text:
Tag: T Cells

Adoptive Cell Therapy Part 1: Chimeric Antigen Receptors

by on Apr.26, 2011, under Oncology

Imagine a person with Stage IV Chronic Lymphocytic Leukemia, a cancer of the white blood cells. A scan of his bone marrow shows almost complete replacement of healthy cells with cancerous. The cancer is chemorefractory, meaning it survives every dose even while his normal rapidly dividing cells do not. Now, instead of the normal treatment progression and a poor prognosis, some healthy T cells are extracted from his blood. They are processed, induced to replicate, and then the large resulting colony of cells is infused back into his blood. Thirty days later, a scan reveals his bone marrow to be clear of the cancer and another 6 months later shows the same; a complete resolution to the cancer.

While I asked you to imagine, you actually don’t have to; the process, the person, and the results are real; part of a clinical trial which is still actively recruiting patients. It is not complete and the information presented in the NIH webcast, which was my original reference for this post, has not been audited let alone published1. The same however, was not the case in all CAR trials, two courses in others, resulting instead, sadly, in fatalities2. However, as I will present in my next post, the protocol was changed for the second group and there were special circumstances. (* See Note: I am not a physician, I am self-taught in the bio-sciences).

This new approach to cancer treatment, which includes the specific therapy that killed this man’s cancer, is known as Adoptive Cell Therapy. Specifically in this case, engineered genes coding for what is known as a Chimeric Antigen Receptor (CAR) were introduced into the T cells extracted from his blood via a retro-viral vector. I wrote about Antigen Receptors over my last four posts and the word Chimeric in the world of molecular biology refers to the fact that the gene is actually a combination of other genes or gene segments brought together from different sources. You may note that the concerns from previous attempts at using retroviruses are mitigated here because the transfection actually occurs, effectively, in a petri dish rather than in the body of the patient. Further, using a cytotoxic T cell is preferable to say antibody treatment since rather than relying on an orchestrated immune response to the antibody binding of its ligand to kill a target cell; cytotoxic T cells kill directly and serially.

There are essentially three steps in the engineering of a gene which encodes the CAR. The first is to identify a molecule, the new receptor’s ligand, that exists on the surface of the cells that are to be destroyed. The second is to find a molecule that has binding specificity for that ligand, perhaps a variable region from an antibody or the extracellular region of a co-stimulatory receptor.

For example Herceptin is a monoclonal antibody used in the treatment of breast and other cancers. It has binding specificity for erbB2 which is highly expressed on the surface of malignant cells. Another example comes from the fact that the CD8 receptor found on T Cells happens to bind with high affinity to the glycoprotein GP120 which is present on the envelope of HIV.

If an antibody is chosen, segments of the genes that encode the variable regions of the heavy and light chains (see previous posts) are linked together from the 3’ end of the light chain to the 5’ end of the heavy (note that DNA molecules are formed in one direction 5’ to 3’)3. This produces a gene which encodes a single protein designated scFab or Single Chain Antigen Binding Fragment.

The next step is to find a suitable signal generation protein chain for the intracellular domain of the chimeric receptor. This step is far simpler than the first two given that it appears that there a relatively small number which can initiate T cell effector programs such as cytotoxicity. Second generation CARs, for example, used the zeta ( ζ) chain of the T Cell Receptor Complex joined to the scFab via the transmembrane region of a co-stimulatory molecule such as CD 8 or CD282. Third generation CARs use the intracellular signaling domains from 4-1 bb or OX402. I haven’t read of the reasoning for the change, but my thoughts are that it stems from the fact that 4=1 bb and OX40 are present only on T cells which are already activated. The ζ chain, on the other hand is involved in the initial activation of a T cell. Therefore the results of the signaling through 4-1 bb and OX40 would be more specific to cytotoxic effector function rather than the proliferative and cytokine release functions that are part of the in the initial activation of a T cell. This means that there wouldn’t be cascading bursts of T cell proliferation and cytokine production following each encounter with the CAR and it’s antigen thus lessening the potential for a massive expansion of the T cell population after injection and adverse reactions to very large releases of cytokines.

To illustrate the need for a signaling region, consider the ζ chain. The T and B Cell Antigen Receptors, whose formation I presented in my previous four posts, are key to the function of our adaptive immune response. However, they are not present in the membrane alone and they are not actually capable of producing an intracellular signal. Though I didn’t mention the other proteins in my posts, the Antigen Receptors are actually part of a complex which includes other proteins in close association which are capable because they contain ITAMs. The ITAMs; Immunoreceptor Tyrosine-based Activation Moieties, are initiators of stimulatory signals and are activated when the Antigen Receptor binds its ligand. In a T cell these proteins are collectively known as CD3 and together with the Antigen Receptor; the T Cell Receptor Complex.

Figure 1 – T cell Receptor Complex

Returning to our hero and the generation of the Chimeric Antigen Receptors that killed his cancer… In the lab (in vitro), the proliferation of his T Cells was induced, amazingly, using beads engineered to mimic the activity of dendritic cells which are the most proficient presenters of antigen to T cells in the body (in vivo). Then the genes encoding the third generation CAR are delivered to those cells, via a retrovirus. His T cells are subjected to a battery of quality tests and then cryogenically frozen until he was ready to receive them.

The scFab region of this CAR has binding affinity for a molecule (the receptor’s “ligand”) expressed on the surface of the malignant cells known as CD19. When the millions of his T Cells, rendered cytotoxic and specialized through synthetic bioengineering, were injected into his blood, the cancer was gone within 30 days.

Despite this astounding result, and the result of others in the trial, the work, is still far from complete. CD19 may be expressed on his malignant cells, but those cells were B cells, and CD19 is expressed on virtually all B Cells. So at 6 months, while his bone marrow was clear of the malignant cells, it was also clear of any B cells. While this was actually a big step to the positive given immunosuppressive chemo isn’t usually so selective, an “on-target but off-organ” effect has been seen in this and other studies2. This occurs when the target of the anitgen targeted by the T cells is expressed on healthy cells not intended as targets. In the case of CD19, this is less an issue because the Immune System is regenerative and its function is specific. However, if the target is expressed on the cells of healthy tissue to a high enough degree, the results can be devistating.

The people included in the trail, as I interpret the information, had a very poor prognosis with advanced, chemorefractory cancers. The two fatalities in another CAR trial involved several differentiating factors, but the exact cause of death was presented as inderterminate. In one case there was the possibility of an unrelated infection as the cause, but in the other “on-target, off-organ” seemed likely. I will present more information on this as well as the “on-target but off-organ” effect in my next post.

* Note: I’m not a researcher nor a clinician, and nothing I present in this post, or any other post I may make on a health science topic, should in any way be considered medical advice, the intent of the authors of any of the texts or research I reference, or an authoritative presentation on any source used. This post is solely my understanding along with, perhaps, my ideas based on my understanding of the material I’ve read.

1. “Adoptive T Cell Therapy: Entering the era of Synthetic Biology”
Carl June
University of Pennsylvania

2. “Safer CARs”
Helen E Heslop
Molecular Therapy (2010) 18 4, 661–662. doi:10.1038/mt.2010.42

3. “Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the y or C subunits of the immunoglobulin and T-cell receptors”
Proc. Natl. Acad. Sci. USA
Vol. 90, pp. 720-724, January 1993

4. “HER 2/neu protein expression in colorectal cancer”
B Schuell (a) , T Gruenberger (b) , W Scheithauer (a) , Ch Zielinski (a) and F Wrba (c)
a. Department of Internal Medicine I, Division of Clinical Oncology, University Hospital, Vienna, Austria
b. Department of Surgery, University Hospital, Vienna, Austria
c. Department of Pathology, University Hospital, Vienna, Austria

5. “Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors”
Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc. Natl. Acad. Sci. USA
Vol. 90, pp. 720-724, January 1993

Leave a Comment :, , , , , , , , more...

Somatic Recombination Part 4: Cutting up your DNA

by on Mar.06, 2011, under Immunology

So you’ve been told that all the cells in your body contain the same genetic material? I’ve seen it written as a general principle of Genetics and a quick search around the web will yield many sources indicating that all somatic cells contain the exact same DNA. I did find a few articles in science magazines which “revealed” that this may not be the case, but the general consensus that they do was prevalent.

From all I’ve read, research and texts included, the DNA contained in all somatic cells is the same with one exception; the hematopoietic cells. These cells are the cells of the blood and they all descend from a single progenitor, the Human Hematopoietic Stem cells which can be found in bone marrow. These stem cells give rise to a diverse population of progeny including erythrocytes (red blood cells), T Cells, B Cells, Macrophages, and Natural Killer cells. To be accurate, the stem cells and their immediate descendants contain “germ-line” DNA, which is DNA that was formed during the individual’s fertilization event and is shared with virtually every other somatic cell in the body. However, as the hematopoietic descendants start to specify into the progenitors of T and B cells or “lymphopoietic” progenitors, the process of Somatic Recombination which creates the antigen receptors I’ve been writing about cuts out and discards parts of certain chromosomes thus creating genetically distinct human cells within our own bodies.

In my last post I presented the gene loci on which this process acts and highlighted the first actors in the process; the Recombination Activating Gene 1 & 2 proteins (RAG1 & RAG2). The arrangement of the gene loci is very important in this discussion and the rest of what I’m about to present doesn’t make much sense without this knowledge, so you can click this link to read that post if necessary. The process is performed by the V(D)J Recombinase and the process progresses as the molecules that make it up are assembled, I will introduce them as I describe the process.

It begins with two molecules each containing one RAG1 and one RAG2. These complexes then randomly bind, one each, to two of the hundreds of Recombination Signaling Sequences (RSSs) found surrounding each gene segment in the target antigen locus. It should be noted that the selection is not random across the segment. For example, two V regions will not join; it must be a V and J, for example, in a light chain locus. After binding, the two complexes come together and bind resulting in the formation of a loop of DNA between them which contains all the gene segments that may have been between the two segments brought together.

