instruction: hi doctor my brother was diagnosed to have alk positive before two years he had brain and bone metastasis he got a brain surgery war and spine radiation he was on crizotinib for 10 months and after brain and bone metastasis progression he was on ceritinib for months in the latest scan the disease progression was seen again in bone and also there was a new brain metastasis unfortunately in my country there is no next generation inhibitor of ceritinib what are the options now is there any chance to use crizotinib again he has some bone fractures also we are feeling helpless he is just 35 only already he had war twice what are the next treatment options when he was on crizotinib he felt very active but while on ceritinib he mostly used to stay on the bed kindly suggest some option
output: hello I understand your plight for further information consult a medical oncologist online