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Gene Expression-Based Dosimetry by Dose and Time in Mice
Following Acute Radiation Exposure  PLoS ONE  2013;8(12):e83390.
Rapid and reliable methods for performing biological dosimetry
are of paramount importance in the event of a large-scale
nuclear event. Traditional dosimetry approaches lack the
requisite rapid assessment capability, ease of use, portability
and low cost, which are factors needed for triaging a large
number of victims. Here we describe the results of experiments
in which mice were acutely exposed to 60Co gamma rays at doses
of 0 (control) to 10 Gy. Blood was obtained from irradiated mice
0.5, 1, 2, 3, 5, and 7 days after exposure. mRNA expression
levels of 106 selected genes were obtained by reverse-
transcription real time PCR. Stepwise regression of dose
received against individual gene transcript expression levels
provided optimal dosimetry at each time point. The re