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ABSTRACT: Sympathetic nervous system (SNS) fibres and alpha- and
beta-receptors are present in bone, indicating that the SNS may
participate in bone metabolism. The importance of these
observations is controversial because stimulation or inhibition
of the SNS has had various effects upon both anabolic and
catabolic activity in this tissue. In this study we evaluated
the effects of pharmacological sympathectomy, using chronic
treatment of maturing male rats with 40 mg of guanethidine/kg
i.p., upon various parameters in bone. Double labelling with
tetracycline injection was also performed 20 and 2 days before
sacrifice. Bone mass, mineral content, density and
histomorphometric characteristics in different skeletal regions
were determined. Bone metabolic markers included urinary
deoxypyridinoline and serum osteocalcin measurements.
Guanethidine significantly reduced the accretion of lumba