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vol.84 issue3Genes in their environment: how can we read the
riddles?Withdrawal from glucocorticosteroid therapy: clinical
practice recommendations author indexsubject indexarticles
search Home Pagealphabetic serial listing    Jornal de Pediatria
Print version ISSN 0021-7557  J. Pediatr. (Rio
J.) vol.84 no.3 Porto Alegre May/June 2008     Systemic
infection and brain injury in the preterm infant    Richard A.
Polin  MD. Professor of Pediatrics, College of Physicians and
Surgeons, Columbia University, New York, USA    In this issue of
Jornal de Pediatria, Silveira et al.1 investigated risk factors
for the development of periventricular leukomalacia (PVL) in a
cohort of very low birth weight (VLBW) infants. A significantly
greater number of infants with PVL had documented sepsis and/or
were ventilated for more than 24 hours. This well-designed study
adds supportive evidence for the role of postnatal infection in
the pathogenesis of PVL.2 While the data are provoca