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brcKargerHomeAlertsResources Breast Care (Basel). 2010 April;
5(2): 86–90. Published online 2010 April 9. doi: 
10.1159/000298962 PMCID: PMC2931041 NHERF1/EBP50 in Breast
Cancer: Clinical Perspectives Antonia Bellizzi,a* Andrea
Malfettone,a* Rosa A. Cardone,b and Anita Mangiaa* aClinical
Experimental Oncology Laboratory, National Cancer Centre, Bari
bDepartment of General and Environmental Physiology, University
of Bari, Italy *Anita Mangia, PhD, Clinical Experimental
Oncology Laboratory, National Cancer Centre, Via Hahnemann, 10,
70126 Bari, Italy, Tel. +39 0805555527 ; a.mangia/at/ *Both
authors equally contributed to this work. Na+/H+ exchanger
regulatory factor 1 (NHERF1) is a postsynaptic density 95/disc-
large/zona occludens (PDZ) domain-containing protein that
recruits membrane receptors/transporters and cytoplasmic
signaling proteins into functional complexes. NHERF1 expression
has been demonstrated to be altered in breast cancer, but its
role in mammary canceroge