Chain-reactive burst  We designed “chain-reactive burst” system
as follows. Each liposome contains triggers and drugs inside,
and aptamers for the trigger on its surface. When liposomes are
destroyed, new triggers and drugs are released. To achieve
liposomal burst by outside triggers, we propose the following
two approaches.    • i) Bending approach   • ii) Flower micelle
approach    • First, we considered a theory to disrupt liposomes
by a trigger DNA signal through calculation. If a liposome is
destroyed, its size becomes smaller. We estimated the free
energy gap between the two liposomal states: a large liposome
and a small one. And discuss which size of liposomes is more
stable.     Please see the details (Go to Calculation).
i)Bending Approach      Fig.1 Process of bending approach
Our bending approach consists of the following four steps.
1.Cholesterol-conjugated DNA strands (in the rest of this
document, referred to as “aptamers”) attach to the surfaces of
liposomes.     2. Then, DNA orig