Email updates   Open Access Highly Accessed Research article
Integration of time-resolved transcriptomics data with flux-
based methods reveals stress-induced metabolic adaptation in
Escherichia coli  Nadine Töpfer1, Szymon Jozefczuk2 and Zoran
Nikoloski1*  Author Affiliations  1 Systems Biology and
Mathematical Modeling Group, Max-Planck-Institute of Molecular
Plant Physiology, 14476 Potsdam, Germany  2 ETH Zurich,
Institute of Molecular Systems Biology, 8093 Zurich, Switzerland
For all author emails, please log on.  BMC Systems Biology 2012,
6:148  doi:10.1186/1752-0509-6-148   Received:1 May 2012
Accepted:7 November 2012 Published:30 November 2012  © 2012
Töpfer et al.; licensee BioMed Central Ltd.     Changes in
environmental conditions require temporal effectuation of
different metabolic pathways in order to maintain the organisms’
viability but also to enable the settling into newly arising
conditions. While analyses of robustness in biological systems
have resulted in the characterization of reactions