 PLoS Genet. Oct 2005; 1(4): e48. Published online Oct 28, 2005.
doi:  10.1371/journal.pgen.0010048 PMCID: PMC1270006
Cytoskeletal Rearrangements in Synovial Fibroblasts as a Novel
Pathophysiological Determinant of Modeled Rheumatoid Arthritis
Derry C Roopenian, Editor   Rheumatoid arthritis is a chronic
inflammatory disease with a high prevalence and substantial
socioeconomic burden. Despite intense research efforts, its
aetiology and pathogenesis remain poorly understood. To identify
novel genes and/or cellular pathways involved in the
pathogenesis of the disease, we utilized a well-recognized
tumour necrosis factor-driven animal model of this disease and
performed high-throughput expression profiling with subtractive
cDNA libraries and oligonucleotide microarray hybridizations,
coupled with independent statistical analysis. This twin
approach was validated by a number of different methods in other
animal models of arthritis as well as in human patient samples,
thus creating a unique list of disease modif