Kinetic Analysis of npBAF to nBAF Switching Reveals Exchange of
SS18 with CREST and Integration with Neural Developmental
Pathways.  J Neurosci Publication Year:  Brett T Staahl , Jiong
Tang , Wei Wu , Alfred Sun , Aaron D Gitler , Andrew S Yoo ,
Gerald R Crabtree Public Summary:  Scientific Abstract:  During
the development of the vertebrate nervous system, neural
progenitors divide, generate progeny that exit mitosis, and then
migrate to sites where they elaborate specific morphologies and
synaptic connections. Mitotic exit in neurons is accompanied by
an essential switch in ATP-dependent chromatin regulatory
complexes from the neural progenitor Brg/Brm-associated factor
(npBAF) to neuron-specific nBAF complexes that is in part driven
by miR-9/9* and miR-124. Recapitulating this microRNA/chromatin
switch in fibroblasts leads to their direct conversion to
neurons. We have defined the kinetics of neuron-specific BAF
complex assembly in the formation of induced neurons from mouse
embryonic stem cells, human fi