postdoctoral positions at Duke  John McCusker mccus001 at Fri
Feb 9 02:43:13 EST 2001  Postdoctoral Positions are available in
three NIH funded project areas: I. Saccharomyces cerevisiae
Pathogenesis and Quantitative Genetics (one         We have
developed the model eukaryote S. cerevisiae as a model for the
pathogenic fungi and as a microbial model for quantitative
genetics. Quantitative genetics is the study of polygenic
traits.  Since most of the phenotypic variation in natural
populations is polygenic, quantitative genetics is fundamentally
important.  Quantitative traits have been most extensively
studied in higher eukaryotes.  However, detailed genetic and
molecular analysis in higher eukaryotes is quite difficult
compared to microbial systems.  We will use the
simplicity/genetic manipulability of S. cerevisiae and whole
genome analysis (1, 2, 3) to dissect the ability to grow at high
temperatures -- high temperature growth is both a quantitative
trait and a virulence trait (4, 5).         With respect to
fungal path