Document Detail  MedLine Citation: PMID:  23013520     Owner: 
NLM     Status:  MEDLINE     Exercise-induced muscle damage
(EIMD) is a common condition resulting from a bout of vigorous
exercise, particularly if the individual is unaccustomed to
performance of the given movement. Symptoms of EIMD include
delayed-onset muscle soreness (DOMS) and a loss of physical
function. Nonsteroidal anti-inflammatory drugs (NSAIDs) are
routinely prescribed post-exercise to alleviate these symptoms
and restore normal physical function. Of potential concern for
those who use NSAIDs to treat EIMD is the possibility that they
may impair the adaptive response to exercise. Specifically,
there is emerging evidence that the action of cyclo-oxygenase
(COX) enzymes, and COX-2 in particular, are important and even
necessary to achieve maximal skeletal muscle hypertrophy in
response to functional overload. Given that NSAIDs exert their
actions by blocking COX and thus suppressing prostaglandin
production, a theoretical rationale exist