 PLoS Pathog. Feb 2010; 6(2): e1000764. Published online Feb 12,
2010. doi:  10.1371/journal.ppat.1000764 PMCID: PMC2820531  Six
RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation
of Small RNA Repertoires in Vertebrate and Invertebrate Systems
Charles M. Rice, Editor   We have used multiplexed high-
throughput sequencing to characterize changes in small RNA
populations that occur during viral infection in animal cells.
Small RNA-based mechanisms such as RNA interference (RNAi) have
been shown in plant and invertebrate systems to play a key role
in host responses to viral infection. Although homologs of the
key RNAi effector pathways are present in mammalian cells, and
can launch an RNAi-mediated degradation of experimentally
targeted mRNAs, any role for such responses in mammalian host-
virus interactions remains to be characterized. Six different
viruses were examined in 41 experimentally susceptible and
resistant host systems. We identified virus-derived small RNAs
(vsRNAs) from all six viruses