Emotional Shot to the Gut (Spoilerburgh)  That a manly enough
title for you? Some games I spend enough time with that I become
attached to the characters. It's different than a book or a
movie, but there's still a connection, and the investment of
time and interest can lead to some pretty hard-hitting moments
for the more sensitive of us, of which I'm one. I don't expect
everyone to make a list like this, or even really understand
what I mean, but here's mine. I'm pretty much going to
Spoilertown with this, so that's my warning. As I expand this
list, I realize that I actually have trouble remembering a lot
of my strong reactions, even though I'm pretty sure I've had my
fair share. Most games don't tend to sit nearly as deeply as
films or books do with me, I guess.  List items  Posted by
Adaptor  Great list! My personal favorite is Shadow of the
Colossus. [spoiler ahead]  When Agro fell to her death I was so
sad I had to... eh.. well, it felt like a shot to the gut ;) 
Can't wait to see what The Last Guardian