A word originating from Orlando, FL having a somewhat dual
meaning in referring to a girl who frequents the downtown club
and party scene and is essentially "down" for whatever,
generally in terms of wild partying, sex, drugs, and alcohol
abuse. While this word intially had derogatory connotations it
has in many circles become a term of endearment, much like
"bitch", "nigga", or "motherfucker". Example 1  Fabiano: "Yo
does that girl party?" Corey: "Fuck yeah she's a sick downy!"
Example 2 "I was up all night drunk as fuck, rolling my balls
off, and blowing rails with six downies, smashing out on all of
them!"  Example 3 "That's not Lex's girlfriend, but she's his
main downy. If you fuck with her he might still kick your ass!"
by LVCOrlando January 06, 2012 Top Definition Refering to
someone with Downs Syndrome - so really should be "downsie" It
is a genetic condition that is increasingly common the older the
mother of a child is when she falls pregnant. Downs Sydrome is
caused by non disjunction of the 21st