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Researchers Go Fishing, Pull Out Antigens  Researchers at
National Jewish Medical and Research Center have developed a
method for finding the molecular targets of the immune system,
known as antigens. The method extends a widely used technique,
called library display, to more complex proteins. It could have
broad applications in biological and medical research. The
research team, led by National Jewish and Howard Hughes Medical
Institute immunologist John W. Kappler, Ph.D., is already
collaborating with teams looking for causes of the autoimmune
disease rheumatoid arthritis, developing cancer vaccines, and
understanding the molecular triggers of chronic beryllium
disease. The technique is described in the April 2004 issue of
PloS Biology (http://www.plosbiology.org), a publication of the
Public Library of Science.  "Our technique allows us to fish in
a vast library of protein fragments for the sp