Mark Hlatky, MD  Publication Details    • A Randomized Trial of
Therapies for Type 2 Diabetes and Coronary Artery Disease NEW
ENGLAND JOURNAL OF MEDICINE Anonymous 2009; 360 (24): 2503-2515
Optimal treatment for patients with both type 2 diabetes
mellitus and stable ischemic heart disease has not been
established.We randomly assigned 2368 patients with both type 2
diabetes and heart disease to undergo either prompt
revascularization with intensive medical therapy or intensive
medical therapy alone and to undergo either insulin-
sensitization or insulin-provision therapy. Primary end points
were the rate of death and a composite of death, myocardial
infarction, or stroke (major cardiovascular events).
Randomization was stratified according to the choice of
percutaneous coronary intervention (PCI) or coronary-artery
bypass grafting (CABG) as the more appropriate intervention.At 5
years, rates of survival did not differ significantly between
the revascularization group (88.3%) and the medical-therapy
group