Figure 1.  Positional Cloning of l11Jus1 and l11Jus4. A.
Exclusion Mapping Breeding Scheme. Blue line: ENU-mutated allele
(l11Jus1; C57BL/6J); Green line with the double arrow: 34 Mb
inversion (In(11Trp53;11Wnt3)8Brd; 129S6/SvEvTac); yellow line:
dominant Rex allele (129S6/SvEvTac), which confers a curly coat.
Plus sign: wild type locus. All animals carrying two copies of
the l11Jus1 allele will die in utero. Representative phenotypes
and crossover events are depicted in the F2 generation. B.
Mapping the Nle1 mutation by haplotype analysis in the
F2generation. Each box represents a locus within Mmu 11. Yellow
boxes are homozygous 129S6/SvEvTac genotypes; green boxes are
heterozygous for 129S6/SvEvTac and C57BL/6J genotypes; while
blue boxes indicate homozygous C57BL/6J genotypes. Wsb1
&D11Mit120 define the boundaries of the critical region. C.
Physical map of the non-recombinant interval. Nle1 lies ~700 kb
centromeric to D11Mit120. D. Mutation analysis. Arrows indicate
the location of each mutation. Stacked c