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Publications  Regional cerebral blood flow alterations in
obstructive sleep apnea.  Yadav SK, Kumar R, Macey PM,
Richardson HL, Wang DJ, Woo MA, Harper RM.  Obstructive sleep
apnea (OSA) is a condition characterized by upper airway muscle
atonia with continued diaphragmatic efforts, resulting in
repeated airway obstructions, periods of intermittent hypoxia,
large thoracic pressure changes, and substantial shifts in
arterial pressure with breathing cessation and resumption. The
hypoxic exposure and hemodynamic changes likely induce the
structural and functional deficits found in multiple brain
areas, as shown by magnetic resonance imaging (MRI) procedures.
Altered cerebral blood flow (CBF) may contribute to these
localized deficits; thus, we examined regional CBF, using
arterial spin labeling procedures, in 11 OSA (age, 49.1±12.2
years; 7 male) and 16 control subjects (42.3±10.2 years; 6 male)
with