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BioPortfolio  Measurement of anti-beta amyloid antibodies in
human blood.  03:48 EST 13th December 2013 | BioPortfolio
Summary of "Measurement of anti-beta amyloid antibodies in human
blood."  The human IgG repertoire contains endogenous antibodies
against beta amyloid (Aβ) that may be relevant to the
pathogenesis and treatment of Alzheimer's disease. There have
been widely disparate estimates of the levels of these
antibodies in human plasma. We identify factors that have
contributed to these disparities and describe improved methods
for measuring anti-Aβ antibodies in blood. These methods include
isolating immunoglobulin by thiophilic chromatography and using
chaotropic salts to dislodge weakly bound antibodies without
significantly reducing the binding of specific anti-Aβ
antibodies. Using these methods, we show that human blood
contains polyvalent IgG antibodies that bind to Aβ with
relatively low avidity and specificity, as well as IgG
antibodies t