We've developed and patented two robust platforms for creating
drug candidates  Cells communicate through the release of
specific signaling proteins that bind to their respective cell-
surface receptors and transmit a signal to the cell through the
receptor. Signaling proteins play important roles in many
critical cellular and biological processes, but their over
expression, and resulting over activity, may also contribute to
a variety of diseases.  In such cases, blocking the signaling
protein from binding with its receptor may yield substantial
clinical benefit. However, an important challenge remains - many
receptor systems are complex, requiring two or more distinct
receptor components to bind signaling proteins with high
affinity. Moreover, it is sometimes advantageous to block
multiple signaling proteins that can activate a given receptor
signaling pathway.  Building on insights into the basic
mechanisms of receptor action discovered at Regeneron, our
scientists developed a general approach to create hig