Sign up ×  What happens in liver when large amount of fructose
is consumed?  I vaguely remember my biochemistry lecturer
telling us that the enzymes that process fructose in the liver
does not have negative feedback to control the rate of reaction.
But I cannot find a reliable source. How is it regulated if it
is?  share|improve this question  1 Answer 1  up vote 5 down
vote accepted  The main reaction of fructose in liver is
phosphorylation, catalyzed by ketohexokinase (UniProt P50053).
In one paper with rats it was shown that fructose load can
deplete the liver of nucleotide triphosphates (ATP, GTP)
although ADP and GDP are inhibitors of the enzyme. This shows
there is no effective regulation.  M. I. Phillips, D. R. Davies:
The mechanism of guanosine triphosphate depletion in the liver
after a fructose load. The role of fructokinase. In: The
Biochemical journal. Vol 228, Nr 3, Jun 1985, p. 667–671,
{{ISSN|0264-6021}}. PMID 2992452. PMC 1145036.  share|improve
this answer great answer. thanks. It sounds like