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Burkholderia pseudomallei transcriptional adaptation in
macrophages  Sylvia Chieng1, Laura Carreto2 and Sheila Nathan1*
Author affiliations   2 CESAM and Departamento de Biologia,
Universidade de Aveiro, Campus de Santiago, Aveiro, 3810-193,
Portugal  For all author emails, please log on.  Citation and
License  BMC Genomics 2012, 13:328  doi:10.1186/1471-2164-13-328
Published: 23 July 2012    Burkholderia pseudomallei is a
facultative intracellular pathogen of phagocytic and non-
phagocytic cells. How the bacterium interacts with host
macrophage cells is still not well understood and is critical to
appreciate the strategies used by this bacterium to survive and
how intracellular survival leads to disease manifestation.
Here we report the expression profile of intracellular B.
pseudomallei following infection of human macrophage-like U937
cells. During intracellular growth over the 6 h infection
period, approximately 22 % of the B. pseudomallei genom