Figure 2.  Comparison of the TCA cycle in five metabolic pathway
databases. Map illustrating the (lack of) consensus for the TCA
cycle. Metabolites are represented by rectangles, genes by
rounded rectangles, and EC numbers by parallelograms. Color
indicates how many of the five databases agree on a specific
entity (gene, EC number, reaction). We first matched reactions
based on their metabolites. Genes and EC numbers were matched
within matching reactions. Color of an arrow indicates the
number of databases that agree upon an entire reaction, i.e.,
all its metabolites (except H+ which was matched separately).
'x' denotes a missing EC number. Areas labeled A-D highlight the
reactions that are discussed in the running text as examples of
differences caused by a disagreement on pathway definition.
Stobbe et al. BMC Systems Biology 2011 5:165  
doi:10.1186/1752-0509-5-165 Download authors' original image