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Sep 5, 2000; 192(5): 659–670. PMCID: PMC2193276  Cloning of the
Murine Thymic Stromal Lymphopoietin (Tslp) Receptor  Formation
of a Functional Heteromeric Complex Requires Interleukin 7
Receptor   The cellular receptor for murine thymic stromal
lymphopoietin (TSLP) was detected in a variety of murine, but
not human myelomonocytic cell lines by radioligand binding. cDNA
clones encoding the receptor were isolated from a murine T
helper cell cDNA library. TSLP receptor (TSLPR) is a member of
the hematopoietin receptor family. Transfection of TSLPR cDNA
resulted in only low affinity binding. Cotransfection of the
interleukin 7 (IL-7)Rα chain cDNA resulted in conversion to high
affinity binding. TSLP did not activate cells from IL-7Rα−/−
mice, but did activate cells from γc−/− mice. Thus, the
functional TSLPR requires the IL-7Rα chain, but not the γc chain
for signaling.  Keywords: cytokine receptors, in