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Destruction: the methyl-degron  Molecular cell 
2012;48(4):487-488. In this issue, Lee et al. (2012) demonstrate
that the degradation of RORα is regulated by the
EZH2–DCAF1/DDB1/CUL4–proteasome axis, thus, identifying protein
methylation as a post-translational modification that can
orchestrate protein destruction through a motif termed the
“methyl-degron.” PMCID: PMC3563253  PMID: 23200121 2. 
Identification of Small-Molecule Enhancers of Arginine
Methylation Catalyzed by Coactivator-Associated Arginine
Methyltransferase 1  Journal of medicinal chemistry 
2012;55(22):9875-9890. Arginine methylation is a common post-
translational modification that is crucial in modulating gene
expression at multiple critical levels. The arginine
methyltransferases (PRMTs) are envisaged as promising druggable
targets but their role in physiological and pathological
pathways is far from being clear, due to