X-linked agammaglobulinemia  From Wikipedia, the free
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agammaglobulinemia Classification and external resources ICD-10
D80.0 ICD-9 279.04 OMIM 300300 DiseasesDB 1728 MedlinePlus
001307 eMedicine ped/294 derm/858  X-linked agammaglobulinemia
(also called X-linked hypogammaglobulinemia, XLA, Bruton type
agammaglobulinemia, Bruton syndrome, or Sex-linked
agammaglobulinemia[1]:83) is a rare X-linked genetic disorder
discovered in 1952 that affects the body's ability to fight
infection. XLA is an X-linked disorder, and therefore is much
more common in males. XLA patients do not generate mature B
cells,[2] which manifests as a complete lack of antibodies in
their bloodstream. B cells are part of the immune system and
normally manufacture antibodies (called immunoglobulins), which
defend the body from infections by sustaining an immunological
humoral antibody response. Patients with untreated XLA are prone
to develop serious and even fatal infections. A mutation occur