Search tips Search criteria  Results 1-8 (8)  Clipboard (0)
Select a Filter Below  more » Year of Publication Document Types
1.  Parkinson's disease-associated DJ-1 mutations impair
mitochondrial dynamics and cause mitochondrial dysfunction 
Journal of neurochemistry  2012;121(5):830-839. Mitochondrial
dysfunction represents a critical event during the pathogenesis
of Parkinson’s disease (PD) and expanding evidences demonstrate
that an altered balance in mitochondrial fission/fusion is
likely an important mechanism leading to mitochondrial and
neuronal dysfunction/degeneration. In this study, we
investigated whether DJ-1 is involved in the regulation of
mitochondrial dynamics and function in neuronal cells. Confocal
and electron microscopic analysis demonstrated that M17 human
neuroblastoma cells over-expressing wild-type DJ-1 (WT DJ-1
cells) displayed elongated mitochondria while M17 cells over-
expressing PD-associated DJ-1 mutants (R98Q, D149A and L166P)
(mutant DJ-1 cells) showed significant increase of f