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Jobfully Blog

Keeping Age Out of Your Job Search

Mature workers are sometimes concerned that their age may prevent them from getting hired. The reality is that age alone is very rarely a reason for eliminating a job candidate. Hiring managers are always looking for the best person to get the job done. Age is irrelevant if capability, likability and fit are all strong. When applying and interviewing:

  1. Never assume age is the issue. Your mindset and attitude are what hiring managers notice. By going in with the preconceived notion that your age may prevent you from being hired, you may project that concern. Assume the best and be positive.
  2. Understand the true concerns of hiring managers, so that you can proactively present yourself in ways that put those concerns to rest.
  3. If you are asked a question you believe points to an issue with age, be prepared to answer it wisely, eliminating any age related concerns.

We often hear older job seekers suspecting certain interview questions are directed at their age.  Here is a suggestion – answer them without thinking about age.  Instead, think about how topics hiring managers bring up relate to the position and how you can demonstrate you’re a good match.

The interviewer says: “This is a high energy position”, “We need a real go-getter”
What’s the real question? The candidate’s ability to do the job including drive, persistence, and enthusiasm.
How to answer: Show your positive attitude.  Share recent examples of your drive, persistence and follow-throughs leading to success.

The interviewer says: “We’re looking for someone to grow in this position”, “This is a long term proposition”.
What’s the real question? Are you in it for the long haul or will you leave soon?
How to answer: Stress how much you enjoy creating success to an employer by seeing things through.  Consider saying something like “I’m looking for a place where I can add value and grow for a long time.”

The interviewer says: “This is a fast paced environment”, “We work with a lot of young people”, “We’re very collaborative”,  “Our environment (or communication style) is very casual”.
What’s the real question? The candidate’s ability to fit into their culture and work environment.
How to answer: Give examples of times you’ve worked successfully with a wide variety of people.  Demonstrate flexibility and successes you have had in open and collaborative environments. Focus on traits and work styles that lead to positive results.

The interviewer says: “The technology is changing so fast”, “We’re constantly evolving as the technology changes”, “The job has a steep learning curve”.
What’s the real question? The candidate’s ability to keep up, learn evolve.
How to answer: Give examples of times you have been part of an evolution, been successful and even helped others evolve. Show you are a life-long learner who embraces the new and needs little or no help to pick things up.

The interviewer says: “This job is a great starting point for someone who wants to go far in this industry”, “This position would have reported to you at your last job”.
What’s the real question? Will you be satisfied at this position?
How to answer: Express your desire to continuously grow in the industry and to bring great value. Emphasize your wonderful combination of enough experience to hit the ground running and learning constantly to bring long lasting value to the company. Read more about avoiding being “overqualified”.

Remind yourself that age is rarely the underlying issue. The real issue for the hiring manager is whether you can do the job. As you determine any concerns about why you might not be able to do the job, you can answer to them by bringing out traits and past successes that show you to be capable and a great match.

More help for mature workers:

Keeping Your Age from Being an Issue

Job Search Strategies for Mature Workers

Are You Coming Across as Old?

Is it Age Discrimination or Something Else?

  1. anwar ahmad alawi
    Posted December 17, 2010 at 11:03 pm | Permalink

    This site is very encouraging for me , a 50 plus professional in Middle East with MBA from Stratford wyoming in 2004

  2. Posted December 20, 2010 at 3:07 pm | Permalink

    Anwar, I’m glad you’re finding it valuable. If you have any job search related questions we can answer, please feel free to ask!

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  1. [...] This post was mentioned on Twitter by Carrie Krueger, Jobfully. Jobfully said: Don't assume it's your age! Why age is rarely the issue and what to do if you think it is in today's blog. #olderworker [...]

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As you know, Twitter decided to drop support for Share Counts on November 20th, 2015. Twitter share buttons still works, but they no longer have share counters.

We were curious as to whether this change would lead to a decline in sharing activity and share of voice* for Twitter, so we pulled together and analyzed sharing activity data generated across 300,000+ sites that are powered by Shareaholic’s Content Amplification Platform. These sites collectively reach over 450 million unique visitors each month.

* Share of voice is the percentage of Twitter shares, relative to other sharing destinations available such as Facebook, Pinterest, LinkedIn, etc.

Did share counts influence Twitter sharing activity?

It appears so. Sharing activity to Twitter has declined by 11.28% since November 20th.

What does this mean for site owners?

