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Clipboard (0)  Related Articles  1.  Complement C1s activation
in degenerating articular cartilage of rheumatoid arthritis
patients: immunohistochemical studies with an active form
specific antibody  Annals of the Rheumatic Diseases 
1999;58(3):175-181. OBJECTIVE—The first complement component C1s
was reported to have novel functions to degrade matrix
components, besides its activities in the classic complement
pathway. This study explores participation of C1s in articular
cartilage degradation in rheumatoid arthritis
(RA). METHODS—Normal articular cartilage (n=6) and cartilage
obtained from joints with RA (n=15) and osteoarthritis (OA,
n=10) were immunostained using anti-C1s monoclonal antibodies
PG11, which recognises both active and inactive C1s, and M241,
which is specifically reactive to activated C1s. The effects of
inflammatory cytokines on C1s production by human articular
chondrocytes were also examined by sandwich ELISA. RESULTS—In
normal articular