Gut 60:544-552 doi:10.1136/gut.2010.218461   • Recent advances
in basic science  The acinar-ductal tango in the pathogenesis of
acute pancreatitis    1. Zoltán Rakonczay Jr1   1. 1First
Department of Medicine, University of Szeged, Szeged, Hungary
2. 2Department of Medicine, Veterans Affairs and University of
California, Los Angeles, California, USA   3. 3Department of
Pharmacology and Pharmacotherapy, University of Szeged, Szeged,
Hungary   1. Correspondence to Dr Péter Hegyi, First Department
of Medicine, University of Szeged, Korányi fasor 8-10, Szeged
H-6720, Hungary; hep{at}   There is an unacceptably high
mortality in acute pancreatitis, which is due to the lack of
specific treatments for the disease. A major reason stated to
account for the inability to develop effective treatments is
that there are multiple pathobiologic pathways activated in the
acinar cell mediating pancreatitis making it difficult to choose
molecular targets for therapeutic strategies. However, this
reasoning limits opportunities