text: As such, given that well designed, adequately powered randomized controlled trials investigating patient-relevant outcomes of low-fat diets for otherwise healthy people with hypercholesterolaemia are lacking; large, parallel, randomized controlled trials are still needed to investigate the effectiveness of a cholesterol-lowering diet and the addition of omega-3 fatty acids, soya protein, plant sterols or stanols, especially in the case of familial hypercholesterolemia.