Dictionary » C » Centronuclear myopathy  Centronuclear myopathy
Centronuclear myopathy  Slowly progressive generalised muscle
weakness and atrophy beginning in childhood; on biopsy of
skeletal muscle, the nuclei of most muscle fibres are seen to be
located near the centre of a small fibre (the normal position
for a 10-week embryo) rather than at the periphery of the fibre;
familial incidence. Autosomal dominant recessive and x-linked
[310400] forms occur.  Synonym: myotubular myopathy.  distal
myopathy, myopathy affecting predominantly the distal portions
of the limbs; onset is usually after age 40, with weakness and
wasting of small muscles of the hands; The infantile form and
the swedish later-onset are autosomal dominant and there is a
Japanese late-onset type that is recessive.  Minicore-multicore
myopathy, an uncommon nonprogressive myopathy with early onset,
proximal weakness, and hypotonia. Muscle fibres show focal
defects of oxidative and myofibrillar adenosine triphosphatase
enzymes with disorganiza