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2011; 2011: 792362. Published online Feb 14, 2011. doi: 
10.1155/2011/792362 PMCID: PMC3070260  Genetics, Cytogenetics,
and Epigenetics of Colorectal Cancer   Most of the colorectal
cancer (CRC) cases are sporadic, only 25% of the patients have a
family history of the disease, and major genes causing syndromes
predisposing to CRC only account for 5-6% of the total cases.
The following subtypes can be recognized: MIN (microsatellite
instability), CIN (chromosomal instability), and CIMP (CpG
island methylator phenotype). CIN occurs in 80–85% of CRC.
Chromosomal instability proceeds through two major mechanisms,
missegregation that results in aneuploidy through the gain or
loss of whole chromosomes, and unbalanced structural
rearrangements that lead to the loss and/or gain of chromosomal
regions. The loss of heterozygosity that occur in the first
phases of the CRC cancerogenesis (in particular fo