instruction: hi doctor my husband was diagnosed with all before six years he underwent treatment by following the pethema protocol for all after consolidation phase ma revealed there is still of pal ra using fish ra test while negative on cytogenetics his doctor proceeded to his maintenance phase two years on atra mercaptopurine and methotrexate for two years monitoring blood counts are within the normal range ma was done this year and revealed there is still on fish ra is this considered a minimal residual disease or incomplete remission does he need to undergo chemo again or start a new atra
output: hello sorry to hear about your husband diagnosis he is having acute promyelocytic leukemia cancer and it is considered among favorable outcome leukemia after starting chemotherapy complete remission includes less than blast in bone marrow aspirate and more then 1500 platelets more than lakh extramedullary hematopoiesis absent and molecular testing negativity after consolidation chemotherapy if cytogenetic study remains positive then prognosis cannot be considered good as compared to a negative cytogenetic leukemia patient after chemotherapy and it can be considered here as a minimal residual disease treatment was given in the right way along with proper chemotherapy and retinoic acid as well but you have to discuss your case with your treating oncologist and he will guide you further about what is the future treatment protocol I hope this helps