Email updates   Open Access Highly Accessed Perspective  Over-
stimulation of insulin/IGF-1 signaling by Western diet may
promote diseases of civilization: lessons learnt from Laron
syndrome  Bodo C Melnik1*, Swen Malte John1 and Gerd Schmitz2
Author Affiliations   2 Institute for Clinical Chemistry and
Laboratory Medicine, University Clinic of Regensburg, Franz-
Josef-Strauss-Allee 11, D-93053 Regensburg, Germany  For all
author emails, please log on.  Nutrition & Metabolism 2011,
8:41  doi:10.1186/1743-7075-8-41   Received:27 March 2011
Accepted:24 June 2011 Published:24 June 2011  © 2011 Melnik et
al; licensee BioMed Central Ltd.    The insulin/insulin-like
growth factor-1 (IGF-1) pathway drives an evolutionarily
conserved network that regulates lifespan and longevity.
Individuals with Laron syndrome who carry mutations in the
growth hormone receptor (GHR) gene that lead to severe
congenital IGF-1 deficiency with decreased insulin/IGF-1
signaling (IIS) exhibit reduced prevalence rates of acne,
diabetes and