The variability of two remote hybrids between Saccharomyces cerevisiae and Schizosaccharomyces pombe was compared in the course of their vegetative splitting. Hybrid 69 was obtained upon fusion of germinating spores, hybrid 92 was produced by copulation of vegetative cells. The variability of hybrid 92 was more diverse in terms of the size and shape of its cells; moreover, the hybrid yielded adenine-dependent haploid cells typical of S. cerevisiae with red colonies as well as dividing cells very similar to S. pombe with cross septa. Hybrid 69 did not produce such cultures.