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Multifunctional Double-negative T Cells in Sooty Mangabeys
Mediate T-helper Functions Irrespective of SIV Infection  PLoS
Pathogens  2013;9(6):e1003441. Studying SIV infection of natural
host monkey species, such as sooty mangabeys, has provided
insights into the immune changes associated with these
nonprogressive infections. Mangabeys maintain immune health
despite high viremia or the dramatic CD4 T cell depletion that
can occur following multitropic SIV infection. Here we evaluate
double-negative (DN)(CD3+CD4−CD8−) T cells that are resistant to
SIV infection due to a lack of CD4 surface expression, for their
potential to fulfill a role as helper T cells. We first
determined that DN T cells are polyclonal and predominantly
exhibit an effector memory phenotype (CD95+CD62L−). Microarray
analysis of TCR (anti-CD3/CD28) stimulated DN T cells indicated
that these cells are multifunctional a