so I really acknowledge you for For being for being honest and authentic and vulnerable with me and one final question for you What's your definition of greatness?
3
SPEAKER_01
 I think greatness is recognition and exploiting your gift.
3
SPEAKER_01
There you go.
3
SPEAKER_01
What is your gift?
3
SPEAKER_01
And then, you know, doing your very best to get as much out of it as you possibly can.
3
SPEAKER_01
Yeah.
3
SPEAKER_01
Awesome, David.
3
SPEAKER_01
Thanks, man.
3
SPEAKER_01
I appreciate you.
3
SPEAKER_01
Thank you.
3
SPEAKER_01
Appreciate it, man.
3
SPEAKER_00
 Thank you so much for listening.
3
SPEAKER_00
I hope you enjoyed today's episode and inspired you on your journey towards greatness.
3
SPEAKER_00
Make sure to check out the show notes in the description for a full rundown of today's show with all the important links.
3
SPEAKER_00
And also make sure to share this with a friend and subscribe over on Apple podcasts as well.
3
SPEAKER_00
 I really love hearing feedback from you guys, so share a review over on Apple and let me know what part of this episode resonated with you the most.
3
SPEAKER_00
And if no one's told you lately, I want to remind you that you are loved, you are worthy, and you matter.
3
SPEAKER_00
And now it's time to go out there and do something great.