• cell adhesion;   • fibrin sealants;   • fibrin structure;   •
fibrin(ogen);   • wound healing  Summary  Fibrinogen and fibrin
play an important role in blood clotting, fibrinolysis, cellular
and matrix interactions, inflammation, wound healing,
angiogenesis, and neoplasia. The contribution of fibrin(ogen) to
these processes largely depends not only on the characteristics
of the fibrin(ogen) itself, but also on interactions between
specific-binding sites on fibrin(ogen), pro-enzymes, clotting
factors, enzyme inhibitors, and cell receptors. In this review,
the molecular and cellular biology of fibrin(ogen) is reviewed
in the context of cutaneous wound repair. The outcome of wound
healing depends largely on the fibrin structure, such as the
thickness of the fibers, the number of branch points, the
porosity, and the permeability. The binding of fibrin(ogen) to
hemostasis proteins and platelets as well as to several
different cells such as endothelial cells, smooth muscle cells,
fibroblasts, leukocytes, and kera