Document Detail  Single atom substitution in mouse protein
kinase G eliminates oxidant sensing to cause hypertension. Jump
to Full Text MedLine Citation: PMID:  22245782     Owner:  NLM
 Status:  MEDLINE     Blood pressure regulation is crucial for
the maintenance of health, and hypertension is a risk factor for
myocardial infarction, heart failure, stroke and renal disease.
Nitric oxide (NO) and prostacyclin trigger well-defined
vasodilator pathways; however, substantial vasorelaxation in
response to agents such as acetylcholine persists when the
synthesis of these molecules is prevented. This remaining
vasorelaxation activity, termed endothelium-derived
hyperpolarizing factor (EDHF), is more prevalent in resistance
than in conduit blood vessels and is considered a major
mechanism for blood pressure control. Hydrogen peroxide (H2O2)
has been shown to be a major component of EDHF in several
vascular beds in multiple species, including in humans. H2O2
causes the formation of a disulfide bond between the two