DeutschClear Cookie - decide language by browser settings
Haserück, Nadine (2007): Platelet activation and platelet-
monocyte aggregate formation by the atherosclerotic plaque lipid
lysophosphatidic acid. Dissertation, LMU München: Faculty of
Medicine    Oxidized LDL and platelets play a central role in
the pathogenesis of atherosclerosis and ischemic cardiovascular
diseases. Lysophosphatidic acid (LPA) is a thrombogenic
substance that accumulates in mildly-oxidized LDL and in human
atherosclerotic lesions, and is responsible for the initial
platelet activation, shape change, induced by mildly-oxidized
LDL and extracts of lipid-rich atherosclerotic plaques (Siess et
al., 1999 Proc Natl Acad Sci USA 1999). LPA directly induced
platelet shape change in blood and platelet-rich plasma (PRP)
obtained from all blood donors. Albumin was one of the main
inhibiting factors of platelet shape change in plasma.
Interestingly LPA, at concentrations slightly above plasma
levels, induced platelet shape change and aggregation