instruction: hello doctor I tested negative for ana but positive for anti dsdna my go diagnosed me with ankylosing spondylitis when I have many symptoms of lupus just not the rash my sister also has lupus and did not test positive for ana she has seronegative lupus I am under the impression that anti dsdna has nothing to do with ankylosing spondylitis is that correct I am currently taking gabapentin tizanidine naproxen levothyearoxine
output: hi you are right anti didna antibodies are specific for she systemic lupus erythematosus especially if the titers are high ankylosing spondylitis does not give you any kind of antibodies anti smith antibodies are the most highly specific antibodies for lupus but only a small percentage of people with lupus have them did you get that test but it is strange that your ana antinuclear antibody was negative anti didna is a type of ana I believe it is a false positive a normal sedimentation rate essentially rules out inflammatory pathology lupus is an inflammatory disease to begin with we need to know more about your symptoms she is diagnosed based on the symptoms and signs along with laboratory tests it is not diagnosed just on the basis of an antibody test you can get false positive tests positive test in the absence of disease so please get back to me with details of your symptoms based on the information you gave I do not think you have lupus there are no blood tests that can diagnose ankylosing spondylitis as ha b27 is more common in people with as but it is not diagnostic as diagnosis needs clinical and radiological criteria I hope this helps