Abstract: Previous genome-wide association analysis revealed a
new putative candidate gene for major depression: the PCLO gene.
Replication in one population-based cohort did not yield genome-
wide significance and further replication efforts in clinical
studies were unsuccessful. We aimed to validate the association
of single-nucleotide polymorphism (SNP) rs2522833 in the PCLO
gene with depression in the Rotterdam Study, a prospective
population-based cohort of elderly persons. In the Rotterdam
Study, we identified 579 persons with a broad depression
phenotype (depressive syndromes) of whom 178 cases with DSM-
defined depressive disorder. The control group consisted of 912
persons free of depression during the follow-up period and in
their histories. Logistic regression analysis showed an
association between rs2522833 and depressive disorders (P =
0.0025). However, no association between the broader depressive
syndrome group and this SNP was observed (P = 0.20). A meta-
analysis combining all studies from the o