  Questions To Consider in Developing an Antimicrobial
Stewardship Program To Reduce C. Difficile Infection  This
toolkit describes an individualized approach and tailoring of
selected stewardship interventions based on the results of
limited case-control studies and identified issues at each
facility. As you begin to identify antibiotics to target, you
will also need to look at prescribing practices that will be
targeted for change. You will need to plan the strategies you
will use with prescribers to appropriately limit the targeted
antibiotics in use. The strategy will depend on a combination of
known evidence-based promising practices and what will work in
your organization. To address these issues, you should consider
four questions, discussed in the following sections.  2.1. What
is the institutional risk assessment approach and how can it
help us?  For many reasons, a targeted risk assessment offers a
promising path for identifying antimicrobial stewardship
interventions to reduce C. difficile. First,