Localization and function of KLF4 in cytoplasm of vascular
smooth muscle cell.  TitleLocalization and function of KLF4 in
cytoplasm of vascular smooth muscle cell. Publication
TypeJournal Article Year of Publication2013 AuthorsLiu Y, Zheng
B, Zhang X-H, Nie C-J, Li Y-H, Wen J-K JournalBiochemical and
biophysical research communications Date Published2013 Jun 28
The Krüppel-like factor 4 is a DNA-binding transcriptional
regulator that regulates a diverse array of cellular processes,
including development, differentiation, proliferation, and
apoptosis. The previous studies about KLF4 functions mainly
focused on its role as a transcription factor, its functions in
the cytoplasm are still unknown. In this study, we found that
PDGF-BB could prompt the translocation of KLF4 to the cytoplasm
through CRM1-mediated nuclear export pathway in vascular smooth
muscle cells (VSMCs) and increased the interaction of KLF4 with
actin in the cytoplasm. Further study showed that both KLF4
phosphorylation and SUMOylation induced