Microscopic Description -- history of colonic adenocarcinoma
The normal small intestinal villi and crypts are well
represented (FIGURE 1). Further along the mucosal surface of
this slide, there is an abrupt transition from the benign
appearing columnar epithelium to more hyperchromatic nuclei and
adenomatous appearing epithelium (FIGURE 2). The architecture is
that of a villous adenoma. The progression of this adenoma
towards a well differentiated mucin producing adenocarcinoma is
evident by the nuclear stratification, prominent nucleoli,
increased nuclear to cytoplasmic ratio, and nuclear pleomorphism
(FIGURES 3, FIGURE 4, and FIGURE 5). There is also evidence of
invasion into the muscularis mucosa with extension through the
bowel wall. The invasive adenocarcinoma approached the hepatic
capsule but did not invade the hepatic parenchyma (FIGURE 6).
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