Search tips Search criteria    PLoS One. 2012; 7(8): e43193.
Published online Aug 17, 2012. doi: 
10.1371/journal.pone.0043193 PMCID: PMC3422309 Mutant Amyloid
Precursor Protein Differentially Alters Adipose Biology under
Obesogenic and Non-Obesogenic Conditions Linnea R. Freeman, Le
Zhang, Kalavathi Dasuri, Sun-Ok Fernandez-Kim, Annadora J.
Bruce-Keller, and Jeffrey N. Keller* Pennington Biomedical
Research Center/LSU System, Baton Rouge, Louisiana, United
States of America Hemachandra Reddy, Editor Oregon Health &
Science University, United States of America * E-mail:
Jeffrey.Keller/at/ Conceived and designed the experiments: JNK
ABK LRF. Performed the experiments: LRF LZ KD SFK. Analyzed the
data: LRF LZ. Contributed reagents/materials/analysis tools: JNK
ABK. Wrote the paper: LRF JNK. Received June 4, 2012; Accepted
July 20, 2012. Mutations in amyloid precursor protein (APP) have
been most intensely studied in brain tissue for their link to
Alzheimer’s disease (AD) pathology. However, APP is highly
expres