With the loop formed, the RAG complex will cut the strand exactly at the points where the RSS ends and the coding segment begins (see diagram below). This happens because the RAG complex has an inherent ability to act as an endonuclease. This essentially means that it is a protein that can break a DNA molecule into parts. This is the action that excises a piece of our DNA which is called the signal joint (because the RSS of each segment are joined flush). At this point, because of reasons relating to the chemical properties of the structure of a molecule of DNA, the ends of each strand which are cut fuse to form hairpins.

At this point other proteins join the complex to complete the recombinase and the process. These proteins are actually ubiquitous in human cells and I believe they are present for every mitotic and meiotic event that occurs over an individual’s lifetime. The first two proteins to bind to the growing V(D)J Recombinase are named Ku70:80 and they hold together both the ends of the chromosomal DNA strand, and those of the signal joint. Note, that this is the last I will mention the signal joint as once it’s ends are fused, it is no longer part of our story.

It is here where the process becomes a little unnerving for me. The very precise cut made by the RAG1/RAG2 complex to setup the joining of gene segments is one thing, but what happens next, to me, is another. The following video presents an excellent visualization of the entire process with a voice-over by Dr. Julie Theriot; a brilliant mind. I will, however, go into a little more detail below.

A protein named DNA-PK, or DNA-dependent Protein Kinase, is formed when another protein named DNA-PKcs binds tightly with Ku after the strands are bound. And to this another protein named Artemis joins. Artemis is also an endonuclease without which we would be ending our story with a broken strand of DNA. Artemis cuts the hair pins formed after RAG1/RAG2 excised the signal joint, but the location of its cut appears to be random. It has been found that they occur anywhere along the hair pin and this is where the fun starts.

With the location being random, unequal ends are often left which must be equalized before the DNA can be rejoined. Enter another protein that is found in all our cells and has a great name; Terminal Deoxynucleotidyl Transferase (TdT). TdT randomly adds bases to the cut ends resulting in what is essentially a newly formed random sequence on each. At the same time, two more newcomers bind to each other and then the Recombinase; DNA Ligase IV and XCR44. There are ubiquitous DNA repair proteins which and as soon as they bind, they start trying to re-join the strands; the name Ligase actually comes from the Latin “ligare” meaning “to bind or tie”. With TdT inserting random bases, the repair/ligation complex may need to knock out and replace non-complementary pairings such as a Guanine to a Thiamine.

With the ligation effort winning out in the end and the chromatid now back in one piece, the process of Somatic Recombination is complete. With just a few more steps we have a complete gene which, when transcribed will form one of the two chains in an Immunoglobulin. The process, however, has left the chromatid irrevocably changed; it is unique, different from any other member of its chromosome pair in the body, including other B cells. I’d like to note again that this change is key to the efficacy of our adaptive immune response. Without the enormous diversity generated by this process, neither the B and T cell antigen receptors nor the antibodies secreted by the former would be capable of binding effectively to the diverse and ever changing peptides making up evolving pathogens. However, it also introduces a potential for a number of pathologies, including cancer.

It has been shown in research1 that if the DNA repair mechanisms like DNA Ligase IV\XCR44 and the DNA damage checkpoints are not functioning properly, Somatic Recombination can result in several pathologies. These include aneuploidy, an abnormal number of chromosomes, translocations, where one part of a chromosome is fused with another, and neoplastic transformation, cancer.

In fact, according to both Janeway’s Immuno Biology (p 312) and a paper published in Nature Immunology in 20071, translocations are found in most lymphoma tissues. What is compelling for me about these translocations is that they most often involve what are known as proto-oncogenes which are genes encoding proteins that, when not functioning properly, cause cancer.

What causes DNA checkpoints and the DNA repair proteins to malfunction? I’ve seen the research showing the obvious conclusion; mutations forming in the genes coding for the proteins which carry out the functions. However, I suspect epigenetics may play a role in at least some of the scenarios. What causes these translocations? Given the fact that many lymphomas are age onset, I would conclude that probability must be considered, but the translocations of proto-oncogenes suggest to me that epigenetic factors should be examined. There are genes such as Myc (Myelocytomatosis)that regulate the expression of up to 15% of our entire genome and do so through epigenetic factors such as HAT (Histone Acetyltransferase). It should not be surprising that Myc is an oncogene and it is, in fact, one that is involved in the translocations found in lymphoma tissues.

1. Nature Immunology 8, 801 – 808 (2007)
Published online: 19 July 2007 | doi:10.1038/

Leave a Comment :, , , , , , , , more...

Looking for something?

Use the form below to search the site:

Still not finding what you're looking for? Drop a comment on a post or contact us so we can take care of it!

A few highly recommended websites...


Content-Type: application/http; msgtype=response

WARC-Identified-Payload-Type: application/xhtml+xml

WARC-Type: response

text:
Thursday, 29 March 2018

Meet the Maker - Elaine Mellor

I have been a Stix2 demonstrator for almost a year but I have used Stix2 for as long as I can remember . I’m seriously thrilled I get to demonstrate such great products and still pinch myself. I’m also on 2 design teams which I love being part of too. I love how I can intermingle different craft products that I love and lots of things work so well together.

I live in the West Midlands and spend hours in my craft room. I travel to to demo days as far as north Nottingham visiting some amazing craft shops and meeting some fabulous people.

How you started
Well I started crafting almost 12 years ago. I saw a simple handmade card and thought I would love to have a go. My first purchases were blank cards and peel offs. I’ve never looked back since.

Favourite to make
I love to make anything to be honest. If I’m creating I’m happy.

I’m quite a tidy crafter but when I’m busy prepping it can get quite messy in my room.

Can’t live without
Well where do I start....Stix2 adhesives is a must and I use all different sorts depending on what I’m doing. I’m a massive fan of Stix2 card in every variety and colour and it’s on almost everyone of my makes along with the card blanks which are 300gsm and amazing. Finally my trusty guillotine and Sizzix big-shot,  these are 11 years old and still going strong.

Creative friends
I have met some truly wonderful people over the years and have made some amazing friends at my local craft shop where I go to craft once a week to relax with like minded ladies. I have to give a mention to the Stix2 team who have been so wonderful & supportive.

Visit to see when Elaine is next demonstration.

For further information contact us on the details below.
T: 0191 2697810

Wednesday, 28 March 2018

Meet the Maker - Rushanne Young

I'm a Stix2 demonstrator and freelance craft tutor living in 'not as flat as you think' East Anglia, where we have several very good independent craft shops.

How you started
That's all thanks to my Mum, her ability and encouragement to try anything creative.  I love to find as many uses for things as possible, to mend and recycle where I can.

Favourite project
A papier mache head, decorated with die cut cereal box shapes and broken jewelry stuck on with hot glue, painted and waxed.  A handy stand for headphones.

Favourite tool/product
The Stix2 2in1 glue pen and Transfer Foils - write, draw or stamp something with the glue and foil it, no need to buy an expensive machine. Mounting Foam - now I have a stamp platform I'm re-mounting my old rubber stamps to fit the press and using the redundant wooden blocks for altered art.

Can't live without
A non-stick crafting sheet, heat resistant and so easy to clean makes it a MUST have.

This comes from everything, anything and anyone. Other crafters are a mine of inspiration, whether it's my local group or a well known blogger. Also look at things with a view to what else could you make from it, an empty malt drink plastic pot makes a great child safe night light with an LED tea light inside.

Visit to follow Rushanne when she is demonstrating.

For further information on Stix2 products please contact us on the details below.
T: 0191 2697810

Meet the Maker - Jan Curtis

Hi I am Jan Curtis demonstrator and tutor. I live in West Wales by the sea. After working in education for over 22 years, I retired to relax and do my own thing .( I have always been a crafter) well I visited a craft shop in Milford Haven and it has been all go since!!!

I teach all paperbacks to over 20 ladies and 2 gentlemen every week. My inspiration comes from my ladies asking me can we do this or that from paint techniques to folding paper. I come up with a plan and all are happy.

As requested by a lady to make a suitcase and album which has turned out ok this is my latest and favourite project. The other ladies want to make it too now!! Here are some photos of my craft room view from my window working in class.

Find out when Jan is demonstrating for Stix2 by visiting

Contact the Stix2 team for further information on the details below.
T: 0191 25697810

Have Fun Crafting!

Tuesday, 27 March 2018

Meet the Maker - Jane Collman

I have been crafting forever! Taught well by my late parents, drawing, sewing and knitting etc.
I started making cards over 20 years ago before my youngest daughter was born and then worked in various craft shops, teaching and demonstrating the wonderful array of products!
I have also been lucky enough to have had projects in a number of magazines in the past.

I live in Surrey, just a half an hour train ride south of London, and 10 minutes from the biggest car park in England....the wonderful M25!!  We all hate it but use it frequently.

I am lucky enough to have a big cabin in my garden which is my workroom, storeroom and classroom.  It’s very much my Sanctuary and I can lose myself out there for hours!  No children, dogs or husband.....just crafting.  I hold workshops in there and I have everything including the kitchen sink!  Photo shows half the cabin, bit of a mess at the moment...sorting out cupboards again! Help...I’ve run out of space!

Favourite Project
My favourite project ever has to be the glass bottle I painted for a class project.  Couldn’t have done it without the aid of Stix2 extra sticky doublesided tapes and hot glue!  Photo shows bottle with and without lights.

Tools and Materials
What do I reach for most....hmmm, couldn’t be without my trusty scissors, knife and guillotine.

I was thrilled to be asked to demo for Stix2 several years ago. This has enabled me to visit some amazing craft shops in the South East and meet more lovely crafters.  I do enjoy being able to show the great and varied products Stix2 have.

Thank you to the wonderful Michelle Johnson for introducing me to Ruth and her brilliant team at Stix2!

Visit to see when Jane is next demonstration.

For further information contact us on the details below.
T: 0191 2697810

Have Fun Crafting!

