instruction: hi doctor I have cos hypothyearoidism and pituitary cushing disease I am taking yasmin glucophage 850 my and to 150 my as I have to take metyearapone for cushing my doctor recommended stopping yasmin but if I stop it I do not have period for months and I get acne all over my body what can I use instead of yasmin in order to control cos can I get it cured by removing ovaries
output: hello metyearapone metopirone is an orphan medication that holds the fda approval food and drug administration for the diagnosis of cushing syndrome and is occasionally used off label for short term treatment of cushing syndrome prior to surgery metyearapone prevents cortisol synthesis by inhibiting hydroxylase the enzyme responsible for the conversion of deoxycortisol to cortisol the restricted access and adverse reactions of metyearapone are associated with increased androgen and mineralocorticoid production which limits the use of this medication for the treatment of cushing syndrome it can cause a negative feedback increase of act adrenocorticotropic hormone leading to acne hirsutism excessive male pattern hair growth hyperkalemia however yasmin drospirenone and ethinyl estradiol is a low dose sequential pill which has been given to regularize your cycles they really do not actually affect the cortisol levels due to cushing and not really interact with metyearapone either it is often associated with weight gain so for that you may opt for dinette 35 combination of ethinyl estradiol and cyproterone acetate tablet monthly for next months to regularize cycles and balance hormones there is no need at all for ophorectomy for cos polycystic ovarian syndrome it is never indicated it can be controlled by medication as advised and revised now for further information consult an obstetrician and gynaecologist online