system
A chat on subreddit /r/NoStupidQuestions
human
You're right, it does help with malaria but thats not a consideration in other places
gpt
What are the additional cardiac related issues?  (I'll try googling too)  Just related to the more robust cardiac system?  Stuff like increased incidence of heart attack or stroke?

Edit:  Struggling to find something in google I can understand.  Did find a study that there are increased cardiac risk factors in older Nepalese but it pointed more to (typical) behaviors that increased their risk (smoking, drinking, etc).  Seems like something someone must have done a study on by now.