Over the past few days, quite a few of you reached out wondering whether you should still keep the Twitter share button active on your site. Although early data suggests that there has been a decline in Twitter sharing activity, Twitter remains one of the most popular destinations for sharing content with over 320 million active users. For now we recommend keeping the Twitter Share Button active.

The information published on this blog is free for your use with appropriate attribution to Shareaholic. We welcome your feedback, suggestions, and questions. Please contact us. Additionally, all photos that appear on this site are copyrighted by their respective owners. If you own the rights to any of the images and do not wish for them to appear here please contact us and the images will be promptly removed.

We’re always looking for fresh content! Apply to be a guest writer.

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Day 11- Creation Station Christmas Countdown

shhhhh…. This is something special for big kids to have fun making Christmas decorations too.

To make this activity suitable for a younger child use pipe cleaners instead of straws and spray paint, then tie them together with string or ribbon. Try cutting the pipe cleaners to different lengths to make different sized decorations. You can even get super special sparkly pipe cleaners here.

You will need:

  • Straws (about 10 for each decoration)
  • Cable ties
  • Plastic spray paint
  • String

Step One:

Group straws together and place cable tie around them in the middle and pull tightly. Cut of the access of the cable tie. This will splay the straws out as shown.

Step Two:

Paint the decoration using the spay paint, leave to dry.

Step Three:

Once dry, tie string around center, pop a loop on the other side and hang on tree.

Thank you to The Creation Station Leicestershire North West for this fab activity.

Become a follower of our blog for more exciting activity ideas to do at home.

We would love to see your straw decorations, so please send photos of them to or share with us on twitter with #creationstation.

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Five Reasons Why ISO 27001 Certification Matters

Posted by on July 24th, 2017
July 24th, 2017

ThousandEyes recently announced our achievement of ISO/IEC 27001:2013 certification for the Information Security Management System (ISMS) supporting our network performance management software-as-a-service application. Historically, Europe and East Asia have been the leaders in terms of the number of certifications issued, but in recent years, North America has had an increasing share of the world’s certifications.… Read More »

2017 Update: Comparing Root Server Performance Globally

Posted by on June 26th, 2017
June 26th, 2017

Back in February 2015, guest blogger Mehmet Akcin conducted a study comparing availability and latency across all of the DNS root servers, measured from hundreds of vantage points around the world. Now that two years have passed, we’ve decided to refresh the data presented in Mehmet’s post and present an update on how the global performance of the root servers has changed.… Read More »

Complete VoIP Visibility with SIP and RTP

Posted by on June 21st, 2017
July 13th, 2017

Unified communications (UC) is an integral part of enterprise service delivery. Despite its importance, troubleshooting and maintaining a reliable voice network and end-user experience has always been challenging. Irrespective of the type of voice deployment (on-premises, hybrid or cloud), the impact of the underlying network on voice performance is undeniable. Packet loss, jitter and latency influence voice quality and the sometimes transient nature of these issues makes VoIP troubleshooting tricky.… Read More »

Monitoring IPv6 Networks

Posted by on May 31st, 2017
November 10th, 2017

IPv6 has been around for two decades, and yet it is only now making up a meaningful portion of Internet traffic. Reports today find that there are between 10-15 billion Internet-connected devices (each requiring an IP address), yet only 2.8 billion routed IPv4 addresses. The conclusion? Most connected devices do not have unique, public IPv4 addresses and instead utilize network address translation (NAT) to communicate with the Internet.… Read More »

2017 Update: Comparing the Performance of Popular Public DNS Providers

Posted by on May 15th, 2017
May 25th, 2017

In May 2015, guest blogger Mehmet Akcin wrote about his findings from measuring and comparing latency to a number of popular public DNS services from hundreds of vantage points located across the globe. But two years have passed since then, and the landscape of public DNS continues to change as sites are added and services are optimized.… Read More »

New in ThousandEyes: Dashboard Widgets, APIs and More

Posted by on May 5th, 2017
May 5th, 2017

At ThousandEyes we release new code every two weeks, adding new features, enhancing existing ones and squashing any bugs. Using ThousandEyes to its full potential often requires staying on top of these changes. To keep you abreast of areas of product development, we’ll publish a quarterly update of key features and enhancements, in addition to our bi-weekly release notes.… Read More »

