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Agricultural Research Service  Research Project: Intervention
Strategies to Control Viral Diseases of Swine Project Number:
5030-32000-108-00 Project Type: Appropriated  Start Date: Oct
19, 2011 End Date: Oct 18, 2016  Objective 1: Identify
mechanisms of porcine respiratory and reproductive syndrome
virus (PRRSV) pathogenesis and develop vaccination strategies to
enhance immunity and prevent the infection of swine herds.
Subobjective 1.1: Identify PRRSV determinants of viral
pathogenesis, immune evasion, and transmission. Subobjective
1.2: Use reverse genetic technology to design live attenuated
vaccine strains that provide broad protection against PRRSV
infection and allow differentiation of infected from vaccinated
animals. Objective 2: Identify mechanisms of swine influenza
virus (SIV) pathogenesis and develop vaccination strategies that
provide broad cross-protection against subtypes of SIV that are
emerging worldwide. Subobjective 2.1: Improve SIV vac