, Volume 30, Issue 2, pp 123-142  Suicidality and Antiepileptic
Drugs  368 Downloads 200 Citations 9 Comments  Purchase on
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local VAT.  Get Access   The main purpose of the present article
is to review the possible risk factors for suicidal behaviour in
epilepsy with a special emphasis on the different antiepileptic
drugs (AEDs).  Epidemiological data show that, in general, the
suicide rate among patients with epilepsy is 5-fold higher than
that in the general population, while in temporal lobe epilepsy
and complex partial seizures it is approximately 25-fold higher.
A certain psychiatric comorbidity may provoke suicidality in
patients with epilepsy, and depression and cognitive impairment
seem to be the main risk factors for suicidality in epilepsy. In
addition, depression and cognitive deterioration in epilepsy may
share common neuropsychological mechanisms in terms of
hypofrontality.