Best Practices for an Internet-based SD-WAN

Posted by on May 3rd, 2017
May 3rd, 2017

CIOs and IT executives are constantly challenged with reducing IT spend, optimizing operating expenditures while increasing service agility, delivering and maintaining superior quality of service. Enterprises are constantly searching for innovative solutions to execute on these business objectives.… Read More »

Rostelecom Route Leak Targets E-Commerce Services

Posted by on May 1st, 2017
May 1st, 2017

Last week Rostelecom, one of Russia’s largest, partially state-owned Internet service providers, leaked dozens of routes pertaining to IP addresses that belong to major financial services firms. This route leak redirected Internet traffic bound for these financial firms to Rostelcom, as some routers around the Internet decided that the new, leaked routes were preferable to the legitimate ones. … Read More »

Automating Performance Monitoring at Microsoft

Posted by on April 27th, 2017
April 27th, 2017

Last week we took ThousandEyes Connect to the road and visited Seattle, bringing together network engineers, architects and site reliability teams to discuss network performance. Scott Hinckley, Sr. Site Reliability Engineer for Microsoft Dynamics 365, opened up the morning presentations.… Read More »

What Is Net Neutrality?

Posted by on April 18th, 2017
April 18th, 2017

Over the past 3 years, net neutrality has been a hot political topic as the Obama and Trump administrations have taken diverging positions. Most recently, with a repeal of 2015 privacy protections, the Trump Administration has signalled a move away from the principle of net neutrality. … Read More »


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WinCo Ranch Dressing Recall

Posted on December 19, 2016 by

VanLaw Food Products, Inc. is recalling WinCo Brand Ranch Dressing with code date of Best By 08/23/17. The back label was mislabeled with WinCo Fat Free Ranch Dressing label, and in particular the label is missing an egg allergen declaration.

The products were distributed to a limited numbers of WinCo stores in Arizona, Idaho, California, Nevada, Oregon, Texas, Utah and Washington. There are approximately 460 cases that may have been purchased by consumers with this particular code date of 08/23/17. The code can be found above the back label on the bottle. No other WinCo Foods products and/or code dates are involved by this voluntary recall.

VanLaw Food Products, Inc. initiated the recall after it was discovered that a limited amount of WinCo Ranch Dressing were mislabeled with the back label of WinCo Fat Free Ranch Dressing. No illnesses have been reported to date in connection with this mislabeling.

Consumers who have purchased the specific recalled products are advised not to consume them and to return the product to their point of purchase for refund. Consumers with questions may contact Suzanne Gibson at (714) 870-9091 (8:00am – 5:00 pm PST).

Product Photos

  • WinCo Foods Creamy Ranch Dressing 16 FL. OZ Front Label
  • WinCo Foods Cream Ranch Dressing Fat Free Back Label

  • © 2016 US Food Safety Corporation. No copyright claim is made for portions of this blog and linked items that are works of the United States Government, state governments or third parties.

    Posted in: Family safety


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Niagara-on-the-Lake is approximately 90 minutes by car from Toronto, and less than 30 minutes from Buffalo.

Wine Country Ontario site map


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Kate Hudson packs on the PDA in front of Ryder

Sara McGinnis

posted: March 3, 2013, 10:00 am

in: You and Your Family, Relationships, Celebrities

Kate Hudson and Matt Bellamy are acting like any engaged couple on vacation ought to, but how much kissing and canoodling is to be done in front of the kids?

The actress was recently spotted locking lips and climbing on top of her Muse man while poolside in Miami, right next to son Ryder. The boy, who spent some time plugged into what looks to be a video game, is Kate Hudson’s son from her first marriage to Chris Robinson, while the 33-year-old blonde and her fiancé are parents to Bingham, born in July of 2011.

Speaking of getting around to planning a wedding, Kate Hudson recently explained to Closer magazine, “Now it’s just nice if we manage any time together because we have a 19-month-old and a 9-year-old! We will get married, but we just don’t know, where or what. We just have no time.”

Understandable, then, that being on vacation in Miami means time to relax and get romantic — but I can’t help but think of my own 8-year-old son while looking at the photos of Ryder. My boy has just started to hit that magical age where he makes disgusted noises at the sight of the husband and I having a cuddle or kissing.

We haven’t stopped showing affection to each other in front of the boy, but I do find myself being very conscious of when he’s around, swatting away butt-grabs from the husband and keeping the canoodling fairly minimal.

