Display Settings:   Send to:  Choose Destination Pathol Biol
(Paris). 2007 Feb;55(1):73-83. Epub 2006 Jul 3.  The BCL6 proto-
oncogene: a leading role during germinal center development and
lymphomagenesis.  Author information    • Département
d'Hématologie Clinique, Centre Henri-Becquerel, Rouen, France.
fabrice.jardin@rouen.fnclcc.fr   The BCL6 proto-oncogene encodes
a nuclear transcriptional repressor, with pivotal roles in
germinal center (GC) formation and regulation of lymphocyte
function, differentiation, and survival. BCL6 suppresses p53 in
GCB-cells and its constitutive expression can protect B-cell
lines from apoptosis induced by DNA damage. BCL6-mediated
expression may allow GCB-cells to sustain the low levels of
physiological DNA breaks related to somatic mutation (SM) and
immunoglobulin class switch recombination which physiologically
occur in GCB-cells. Three types of genetic events occur in the
BCL6 locus and involve invariably the 5' non-coding region and
include translocations, deletions and S