SGD Paper Help  Venkatesh S, et al.  (2012) Set2 methylation of
histone H3 lysine?36 suppresses histone exchange on transcribed
genes. Nature 489(7416):452-5  Abstract: Set2-mediated
methylation of histone H3 at Lys?36 (H3K36me) is a co-
transcriptional event that is necessary for the activation of
the Rpd3S histone deacetylase complex, thereby maintaining the
coding region of genes in a hypoacetylated state. In the absence
of Set2, H3K36 or Rpd3S acetylated histones accumulate on open
reading frames (ORFs), leading to transcription initiation from
cryptic promoters within ORFs. Although the co-transcriptional
deacetylation pathway is well characterized, the factors
responsible for acetylation are as yet unknown. Here we show
that, in yeast, co-transcriptional acetylation is achieved in
part by histone exchange over ORFs. In addition to its function
of targeting and activating the Rpd3S complex, H3K36 methylation
suppresses the interaction of H3 with histone chaperones,
histone exchange over coding regions and