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author:("seeley, Marc") BMC Medical Genetics  2012;13:78.
PMCID: PMC3495046  PMID: 22947327 PLoS ONE  2012;7(5):e36512.
PMCID: PMC3344899  PMID: 22574174 3.  CCR5Δ32 Genotype Leads to
a Th2 Type Directed Immune Response in ESRD Patients  PLoS ONE 
2012;7(2):e31257. In patients with end stage renal disease
(ESRD) we observed protection from inflammation-associated
mortality in CCR5Δ32 carriers, leading to CCR5 deficiency,
suggesting impact of CCR5Δ32 on inflammatory processes. Animal
studies have shown that CCR5 deficiency is associated with a
more pronounced Th2 type immune response, suggesting that in
human CCR5Δ32 carriers the immune response may be more Th2 type
directed. So, in the present study we determined the Th1-Th2
type directed immune response in ESRD patients carrying and not
carrying the CCR5Δ32 genetic variant after stimulation.
Methodology/Principal Findings We tested this hypo