Meet the Maker - Clare Brown

Stix2 demonstrator,  Freelance designer  for Making Cards Magazine and co-owner of Paper, Pen and Plan. This is me at my very first demonstration day at Sew Yarn Crafty in Dunfermline. As you can see from my huge smile I was having an amazing day!

I work pretty much everywhere. Mostly in my office when I’m not demoing but during the warming months I’ll take my work outside if I can.

Time to Relax
I love to doodle in my sketch book especially just before bedtime as it helps me get out of work mode.

Keep an eye on the Stix2 website to see when Clare is next working near you.

For more information on any Stix2 product please contact us on the details below:
T: 0191 2697810

Have Fun Crafting!

Monday, 26 March 2018

Meet the Maker - Debbie Frost

Hi my name is Debbie Frost & I live in South Devon. I've been a demonstrator for Stix2 for almost 4 years which I love. I'm also a craft tutor & I regularly run my own workshops on a variety of different topics & techniques

I live in sunny Exmouth, Devon which not only has a stunning4 mile beach but beautiful  scenery & nature at the estuary where the river Exe meets the sea.

How you started
I have been a crafter for as long as I can remember but got more interested in card making when I got a job in the local craft shop (Japonica- sadly no longer open!). I then went on to win a couple of competitions in craft magazines, was a DT member for the Woodware blog & was finally approached by Stix2 to become one of their demonstrators. The rest is history!

Favourite to Make
Anything messy & mixed media with lots of texture,colour & different techniques especially canvases!

Overlooking my garden but don't too too closely at the mess!

Can't Live Without
My trusty Stix2 Hot Melt glue gun! Always on my desk & useful for all kinds of  craft techniques not to mention household repairs.

Customers & Feedback
Nothing gives me a greater buzz  when I've been to one of my Stix2 demo days at one of my crafty retailers than knowing I've done a good job & everyone had a good time. So thanks to all my loyal retailer supporters! The ladies at Somer Craft Addix

Creative Friends
Of course I count all those associated with Stix2 as my creative friends but we all have special ones don't we? I feel privileged to count this fine trio of ladies as my close crafty friends.

My craft bestie Jan Caudrelier - that's us with the award for Best Craft Retailer in 2014 awarded to Japonica at the NEC.

Fellow demonstrators Jenny Redfern  & Jane Williams

To find out more on Stix2 demo days or Debbie Frost please visit
or contact us on the details below:
T: 0191 2697810

Have Fun Crafting!

Wednesday, 7 March 2018

Make your own Benny the Bunny Easter Box

Great way to present chocolate, Chicks or any Easter gift thanks to Jenny Redfern.

To make your own Benny Bunny you will need ...

A4 Pearl Bronze Card A4300PEARLBRONZE
A4 Pearl Misty Rose Card A4300PEARLMISTY
A4 Pearl White Ice Card A4300PEARLWHITEICE
A4 Pearl Oyster Shell Cream Card A4300PEARLOYSTERSHELL
Craft Foam Pads 5mm x 5mm x 2mm S57082
Ultra Clear Tape 6mm x 15m  S57085

Heart Punch
Die Cutting Machine
Hole Punch

How to...

  • Cut Bronze card 29.5cm by 21cm and score this at 4,14,18 and 28cm the extra bit is the flap to stick it together.
  • Score the shorted side at 2cm (this is the bottom of the box)
  • Using tonic layering dies Oval and Circles - die cut- (Sizes count from the smallest die out)
    • 2 x Eyes from White Ice Card, size 1, circle die
    • 2 x Cheeks from Bronze Card, size 2, circle die
    • 1 x Head from Bronze Card, size 9, circle die
    • 2 x Ears from Bronze Card, size 6, oval die
    • 2 x Inner Ear from Misty Rose Card, size 3, oval die
    • 2 x Feet from Bronze Card, size 4, oval die
    • 2 x Inner feet, from Oyster Shell Cream Card, Size 3, oval die
    • 1 x Tail, from Bronze Card, size 6, oval die
    • 1 x Inner Tail from Oyster Shell Cream Card, size 4, oval die
    • 2 x Hands (paws) from Bronze Card, size 4, oval die
    • 1 x Nose from White Ice Card, size 1, circle die.
    • 1 x Teeth from White Ice Card, Heart Punch
  • Die Cut a hole in the front panel for the window, Using the Ultra Clear Tape, stick a rectangle of Extra Thick Acetate behind. Everything else is layered up with 2mm foam pads.
  • Fold the edges of the card in to create your basic box and stick together with Ultra Clear Tape.
  • Hole punch the card at the top to be able to thread the ribbon before attaching the head.
  • Cut whiskers from the White Ice Card and stick to the head using the 2 in 1 Glue Pen along with the eyes, nose, cheeks and teeth to the head.
  • Using the Foam Pads later up and attach the ears to the head and then the head to the body.
  • Layer up the feed and tail with the Foam Pads and again using the Foam Pads attach this to the body.
  • Attach the paws with Foam Pads
  • Use the ribbon to give Benny a bow
  • Fill your box and tie the bow
Thank you Jenny for this wonderful box. Please visit Jennys Blog for more of her work.

For information on Stix2 products contact :
T: 0191 2697810

Have Fun Crafting!

Tuesday, 6 March 2018

Make a Mother's Day Wallet ...Hand Made

Mothers Day will soon be on us and Babs has made this lovely Wallet to put special memories, Tickets or a treat!

Babs has used...

Large White Alteration Tags S57324
Red Gingham Card A4250REDSMALLGHIN
Die Cut Clover Flower White S57299
Tinted Card Intensive Red A4250TINTRED
Tape Runner S57269 / Refill S57270

Along with many other products.

For further information please contact 0191 267810 or

Have Fun Crafting!

Wednesday, 21 February 2018

Create and Craft with Stix2 and Michelle

22nd February 1pm - 2pm

New and Exclusive products from Stix2 will be featured on...

Presented by Dean Wilson & Michelle Johnson

Sky 674, Freeview 23, Virgin 784, Freesat 813, Apple TV & Amazon Fire.

With some exciting New and Exclusive kits
Containing Tools for the Trade, New PVA, Card and more....

If you can IMAGINE IT you can DO IT!

Monday, 29 January 2018

Stix2 Workshops at Stitches

Free daily workshop running with Michelle Johnson and Karen Mackie
 Showcasing new Stix2 products and techniques ...

2 Weeks to go ... BOOK NOW  to not miss out!

Melt & Mould Foam
Introducing a fantastic new 3D foam, with adhesive on one side, that you can use with glitter, foil, beads, paint and an amazing new way to heat and shape with embossing powders.

Sunday - 9:30am - Booking Code: SU3B
Monday - 3:45pm - Booking Code: MO3N
Tuesday- 2:30pm - Booking Code: TU3K

Tools of the Trade
Stix2 have been adding yet more exciting tools, which they are sharing with you. New ideas, projects and techniques to use within all crafting projects.

Sunday - 12:00 Noon - Booking Code: SU3F
Monday - 10:45am - Booking Code: MO3D
Tuesday- 12:00 Noon - Booking Code: TU3F

Or visit us on Stand D06 to find our more.

For further information on Stix2 products please contact 0191 2697810 or
Please visit for Stitches information.

Have Fun Crafting!

Tuesday, 23 January 2018

Window Clings

Our demonstrators are very clever girls! Rushanne has made some Window Clings using Non-Slip Grip Coloured CardPunch Sheets and Alcohol Markers.

Die Cut a basic shape from your Non-Slip Grip and any shape of your choice from your Card and Punch Sheets, attach the two together and you are ready to go! for intricate dies like the butterfly colour the gaps for a rainbow effect.

Perfect for kids and can be used all year round;
Easter, Halloween, Birthdays and Christmas!

If stored correctly they can be used over and over again!

For more information on Stix2 products please contact 0191 2697810 or

Tuesday, 16 January 2018

Valentine's Day Inspiration

You too can make this beautiful Valentine's card with some of our most favourite Stix2 products. Thank you to Michelle Johnson for sharing this with us.

You will need:

Extra Thick Acetate S57320
White Fabric Spray Paint MGPA320J
Hotmelt Glue Gun S57234
Hotmelt Glue Sticks S57235
A4 White Tinted Card A4250TINTWHITE

For more information contact 0191 2697810 or

Have Fun Crafting!

warcinfo:
isPartOf: CC-MAIN-2019-30
publisher: Common Crawl
description: Wide crawl of the web for July 2019
operator: Common Crawl Admin (info@commoncrawl.org)
hostname: ip-10-232-173-83.ec2.internal
software: Apache Nutch 1.15 (modified, https://github.com/commoncrawl/nutch/)
robots: checked via crawler-commons 1.1-SNAPSHOT (https://github.com/crawler-commons/crawler-commons)
format: WARC File Format 1.1
conformsTo: http://iipc.github.io/warc-specifications/specifications/warc-format/warc-1.1/


WARC-Identified-Payload-Type: text/html

text:
Tag Archives: health

Why Teachers Need to care about self-care – Part 1

image source: bigstockphoto.com

Why Teachers Need to Care about Self-Care

Have you ever thought about self-care? Do you practice self-care now?  Unfortunately, self-care was never part of my vocabulary, so when I left teaching in December 2015 due to professional burn-out, I never thought about my own needs.  When I returned to teaching in November 2017, I knew that I needed to practice self-care.  This post discusses what I have learned about teacher self-care and the information shared in a December 7, 2018 TESL Ontario webinar. I also include some valuable insights and comments from more than 80 participants who took part.

