Doom Supreme arrives on Earth-616 after Agamotto had broken up the fight between the Avengers and the Prehistoric Avengers. He proceeded to remove Agamotto's eyes and then kills the Prehistoric Star Brand as the rest of the Multiversal Masters of Evil arrive. After the Prehistoric Ghost Rider subdued Hound, Odin fights Doom Supreme as Valkyrie frees Odin from one of Doom Supreme's spells. After being told by Dark Phoenix that the fight is taking too long, Doom Supreme casts a spell to wipe out the ancestral ape-men.