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Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining
the Capacity of the Readily-Releasable Pool of Synaptic Vesicles
Taulant Bacaj et al. info:doi/10.1371/journal.pbio.1002267
2015-10-05T21:00:00Z 2015-10-05T21:00:00Z <p>by Taulant Bacaj,
Dick Wu, Jacqueline Burré, Robert C. Malenka, Xinran Liu, Thomas
C. Südhof</p> In forebrain neurons, Ca<sup>2+</sup> triggers
exocytosis of readily releasable vesicles by binding to
synaptotagmin-1 and -7, thereby inducing fast and slow vesicle
exocytosis, respectively. Loss-of-function of synaptotagmin-1 or
-7 selectively impairs the fast and slow phase of