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of Publication Document Types 1.  Effect of acute physiological
hyperinsulinemia on gene expression in human skeletal muscle in
vivo  This study was undertaken to test the hypothesis that
short-term exposure (4 h) to physiological hyperinsulinemia in
normal, healthy subjects without a family history of diabetes
would induce a low grade inflammatory response independently of
glycemic status. Twelve normal glucose tolerant subjects
received a 4-h euglycemic hyperinsulinemic clamp with biopsies
of the vastus lateralis muscle. Microarray analysis identified
121 probe sets that were significantly altered in response to
physiological hyperinsulinemia while maintaining euglycemia. In
normal, healthy human subjects insulin increased the mRNAs of a
number of inflammatory genes (CCL2, CXCL2 and THBD) and
transcription factors (ATF3, BHLHB2, HES1, KLF10, JUNB, FOS, and
FOSB). A number of other genes were upregulated in response to
insulin, including RRAD,