Display Settings:   Send to:  Choose Destination Brain Res. 2002
Nov 8;954(2):173-82.  Effects of sex, age, and aggressive traits
in man on brain serotonin 5-HT1A receptor binding potential
measured by PET using [C-11]WAY-100635.  Author information    •
Division of Neuroscience, Department of Psychiatry, Columbia
University College of Physicians and Surgeons, New York, NY
10032, USA. rparsey@neuron.cpmc.columbia.edu   Serotonin (5-HT)
1A receptors have been implicated in a variety of conditions
including, depression, suicidal behavior, and aggression. Post-
mortem brain studies and in vivo imaging studies report a
variety of age and sex effects on brain 5-HT(1A) binding.
Behavioral data from 5-HT(1A) specific pharmacological
challenges suggest a role for 5-HT(1A) receptors in aggression.
The goal of the present study was to determine age, sex, and
severity of life-time aggression effects on 5-HT(1A) binding
potential (BP) in vivo using positron emission tomography (PET)
and the high affinity 5-HT(1A) antagoni