TY - JOUR T1 - MUltiple myeloma with new bone formation AU -
KRAININ P AU - D'ANGIO CJ AU - SMELIN A Y1 - 1949/12/01 N1 -
10.1001/archinte.1949.00230060133010 JO - Archives of Internal
Medicine SP - 976 EP - 982 VL - 84 IS - 6 N2 - THERE that the
typical and characteristic lesion of bone in multiple myeloma is
a discrete osteolytic involvement. The roentgenographic
appearance is usually that of a punched-out area with sharp
margination and without evidence of surrounding productive
reaction. In a description of multiple myeloma Boyd1 stated, "It
is a pure rarefying lesion with no formation of new bone." To
quote Geschichter2: "The widespread occurrence of small, sharply
demarcated defects in the marrow cavity, unaccompanied by
bending deformity or the formation of new bone, are the cardinal
features in the diagnosis of multiple myeloma." Snapper3
affirmed that in multiple myeloma "no new formation of bone
takes place." Shanks, Kerley and Twining4 declared categorically
concerning the osseous lesions of multip