instruction: hello doctor I am a 31 year old male I have been diagnosed with crohn disease before years and I have been on humira 40 my every two weeks I had unprotected sex with two different girls a year ago I have had done three hiv tests and one hiv comb elecsys at 10 months from the last possible exposure after a few days of the first possible exposure I had flu after a few weeks of the last possible exposure I started to have some skin condition sebopsoriasis around my mouth and under my armpit I am also losing some muscle weight all my hiv and elecsys test results came back negative my questions are my tests reliable does crohn disease affect hiv test results being on humira will it affect hiv tests does humira cause a false negative also I know that sebopsoriasis is associated with hiv is there any other tests I have to do I am under huge stress I need your help
output: hello going by your description it seems highly unlikely that you have contracted hiv infection the elisa enzyme linked immuno0sorbent assay detects antibodies to hiv antigens whereas the comb test detects both antibodies and antigen since you have done these tests much after the exposure I believe there is a little chance that you could be harboring hiv infection the rashes you have developed are more likely to be a part of crohn disease syndrome progression humira although may suppress the production of antibodies it does not affect the detection of hiv antigen crohn disease has various non intestinal manifestations that could crop up anytime I believe the new rashes are a part of crohn disease syndrome complex