, Volume 41, Issue 4, pp 789-796  Novel S100A7
(psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous
but distinct in regulation and function  Purchase on
Springer.com  $39.95 / €34.95 / £29.95*  Rent the article at a
discount  Rent now  * Final gross prices may vary according to
local VAT.  Get Access   S100A7 (psoriasin) and S100A15
(koebnerisin) were first identified in inflamed psoriatic skin.
They are of major interest because of their putative functional
roles in innate immunity, epidermal cell maturation, and
epithelial tumorigenesis. Human S100A7 and S100A15 have lately
evolved by gene duplications within the epidermal
differentiation complex (chromosome 1q21) during primate
evolution forming a novel S100 subfamily. Therefore, S100A7 and
S100A15 are almost identical in sequence (>90%) and are
difficult to discriminate. Despite their high homology, S100A7
and S100A15 are distinct in tissue distribution, regulation, and
function, and thus, exemplary for the diversity within the S100
family. Thei