UMHS LOGOUniversity of Michigan Department of Pediatrics
Evidence-Based Pediatrics Web Site  Topiramate Has Not Proven
Efficacious In Pediatric Migraine Prophylaxis     • In children
with frequent migraines requiring prophylaxis, is topiramate
effective for decreasing migraine frequency?  Clinical Bottom
Lines    1. Topiramate has been show to be effective in adults
for migraine prophylaxis, but this study did not show efficacy
of topiramate in the pediatric population, compared to placebo.
2. For the primary outcome (reduction in number of migraine days
per month compared to baseline phase), there was no
statistically significant difference between those receiving
topiramate versus placebo.   3. There was a statistically
significant reduction in number of migraine days per month for
topiramate-treated patients during the last 28 days of
treatment.  Summary of Key Evidence  1. Industry-sponsored,
randomized, double-blind, placebo-controlled study of 162
children at 17 non-academic clinics. 2. Patients were