Journal of Theoretical Medicine Volume 5 (2003), Issue 3-4,
Pages 137-153 Review Article  Tumour-Induced Angiogenesis: A
Review   Received 9 March 2004; Accepted 9 March 2004
Angiogenesis, the formation of new blood vessels, has become a
broad subject and is a very active area for current research.
This paper describes the main biological events involved in
angiogenesis and their importance in cancer progression. In the
first section, a fundamental overview of tumour biology is
presented. In the second section, the biology of healthy blood
vessels is described and, in the third section, the mechanisms
of cell migration and proliferation, which are crucial to
angiogenesis, are discussed. In the fourth section, a detailed
account of tumour-induced angiogenesis is given, whilst the pro-
and anti-angiogenic factors involved are reviewed in the fifth
section. Finally, the processes of tumour invasion and
metastasis are examined in the sixth section.