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search  Nuclear factor of activated T-cells (NFAT) is a general
name applied to a family of transcription factors shown to be
important in immune response. One or more members of the NFAT
family is expressed in most cells of the immune system. NFAT is
also involved in the development of cardiac, skeletal muscle,
and nervous systems.  The NFAT transcription factor family
consists of five members NFATc1, NFATc2, NFATc3, NFATc4, and
NFAT5.[1] NFATc1 through NFATc4 are regulated by calcium
signaling. Calcium signaling is critical to NFAT activation
because calmodulin (CaM), a well-known calcium sensor protein,
activates the serine/threonine phosphatase calcineurin (CN).
Activated CN rapidly dephosphorylates the serine-rich region
(SRR) and SP-repeats in the amino termini of NFAT proteins,
resulting in a conformational change that exposes a nuclear
localization signal, resulting in NFAT nuclear import.  Nuclear
import of NFAT proteins is opposed by mainten