Mesoscopic physics also addresses fundamental practical problems which occur when a macroscopic object is miniaturized, as with the miniaturization of transistors in semiconductor electronics. The mechanical, chemical, and electronic properties of materials change as their size approaches the nanoscale, where the percentage of atoms at the surface of the material becomes significant. For bulk materials larger than one micrometre, the percentage of atoms at the surface is insignificant in relation to the number of atoms in the entire material. The subdiscipline has dealt primarily with artificial structures of metal or semiconducting material which have been fabricated by the techniques employed for producing microelectronic circuits.