I had thought, “Oh, we’ll just be open and loving from the get-go and they’ll grow up thinking that’s normal,” but while that may have been accomplished to some extent, I seem to have forgotten that no one really likes to see their parents be mushy after a certain age.

Where do you draw the line at PDA in front of the kids?

Here’s a look at famous couple who’ve been caught on the Kiss Cam — some willingly, some not so much!
[Gallery 13089 not found]

Photos: INF

Sara McGinnis

Sara McGinnis lives in the Pacific Northwest with her two sons, ages 13 and 11, her husband, and enough pets...

Read Sara's full bio
  • Wanda

    I love my husband and I love my kids. We kiss and cuddle in front of our sons. With so many divorced parents, I want them to learn what a healthy marriage is. My 7 year old did the “ugh” and “blah” for a couple of weeks but did not lasted long. We do refrain from anything looking sexual but kisses in the mouth, hugs and cuddles are always welcomed!

  • Chi

    I think kissing and cuddling is one thing but she is on top of him next to her child and I think that’s gross. I wouldn’t do that type of thing in public anyway, and definitely not in front of my child. But, to each their own.

  • Let’s not forget, this isn’t his father she is doing that with, it’s not even his step-father. I don’t mind kissing and hugging on my husband in front of my stepkids, but I wouldn’t get on top of him like that. It just seems weird. It’s his mother’s fiance. But who knows. Could have just been a “money shot” that made this look a little worse than what it was.

  • Anne

    Hugs, kissing and cuddling yes. Climbing on top of one another no. Even though kids grow up seeing their parents express affection, having been through it with my older two, kids do not like seeing it. A kiss on the cheek would set off my oldest two. My 4-year-old is just starting to roll her eyes. I’m surprised a variety of gagging noises were not heard from the peanut gallery. Then again, the pull of the video game may have been enough to ignore what his mother was doing. I would cool it.

  • guest

    Kids do NOT need to see their parents being affectionate. That is a PRIVATE matter. Od course anyone with half a brain knows Kate is a self-centered floozy. Appropriate behavior is not in her vocabulary.

  • za

    WRONG! WRONG! WROnG! She’s white trash. And her butt’s fat.

  • Denise

    When it is the child’s Mother and Father, I give PDA’s more leeway. However, this is NOT the kid’s Father, this is just her BOYfriend. Big difference. Yes, I think it is bad parenting to be making out on top of your boyfriend with your child right there. I would not even take a boyfriend on vacation with me and my child.

  • Susan

    I think it is good for kid to see parents that are in love and affectionate, but also with appropriate decorum for the situation. A kiss, snuggle, butt grab in the kitchen at home seems fine to me. However, that picture of her astride him is in bad taste period – whether her child with a different man is there or not. If I am poolside next to them in Miami – I don’t want to see that, nevermind her son being subjected to it!

  • Pl

    What’s wrong with you guys she’s just leaning over and kissing him no straddling involved. He’s more than just her boyfriend too, they’re a family and have another son together.

  • Milly

    WOW!!! I am shocked with all the negative comments on here. I see absolutley nothing wrong with what she is doing. Bad would be her leaving her son with a sitter so she can enyjoy time alone with her BF. I breastfeed my 20-month old daughter in front of my 11 yr old son. Sometimes when the other restroom is being used up by my husband, my son walks in while I’m showering to go pee pee…I am very confident with my body and being naked around my kids. I hope when I’m 100yrs old my kids are the ones bathing me not some stranger. It does not matter that he’s not his father, it takes a real man to see someones elses child as their own, and that’s what should be important…

  • Cristina

    Anytime my husband tries to sneak a kiss it immediately triggers the sound of tiny feet running to interject a small body between us while wailing “mommy, mommy!” With three kids (18 mos – 6 yrs)they often tag team or just take it in shifts.

  • guest1234

    White socialite talentless trash!

  • Danie

    I think its beautiful. With so much ugly in the world and absentee parents its a blessin for a child to witness love. As long as there is no fondling I say go for it.

  • Tina

    Wow! I’m with Milly on this one. WTF is going on here, people being so nasty about this or her. Damn, I mean just damn! It takes ALL kinds people.

  • Laura E.

    Oh c’mon. Seriously? Kids shouldn’t witness their parents being affectionate with each other? Why not, exactly? It’s showing a healthy relationship.

    As for the fact that he’s not the boys father, he IS the father of his half brother. It’s not some random Joe she picked up off the street last week. I think it’s totally normal for them to be on vacation together.

