Document Detail  Targeting TLR/IL-1R signalling in human
diseases. Jump to Full Text MedLine Citation: PMID:  20396389
 Owner:  NLM     Status:  MEDLINE     The members of Toll-like
receptor/interleukin (IL)-1 receptor (TLR/IL-1R) superfamily
play a fundamental role in the immune response. These receptors
detect microbial components and trigger complex signalling
pathways that result in increased expression of multiple
inflammatory genes. On the other hand, an aberrant activation of
TLR/IL-1R signalling can promote the onset of inflammatory and
autoimmune diseases, raising the interest in the development of
therapeutic strategies for the control of their function. In
this review, we illustrate the structural and functional
features of TLR/IL-1R proteins and discuss some recent advances
in the approaches undertaken to develop anti-inflammatory
therapeutic drugs. In particular, we will focus on inhibitors,
such as decoy peptides and synthetic mimetics, that interfere
with protein-protein interactions between