Figure 5.  Hierarchical analysis approach. Genes were first
classified as EGF responsive by performing a likelihood ratio
test to compare the fits of maximum likelihood estimated mixed
models with and without EGF terms. EGF responsive genes were
then classified as to whether or not they had a significant
EGF:CT interaction, as determined by a Wald F-test of the REML
estimated full model. EGF responsive genes with EGF:CT
interactions were then classified according to whether they were
responsive to EGF during the day only, during the night only, or
at both times. Genes with significant EGF:CT interactions were
then subdivided according to the directionality ofthe responses.
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