Figure 5.  Model of Action of c-Myc, E2F1 and 14-3-3ζ. Model of
the downstream events product of the overexpression and/or
amplification of c-Myc, and its collaboration with the
transcription factor E2F1. c-Myc promotes the expression of
proteins that lead to survival and proliferation through
processes such as metabolism, protein biosynthesis and
transcription factors. Likewise, it enables the expression of
proteins involved in epithelial mesenchymal transition. E2F1 and
c-Myc work together to promote the expression of Cyclins and E2F
factors that boost the transition between G1 and S phases of
mitosis, as well as the expression of 14-3-3ζ and Bcl-2. Bcl-2
is an antiapoptotic protein that prevents the release of
cytochrome c. The overexpression of 14-3-3ζ results in
instability and degradation of p53, increased cell
proliferation, and cytoplasmic sequestration of BAD with what
brings drastic decrease of apoptosis.  Higareda-Almaraz et al.
BMC Systems Biology 2011 5:96   doi:10.1186/1752-0509-5-96
Download au