Figure 4.  Reducing the level of hRev7 in human fibroblast cells
renders them more sensitive to the cytotoxic effects of a
variety of different types of DNA damaging agents. Cell strains
2.5 and 3.2, which have significantly reduced hRev7 protein,
(closed symbols) were compared to their parental strain and the
vector control strain (open symbols) for their sensitivity to
the cytotoxic effects of (A) the DNA cross-linking agent
cisplatin, (B) ionizing radiation (IR), and (C) the alkylating
agent N-methyl-N-hydroxyurea (MNU). The lines represent the
least squares regression for the data.  Neal et al. BMC Cell
Biology 2010 11:97   doi:10.1186/1471-2121-11-97 Download
authors' original image