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answer If I recall correctly, there are also some nerves in the
jawline that can get triggered by the jaw being slammed shut by
the punch, so that might also factor in. –  Sean Duggan May 15
at 16:07 @SeanDuggan That would be the Trigeminal Nerve, which
is (generally) located just to the side of the chin. Possible to
activate with a straight punch, but better chance when offset to
the side a little. –  AerusDar May 16 at 0:36  Slightly behind
either ear is the place to hit if you want a knockout. 43 years
experience in martial arts, military and personal body guarding
has proven this to me. As a former corrections officer, it is a
statistical fact that knocking a person out rather than
continuing to fight with them is a more humane way to end an
altercation. The longer an altercation continues, the more
likely you are to get hurt and/or inflict more damage on the
other person. Most knockout