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Clipboard (0)  Related Articles  1.  REM Sleep Behavior Disorder
and Prodromal Neurodegeneration – Where Are We Headed?  Tremor
and Other Hyperkinetic Movements  2013;3:tre-03-134-2929-1.
Rapid eye movement (REM) sleep behavior disorder (RBD) is
characterized by loss of normal atonia during REM sleep, such
that patients appear to act out their dreams. The most important
implication of research into this area is that patients with
idiopathic RBD are at very high risk of developing synuclein-
mediated neurodegenerative disease (Parkinson's disease [PD],
dementia with Lewy bodies [DLB], and multiple system atrophy),
with risk estimates that approximate 40–65% at 10 years. Thus,
RBD disorder is a very strong feature of prodromal
synucleinopathy. This provides several opportunities for future
research. First, patients with REM sleep behavior disorder can
be studied to test other predictors of disease, which could
potentially be applied to the general population. T