instruction: hello doctor my brother os recently on tagrisso his recent scan is attached which shows improvement he is vomiting while eating grains what is the reason for vomiting and what can be done for this please tell me about this response to tagrisso if it is good how much time does tagrisso take for the remission if it works like this what is the average duration for tagrisso to become resistant please clear my doubts
output: hi welcome to icliniq com in reply to your question for osimertinib tagrisso osimertinib demonstrated improvement in pas 18 versus 10 months he 46 95 ci 37 57 and duration of response 17 versus 5 months relative to other ski the pas progression free survival benefit was consistent across subgroups including either patient with or without brain metastases response rates for osimertinib is around 80 to put it to simple terms the disease is controlled for more than 5 years with osimertinib treatment with an egfr ski is generally continued until there is disease progression if there is persistent vomiting we need to do more tests to confirm whether it is leptomeningeal am disease which is diagnosed in approximately percent of patients with metastatic cancer the most common solid tumors giving rise to am are breast cancer 12 to 35 percent lung cancer 10 to 26 percent melanoma to 25 percent headache is the most common initial symptom of am present in 30 to 50 percent of patients with symptoms of confusion forgetfulness disorientation subtle personality changes and or lethargy collectively referred to as encephalopathy or altered mental status are common in patients with am I would request to do gadolinium enhanced magnetic resonance imaging mri of the brain and spine which often provides important evidence of am the definitive diagnostic finding for am is the cytologic identification of malignant cells within the csi cerebrospinal fluid