Continue reading

Timely Talk About Tobacco

image source: Toronto Public Health

You’ve noticed that many students in your class smoke.  Is quitting smoking something you should talk about? Is it any of your business?  Many of your students have children.  Do they smoke around their children?  Is it part of your role as an instructor to discuss the negative health effects of smoking?  Continue reading

Notes From a Registered Dietitian: Helping Newcomers Make Healthier Choices at the Grocery Store

Image says "Join the movement. Bike. Walk. Play. activeto.caIn my practice as a Registered Dietitian at Toronto Public Health, I have heard many newcomers tell me that they get overwhelmed by the huge number of choices at the grocery store. Think about the last time you went down the cereal aisle. How many different cereals were there? What are the factors you considered in making your choice? Did you read the fine print? Was it just based on the price tag? Or did the cartoon characters or other pictures convince you (or your child) to pick them?

Helping your learners interpret the fine print on nutrition labels can make Continue reading

Notes From a Registered Dietitian: Talking About Healthy Eating

Image says "Join the movement. Bike. Walk. Play. activeto.caAs a dietitian with Toronto Public Health’s Chronic Disease and Injury Prevention program for the past 11 years, I have had many years of experience bringing healthy eating messages to newcomers. In my experience, what influences my audience isn’t dazzling them with details about the science of nutrition, it’s helping them to understand how to make healthier choices delicious, easy and practical.

Healthy eating is one of those topics that can be complicated to communicate. Often people get caught in the details, like the whole butter vs. margarine debate.  Continue reading

Anaphylaxis in the Classroom – Do you know what to do?

Image source: www.bigstockphoto.com
Image source: www.bigstockphoto.com

Food allergies are on the rise, so it’s safe to say that you may know at least one person who has to stay away from common or obscure dietary allergens and intolerances.  With both adults and children affected, (mine included), you will inevitably come across someone dealing with food allergies in your classroom. In fact, this topic may have already been covered in your work module. Here are some good facts and tips that may simplify this topic, helping to create a healthy discussion amongst coworkers and students alike.

Disclaimer: The following content is for information purposes only. I’m not a health expert, but I know a lot from personal experience. Always seek advice from a trained professional. Continue reading


text:
We’re launching our new ReactJS course to help you grow your career. This course condenses 1,000+ hours of learnings that we gained from teaching our own development team how to build our platform using ReactJS.

The technical skills gap in today’s world is massive. That’s why we started Firehose over 4 years ago: to give people the technical skills that aren’t taught in a traditional 4-year college program.

For us, education needs to be personal and smart. We set out on our journey to build a platform that allows students to absorb these technical skills.

Creating this type of experience is extremely challenging. Ultimately it comes back to the fundamentals of building a lesson and developing a curriculum that can support this type of smart education. Thanks to these learnings, we watched more and more of our students develop the right skills, and launch successful careers in web development. We realized that as our students continued to develop as developers, there are a shortage of options to facilitate their continued growth.

As our students grew, it was important for us to grow with them. We wanted to provide a platform to help existing developers learn new skills, in addition to our mission of helping people launch their successful development careers.

Today we are moving one step closer to this goal with the launch of our new ReactJS course. Before I share the details of what we’ve done, I want to walk you through the evolution of Firehose and how we’ve gotten here.

2013: Teaching Web Development in Person

Firehose started with the founders teaching hundreds of students in classroom sessions at places like Harvard, Carnegie Mellon, Brown University, and Babson University.

When my co-founder Ken and I developed our first set of curriculum to teach 25 eager students, the goal was to teach them how to build a web application in a single weekend.

Firehose Project in-person coding bootcamp

We may not have known the best teaching practices when we started out, but we had experience with software engineering and web development. This knowledge even gave us the opportunity to teach software engineering at Harvard, Carnegie Mellon, Brown University, and others, while also teaching an entire Computer Science department at Boston University.

To speed up our learning process, we constantly tested our curriculum and teaching skills in the classroom.

The Firehose teaching style was developed through A/B testing our curriculum live in the classroom

Using our product background, we knew that the fastest way to a great user experience is direct feedback from the students we were teaching. In each classroom, we presented multiple different versions of explaining the same abstract coding concept to each set of students. Based on their reaction and understanding of the materials, we calculated a “knowledge gain impact” score.

We then picked the highest scoring versions and repeated the same feedback loop over and over again. Essentially, we live A/B tested how to teach technical knowledge.

Developing our learning experience allowed us to craft an optimal learning experience: efficient learning speed combined with knowledge that sticks.

The optimal learning experience combines efficient learning speed with knowledge that sticks

2014: Building an Online Education Platform

From the very beginning, we knew that we wanted to reach as many people as possible. Within a classroom, there would always be a limit to the number of people we could teach, so we made the decision to go online. This meant we could apply the same principle we discovered was successful in the classroom: a consistent feedback loop to always improve how we teach.

Fast forward to today, after teaching thousands of students, we are no longer starting from the beginning. We’re running a thriving company with a goal to be out front, shaping the future of online education.

Our goal is to be out front, inventing the future of online education.

Our original classroom curriculum expanded by a factor of 100 and while we still follow our original direct feedback loop, we beefed up our knowledge on how to build the perfect learning experience.

At its core, Firehose lessons are project-based modules that interweave theoretical knowledge with practical application. In each module, we use repetitive practice as the fastest way to make new knowledge stick. We then deconstruct all abstract concepts into small steps to help students relate and understand as fast as possible.

For every lesson we build we ask ourselves: “how can a student go through this curriculum as efficiently as possible while also understanding everything as quickly as possible”. If we do this correctly, our materials are understandable after the first read and the student understands everything we want to convey.

How can a student go through the Firehose curriculum as efficiently as possible while also understanding everything as quickly as possible?

Crafting this balance between direct real-world application of new knowledge isn’t easy. Students need to repeat key elements of what they learn and understand the “why” behind the way we do things. However, it’s this balance that makes differentiates Firehose from other online learning resources.

2017: Growing With Our Students and Launching Standalone Courses

At its core, Firehose is built by developers, for developers – both existing and aspiring. We’re unique because every team member is technical. We believe that the people you trust your educational future with should have actual experience doing what you’re setting out to do.

With this mindset, we started developing our latest JavaScript programming courses, with our ReactJS course at the forefront. These courses are built on a new platform to host all the exciting things to come.

This journey wasn’t easy and started out with a big disappointment. We taught ourselves ReactJS and spent months building out a curriculum, just to throw it all away. What we built didn’t have the efficiency (think “learning speed”) and impact (think “digestible knowledge”) that we stand for.

We used the Firehose ReactJS course, teaching our own development team how to build the new course platform using ReactJS.

After our first failed curriculum attempt, the Firehose team set themselves an amazing goal: our ReactJS course needs to be so good that our own team can use it and build the Firehose platform that hosts our new curriculum using ReactJS.

It was an audacious goal. If we wanted to build the best learning experience online, we should use what we build ourselves. We should test its impact by running our new ReactJS course on a platform that’s built using ReactJS.

After 4 weeks our team was delivering in a big way. They understood ReactJS and were halfway done building part of our Firehose learning platform. While we continued to build our new platform parts, we continually returned and integrated every new lesson that we learned along the way.

What started as a simple piece of curriculum, turned into a jam-packed course, full of over 1,000 hours of learnings. These learnings navigate every single intricacy of a new JS framework.

But we didn’t stop there. After we felt confident in our product, we gave it to some of our own bootcamp graduates and received their feedback. We then took the feedback from students into account and gave our curriculum another round of improvements.

This improved curriculum is what we are launching today.

Into The Future: Continuing to Stay Ahead of the Curve

At Firehose, we believe that selling stale knowledge is fighting a losing battle. If we don’t keep our curriculum ahead of the curve, we’re not growing with you.

There are already too many online learning experiences where teaching stale knowledge is part of the way the curriculum is developed. We don’t want to be one of them: we want to facilitate the long-term growth of developers.

Instead, we see our students consistently return to freshen up their knowledge and review our updated materials. If something changes in the industry, we update our lessons to reflect the change. In our opinion, it’s what a true education platform should be like.

We would love for you to try our ReactJS course. You can experience the first 4 lessons for free!

AuthorMarco Morawec

Marco is the CEO and co-founder at Firehose. He believes in making online education personal and smart.

One thought on “Growing With You: Introducing Our New ReactJS Course

Leave a Reply

Your email address will not be published. Required fields are marked *


text:
Scribe For Action Producer POV from 2016 Winners

Scribe For Action Producer POV from 2016 Winners
August 17, 2017 abe

Scribe For Action

North Star Alliance’s network of Blue Box clinics help hard-to-reach populations in Africa; mobile populations left without access to the most basic health services. Since 2006 they have expanded to 40 clinics, 3 laboratories in 10 countries and approximately 200 employees. They were a great candidate for Scribe For Action.

North Star works within the communities to ensure their services are relevant and effective. Their strategy has provided 1.5 million healthcare sessions from counselling, testing, treatment and education. But they needed to spread the word to bring more partnerships and contributions.

“I wanted to let you know we have had such a great response to our latest Truscribe video and we are rolling it out to our regions encouraging our staff to share it where possible.”
Bronwyn Cawood – Regional Strategist & Communications Manager – South Regions

March of Dimes has accomplished great things in eradicating Polio but they aren’t stopping there. In 2003 they took on another seemingly impossible challenge, to understand and eliminate premature birth, the #1 cause of death in newborns.

March of Dimes is the only organization focusing solely on preterm birth and won’t stop until every baby is born full-term and healthy. March of Dimes is in need of help and financial support to make premature births a thing of the past.

“Thank you for everything your work is amazing and we are so proud to work with you and your team to produce such a moving piece!!!”
Ashley Mucek –
Senior Development Manager – Western Wisconsin Market

Mercy Corps understands that struggling communities are the best agents of their own change, and local markets are the best engines of long-term recovery. In more than 40 countries, they partner to put bold solutions into action, helping people triumph over adversity and grow stronger from within. Mercy Corps has responded to nearly every global emergency over the past 20 years. Since 1979, they have provided $3.7 billion in lifesaving assistance throughout the world. Each year, they infuse millions of dollars into local economies through small business loans and grants to provide livelihoods for the world’s most vulnerable people.

