instruction: hello doctor I am 38 years old and my wife is 36 years old we are married for the last two years and trying for a baby for the last one year almost by our gynecologist advise we underwent an I cycle which resulted in missed abortion at seven weeks due to no growth of fetus after five weeks done and karyotype of abortion showed a chromosomal abnormality remarks as below aborted fetus karyotype 69 ex banded metaphase shows triploidy wife condition a age 36 years no issue yet has a subserous uterus fibroid of size 68 62 my and bulky uterus had thyearoid and she takes thyearoxin 50 my every day last ash is 48 sugar is under control and tac is normal in childhood she had one occurrence of epilepsy husband condition a age 38 years nonsmoker and non drinker semen analysis result is normal fertile specimen shaving a bit high uric acid in the last one year under medicine karyotyping results of partners husband 46 xy banded metaphase shows normal karyotype wife 46 ex high frequency of banded metaphase shows telomeric association of chromosomes 3 16 my questions are is it possible that after fibroid removal she can conceive a baby in a normal way can there be any bad effect on baby health physical and mental due to the dna abnormality found in her report
output: hello welcome to icliniq com as far as the subserous nature of the fibroid is concerned which is around 7cm am it per se is not going to have an effect or cause hindrance in conception but it is likely that it can cause problems during the pregnancy and in the late third trimester due to abdominal pain so it is advisable that it should be removed anyways as the size is a concern here and can cause incoordinate uterine contractions during labor later and also chances are that it would further grow under estrogen effect hence better get it removed as the fetus showed triploidy banded metaphase which as per the mother report she has high chances of replication of similar results in future pregnancies as well which may not be compatible with life and likely missed abortions may occur in future hence it is suggested that both of you should try for an if in vitro fertilization with ovum and sperm harvesting and in vitro fertilization of the egg by your sperm and subjecting the embryos to preimplantation genetic screening with fish fluorescence in situ hybridization technique or per polymerase chain reaction or comparative genomic hybridization cgh before selecting the embryo for transplanting into the uterus though the frequency of banded metaphase telomeric association is high for 3 16 and chromosome the chances of the fetus getting triploidy are very high another best option for you as a couple would be to opt for a donor egg from another woman which can be fertilized in vitro by your sperm and then the embryo after pre implantation genetic screening can be implanted in your wife womb to improve the chances of having a healthy conception I hope this helps