were due to  Congenital adrenal hyperplasia due to 17 alpha-
hydroxylase deficiency  Congenital adrenal hyperplasia due to
17α-hydroxylase deficiency is an uncommon form of congenital
adrenal hyperplasia resulting from a defect in the gene for the
enzyme CYP17A1. It produces decreased synthesis of both cortisol
and sex steroids, with resulting increase in mineralocorticoid
production. Thus, common symptoms include mild hypocortisolism,
ambiguous genitalia in genetic males or failure of the ovaries
to function at puberty in genetic females, and hypertension
(respectively).   This form of CAH results from deficiency of
the enzyme 17α-hydroxylase (also called CYP17A1). It accounts
for less than 5% of the cases of congenital adrenal hyperplasia
and is inherited in an autosomal recessive manner with a
reported incidence of about 1 in 50,000 births.  The most common
abnormal alleles of this condition impair both the
17α-hydroxylase activity and the 17,20-lyase activity of
CYP17A1. Like other forms of CAH, 17α-hydrox