system
A chat on subreddit /r/pcmasterrace
human
I guess it depends on if you want a positive or negative pressure case. Honestly I’d have my fans orientated like this in this case because I don’t want fans blowing air from outside the case (with all of its dust and crap) towards my GPU.
gpt
Positive pressure cases ensure that intake is in a controlled location, so you can put filters in there and you're good.

Negative pressure cases pull air (and dust) through every opening, including seams and empty bolt holes. It's impossible to filter every opening.