PC-AssayDescription ::= { aid { id 687, version 1 }, aid-source
db { name "PCMD", source-id str "FXIA_SINGLE" }, name "Factor
XIa Single Well HTS", description { "Molecular Library Screening
Center Network (MLSCN)", "Penn Center for Molecular Discovery
(PCMD)", "Assay Provider: Scott L. Diamond, University of
Pennsylvania", "MLSCN Grant: X01-MH076406-01", "", "Target", "",
"Factor XI (FXI) circulates as a complex with high molecular
weight kininogen (HK) in the plasma at a concentration of 5
ug/ml (equivalent to 31.3 nM, dimeric concentration) as a
homodimeric glycosylated blood plasma zymogen of approximately
160 kDa, containing monomeric subunits of 80 kDa each (1).
Thrombin (2, 3), factor XIa (FXIa) (3), and factor XIIa alpha
(FXIIa) (4), all cleave an internal R369-I370 bond in each
monomer of FXI, yielding the enzyme FXIa. ", "", "After
activation from FXI to FXIa, FXIa possesses a heavy chain of 369
residues and a light chain of 238 residues. The heavy chain
consists of four apple domains (A1-A4) and th