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» Year of Publication Document Types author:("Wang, danxi") 1. 
Polymorphism in glutamate cysteine ligase catalytic subunit
(GCLC) is associated with sulfamethoxazole-induced
hypersensitivity in HIV/AIDS patients  BMC Medical Genomics 
2012;5:32. Sulfamethoxazole (SMX) is a commonly used antibiotic
for prevention of infectious diseases associated with HIV/AIDS
and immune-compromised states. SMX-induced hypersensitivity is
an idiosyncratic cutaneous drug reaction with genetic
components. Here, we tested association of candidate genes
involved in SMX bioactivation and antioxidant defense with SMX-
induced hypersensitivity. Seventy seven single nucleotide
polymorphisms (SNPs) from 14 candidate genes were genotyped and
assessed for association with SMX-induced hypersensitivity, in a
cohort of 171 HIV/AIDS patients. SNP rs761142 T > G, in
glutamate cysteine ligase catalytic subunit (GCLC), was
significantly associated with SMX-induced hypersensitivity