Search tips Search criteria    Schizophr Bull. 2007 July; 33(4):
932–936. Published online 2007 June 16. doi: 
10.1093/schbul/sbm064 PMCID: PMC2632324 Searching for Unique
Endophenotypes for Schizophrenia and Bipolar Disorder Within
Neural Circuits and Their Molecular Regulatory Mechanisms
Francine M. Benes1,2,3 2Program in Structural and Molecular
Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA
02478 3Program in Neuroscience and Department of Psychiatry,
Harvard Medical School, Boston, MA 1To whom correspondence
should be addressed; tel: 617-855-2401, fax: 617-855-3199,
e-mail: fbenes/at/ The endophenotype is a construct that has
utility for the study of postmortem brains from patients with
psychotic disorders. By identifying networks of genes that show
changes in expression within specific neuronal populations
implicated in the pathophysiology of schizophrenia and bipolar
disorder, it may be possible to move toward understanding these
disorders at the cellular and molecular levels. The ultimate