 Logo of bmcgenoBioMed Centralsearchsubmit a
manuscriptregisterthis articleBMC Genomics BMC Genomics. 2010;
11(Suppl 1): S8. Published online 2010 February 10. doi: 
10.1186/1471-2164-11-S1-S8 PMCID: PMC2822536  Bimodal gene
expression patterns in breast cancer   We identified a set of
genes with an unexpected bimodal distribution among breast
cancer patients in multiple studies. The property of bimodality
seems to be common, as these genes were found on multiple
microarray platforms and in studies with different end-points
and patient cohorts. Bimodal genes tend to cluster into small
groups of four to six genes with synchronised expression within
the group (but not between the groups), which makes them good
candidates for robust conditional descriptors. The groups tend
to form concise network modules underlying their function in
cancerogenesis of breast neoplasms.   Whole-genome gene
expression studies primarily aim to identify conditional
descriptors, i.e. subsets of genes or functional groups whose
express