Funding opportunities  Making Stem Cell Therapies Safer:
Targeting ES Cells with Cell Cycle and miRNA Antagonists
Funding Type:  Basic Biology II Grant Number:  Funds requested: 
$1 382 474 Funding Recommendations:  Not recommended Grant
approved:  Public Abstract:  Stem cell therapies have the
potential to result in entirely new treatments for a vast
variety of currently incurable diseases. The goal of these
therapies is to regenerate lost cells or tissues through the use
of established human embryonic stem cell lines or even from the
patient's own cells. One major limitation of current stem cell
therapy approaches is that they may give rise to cancer.
Embryonic stem cells have a limitless potential to reproduce and
if they remain in an undifferentiated state could give rise to
tumors. This proposal seeks to make stem cell therapies safer by
using two novel targets that can selectively kill
undifferentiated stem cells while sparing differentiated cells
or normal cells. We propose to use small molecule inhib