Distinct cardiogenic preferences of two human embryonic stem
cell (hESC) lines are imprinted in their proteomes in the
pluripotent state.  Biochem Biophys Res Commun Publication
Year:  Jennifer C Moore , Jidong Fu , Yau-Chi Chan , Dawei Lin ,
Ha Tran , Hung-Fat Tse , Ronald A Li Public Summary:  Scientific
Abstract:  Although both the H1 and HES2 human embryonic stem
cell lines (NIH codes: WA01 and ES02, respectively) are capable
of forming all three germ layers and their derivatives, various
lines of evidence including the need to use different protocols
to induce cardiac differentiation hint that they have distinct
preferences to become chamber-specific heart cells. However, a
direct systematic comparison has not been reported. Here we
electrophysiologically demonstrated that the distributions of
ventricular-, atrial- and pacemaker-like derivatives were indeed
different (ratios=39:61:0 and 64:33:3 for H1 and HES2,
respectively). Based on these results, we hypothesized the
differences in their cardiogenic po