Haemophilia C  From Wikipedia, the free encyclopedia Jump to:
navigation, search Haemophilia C Classification and external
resources ICD-10 D68.1 ICD-9 286.2 OMIM 264900 DiseasesDB 29376
eMedicine ped/964 med/3515 MeSH D005173  Haemophilia C (also
known as plasma thromboplastin antecedent (PTA) deficiency or
Rosenthal syndrome) is a mild form of haemophilia affecting both
sexes. However, it predominantly occurs in Jews of Ashkenazi
descent. It is the fourth most common coagulation disorder after
von Willebrand's disease and haemophilia A and B.[1] In the USA
it is thought to affect 1 in 100,000 of the adult population,
making it 10% as common as haemophilia A.[2]  It is caused by a
deficiency of coagulation factor XI and is distinguished from
haemophilia A and B by the fact it does not lead to bleeding
into the joints. Furthermore, it has autosomal inheritance,
since the gene for factor XI is located on chromosome 4 (close
to the prekallikrein gene); and it is not completely recessive,
individuals who are het