Freedhoff married Stephen Freedhoff when she was around 20. Stephen Freedhoff had graduated with a bachelor of commerce from the University of Toronto in 1957, going on to a career as a chartered accountant and consultant. They had a daughter, Michal Ilana Freedhoff, a son, Yoni Freedhoff, and seven grandchildren. Michal Freedhoff gained a doctorate in solid state chemistry, and went on to serve as a US Congressional Science and Engineering Fellow in the office of Ed Markey. She subsequently worked in a variety of government environmental protection roles, and was appointed Assistant Administrator for the Office of Chemical Safety and Pollution Prevention (OCSPP) of the US Environmental Protection Agency (EPA) in 2021. Yoni Freedhoff is an associate professor of Family Medicine at the University of Ottawa and author. Helen Freedhoff's personal pastimes included reading, playing piano, solving KenKen puzzles, and yoga.