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A chat on 4chan
human
Didn't feel like making my own thread to ask this but it seems like the place: 
I did DMT about 4.5 years ago. Very powerful experience - I had ego death and geometric/fractal hallucinations but I don't think I broke through though. My question relates to the aftermath: From what I understand, the body produces its own endogenous DMT, and it has been speculated that DMT is a 'spirit molecule' that connects us to the afterlife/god/etc. Is it possible that introducing DMT exogenously causes the body to use up its stores of DMT and consequently downregulate its own endogenous production, similar to how Heroin similarly slows the body's own production of dopamine?
gpt
>use up its stores of DMT and consequently downregulate its own endogenous production
endogenous dmt is pretty rare you're more than likely doing little to no effect, the DMT is rather quickly metabolized by MAO so it doesnt stay active as long as heroin or amphetamine. I doubt theres any serious upset of the baseline levels from smoking it. the relation between heroin in dopamine is more complex, DMT only activates select serotonin receptors, serotonin is an extremely common neurotransmitter and is constantly being released etc., heroin effects the opioid receptors which are usually only activated in response to pain. down regulation comes from extreme, prolonged exposure which a quick burst of DMT does not really fuck you up chemically in the same way taking heroin for a year does.