system
A chat on subreddit /r/pcmasterrace
human
The only time I can think of is if it's intentionally used to make a scene feel sort of dreamlike or add a sense of unease. 

Senua's Sacrifice used it liberally to the point of being mildly disorienting, but I thought it worked for that kind of game.
gpt
Another game that it worked perfectly, along with film grain, is Alien Isolation, but only because:

1)It is subtle

2)It works really well for the nostalgia factor, reminding you of the first Alien movie.