By the middle of the sixteenth century, meteorology had developed along two lines: theoretical science based on Meteorologica, and astrological weather forecasting. The pseudoscientific prediction by natural signs became popular and enjoyed protection of the church and princes. This was supported by scientists like Johannes Muller, Leonard Digges, and Johannes Kepler. However, there were skeptics. In the 14th century, Nicole Oresme believed that weather forecasting was possible, but that the rules for it were unknown at the time. Astrological influence in meteorology persisted until the eighteenth century.