A double-blind, double-dummy, randomized, prospective pilot
study of the partial mu opiate agonist, buprenorphine, for acute
detoxification from heroin.  Department of Psychiatry and
Behavioral Sciences, University of Washington School of
Medicine, and Veterans Affairs Puget Sound Healthcare System,
1660 South Columbian Way, Seattle, WA 98108, USA. Drug and
Alcohol Dependence (Impact Factor: 3.14). 02/2005; 77(1):71-9.
DOI: 10.1016/j.drugalcdep.2004.07.008 Source: PubMed  ABSTRACT
The optimum dose of buprenorphine for acute inpatient heroin
detoxification has not been determined. This randomized, double-
blind, double-dummy, pilot study compares two buprenorphine
sublingual tablet dosing schedules to oral clonidine. Heroin
users (N = 30) who met DSM-IV criteria for opioid dependence and
achieved a Clinical Opiate Withdrawal Scale (COWS) score of 13
(moderate withdrawal), were randomized to receive higher dose
buprenorphine (HD, 8-8-8-4-2 mg/day on days 1-5), lower dose
buprenorphine (LD, 2-4-8-4-2 mg/day on da