    While I can see how the first picture could be considered a little too much, it’s also just a picture. Maybe she crawled up to give him a kiss before she left. If you look it the pictures, their bodies aren’t even touching, it’s not like she’s grinding all over him.

    I will kiss my husband and flirt with him in front of both my boys – they need to see examples of how a man and a wife should interact, and I want them to also have an example of how to be affectionate with their wives. You don’t get married and have kids stop needing affection.

  • Corinne

    I think it is totally find. In fact there is a book called Children Who See Too Much that is about children who witness violence. It mentions that children who grow up in a home with adults who are happy and in love and show it appropriately are happier themselves and learn how a relationship should be and are more likely to have healthy relationships themselves. Opposed to those who fight all the time and may be abusive. I think this is just showing her son what a healthy relationship should be as long as all clothes are on and no inappropriate groping. There are lines that shouldn’t be crossed.

  • m90smith

    Wow!! 1) i believe this photo has been taken outta context as shes a) not straddling him b) whose to say it wasn’t a quick peck that the intrusive paprazzi happened to catch?! My husband and I are quite the blended family and are very loving and affectionate in front of our girls and also very loving and affectionate to them. The negative comments here surprised me!

  • Britney

    These pictures look very misleading. She could very well have been leaning over him for a second for a quick kiss. Now, if she had settled on top if him and had a heated make out session then that would be a little inappropriate for my tastes. I don’t see a problem with kissing and cuddling in front of you’re kids. It’s a better message sent then the kids that have to witness abuse. Plus, I’d rather my kids see their parents doi g that in a COMMITTED relationship so they don’t get the idea to do it with everyone and to not hide it.

  • Holly

    Wow – I cannot believe some of the mindless comments I have read on here – good grief! As for the pictures, seriously? This is a question? Since when has it not been ok to show affection? It is ok for kids to watch violence (MMA fighting? Boxing? Violent TV shows?) but not ok to see their parent or parents to express love? My husband and I cuddle, kiss, hug, and tell each other how much we are in love in front of our son ALL the time and I would absolutely NOT do anything differently. My son is 16 months and gives the best hugs, kisses, and snuggles – and I believe because he not only receives this love and affection from us but also imitates what he sees. I cannot predict what he will grow to be like in the future, but I can guarantee he will know what love and affection is. I rather my son see that any day.

  • Cloe

    Im curious because i saw this pic and was thinking ok this looks a little weord BUT if you look for a minute, his legs are crossed to the side. It almost looks like it was totally taken out of context.. looks like she maybe just tried to give him a kiss but theres no space on the side of where hes sitting. I agree anything sexual in front of kids or in public is inappropriate but as per the usual i tend to think the media took this out of context trying to cause drama. And its working.

  • I couldn’t manage this PDA because my 2yr old babyboy would interject and squeal ‘My Moooommmy!’

    He’s going through that ‘She’s MINE!’ phase, which can be annoying sometimes but also awesome most of the time. I’ve never had 2 boys fight over me in my life! Who knew motherhood would be the one to bring it on 😉

  • DaraH

    I dont like what i see in the pictures, it WOULD look awkward to ME just as a passerby to see a woman on top of her man right next to their kid, but at the same time i dont know the dinamics of their family enough to be able to say “this will scar that kid for life” or not. I have a 2 year old and he see’s “mommy and daddy kiss” all the time (and usually tries to get in the middle and get some kisses in for himself too!) so we normally end up in a group cuddling and kiss/laughing episode for a moment or two. but see thats MY FAMILY its not THEIR family and we have no right to say weather or not this is the norm for THEM. their not showing skin,doing anything outwardly nasty, and the kid doesnt see disgusted or disturbed by it so i say just let them have their moment. *shrugs*

  • Laura

    I don’t see anything wrong with it, it’s just her leaning down to kiss him, they’re all fully clothed, etc. I know my husband is not big on kissing PDA, but he is a butt smacker and boob pincher ( I know, I know, I promise, otherwise he’s a very mature man/husband/father). The only issues we’ve had with this is my own kids thinking its ok for them to smack mommy’s bum or punch her “wibbles” as my 2 yo calls them. Cute and funny at home, but we have had to have some conversations about what we can do at home vs. what we can do out in public. It is NOT ok to reach out and give Mommy an unexpected titty twister while she is pushing you around in the buggy at the grocery store:-/.

