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SNP analysis of follistatin gene associated with polycystic
ovarian syndrome  Follistatin has been reported as a candidate
gene for polycystic ovarian syndrome (PCOS) based on linkage and
association studies. In this study, investigation of
polymorphisms in the FST gene was done to determine if genetic
variation is associated with susceptibility to PCOS. The
nucleotide sequence of human follistatin and the protein
sequence of human follistatin were retrieved from the NCBI
database using Entrez. The follistatin protein of human was
retrieved from the Swiss-Prot database. There are 344 amino
acids and the molecular weight is 38,007 Da. The ProtParam
analysis shows that the isoelectric point is 5.53 and the
aliphatic index is 61.25. The hydropathicity is −0.490. The
domains in FST protein are as follows: Pfam-B 5005 domain from 1
to 92; EGF-like subdomain from 93 to 116; Kazal 1 domain, occu