Pancreatic ribonuclease SMART accession number:SM00092 Interpro
abstract (IPR023412): Pancreatic ribonucleases (RNaseA) are
pyrimidine-specific endonucleases found in high quantity in the
pancreas of certain mammals and of some reptiles
[(PUBMED:3940901)]. Specifically, the enzymes are involved in
endonucleolytic cleavage of 3'-phosphomononucleotides and
3'-phosphooligonucleotides ending in C-P or U-P with
2',3'-cyclic phosphate intermediates. Ribonuclease can unwind
the DNA helix by complexing with single-stranded DNA; the
complex arises by an extended multi-site cation-anion
interaction between lysine and arginine residues of the enzyme
and phosphate groups of the nucleotides. Other proteins
belonging to the pancreatic RNAse family include: bovine seminal
vesicle and brain ribonucleases; kidney non-secretory
ribonucleases [(PUBMED:2734298)]; liver-type ribonucleases
[(PUBMED:2611266)]; angiogenin, which induces vascularisation of
normal and malignant tissues; eosinophil cationic protein
[(PUBMED:2473157)],