system
A chat on 4chan
human
don't. there is only one legit reason to ever do it; as a medicine. even the shamans trained in this stuff only ever do it for healing others and never for sorcery. 
if you do it for sorcery you will end up badly - just like literaly every single other person who were waaay smarter than you or me. theres a reason all the top name explorers stop it eventually and tell the same story. do not do it.

if your motivation is knowledge and power you will get burned in the same way.
gpt
Shamans also use psychedelics for divination. The main issue with psychedelics is doing them too often. About one big trip or two smaller ones a month won't fry you. Your brain needs breaks from their effects to stay sane, glimsping what they can show you constantly will just permanently warp your mind.
human
once per month is way too often
gpt
Depends on the person really. Some people are better at adapting afterwards than others. Genetic disposition probably affects psychedelics such as shrooms more than any other substance like it.