Stuart Goodman  Publication Details    • Chronic antigen-
specific immune-system activation may potentially be involved in
the loosening of cemented acetabular components JOURNAL OF
BIOMEDICAL MATERIALS RESEARCH Farber, A., Chin, R., Song, Y.,
Huie, P., Goodman, S. 2001; 55 (3): 433-441       Previous
studies have attempted to determine whether aseptic loosening
and osteolysis are caused by a T cell-mediated type IV
hypersensitivity reaction or a nonspecific foreign body reaction
involving phagocytic macrophages. The purpose of this study was
to examine the role of the B7-CD28 costimulatory pathway (which
is indicative of an activated immune response) in loosening and
osteolysis of total joint replacements (TJRs). We harvested
periprosthetic tissues from 24 loose, cemented, all
polyethylene, acetabular components in patients undergoing
revision total hip replacement surgery for aseptic loosening.
Prostheses were classified radiographically as to whether
ballooning, scalloping osteolysis was present or not. Mon