instruction: hello doctor I am going to be under general anesthesia in coming days for surgery I did let my pre op nurse know and wrote down all current medicines and supplements but have a question about supplements as I am not going to take them the night before anyways but just wanted insight the first is kratom I wanted her to know so the anesthesiologist could dose my pain medicines right during surgery second is phenibut a free amino acid would this would this have any effect on tolerance to the benzodiazepine they choose to administer
output: hi you are taking drugs one of which is psychoactive compound kratom while other one is mind calming magnet phenibut if you are taking those drugs since long time then you may have some tolerance to opioids benzodiazepine other sedative anesthetic medicines so I would suggest you personally inform the anaesthesiologist regarding them so that he can make necessary adjustments in dose of anesthetic agents I just have added effects of these medicines on body kratom contains psychoactive compounds mitragynine c23h30n2o4 molecular weight 398 49 and hydoxymitragynine hmg it is used to treat chronic pain or opioid withdrawal although no scientific evidence supports this use the leaves are used for recreation and for self medicated opioid withdrawal treatment kratom toxic effects include dry mouth changes in urination nausea vomiting and weight loss serious complications such as seizures and coma have been reported the effects of kratom are dose dependent small doses produce cocaine like effects larger doses cause morphine like sedative effects kratom users report increased work capacity alertness sociability and sometimes increased sexual desire phenibut is a modified version of gamma aminobutyearic acid gala which is one of the inhibitor neurotransmitters in the brain it exhibits a relaxing effect and is also describe as producing a euphoriant dis inhibiting and calming state of mind