TY - JOUR A1 - Schmidtko, Achim A1 - Tegeder, Irmgard A1 -
Niederberger, Ellen A1 - Hofmann, Franz A1 - Ruth, Peter A1 -
Geisslinger, Gerd T1 - The role of cGMP and PKG-I in spinal
nociceptive processing N2 - First paragraph (this article has no
abstract) Persistent stimulation of nociceptors results in
sensitization of nociceptive sensory neurons, which is
associated with hyperalgesia and allodynia. The release of NO
and subsequent synthesis of cGMP in the spinal cord are involved
in this process. cGMP-dependent protein kinase I (PKG-I) has
been suggested to act as a downstream target of cGMP, but its
exact role in nociception hadn't been characterized yet. To
further evaluate the NO/cGMP/PKG-I pathway in nociception we
assessed the effects of PKG-I inhibiton and activaton in the rat
formalin assay and analyzed the nociceptive behavior of PKG-I-/-
mice. Open access article. Y1 - 2005 UR -
http://publikationen.ub.uni-
frankfurt.de/frontdoor/index/index/docId/4334 UR - http://nbn-
resolving.de/urn/resolver.pl?ur