Mercy Corps came to TruScribe to create an engaging visual representation of their organizational culture and what they continually aspire to be, based upon their mission and values. Their video is used internally for motivation, recruitment, and onboarding. It was an honor to learn and collaborate with their bright, passionate team members from all over the world.

“…thanks for your patience with us throughout the process! It was a pleasure working with you and we are super excited about the end product.”

Christina Luchetta – Assistant Program Officer – Strategy & Learning

“Dear TruScribe! Thank you SO much for your work on this project for us and with us. It has been a real learning journey and we are thrilled with the final product. Thank you for your flexibility and help to work with us. We are getting really positive feedback when we are testing it with our teams and we have just started to do voice overs in other languages as well. Again – thank you.”

Anna Young – Director – Strategy & Learning

Apply for Scribe For Action

Leave a reply

Your email address will not be published. Required fields are marked *

Start your Next video with Us

Contact Us


text:
Make your own free website on
10 Dec, 07 > 16 Dec, 07
10 Sep, 07 > 16 Sep, 07
3 Sep, 07 > 9 Sep, 07
20 Aug, 07 > 26 Aug, 07
30 Jul, 07 > 5 Aug, 07
2 Jul, 07 > 8 Jul, 07
18 Jun, 07 > 24 Jun, 07
9 Apr, 07 > 15 Apr, 07
2 Apr, 07 > 8 Apr, 07
19 Mar, 07 > 25 Mar, 07
12 Mar, 07 > 18 Mar, 07
26 Feb, 07 > 4 Mar, 07
19 Feb, 07 > 25 Feb, 07
12 Feb, 07 > 18 Feb, 07
5 Feb, 07 > 11 Feb, 07

officially sanctioned links
a website
a myspace

Blog Tools
Edit your Blog
Build a Blog
RSS Feed
View Profile

i am winston echo

(this is my blog so i get to say whatever i like. have a quick look and you'll see there's mp3s available, if you want to listen to them try streaming by all means but sometimes it doesn't work too well, in which case right click and save and listen at yr leisure. also, if you find that yr in a position to get upset at me posting these mp3s and would like them taken down then please let me know and i'll chop em ok? also also, go and buy music as well cheapskates) look at the rest of my site
Tuesday, 3 July 2007
Great Jorb!

In the past couple of weeks I've spent too many nights sleeping on my friends' sofa.  Their hospitality is truly invincible.  I know how irritating I can be and it's a wonder I've woken up at all some mornings, knowing that these guys have had the chance to quietly suffocate me beneath a couch cushion.  Well done to them

In the past week or so and a bit or something I've been catching up with some viewing which I'd promised myself.  So I watched Everything Is Illuminated and The Squid & The Whale (which were both very good, go watch) and also For Your Consideration, as part of a new secret flim night I'm involved in.  All fantastic.  I also strongly recommend watching Who I Am And What I Want, co-directed by my personal favourite man with a pen David Shrigley.  Probably the most special thing I've been watching at with my eyes is the first series of Tim And Eric Awesome Show, Great Job (part of the insane Adult Swim family of television programmes.)  The show is really hard to describe but I like to think of as a sketch show made by people who have never seen a sketch show before.  Go and watch an episode, it's not long.

And listening to music.  Here's Zeek Sheck, who I know nothing about at all.  2 songs.  Listen.

Zeek Sheck - Ghostrem's Left Leg

Zeek Sheck - Chess

Posted by winston at 8:34 PM BST
Thursday, 21 June 2007

Earlier this week I went to London for the evening.  I haven't been on the train into St. Pancras for some time so I was a bit upset to find that the station still isn't finished with their big refurbishment (and you've still got the slightly confusing walk from the train platform to the underground station with signs that seem to change before every single trip.)  Apparently all the work will be finished in october this year but I'm not optomistic.  Personally I can't wait for all the scaffolding to come down so everyone can see the full splendor what can only be described as The Most Terrifying Building Of My Childhood.  Having lived in Wellingborough for most of my life I have often been in and out of St Pancras every couple of months and I can't remember a time when the building hasn't given me chills down my spine.  I don't know where I'm going with this but I'm sure these refurbishments will have sucked most of the character out of the building and replaced it with glass and chrome and a pleasant bleached pine effect.

In case yr still reading, the reason I went to London was to see David Cross and the opening night of his 2 week run at the 100 ClubDavid Cross is pretty much my favourite man in the world right now, I'm currently taking in (mostly through osmosis) the 4th and final series of his Python-borrowing sketch show Mr. Show, and his character Tobias from (the amazing) Arrested Development is one of the most absurd, twisted and delightful characters there have been on TV in pretty much forever.  And of course there's his stand-up comedy, which is inspirational and insanely cynical at the same time.
The show was pretty disappointing, the main main reason for this being that David Cross didn't even really do a real set, rather he compered the show, doing about 10 minutes between acts and introducing his friends.  The other acts were really good (Ed Byrne was a bit slick, Kristen Schaal was nice, but I'd really recommend checking out Todd Barry and Eugene Mirman if you get a chance because they were rad) but I (and most people in the room) had come to see a proper David Cross set.  Oh well.

I'm really trying to absorb as much comedy as possible at the moment, maybe to compensate for my empty empty life.

In other news, I'm trying hard to sort out Undereducated shows in the next couple of months.  It's hard sorting out venues sometimes.  We've got Sleeping States coming to Northampton in July and we're doing a show for The Blankket in London.  However, I'm trying my damnedest to sort something out for Shimmy Rivers And And Canal's tour at the end of july, they are such an amazing band live and I want to do a really great show but Northampton kind of sucks.  Fingers crossed.

Shimmy Rivers And And Canal - Lord Justed Hues

Sleeping States - Maider!

Posted by winston at 11:49 PM BST
Sunday, 17 June 2007
Older and wiser

It's been ages since my last confession.  When I started this blog I was determined to keep it regular, but being the lazy scatterbrain good-for-nothing lowlife I am, this whole thing has fallen into a state of disrepair.  I bet you've been chewing away at your own knuckles in anticipation of finding out what I've been doing with my abundance of free time, and wilting away into a mere husk of your former self without the reassurance these blog entries provide you.  Well, I think that says more about you than it does me.

Last weekend Undereducated put on 2 big big days of stuff in Northampton.  And it was good in varying degrees.  Friday I found myself really disappointed, mostly due to the fact I played first, opening the night, and got caught up in my own self-loathing, meaning I couldn't enjoy the rest of the evening.  Which sucks, because I missed the whole of Anni Rossi's set, which I'm told was amazing.  I am an idiot.  Then on saturday we had a whole day with Gay Against You.  Well, not a whole day.  A mixture of traffic problems and other acceptable excuses meant GvsY were not able to carry out the afternoon workshop which we'd planned.  However they did do a great improvised set as part of the Fishmarket's opening of their new Alex Gene Morrison exhibition, and then tore the Labour Club apart with one of the most fun half hours ever.  I also got to meet Gentle, Friendly, who are 2 lovely boys from Birmingham (via London) and played fantastically, House Mouse blew everyone away with his midi-guitar, laptop and interesting hooded sweatshirt, and Thrulk showed how much they are improving and fast becoming my favourite band in Northamptonshire.  Just yesterday I finished uploading a WHOLE BUNCH of videos from the weekend to YouTube so that's worth checking out.

So here's a song by Gay Against You, it's from their album Musclemilk (on Adaadat) and it's ace.  Also, recently I've been listening to the forthcoming Liars (self titled) album and I'm struggling to get to grips with it, it just seems too easy and straightforward.  Anyway this is a track from that.

Gay Against You - I Put My Hood Up

Liars - Clear Island

Posted by winston at 8:14 PM BST
Updated: Sunday, 17 June 2007 8:45 PM BST
Thursday, 12 April 2007

Not very interesting this so I'm sorry.  A few people have complained/commented that they're having trouble streaming the MP3s on this blog.  I don't really understand it myself but, yeah, it's crap innit?  Here's what to do, right-click on the link for the MP3 you wanna check out, then in the little menu thing which should pop out you can either click 'save target as' (it might be 'save link as' or something similar) and then download the track, which is fine.  OR or you can click 'copy link' and then paste in into the 'pay url' option of whatever media player you like to use on you computer.

For Mac users, work it out yourself.  You've onlt got one mouse button and I don't get it.

Told you it wasn't very interesting.

Posted by winston at 8:07 PM BST
Wednesday, 11 April 2007
Your own adventure

On saturday night we all had good fun at the Fishmarket for the opening of the James Jessop and Harry Pye exhibition.  I got lumped with the 'setting up sound gear' job which always stresses me out (though I can't complain too much as I did volunteer, but I do like complaining) but after that got done everything went mostly smoothly.  It was strange seeing the Fishmarket actually looking like a place you'd want to spend time in, very very exciting.  Also, it was very nice seeing everyone who had worked so hard to get it all done, and they've done a great job, able to let their hair down and have nice evening.  A big hand for everyone.

So, what have I been doing.  I recently started working on a little book which eventually I'm gonna photocopy and make available in my shop and wherever else I can.  It's a project I've been talking about doing for some time and I thought I'd better just get on with it and stop procrastinating.  It takes the form of one of those Choose Your Own Adventure books that were popular in the 80s and 90s.  (You might not remember them but apparently the series sold over 250 million copies, so I'm not making it up.)  So, here's a page of the story, it's pretty weird.

Figuring you’ve developed some new and cruel allergy to out-dated dairy products, your stomach instantly does backflips and you run out to the street, instantly hurling your guts into the gutter. This lasts about 10 minutes and you can taste every meal from the past week spilling from you in slow motion. Gross. You gradually regain some semblance of composure, reminding yourself that illness is for the weak and you are better than this, sure you’ve turned into some weird cartoon-ish comedy creature, but in your mind your still a strong independent human being with a conscience and a soul and tickets to see Rod Stewart this weekend. The thought of Rod Stewart forces another little bit of sick up out of your throat. Tears start to well up in your eyes and, unknowingly, you begin to walk towards the town centre. Looking up towards the sun you can actually see and hear the clouds moving, whooshing through the air, you also notice the birds darting in all directions desperately trying to avoid the same moving clouds. It takes a little while to work it out but apparently the clouds are chasing the birds, round and round, about seven clouds to fifteen birds.