  • Danielle

    I personally am not into a whole lot of PDA. I hold my husband’s hand and give him light pecks on the cheek or mouth in public, but that’s about the extent. I do think however that in the home it’s fine for kids to see how in love their parents are by displays of affection. Anything that is borderline sexual should be done behind closed doors, but cuddling,kissing, and hand holding is fine. It’s healthy for a kid to know how in love his parents are and I think in turn it makes them feel more loved.

  • Me

    I think kids NEED to see loving, healthy relationships! I will say that the fact he is the father of her other son, but not this one, could lead to some hard feelings about his own parents being split, but since I don’t know them, I have no idea. My husband and I kiss in front of our kids all the time. This is how you learn what love is!

  • Hannah

    She is clearly just leaning over to give him a smooch, and I am so crazy confused by the people calling her white trash, floozy, self centered, and fat!? Do you people even know who Kate Hudson is? She is unbelievably caring of her children, total crunchy mama, and probably weighs a whopping 110 lbs at most! Get the stick out of your asses people.

  • KerA

    Or why don’t you just mind your own business its none of ur business she is just kissing him get a grip tbh and stop getting involved in their love life and making random crap up u should read wa you put because it just makes you look like your bothered am not bothered am just saying u would never have privacy again when you become famous so stuff saying all the mad stuff about kate u would have felt the same if u was like her :/

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In SAP 9.2  PL09 Most of the time we login SAP through browser access but its closed due to session timeout
Do changes in server file for timeout session.
path:>C:\Program Files (x86)\SAP\SAP Business One BAS GateKeeper\tomcat\conf
In the server, text file made changes in both place Connection timeout in Sec.

Hope your issue resolved.
Tejas P
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  1. Eric Li

    There are different HTTP session inside the Browser Access solution:  one is the HTTP session located on Tomcat side, and the other one is user session hold by the backend B1 process.

    The content mentioned in this blog is just a common way to change HTTP session timeout configuration on tomcat side, unfortunately, it has no effect on the session holding by B1 processes.

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  • Microsoft Plans Large Volume Production of Surface

    Microsoft Corp. seems to be serious about its foray into the tablet market – the software giant is planning large volume production of its Surface tablet in the fourth quarter.

    According to component suppliers in Asia,  Microsoft has placed orders to produce 3 million to 5 million of these tablets in the fourth quarter. That is similar to the orders that were placed for Amazon’s Kindle Fire tablets and Google’s Nexus 7 tablets, these suppliers say.  Some suppliers to Apple in Asia say they have received orders to make more than 10 million units of a smaller tablet for the Cupertino, Calif. company in the fourth quarter.

    Mass production of the Surface tablets began earlier this month, according to two people familiar with the situation.

    Popular on WSJ


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Barry Abernathy on WUNC today

Barry Abernathy - photo by Mark HarvellBarry Abernathy will be the featured guest today on The Story with Dick Gordon, aired on WUNC (North Carolina Public Radio). Barry is the banjo player with Mountain Heart, and performed previously with both Doyle Lawson & Quicksilver and IIIrd Tyme Out.

You would never know it from hearing his music, but Barry had much to overcome in establishing a career as a professional musician. He was born with a deformity of his left hand, and has no fingers – only a thumb and several partial digits. Barry cultivated a fascination with the banjo at a young age, and developed a technique that was within his reach, playing over the top of the neck rather than wrapping the hand around from below. He uses his thumb and the knuckles of his partial fingers to fret the notes, modifying common fingerings and chord shapes allow him to play effective and authentic bluegrass style banjo.

There is much to admire about Barry, and succeeding against great odds is only one thing among many. His tone, command of time, meticulous execution and impeccable sense of appropriateness set him apart as a banjo player without regard to his physical challenges. On top of that, he has consistently refused to trade on his handicap, resisting the “show biz” urge to portray himself primarily in that fashion.

Even more admirably, when he does address it publicly or on stage, it is with humor and a great comfort with his situation. A running joke that involves my company, AcuTab Publications, is always a hit with audiences when he tells it on stage. Barry will mention how other prominent banjo players have had transcription books of their solos published by AcuTab, and then suggest that he has one called “AcuNub,” with every page showing a one finger bar chord diagram.

The interview with Gordon for The Story centers on Barry’s learning to play without fingers. It can be heard today, September 22, at both 1:00 and 8:00 p.m. on WUNC. The station can be heard on 91.5 in central NC, and is streamed live online.

