Email updates   Open Access Research  Transposable element
derived DNaseI-hypersensitive sites in the human genome
Leonardo Mariño-Ramírez and I King Jordan*  Author Affiliations
National Center for Biotechnology Information, National
Institutes of Health, Bethesda, MD 20894, USA  For all author
emails, please log on.  Biology Direct 2006, 1:20 
doi:10.1186/1745-6150-1-20  Published: 20 July 2006
Transposable elements (TEs) are abundant genomic sequences that
have been found to contribute to genome evolution in unexpected
ways. Here, we characterize the evolutionary and functional
characteristics of TE-derived human genome regulatory sequences
uncovered by the high throughput mapping of DNaseI-
hypersensitive (HS) sites.   Human genome TEs were found to
contribute substantially to HS regulatory sequences
characterized in CD4+ T cells: 23% of HS sites contain TE-
derived sequences. While HS sites are far more evolutionarily
conserved than non HS sites in the human genome, consistent with
their functional im