Then something happens. As your eyes start following one particular bird which seems to be struggling with a damaged wing being toyed with by the clouds, the birds manage to escape and fly away to the safety of a nearby tower block. The clouds have stopped darting about and are now all hovering in close formation, and you can’t be sure because they don’t have eyes, but they seem to be focussing on you. Everything’s getting colder and your starting to get a bit scared which is understandable. Like bees and dogs and bus drivers, clouds can apparently smell fear and to them it smells like lunch. Fear turns to the much tastier panic as all seven clouds combine as one large mega cloud and momentarily form a large hand with an index finger pointing straight between your eyes. “Gulp.”

What next?

“I’m not one hundred percent certain but it has occurred to me that this cloud could potentially cause me a measure of bodily harm. I’m not normally a coward but on this occasion I think I’ll make my excuses and leave.”

Or“I bet you I have probably got some really cool special powers, it seems only fair to compensate my loss of good looks with something helpful.”

Now for some music to tide you over (as if anyone is actually still reading this.)  First is a track by Cradle Of Smurf from Strasbourg, France, a mostly electro pop act with art rock tendencies, this track is instrumental but they aren't all instrumental, and you can dance to it.  Then there's a pair of 13 year old girls from Portland, Oregon (indie capital of the world don't you know?) called Blübird, and their song is about global warming.  It's nice.  Listen.  (sorry i'm not writing more, but my eyes are weak from monitor burn)

Cradle Of Smurf - Lactina Park

Blübird - What If We Don't Want To Be Warm?

Posted by winston at 12:09 PM BST
Thursday, 5 April 2007
Press 'random' and repeat

If you spend too much time on the wild wild web (like me) you'll always find things to do, like this blog for instance.  Other things you'll realise are how quickly your tan fades and some people dress funny.  I've kinda become fascinated by the lengths some people go to for fancy dress costumes.  Isn't strange how people can spend there lives being resolutely UNcreative, but give them a chance to dress up funny and they suddenly become a cross between Roy Lichtenstein and Liberace.  Here's some of my recent (kind of) favourites.

I think they're pretty good.  Here's some completely unrelated MP3s for you to listen to while searching google for your own favourite costume.  Montana Pete, Liars, Abe Vigoda and Young Marble Giants.

Montana Pete - Jungle Jane

Liars - We're Still Young Enough To Lay Face Down In Front Of The Speakers (Peel Session)

Abe Vigoda - The Walk

Young Marble Giants - An Ode To Booker T

Posted by winston at 3:06 PM BST
Monday, 2 April 2007
Drum vs, Keyboard

God, I'm getting really slack with this aren't I?  But, hey, hey, nobody's forcing you to read it, and if all you've got to complain about is the fact that I'm not posting twice a day, then you've really got too much time on yr hands (much like myself.)  Besides, I do have other things going on y'know.  For instance...

Last week (and a bit) we did a couple of Undereducated shows.  These were the first we've done at The Fishmarket so it was kind of an experiment, especially considering the amount of building work going on at the moment.  I've got nothing but praise for everyone at The Fishmarket, and over the next few months we'll all be able to see how the whole project will start to pan out.  It's all pretty exciting.

Ill Ease came to play on a thursday.  As with both nights, it was incredibly cold, but we we're all wearing coats and gloves so what's all the whining about?  Also complaining about the cold was National Parks (who is Luke, and my good friends at Kooky are apparently releasing his first EP soon) and Thee Moths (and it will always remain a mystery to me why Alex is not considered in much higher regard, the man is ridiculously prolific and ridiculously imaginative, I pretty much hate him.)  Ill Ease (Liz Sharp from Brooklyn, NY) is a wonderful musician, and armed with sample pedals and live loops she really putting on a mesmerising show, jumping between guitar, bass and drums and creating some dark party jams through the chilly evening air.  There weren't many people in attendance but who cares?  I'm pretty sure everyone went away having learned something.

Ill Ease - Two Party System

Grabba Grabba Tape came to play on a saturday.  GG Tape (as they shall now be known) were having a terrible time, their keyboards had been misplaced somewhere in midday during their flight from madrid courtesy of the ever inefficient Ryanair (later we also discovered they had misplaced a couple of drum stands also) leaving me to beg and borrow some alternative gear.  Help arrived in the form of Thrulk (who were opening and did so in spectacularly obtuse fashion), who came through the doors armed with more keyboards than any one band could possibly need.  The lovely girls of Hip Hip Handmade, after taking charge of a whole day of craft market-ing, had arranged some craft activities for the evening.  With the help of many hands I made a robot head.  If you've not seen Grabba Grabba Tape before then you really need to make a bit more effort.  Dressing like neon pink and marshmallow white yetis and pounding away at drums and synth and yelping through vocoder and smile-worthy Rage Against The Machine and Minor Threat covers equals a wicked good time.

Grabba Grabba Tape - Mainor Zret (Minor Threat cover)

In other news, The Fishmarket is having a launch for their new exhibition of work James Jessop and Harry Pye.  I think it's gonna be rad, but that's just my opinion.  It's this saturday from 6pm, if yr around you should come along, it'll be good.  There's a sweet band playing too.

Posted by winston at 3:43 PM BST
Monday, 19 March 2007
Friends (part 2)

(see part 1)

My friends really are the most inspiring people I know. I'm sure this is the same for everyone, whether they realise it or not. Would you have read that book or seen that one film if yr friend hadn't recommended it? What makes you happier than seeing yr friends succeed? Yr friends are yr friends for a reason and it's nice to sometimes take a step back and look at the things that make yr friends so great... go on... take a moment...

...right, now yr back in the room, I want to tell you a little bit about the group which forced me to do what I do, and I'm really glad to be able to call them friends.

I first saw Lesbo Pig at Truckfest many moons ago. They used to be based in Oxford and then moved to London before kind of splitting up. They decided to do some different things (which I'll go into in a bit) but I always love to go back and listen to their 3"CD At Home With Lesbo Pig and trying to work out how much I ripped them off when I started writing Winston Echo songs. This track here is from a Homocrime compilation (which I also had a song on) I'm pretty sure it was recorded for an old Careless Talk Costs Lives radio show, but don't hold me to it.

Lesbo Pig - Tokyo

Along with a pair of characters called Michal and Lisa, Irene has pushed Lesbo Pig to one side and started shouting loads in the rock band Corey Orbison (or The Corey Os or The Corey 'Boring' Orbisons.) Based mostly in possibly my favourite part of the country, Bristol, Corey Orbison play fast and loud and I am quite comfortable in saying that Michal has one of the wildest vox going. These kids are involved in so many supercool extra-curricular activities it's unreal, most notably Local Kid and Cafe Kino, which I haven't visited yet but I'm sure is suitably amazing.

Corey Orbison - I Cut Things Up

Now then, Ros is close to being a proper Rock Star. As well as her own songs as Ray Rumours, queer punks The Battys and Spanish language campfire pop band Sisisi Sisisi Sisi, Ros plays bass guitar and other instruments for the international megastars Electrelane. I've played with Ray Rumours a bunch of times and it's always always amazing. Undereducated got to release her first CDr (along with our friends at Stitch-Stitch) and it really is beautiful. This song is a new one I believe.

Ray Rumours - Tomorrow

In Other News. I'm doing a column for Music For Squares magazine, it's all written up and will be in the new issue, due in April. If you read it let me know what you think. Also if yr not in Northampton (it's local) and would like to see a copy let me know and I'll see if I can't pop one in the post for you.

Posted by winston at 10:28 PM BST
Updated: Monday, 19 March 2007 10:40 PM BST
Sunday, 11 March 2007

Not everyone can take criticism.  I found this out today courtesy of the people that run Decades, the mid-to-late 90s themed bar/club/venue in Northampton.  I made a few comments on this very blog a while ago, which were apparently read by the landlord and have led to me being banned from the venue.  It is a shame because I played a nice gig there.  It's also a shame because it left me totally stressed out trying to arrange something for Esiotrot this thursday.  They're still playing there thanks to Closed Captioned but I'm not allowed to go.  I find it all a bit immature really.  It's quite easy to get in touch with me through this blog, which would've been vastly preferable to this kind of vaguely threatening tactic.  Oh well.

On a lighter, much more special note, Undereducated are currently booking another UK tour for Thanksgiving in June.  Adrian Orange (for that is his real name) is truly one of the most inspirational people I've been lucky enough to spend time with (despite the fact he's a couple of years younger than me, the bastard), and through his label, Marriage Records, has released a veritable plethora of fantastic albums.   (Whilst we're talking Marriage Records, I'm totally loving Drakkar Sauna's bare bones folk at the moment.)  He'll be touring with the ever charming Francois and we'll be bringing the pair of them to the ever reliable and often wonderful Labour Club in Northampton on June the 8th.  You can't believe how excited I am about this.

So, here to play us out with a track from his album Cave Days And Moments, Thanksgiving!

Thanksgiving - (You Belong To The) Blood

Posted by winston at 9:57 PM BST
Sunday, 25 February 2007
Tough Punx!

Sometimes everything's quite good.  Even though I feel ill, pretty bad, with flu and aching body parts and a vague sense of being at death's door (a bit over the top, maybe), in spite of all of this some days just work out pretty well.  Friday was one of those days.  I played a show at the Labour Club with Foxes and Little Cosmonaut who were both very good, and you can read a bit about them if you look through some older posts.  Unlike some other shows, my set went quite well.  Sure I screwed up a few songs but that's just what I do, but overall I really enjoyed and it seemed like most of the audience did too.  EXCEPT, except for a couple of guys sat right next to the stage.  They'd had a few drinks, got a little rowdy, and, they were punks.  Y'know, real punks.  Like with the spiky hair and combats and Doc Martins.  (For the record, I'm not sure exactly how punk you can really call these kind of fashion choices, these kids still have to go into shops and buy these clothes and they still try and look just like 1977.  What's the difference between this and the Mod revival?)  Punk kids are tough and that means they don't like twee indie pop and they can certainly shout louder than I can.  Hey it's all in good fun, I wasn't too bothered by it all really.

