Seminars - Ray and Stephanie Lane Center for Computational
Biology - Carnegie Mellon University  Upcoming Seminars
4/18/2014 - 11am - 6115 GHC Hector Corrada Bravo, University of
Maryland  Past Seminars  11/15/2013 - 11am - 6115 GHC Kathryn
Roeder , Carnegie Mellon University Statistics and Genetics Open
a Window into Autism Rare variants identified from DNA sequence,
especially de novo loss of function (LoF) mutations, have
identified genes involved in risk for autism spectrum disorders
(ASD). Multiple de novo LoF mutations in the same gene
demonstrate that gene affects risk. De novo mutations occur
twofold more often in ASD probands than their siblings, implying
that half of the genes hit are risk genes. He et al. (2013)
extract more information by using a statistical model, called
TADA for Transmission And De novo Association, that integrates
data from family and case-control studies to infer the
likelihood a gene affects risk. Still, given limited sequence
data, can we garner yet more information? Progre