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Mechanosensing refers to the ability of an organism to respond
to changes in mechanical force on them or their environment. The
mechanical stress can be in a variety of forms:    • Hydrostatic
pressure, as in the case of deep ocean environments   • Fluid
shear stress, as in the case of blood flowing through veins   •
Direct force, as in the case of body weight on a bone   •
Osmotic pressure, resulting from a difference in solute
concentrations across a semi-permeable membrane  High
hydrostatic pressure (HHP) can cause a host of problems,
including dissociation of multimeric proteins, shifts in
reaction equilibria, loss of membrane integrity, and protein
denaturation (reviewed in [1]). In some cases, changes in
mechanical stress result in differential gene expression driven
by mechanosensitive promoters or repressors. Genes that have
increased expression might include cold- and heat-shock and
other stress response proteins[2], barostable polym