Restoration of the wild-type phenotypes in Streptococcus
pyogenes rgg mutant strains depends on the expression level of
Rgg transcriptional regulator  Abstract number: P1839
Dmitriev A.V., McDowell E.J., Kappeler K.V., Anbalagan S.,
Chaussee M.S.  Objectives: The clinical outcomes of
Streptococcus pyogenes infections range from mild pharyngitis to
severe toxic shock syndrome and necrotising fasciitis. The
expression of S. pyogenes virulence factors is coordinately
regulated transcriptionally, translationally and post-
translationally. Rgg is a global transcriptional regulatory
protein necessary for SpeB expression. In a strain-specific
manner, Rgg additionally affects numerous phenotypes such as
virulence, tolerance to thermal and oxidative stress,
fermentation of amino acids during the exponential phase of
growth, and the ability to grow in enriched and chemically
defined media, among others. Given the potential differences in
expression level of Rgg in S. pyogenes strains, it was of
interest to determine if