Email updates   Open Access Research article  Partial
duplication of the APBA2 gene in chromosome 15q13 corresponds to
duplicon structures  James S Sutcliffe*, Michael K Han, Taneem
Amin, Robert A Kesterson and Erika L Nurmi  Author Affiliations
For all author emails, please log on.  BMC Genomics 2003, 4:15 
doi:10.1186/1471-2164-4-15   Received:22 February 2003
Accepted:29 April 2003 Published:29 April 2003     Chromosomal
abnormalities affecting human chromosome 15q11-q13 underlie
multiple genomic disorders caused by deletion, duplication and
triplication of intervals in this region. These events are
mediated by highly homologous segments of DNA, or duplicons,
that facilitate mispairing and unequal cross-over in meiosis.
The gene encoding an amyloid precursor protein-binding protein
(APBA2) was previously mapped to the distal portion of the
interval commonly deleted in Prader-Willi and Angelman syndromes
and duplicated in cases of autism.   We show that this gene
actually maps to a more telomeric location