Incorrect Least-Squares Regression Coefficients in Method-
Comparison  Document Sample Incorrect Least-Squares Regression
Coefficients in Method- Comparison Powered By Docstoc
CLIN. CHEM. 25/3, 432-438           (1979)  IncorrectLeast-
SquaresRegressionCoefficientsin Method-   P. Joanne Cornbleet”
and Nathan Gochman  The least-squares   method isfrequentlyused
tocalculate                         where    x is the
independent            variable     (reference      method), y
is the slope and intercept of thebestline
througha setofdata                         the dependent
variable (testmethod),                             isthe
slope,and points. However, least-squares regression slopes and
in-                               is the intercept        of the
regression       line. tercepts may be incorrect if the
underlying assumptions                             The least-
squares           method is the most commonly
used sta- of the least-squares model ar