Histological evidence of carcinoma in a hepatic tumour
associated with oral contraceptives.  Br Med J 1975; 4 doi:
http://dx.doi.org/10.1136/bmj.4.5995.496 (Published 29 November
1975) Cite this as: Br Med J 1975;4:496   1. M Davis,   2. B
Portmann,   3. M Searle,   4. R Wright,   5. R Williams       A
primary hepatic tumour occurred in a 21-year-old woman who had
been taking oral contraceptives for two years; she was treated
by partial hepatectomy. Part of the neoplasm showed features
suggestive of focal nodular hyperplasia, while the remainder had
the histological characteristics of a well-differentiated
hepatocellular carcinoma. This is the first report of malignant
transformation of a tumour in a patient taking oral
contraceptives.