system
A chat on subreddit /r/pcmasterrace
human
They can be yeah. Lots of thermal throttling. It can depend on case and airflow but generally not a good idea for current gen CPUs.

2 x 120mm is the way to go.
gpt
Even 2x120 is outperformed at a lower cost by dual tower air coolers. Only 280mm and 360mm radiators make much sense to use if your case is big enough to fit a big air cooler