SGD Paper Help  Feng D, et al.  (2013) Molecular signaling
toward mitophagy and its physiological significance. Exp Cell
Res 319(12):1697-705  Abstract: Mitochondrial autophagy or
mitophagy is a cellular metabolic pathway that mediates the
selective elimination of dysfunctional or unwanted mitochondria.
Considerable advancements have been made to elucidate the
molecular mechanism behind mitophagy, particularly Parkin-
mediated mitophagy. Several mitophagy receptors have been
discovered in different physiological settings, including ATG32
in yeast as well as NIX, BNIP3, and FUNDC1 in mammalian cells.
However, the signaling events that regulate these mitophagy
receptors and their physiological significance in human diseases
are poorly understood. In this paper, we review recent
advancements in mitophagy at the cellular and molecular levels.
Status: Published Type: Journal Article PubMed ID: 23603281
Topics addressed in this paper  Number of different genes
curated to this paper: 10  Topics Genes  Author Search