SGD Paper Help  Harris N, et al.  (2003) Mnsod overexpression
extends the yeast chronological (G(0)) life span but acts
independently of Sir2p histone deacetylase to shorten the
replicative life span of dividing cells. Free Radic Biol Med
34(12):1599-606  Abstract: Studies in Drosophila and
Caenorhabditis elegans have shown increased longevity with the
increased free radical scavenging that accompanies
overexpression of oxidant-scavenging enzymes. This study used
yeast, another model for aging research, to probe the effects of
overexpressing the major activity protecting against superoxide
generated by the mitochondrial respiratory chain. Manganese
superoxide dismutase (MnSOD) overexpression increased
chronological life span (optimized survival of stationary (G(0))
yeast over time), showing this is a survival ultimately limited
by oxidative stress. In contrast, the same overexpression
dramatically reduced the replicative life span of dividing cells
(the number of daughter buds produced by each newly born moth