instruction: hello doctor I have read several studies on the effect of autophagy on material fibrilation I cannot understand most of the conclusions and need some help with this I basically follow a regime where I eat every other day and fast at least 24 to 30 hours at a time as I believe autophagy is activated and can have a positive or negative effect on the heart in particular the atrium and remodeling of electrics can you please tell me if you think what I am doing could possible cause fib or remodeling of my heart I have no current issues low cholesterol and be no family history and have a structurally normal heart however due to my years of excess I have this fear of getting fib I am male 35 years old mixed ethnicity
output: hello firstly there is no good evidence for or against this rigorous fasting studies atleast have shown no significant increase in atrial fibrillation with such fasting practically we do not have good evidence for it now if we consider theoretically then yes fasting may stimulate autophagy and may have a beneficial effects on heart atrial fibrillation it does improve your lipid profile and risk of myocardial ischemia which is a risk factor for atrial fibrillation it may also reduce obesity bodily inflammation which is again a risk factor for atrial fibrillation so there is no evidence to suggest that it induces fib or remodeling but such rigorous fasting is not recommended based on current evidence we are also not sure whether you are meeting the daily requirement of essential nutrients dehydration should be strictly avoided you can share some studies with me so that I can clarify on them so fasting for few days say for 5 days a month is acceptable