Search tips Search criteria    DNA Repair (Amst). Author
manuscript; available in PMC 2011 March 2. Published in final
edited form as: PMCID: PMC2827677 Rad54, the Motor of Homologous
Recombination Alexander V. Mazin,* Olga M. Mazina, Dmitry V.
Bugreev, and Matthew J. Rossi Department of Biochemistry and
Molecular Biology, Drexel University College of Medicine,
Philadelphia, PA 19102, USA. *Corresponding Author: Alexander
Mazin, Ph. D., Drexel University College of Medicine, Department
of Biochemistry and Molecular Biology, 245 N 15th Street, MS
497, NCB, Room 10103, Philadelphia, PA 19102-1192, Tel:
215-762-7195; Fax: 215-762-4452, amazin/at/ Homologous
recombination (HR) performs crucial functions including DNA
repair, segregation of homologous chromosomes, propagation of
genetic diversity, and maintenance of telomeres. HR is
responsible for the repair of DNA double-strand breaks and DNA
interstrand cross-links. The process of HR is initiated at the
site of DNA breaks and gaps and involves a search for homo