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Linking enzyme sequence to function using conserved property
difference locator to identify and annotate positions likely to
control specific functionality  Kimberly M Mayer, Sean R
McCorkle and John Shanklin*  Author Affiliations   For all
author emails, please log on.  BMC Bioinformatics 2005, 6:284 
doi:10.1186/1471-2105-6-284   Received:23 May 2005 Accepted:30
November 2005 Published:30 November 2005  © 2005 Mayer et al;
licensee BioMed Central Ltd.     Families of homologous enzymes
evolved from common progenitors. The availability of multiple
sequences representing each activity presents an opportunity for
extracting information specifying the functionality of
individual homologs. We present a straightforward method for the
identification of residues likely to determine class specific
functionality in which multiple sequence alignments are
converted to an annotated graphical form by the Conserved
Property Difference Locator (CPDL) program