text: Although it has received considerable media attention purporting its effects on weight loss, there are important toxicologic contraindications (liver toxicity associated with commercial preparations containing the natural product), and the limited clinical evidence available supports from no difference, to "small… differences in weight loss favouring HCA over placebo" whose "clinical relevance is uncertain," and GI adverse events two-fold more common for HCA over placebo in one study in a 2001 meta-analysis.