Influence of agitation and aeration on growth and antibiotic
production by Xenorhabdus nematophila  World Journal of
Microbiology and Biotechnology (Impact Factor: 1.26).
23(2):221-227. DOI:10.1007/s11274-006-9217-2  ABSTRACT The
effect of agitation and aeration on the growth and antibiotic
production by Xenorhabdus nematophila YL001 grown in batch
cultures were investigated. Efficiency of aeration and agitation
was evaluated through the oxygen mass transfer coefficient (K
a). With increase in K a, the biomass and antibiotic activity
increased. Activity units of antibiotic and dry cell weight were
increased to 232Uml−1 and 19.58gl−1, respectively, productivity
in cell and antibiotic was up more than 30% when K a increased
from 115.9h−1 to 185.7h−1. During the exponential growth phase,
DO concentration was zero, the oxygen supply was not sufficient.
So, based on process analysis, a three-stage oxygen supply
control strategy was used to improved the DO concentration above
30% by controlling the agitation speed