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Clipboard (0)  Related Articles  1.  Investigating drug
repositioning opportunities in FDA drug labels through topic
modeling  BMC Bioinformatics  2012;13(Suppl 15):S6.
PMCID: PMC3439728  PMID: 23046522 2.  Drug repositioning for
orphan genetic diseases through Conserved Anticoexpressed Gene
Clusters (CAGCs)  BMC Bioinformatics  2013;14:288. The
development of new therapies for orphan genetic diseases
represents an extremely important medical and social challenge.
Drug repositioning, i.e. finding new indications for approved
drugs, could be one of the most cost- and time-effective
strategies to cope with this problem, at least in a subset of
cases. Therefore, many computational approaches based on the
analysis of high throughput gene expression data have so far
been proposed to reposition available drugs. However, most of
these methods require gene expression profiles directly relevant
to the pathologic conditions under study, such as those obtained
from pat