Display Settings:   Send to:  Choose Destination Diabetes. 2002
Jul;51(7):2313-6.  A putative functional polymorphism in the
IGF-I gene: association studies with type 2 diabetes, adult
height, glucose tolerance, and fetal growth in U.K. populations.
Author information    • Department of Diabetes and Vascular
Medicine, University of Exeter, Barrack Road, Exeter EX2 5AX,
U.K.   IGF-I has a critical role in growth and metabolism. A
microsatellite polymorphism 1 kb upstream to the IGF-I gene has
recently been associated with several adult phenotypes. In a
large Dutch cohort, the absence of the commonest allele (Z) was
associated with reduced serum IGF-I levels, reduced height, and
an increased risk of type 2 diabetes and myocardial infarction.
This result has not been replicated, and the role of this
polymorphism in these traits in U.K. subjects is not known. We
sought further evidence for the involvement of this variant in
type 2 diabetes using a case-control study and IGF-I and
diabetes-related traits in a pop