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Clipboard (0)  Related Articles  1.  Mapping of partially
overlapping de novo deletions across an autism susceptibility
region [AUTS5] in two unrelated individuals affected by
developmental delays with communication impairment  Autism is a
neurodevelopmental disorder characterized by deficits in
reciprocal social interaction and communication, and repetitive
and stereotyped behaviors and interests. Previous genetic
studies of autism have shown evidence of linkage to chromosomes
2q, 3q, 7q, 11p, 16p, and 17q. However, the complexity and
heterogeneity of the disorder have limited the success of
candidate gene studies. It is estimated that 5% of the autistic
population carry structural chromosome abnormalities. This
article describes the molecular cytogenetic characterization of
two chromosome 2q deletions in unrelated individuals, one of
whom lies in the autistic spectrum. Both patients are affected
by developmental disorders with language delay and communicat