Display Settings:   Send to:  Choose Destination Infect Immun.
2011 Nov;79(11):4401-12. doi: 10.1128/IAI.05562-11. Epub 2011
Sep 12.  Toxoplasma gondii induces B7-2 expression through
activation of JNK signal transduction.  Author information    •
Department of Molecular Biology and Biochemistry, 3238 McGaugh
Hall, University of California, Irvine, Irvine, CA 92697, USA.
Toxoplasma gondii is a globally distributed parasite pathogen
that infects virtually all warm-blooded animals. A hallmark of
immunity to acute infection is the production of gamma
interferon (IFN-γ) and interleukin-12 (IL-12), followed by a
protective T cell response that is critical for parasite
control. Naïve T cell activation requires both T-cell receptor
(TCR) stimulation and the engagement of costimulatory receptors.
Because of their important function in activating T cells, the
expression of costimulatory ligands is believed to be under
tight control. The molecular mechanisms governing their
induction during microbial stimulation, how