Now, 'punk rock' has never really appealed too much to me.  I love The Ramones, but I always found the British take on the genre a little too caught up in spitting and safety pins and standard guitar to get too excited (I'm sure it was great being there at the time but in retrospect it just doesn't appeal to me.)  I've always been more interested in punk as an idea, as opposed to a genre or fashion trend.  The idea of doing what you love and using the resources you have available to get it done.  That being said, I do love some really good, fast and loud pop with a bit of punk thrown in. These 2 mp3s are by bands who I don't really know much about at all, I simply stumbled across their websites by chance and found that the songs totally stuck with me.  So have a listen to Dumb Haircuts and The Coathangers.

Dumb Haircuts - Kill The Trees

The Coathangers - Shut Tha Fuck Up

Posted by winston at 7:50 PM GMT

Newer | Latest | Older


text:
Tuesday, November 22, 2011

May be finished

This blog thing has been so low on the priority list that it is in danger of being shoved off the list.

Too busy? Not really
Too Lazy? Kind of
Don't really care anymore? Pretty much

Had a good stretch of fitness until mid-October. Been really hit and miss since.

Considering only 2 people read this anymore, I may just send you emails


text:
June 17, 2013, 8:04 am

Guide to buying a swimsuit

Bleu swimsuit

A red halter swimsuit is trendy and flattering this season. (Bleu)

The sun is out, the temps are up, the pool party invites are flooding in. Break out the coolers, the sunscreen and – eek! – the swimsuits. Because while, yes, a day in the water sounds positively lovely, it can also strike terror in the hearts of women everywhere. Wanna scare the (fake) tan off a person in an instant? Just suggest a session of swimsuit shopping. So, what will make it a little less painful? Shopping tips from a pro. We asked swimsuit designer Rod Beattie how to make a splash when buying a swimsuit. Dive in!

See red. “Colorwise, it’s all about red,” Beattie says. “Red is the hot color in fashion for spring/summer 2013. We added gold grommets to a glamorous group of red suits to give them a modern nautical look. We also offered up a clean and contemporary red, white and blue stripe. It’s fabulous in a two-piece halter top with skirted bottom, or a tankini.”

Hooray for halters. Is there such a thing as a go-to style that works for pretty much everyone? “Because many American women are pear shaped – a little bigger on the bottom than the top—I have found that halters are the most flattering,” Beattie says. “They give the illusion of broader shoulders, balancing out the bottom.”

He adds that X-back maillots also work on many female body types, “But if you can still rock a tiny bikini, I say go for it!”

Learn your size. When you’re shopping online and can’t try the suit on, be sure to find out the retailer’s shipping and return policies. Also, Beattie advises, your dress size is not necessarily your swimsuit size. “You need to consider your torso length,” he says. “So, if you wear a size 6 dress, but have a long torso, you should order a size 8 (or even a size 10) swimsuit. Also, be sure to see a photo or read a description of the back of the suit. You’ll want to know if there is center back seam, or tie-back, or low or high back, as that greatly affects fit.”

Move around in it. Say your suit looked fab in the dressing room mirror, but is doing crazy things on your beach chair? “When you try on a suit, take the time to put it on correctly and make adjustments,” Beattie says. “For instance, if you are trying on a one-piece suit, hold the suit open in half at the waist, and step into the leg openings. Fit the suit first over your hips and pull firmly up over your waist. Then, holding the top part of the suit, bend over to let your breasts fall into the cup area of the suit. Tie or hook the suit in place. Adjustable straps can give you more — or less — lift and comfort.”

Keep calm and try on. “Allow for plenty of time to try on swimsuits,” he says. “Don’t be in a hurry. Take as many suits into the dressing room as the store will allow. Take in at least two sizes per style that you like. Also, some great suits lack hanger appeal, but look fabulous on the body, so don’t be afraid to try on styles that look ‘different.’ Promise yourself a treat after successfully trying on swimsuits. I suggest a glass of champagne or prosecco. Low in calories and you deserve it!”

Lesley Kennedy writes about online shopping for the Online Shopping Report at ShopAtHome.com. Email her at LKennedy@shopathome.com.

Article Comments

  • We reserve the right to remove any comment we feel is spammy, NSFW, defamatory, rude, or reckless to the community.
  • We expect everyone to be respectful of other commenters. It's fine to have differences of opinion, but there's no need to act like a jerk.
  • Use your own words (don't copy and paste from elsewhere), be honest and don't pretend to be someone (or something) you're not.
Most Popular


text:
Posts by Category: PlatformRSS feed

Crash Bandicoot returns? Playstation Mid East’s cryptic tweet

“Most wanted person…Where are you Crash?” That’s Google Translate’s take on the arabic text on a cryptic tweet posted by Playstation Mid East early Saturday (Feb. 6). Above the text, the tweet features a picture of a full-body wanted poster with Crash Bandicoot on it.

The tweet has the gaming world abuzz with speculation about whether Sony is teasing a new Crash game or a potential remaster. As of right now, there has been no official word from Sony beyond this. Crash first appeared in September of 1996 in “Crash Bandicoot” for the original Playstation. The last Crash Bandicoot game released was Crash Bandicoot Nitro Kart 2 for the iPhone and iPod Touch in 2010.

Naughty Dog was the original developer behind Crash Bandicoot. They have since gone on to develop the Jax and Daxter series, “The Last of Us” and the Uncharted series.

June 10, 2015, 6:00 pm

The Video Game Hall of Fame, first class: Reactions from Game On

In case you haven’t heard, the Strong National Museum of Play announced its inaugural class for the World Video Game Hall of Fame. The inductees from the class of 2015 are Pong, Doom, Super Mario Brothers, Pac-Man, Tetris and World of Warcraft.

Three Game On contributors decided to give their thoughts on the inaugural class and their picks for games that should make the cut in 2016.

Hugh Johnson: Biggest surprise for me is World of Warcraft. The other titles are kind of expected with games like Tetris, Super Mario Bros. Pac-Man etc. Those games are all titans of the industry and are just the iconic titles you think of when you think of a video game hall of fame. They’ve been around for decades. With WoW however, that isn’t the case but the title is no less deserving. The game really has put MMORPGs on the map like no other title and has given us some precious pop culture moments such as the memorable “Make Love not Warcraft” episode of “South Park” and of course the legendary Leeroy Jenkins, which just turned 10 ironically enough.

Read more…

March 6, 2015, 12:12 pm

Kirby and the Rainbow Curse draws mixed emotions (review)

Please enable Javascript to watch this video

Like an old episode of Gumby, Kirby and the Rainbow Curse for the Wii U plops onto the screen with vibrant clay animation that accentuates the pink fluffball’s colorful world.

At the heart of developer HAL Laboratory’s latest installment featuring the veteran hero is a game that takes some bold steps to switch up gameplay and provide fans with a fresh way to experience Kirby. Sadly, the notable strides the game makes aren’t nearly enough.

Kirby’s latest adventure introduces an evil villain known as Claycia. Just as Kirby is about to get his grub on, Claycia sucks all the color out of Kirby’s Dream World, leaving it a monotonous gray throughout. Luckily for Kirby, a magical paintbrush named Elline saves the day by allowing Kirby and his pal Waddle Dee to travel on rainbow-colored ropes to get through the various levels.

Read more…

Most Popular


text:
May 042019

I am quoted in this Channel News Asia article on the Berkshire Hathaway annual meeting.

David Kass, finance professor at University of Maryland, has made the trip each year for the past decade, sometimes with MBA students – a number of whom were granted private meetings with Buffett.

“It’s pretty much a hobby,” said Kass, a Berkshire shareholder since 1985 and the author of a blog on Buffett.

This year he invited 200 of his students to follow the proceedings along with him, broadcast live in one of the university’s auditoriums.

 Posted by at 7:44 am

Sorry, the comment form is closed at this time.


text:
18th Annual Apple Blossom Festival to celebrate Spring

Mother Nature at her best

18th Annual Apple Blossom Festival to celebrate Spring

By Cheryl A. Cuddahy

“April showers bring May flowers that is what they say… but if all the showers turned to flowers, we’d have quite a colorful day!”

Well we have had our share of April showers, and now it’s May and it is time to celebrate the apple blossom flower so dear to Sholan Farms.

The 18th Annual Apple Blossom Festival and Craft Fair will be held from 10 a.m. until 4 p.m. Saturday, May 18, at Sholan Farms, located at 1125 Pleasant St., in Leominster.

Live entertainment will be held throughout the day, featuring music by the Fallbrook Songbirds, International Veterans Chorus, a ukulele sing-a-long by the Sterling Stummers, Latin favorites by Eugenio Burgos and Trio Los Sonadores, the Boston Pipers Society with Brian Quirk and Stuart Paul, and ending the day with some upbeat Chicago Blues by The Mudcutter Blues Band.

A Craft Fair will also be featured with over 40 crafters selling homemade merchandise.

Along with just being out in the fresh air, children will enjoy games, face painting, a visit with Appleseed John and Ady the Armadillo, and reaching new heights on the climbing wall.

Visitors are welcome to take their chance at the gift basket silent auction, a 50/50 raffle and more.

If you are hungry, no worries, there will be several food truck vendors on hand to serve you a variety of foods. Enjoy Mediterranean food at Chez-rafiki; Island Cow Ice Cream; Minuteman Kettle Corn; Roamin’ Pizza; Spanish American Center; Teddy’s Lunch Box; Trolly Dogs; and Uncle E’s BBQ;

Baked goods will also be available for guests with a sweet tooth.

