Email updates   Open Access Methodology article  Hepatitis C
virus whole genome position weight matrix and robust primer
design  Ping Qiu1*, Xiao-Yan Cai2, Luquan Wang1, Jonathan R
Greene1 and Bruce Malcolm3  Author Affiliations  1
Bioinformatics Group and Discovery Technology Department,
Schering-Plough Research Institute, 2015 Galloping Hill Road,
Kenilworth, New Jersey 07033, USA  2 Bioanalytical Department,
Schering-Plough Research Institute, 1011 Morris Avenue, Union,
New Jersey 07083, USA  3 Antiviral Therapy Department, Schering-
Plough Research Institute, 2015 Galloping Hill Road, Kenilworth,
New Jersey 07033, USA  For all author emails, please log on.
BMC Microbiology 2002, 2:29  doi:10.1186/1471-2180-2-29
Received:11 July 2002 Accepted:25 September 2002 Published:25
September 2002     The high degree of sequence heterogeneity
found in Hepatitis C virus (HCV) isolates, makes robust nucleic
acid-based assays difficult to generate. Polymerase chain
reaction based techniques, require efficient and spe