Vial Stoppers That Won't Stop Clumping  Sep 21, 2011 By
Pharmaceutical Technology Editors Untitled Document  Q: In our
manufacturing process, we are running into issues with our vial
stoppers clumping in the feeder bowl. How can we ensure that the
stoppers go through smoothly without clumping up?  A: Clumping
can result from various issues. The design of lyophilization
stoppers can lead to twinning, a condition where the closures’
legs interlock and remain that way during processing.
Autoclaving in an inappropriate container or in a container that
holds closures too tightly may also result in twinning.
Inconsistent siliconization and overprocessing can lead to
clumping. If stoppers are autoclaved or dried too long,
excessive heat may break down the elastomer. The result is a
bowl full of tacky stoppers.  When clumping occurs,
manufacturers must first examine the type of stopper they use.
It may be time to move to a newer product, such as ready-to-use
or ready-to-sterilize stoppers. Suppliers of these componen