Interleukin 35  From Wikipedia, the free encyclopedia Jump to:
navigation, search  Interleukin 35 (IL-35) is an IL-12 family
cytokine produced by regulatory, but not effector, T-cells and
plays a role in immune suppression. It is a dimeric protein
composed of IL-12α and IL-27β chains, which are encoded by two
separate genes called IL12A and EBI3, respectively. Secreted by
regulatory T-cells (Tregs), IL-35 suppresses inflammatory
responses of immune cells. IL-35 is not constitutively expressed
in tissues, but the gene encoding IL-35 is transcribed by
vascular endothelial cells, smooth muscle cells and monocytes
after activation with proinflammatory stimuli. [1]  Studies in
mice show the absence of either IL-35 chain from regulatory
Tregs reduces the cells' ability to suppress inflammation; this
has been observed during cell culture experiments and using an
experimental model for inflammatory bowel disease.[2] To produce
its suppressive effects, IL-35 has selective activities on
different T-cell subsets; it ind