The Story also maintains a show archive, or you can subscribe to receive their podcasts if you miss the show live.

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About the Author

John Lawless

John had served as primary author and editor for The Bluegrass Blog from its launch in 2006 until being folded into Bluegrass Today in September of 2011. He continues in that capacity here, managing a strong team of columnists and correspondents.


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Relevance of Truncating Titin Mutations in Dilated Cardiomyopathy

Published on January 28, 2016

As a continuation to Blueprint Genetics recent collaborative studies on genetics of dilated cardiomyopathy (DCM) (Eur Heart J 2015 and PlosOne 2015), we performed meta-analysis of truncating titin variants in DCM. Others and we have previously estimated TTN truncating variants (TTNtv) – nonsense, frameshift and consensus splice site, to be responsible for 18-25% of familial cases of DCM and 11-15% of sporadic cases in large patient cohorts (Herman et al. 2012, Roberts et al. 2015, Haas et al. 2015, Akinrinade et al. 2015 and Akinrinade et al. 2016). However, clinical interpretation of these variants is known to be challenging, as these variants are also present rarely in reference populations. Our previous study showed that one in 500 individuals carries a truncation in TTN A-band suggesting that the penetrance of these potentially harmful variants is still not fully understood (Akinrinade et al. 2015). Thus, further research was warranted.

Table. Meta-analysis showed enrichment of TTN truncations in DCM patients (n=1768) vs. reference population (n=60,000)

Titin region DCM vs. reference P-value
A-band 12.25% vs. 0.19% p=1.3×10-251
I-band 2.52% vs. 0.07% p=1.9×10-46
M-band 0.62% vs. 0.05% p=3.2×10-08
Z-disk 0.17% vs. 0.03% p=2.4×10-02

Akinrinade et al. 2016, PubMed: 26777568.

Truncating TTN variants affecting five out of seven transcripts in DCM patient were estimated to be disease causing in at least 97.8% of cases (likelihood ratio 42.2). This is an important step towards a better understanding of the titin truncations in cardiomyopathies.

This calls for caution when interpreting TTNtv in individuals and families with or without history of DCM. Considering the size of TTN, expertise in NGS strategies, bioinformatics, systematic variant assessment strategy, and confirmatory sequencing are prerequisites for reliable evaluation of TTN in clinical settings. Importantly, meaningful interpretation of these variants require understanding of structure of titin protein and its isoforms.

Read more about our collaborative achievements in the article published in Clinical Genetics on January 16th, 2016. Link

(1) Akinrinade O, Alastalo TP, Koskenvuo JW. Relevance of Truncating Titin Mutations in Dilated Cardiomyopathy. Clin Genet. 2016 Jan 18, Epub ahead of print. PubMed 26777568. In collaboration with Blueprint Genetics.

(2) Akinrinade O, Ollila L, Vattulainen S, Tallila J, Gentile M, Salmenperä P, Koillinen H, Kaartinen M, Nieminen MS, Myllykangas S, Alastalo TP, Koskenvuo JW, Heliö T. Genetics and genotype-phenotype correlations in Finnish patients with dilated cardiomyopathy. Eur Heart J. 2015 Sep 7;36(34):2327-37. PubMed 26084686. In collaboration with Blueprint Genetics.

(3) Akinrinade O, Koskenvuo JW, Alastalo TP. Prevalence of Titin Truncating Variants in General Population. PLoS One. 2015 Dec 23;10(12):e0145284. doi: 10.1371/journal.pone.0145284. PubMed 26701604. In collaboration with Blueprint Genetics.

(4) Haas J, Frese KS, Peil B, Kloos W, Keller A, Nietsch R, et al. Atlas of the clinical genetics of human dilated cardiomyopathy. Eur Heart J. 2015 May 7;36(18):1123-35a. PubMed 25163546.

(5) Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, et al. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012 Feb 16;366(7):619-28. PubMed 22335739.

(6) Roberts AM, Ware JS, Herman DS, Schafer S, Baksi J, Bick AG et al. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med. 2015 Jan 14;7(270):270ra6. PubMed 25589632.

Full transparency sets a new standard for quality

Published on July 21, 2017

Blueprint Genetics is committed to provide the highest quality genetic testing for our customers. Since quality is something that can be proven, we are proud to transparently share our full set of quality metrics with you. To be able to show the different aspects of quality in genetic testing, we…

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