Intramuscular Lipid Metabolism in the Insulin Resistance of
Smoking    1. Bryan C. Bergman,   2. Leigh Perreault,   3. Devon
M. Hunerdosse,   4. Mary C. Koehler,   5. Ali M. Samek and   6.
Robert H. Eckel   1. From the Division of Endocrinology,
Diabetes, and Metabolism, University of Colorado Denver School
of Medicine, Aurora, Colorado.   1. Corresponding author: Bryan
C. Bergman, Bryan.Bergman{at}   OBJECTIVE Smoking decreases
insulin action and increases the risk of type 2 diabetes in
humans. Mechanisms responsible for smoking-induced insulin
resistance are unclear. We hypothesized smokers would have
increased intramuscular triglyceride (IMTG) and diacylglycerol
(DAG) concentration and decreased fractional synthesis rate
(FSR) compared with nonsmokers.  RESEARCH DESIGN AND METHODS
Nonsmokers (n = 18, aged 20 ± 0.5 years, BMI 22 ± 0.4 kg/m2,
body fat 20 ± 2%, 0 cigarettes per day) and smokers (n = 14,
aged 21 ± 0.7 years, BMI 23 ± 0.4 kg/m2, body fat 20 ± 3%, 18 ±
0.7 cigarettes per day) were studied in a f