Skip Navigation   Reviewed August 2013  What is the official
name of the IKBKG gene?  The official name of this gene is
“inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase gamma.”  IKBKG is the gene's official symbol. The IKBKG
gene is also known by other names, listed below.  What is the
normal function of the IKBKG gene?   The IKBKG protein plays a
regulatory role in the IKK complex. Once the IKBKG protein is
turned on (activated), it activates the other proteins in the
complex, which in turn activates and releases nuclear factor-
kappa-B. The activated factor then moves into the nucleus and
binds to DNA. Nuclear factor-kappa-B regulates the activity of
multiple genes, including genes that control the body's immune
responses and inflammatory reactions. Nuclear factor-kappa-B
also appears to play a role in the signaling pathway that is
critical for the formation of ectodermal tissues including the
skin, hair, teeth, and sweat glands. In addition, it protects
the cell from certain signals th