The popular and humble Butterfly Release Parade will begin at 2:30 p.m. Cost is $5 per butterfly and is a great way to honor a loved one.

“One of the favorite activities is the butterfly release,” says Joanne Dinardo, president of the Friends of Sholan Farms. “We have bagpipers lead a procession through the orchard and then visitors will release over 200 painted lady butterflies in honor of a loved one. Children and adults seem to always be in awe at this event.”

New this year will be lots of information that will be shared with guests of the festival. You will find information tables hosted by AlpaccaLipps Farm, the American Cancer Society, Beacon of Hope, Boys & Girls Club, Foster Parents Ambassadors, Freedom’s Way, Ginny’s Helping Hands, Growing Places, Habitat for Humanity, Leominster Emergency Management, Literacy Volunteers of Montachusett, Luk, Inc., Spanish American Center, Warmer Winters, Worcester County Beekeepers, and the YMCA of Leominster.

Patti LaGrassa, festival chair, would like to thank the many Friends of Sholan Farms volunteers who helped plan the festival over the last four months.

“I would also like to thank all of the generous sponsors and businesses that donated goods to the Silent Auction,” Patti adds. “This event would not be possible without the help provided throughout the community.”

The Friends of Sholan Farms is a non-profit, 501(C)3 organization dedicated to preserving and protecting Sholan Farms, a community owned Apple Orchard.

“Sholan Farms is the community owned farm,” says Joanne DiNardo. “It was saved by the people and continues to thrive as a source of pride and accomplishment.”

Sholan Farms is now entering its 19th year in business. The city took ownership of the property in 2001 and the Friends of Sholan Farms was formed shortly thereafter.

“The farm is a destination for local folks, and people come from far and wide to visit,” she adds. “The property is not only a working farm but also offers open space, hiking trails, and is a showcase for sustainable agriculture.”

Joanne is proud to share that Sholan Farms will be hosting the Envirothon on Friday, May 17, which is “an amazing gathering of educators and youth. Sholan Farms is a one-of-a-kind orchard that gives people the opportunity to nuture the land,” Joanne says.

“In our school tour program, we engage over 2,000 children each year and teach them the importance of farming and how apples grow, how important bees are and all of the basics of farming,” Joanne says. “We now have customers who actually picked their first apple at Sholan Farms – 18 years ago. They come back and bring their children. It is amazing to hear the stories and see the community pride.”

Joanne says that Sholan Farms encourages and welcomes volunteers and visitors all year long.

“We connect people to the earth,” she says. “People need to know where food comes from. They need to know that local food is so much better. Farming is a lot of hard work – but worth the effort. Any society that forgets their roots and past is a society that will fail.”

The Friends of Sholan Farms are excited for the upcoming plans such hosting the FSU Alpha hiking group, bird watchers, and many more groups.

“We recently got a grant from Freedoms Way to design and install story boards that will give visitors a self-guided interpretive experience,” she says happily. “The story boards will tell the story of Sholan Farms along with the history of the farm and growing apples.”

This year Sholan Farms has also partnered with the Spanish Center and will be holding their first Spanish Celebration in September.

“We are trying to find ways to reach across all races and generations,” Joanne says. “The more people that are involved the more likely this farm will be thriving long after we are gone.”

What does the Apple Blossom Festival mean to Joanne?

“I am thrilled to be able to showcase the farm to the many visitors who will come this day,” she says. “Every year I feel magic as I watch the buds swell, the blossoms emerge and the bees and native pollinators swarm over the orchard. It is truly a miracle to watch the families and individuals look at the property and feel wonder and amazement – a true spectacle ~ Mother Nature at her best.”

In case of inclement weather, the festival will be held on Sunday, May 19. For more information, please call 978-840-3276 or visit www.sholanfarms.com

Got a column subject or item for Community Conversations? Email ccuddahy@sentinelandenterprise. Read her blog at blogs.sentinelandenterprise.com/communityconversations

You can leave a response, or trackback from your own site.

Leave a Reply

I can't believe I'm writing this but Best Web Hosting Fans saved my blog.


text:
  • Joe diGenova Bombshell: Brennan & Comey Are in Trouble

    Don't forget to Like Blood Red Patriots on Facebook & Twitter.

    Former US Attorney Joe diGenova believes James Comey and John Brennan are in serious trouble for their roles in the spygate scandal.

    Appearing on Ingraham Angle on Fox Tuesday, diGenova did not hold back:

    Joe diGenova: This is very serious business. For the first time I believe some of these guys are going to prison… Let me tell you something, Horowitz has already concluded that the final three FISAs were completely illegal. He’s now on the brink of finding that the first FISA was completely illegal. Durham has already used a grand jury in Connecticut. They’ve already gotten documents. He’s already talked to the intel people.

    Laura Ingraham: How long has this been going on?

    Joe diGenova: Durham’s been working for a couple months. The bottom line is this. This is now – big time! This is where Brennan needs five lawyers. Comey needs five lawyers.

    Source link


text:
Obama Photographer Dings Trump With Frosty ‘Presidential Harassment’ Snap

Former White House photographer Pete Souza had a frosty comeback for Donald Trump after the president claimed on Thursday that he was the victim of “presidential harassment.

Souza shared this old photograph of President Barack Obama on Instagram:

Trump made the claim on Twitter after House Intelligence Committee Chairman Adam B. Schiff (D-Calif.) announced a decision to ramp up investigations into the current administration.

The snowman snap was the latest in a long line of anti-Trump posts that Souza has shared to the social media platform, almost all of which feature photographs he took during his time covering the Obama White House.

Souza recently trolled Trump over his State of the Union address with this picture:

Souza also riffed on Trump’s extensive use of “executive time” with this post:

Read more: http://www.huffingtonpost.com/entry/pete-souza-barack-obama-trolling-trump-presidential-harassment_us_5c5d406ce4b0e01e32ab465f

Leave a Reply

Your email address will not be published. Required fields are marked *


text:
Sie sind nicht angemeldet.

WoltLab Burning Board Lite

Lieber Besucher, herzlich willkommen bei: WoltLab Burning Board Lite. Falls dies Ihr erster Besuch auf dieser Seite ist, lesen Sie sich bitte die Hilfe durch. Dort wird Ihnen die Bedienung dieser Seite näher erläutert. Darüber hinaus sollten Sie sich registrieren, um alle Funktionen dieser Seite nutzen zu können. Benutzen Sie das Registrierungsformular, um sich zu registrieren oder informieren Sie sich ausführlich über den Registrierungsvorgang. Falls Sie sich bereits zu einem früheren Zeitpunkt registriert haben, können Sie sich hier anmelden.

[Heute, 09:19] Cedrick: I work for myself detrol la generic for The Weather Channel said it was popular in February because of its live coverage of winter storms

[Heute, 09:13] Odell: I'm about to run out of credit anaconda nicki minaj drake She got her 2015 off to a rousing start at the Armory Track Invitational on 168th St

[Heute, 09:13] Domenic: History imidacloprid confidor prezzo Hogan Gidley, a veteran GOP operative in South Carolina who worked for Rick Santorum and former Arkansas Gov

[Heute, 09:12] Mauricio: How do you know each other? purchase furosemide But Detroit Lions star Calvin Johnson won’t be a matchup nightmare for the Giants on Monday night

[Heute, 09:11] James: Which year are you in? generic name for lotrisone cream The three were identified as Mohammed Abu Shamala, Raed al-Atar and Mohammed Barhum.

[Heute, 09:07] Donald: Could you tell me the dialing code for ? comprar doxazosina 11, 2001, Hagel said it was "as sophisticated and well-funded as any group we have seen."

[Heute, 09:05] Kareem: I can't get a dialling tone revia to quit smoking Shares in larger rival AstraZeneca, which hadrebuffed its own takeover deal by U.S

[Heute, 09:04] John: The United States bula do levitra odt Louis’ enthusiasm, it’s creating an exciting, light atmosphere around an already successful team.

[Heute, 09:02] Lynwood: I enjoy travelling prazosin 1 mg capsule para que sirve based on purchasing power parity, whichadjusts for price differences between nations.

[Heute, 09:02] Fausto: I've only just arrived revia cost per pill In2006, the Southeast Asian country was overtaken by Qatar as theworld's largest LNG exporter.

[Heute, 09:00] Daniel: I read a lot teresa calandra compra online For those living far from their nearest specialist hospital, the additional travel can really take its toll

[Heute, 08:59] Markus: We need someone with experience himalaya himcolin With 81 Nobel laureates having ties to MIT, the perception of the student body is one of bookish scholars

[Heute, 08:57] Roman: I work with computers buy midamor "There are significant savings for the Irish sovereign," the official told reporters.

[Heute, 08:56] Federico: What's the interest rate on this account? eriacta 100mg review He broke the Florida State record of 212 receptions, set by Ron Sellers (1966-68)

[Heute, 08:54] Russel: I'll put her on…n-etkileri.aspx requip gambling sex lawsuit Would you do anything the same? We make life and meaning together, in the context of others

[Heute, 08:54] Connor: I'd like to pay this in, please femara vs clomid bodybuilding “It is time to own Pearson again,” the broker said, as quoted by the Financial Times

[Heute, 08:53] Brian: Free medical insurance when does actos expire But there is still more work to do," Foreign Secretary Philip Hammond said in a statement

[Heute, 08:51] Patrick: I sing in a choir forzest by ranbaxy This shape allows the boiling water to penetrate the gluten and starch much faster

[Heute, 08:48] Gaylord: I'm doing a masters in law forzest ranbaxy kaufen Shares of the fund have fallen 11 percent and touched anall-time low of $105.19 on Tuesday

[Heute, 08:43] David: The manager onde comprar parietaria “You’ve got to find a different motivation outside of this game to push you,” Jennings said

903 774 Mitglieder - 26 272 Themen - 55 840 Beiträge (22,61 Beiträge pro Tag)
Unser neuestes Mitglied heißt: TriciaAust.