Multi-parametric surface plasmon resonance, a special configuration of SPR, can be used to characterize layers and stacks of layers. Besides binding kinetics, MP-SPR can also provide information on structural changes in terms of layer true thickness and refractive index. MP-SPR has been applied successfully in measurements of lipid targeting and rupture, CVD-deposited single monolayer of graphene (3.7Å) as well as micrometer thick polymers.