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ABSTRACT: We compared healing after laparoscopic cystotomy using
fibrin glue, sutures, or a combination to determine whether
fibrin glue can obviate the need for sutures and whether there
is any detriment when glue is used in the presence of sutures.
In 24 Yorkshire pigs, a 3.5 cm vertical cystotomy was created
laparoscopically and repaired as follows: Group 1--no closure;
group 2--fibrin glue closure; group 3--suture repair; group 4--
combined fibrin glue and suture repair. All animals had a Foley
catheter for 1 week. In each group, three animals were harvested
at 1 week (acute) and three animals were harvested at 6 weeks
(chronic). Acute: Group 1--all pigs had an unhealed defect that
leaked when evaluated by cystography. Groups 2, 3, 4--mean leak
pressures were 80, 97, and 60 cm H(2)O (P = 0.36), respectively.
Mean bladder capacity was not significantly different between
groups. Chronic: N