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of Publication Document Types author:("Wen, zhang T.") 1. 
Opportunities for Disrupting Cariogenic Biofilms  Advances in
dental research  2009;21(1):17-20. Bacteria adhere to a surface
and, through cell division and coordinated expression of gene
products, to develop into a structurally-complex population of
adherent cells. This process, known as biofilm formation,
requires that intrinsic and extrinsic signals are transduced
into appropriate gene expression patterns as biofilms mature.
Mutational analysis has begun to reveal the complexity of
systems used by Streptococcus mutans to ensure proper biofilm
formation. These studies have revealed new and unique targets
for the design of broadly-effective anti-caries strategies.
PMCID: PMC2853230  PMID: 19710079 2.  CcpA Regulates Central
Metabolism and Virulence Gene Expression in Streptococcus
mutans▿ †   Journal of Bacteriology  2008;190(7):2340-2349. CcpA
globally regulates transcription in respon