Email updates    Lymphatic endothelial differentiation: start
out with Sox - carry on with Prox  Friedemann Kiefer1 and Ralf H
Adams23*  Author Affiliations  1 Max-Planck-Institute for
Molecular Biomedicine, Department of Vascular Cell Biology,
D-48149 Münster, Germany  2 Max-Planck-Institute for Molecular
Biomedicine, Department of Tissue Morphogenesis, D-48149
Münster, Germany  3 University of Münster, Faculty of Medicine,
D-48149 Münster, Germany  For all author emails, please log on.
Genome Biology 2008, 9:243  doi:10.1186/gb-2008-9-12-243
Published:29 December 2008  © 2008 BioMed Central Ltd   The
transcription factor Prox1 is the master regulator of lymphatic
endothelial cell differentiation and its expression initiates
the morphogenesis of the lymphatic vasculature in the early
embryo. Two new studies now answer some fundamental questions
concerning Prox1 biology.   The bodies of higher vertebrates
contain two highly branched hierarchical networks of endothelial
tubules. One comprises the blood vess