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HLA-DR Specific Monoclonal Antibodies Block Lymphoproliferative
Response to Measles Vaccine in vitro: a pilot study  Vaccine 
2012;30(47):6628-6631. Humoral and cell-mediated immune
responses are important in protection against measles. Non-
response to vaccination has been associated with specific HLA-DR
and HLA-DQ alleles; however, little is known about the relative
importance of these alleles in the cellular immune response
induced by measles virus vaccine. To investigate the role of
HLA-DR/DQ class II restriction, a small pilot study was
conducted. Lymphoproliferation assays using class II DR and DQ-
specific monoclonal antibodies (MoAb) were performed at one week
and two weeks post immunization with MMRII vaccine. The mean
stimulation index (SI) was 4.4 and 5.3 at one and two weeks with
reductions in SI of 47.6% and 70.2%, respectively, following the
addition of DR-specific MoAb (p<0.