Stat4 limits DNA methyltransferase recruitment and DNA
methylation of the IL‐18Rα gene during Th1 differentiation  Qing
Yu, Vivian T Thieu, Mark H Kaplan  Author Affiliations    1.
Qing Yu1,2,   2. Vivian T Thieu1,2 and   3. Mark H Kaplan*,1,2
1. 1 Departments of Microbiology and Immunology, and Pediatrics,
Walther Oncology Center, HB Wells Center for Pediatric Research,
Indiana University School of Medicine, Indianapolis, IN, USA
2. 2 Walther Cancer Institute, Indianapolis, IN, USA   1.
*Corresponding author. Departments of Pediatrics and,
Microbiology and Immunology, HB Wells Center for Pediatric
Research, Indiana University School of Medicine, 702 Barnhill
Dr, RI 2600, Indianapolis, IN 46202, USA. Tel.: +1 317 278 3696;
Fax: +1 317 274 5378; E-mail: mkaplan2{at} View Full Text
Stat4 is required for Th1 development, although how a
transiently activated factor generates heritable patterns of
gene expression is still unclear. We examined the regulation of
IL‐18Rα expression to define a mechanism for Sta