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author:("nikkanen, emm") 1.  Genome-wide association study
identifies multiple loci influencing human serum metabolite
levels  Nature genetics  2012;44(3):269-276. PMCID: PMC3605033
 PMID: 22286219 PLoS Medicine  2013;10(2):e1001383. A mendelian
randomization study based on data from multiple cohorts
conducted by Karani Santhanakrishnan Vimaleswaran and colleagues
re-examines the causal nature of the relationship between
vitamin D levels and obesity. Methods and Findings Associations
between vitamin D scores and BMI were confirmed in the Genetic
Investigation of Anthropometric Traits (GIANT) consortium
(n = 123,864). Each 1 kg/m2 higher BMI was associated with 1.15%
lower 25(OH)D (p = 6.52×10−27). The BMI allele score was
associated both with BMI (p = 6.30×10−62) and 25(OH)D (−0.06%
[95% CI −0.10 to −0.02], p = 0.004) in the cohorts that
underwent meta-analysis. The two vitamin D allele score