Display Settings:   Send to:  Choose Destination Clin Cancer
Res. 2011 Mar 15;17(6):1452-62. doi:
10.1158/1078-0432.CCR-10-2694. Epub 2011 Feb 10.   Author
information    • Department of Medical Oncology, Dana-Farber
Cancer Institute and Harvard Medical School, Brigham and Women's
Hospital and Harvard Medical School, Boston, Massachusetts
02115, USA.    STAT3 is a transcription factor that is
constitutively activated in some cancers. It seems to play
crucial roles in cell proliferation and survival, angiogenesis,
tumor-promoting inflammation, and suppression of antitumor host
immune response in the tumor microenvironment. Although the
STAT3 signaling pathway is a potential drug target, clinical,
pathologic, molecular, or prognostic features of STAT3-activated
colorectal cancer remain uncertain.   Utilizing a database of
724 colon and rectal cancer cases, we evaluated phosphorylated
STAT3 (p-STAT3) expression by immunohistochemistry. The Cox
proportional hazards model was used to compute mortality HR,
adjustin