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Year of Publication jtitle_s:("Age (dodr)") 1.  Effects of
calorie restriction on chromosomal stability in rhesus monkeys
(Macaca mulatta)  Age  2006;29(1):15-28. The basic tenet of
several theories on aging is increasing genomic instability
resulting from interactions with the environment. Chromosomal
aberrations have been used as classic examples of increasing
genomic instability since they demonstrate an increase in
numerical and structural abnormalities with age in many species
including humans. This accumulating damage may augment many
aging processes and initiate age-related diseases, such as
neoplasias. Calorie restriction (CR) is one of the most robust
interventions for reducing the frequency of age-related diseases
and for extending life span in many short-lived organisms.
However, the mechanisms for the anti-aging effects of CR are not
yet well understood. A study of rhesus monkeys was begun in 1987
to determine if CR is also effective in