CBSU bibliography search   Parkinson's disease and dopaminergic
therapy - differential effects on movement, reward and
cognition. ROWE, J.B,. HUGHES, L,, Ghosh, B.C., Eckstein, D.,
Williams-Gray, C.H., FALLON, S., Barker, R.A., OWEN, A.M. Brain,
131(8), 2094-2105 Year of publication: CBU number: Cognitive
deficits are very common in Parkinson's disease particularly for
'executive functions' associated with frontal cortico-striatal
networks. Previous work has identified deficits in tasks that
require attentional control like task-switching, and reward-
based tasks like gambling or reversal learning. However, there
is a complex relationship between the specific cognitive
problems faced by an individual patient, their stage of disease
and dopaminergic treatment. We used a bimodality continuous
performance task during fMRI to examine how patients with
Parkinson's disease represent the prospect of reward and switch
between competing task rules accordingly. The task-switch was
not separately cued but was based on th