Figure 7: Phylogenetic tree of vertebrate CEL with human and
mouse CES1, CES2, CES3, CES4, and CES5 amino acid sequences. The
tree is labeled with the gene name and the name of the
vertebrate. Note the major cluster for the vertebrate CEL
sequences and the separation of these sequences from human and
mouse CES1, CES2, CES3, CES4, and CES5 sequences. The tree is
“rooted” with the CES sequence (T27C12) from a nematode
(Caenorhabditis elegans). See Table 1 for details of sequences
and gene locations. A genetic distance scale is shown (% amino
acid substitutions). The number of times a clade (sequences
common to a node or branch) occurred in the bootstrap replicates
are shown. Only replicate values of 90 or more which are highly
significant are shown with 100 bootstrap replicates performed in
each case.