   Genetic and Rare Diseases Information Center (GARD)  Print
friendly version  Parkes Weber syndrome  Other Names for this
Disease   • Cutaneous flush with underlying multiple micro
arteriovenous fistulas, soft tissue and skeletal hypertrophy of
the affected limb   • PKWS   What is Parkes Weber syndrome?  How
might Parkes Weber syndrome be treated?  What is Parkes Weber
syndrome?  Parkes Weber syndrome (PWS) is a rare congenital
condition causing an individual to have a large number of
abnormal blood vessels. The main characteristics of PWS
typically include a capillary malformation on the skin;
hypertrophy (excessive growth) of the bone and soft tissue of
the affected limb; and multiple arteriovenous fistulas (abnormal
connections between arteries and veins) which can potentially
lead to heart failure. Individuals may also have pain in the
affected limb and a difference in size between the limbs.[1]
There has been evidence that some cases of PWS are caused
by mutations in the RASA1 gene[2] and are inherited