Mauderli trained in the dosimetry of low- and high-energy radiations at the University of Zurich Medical Center with Professor Rolf Widerøe, the developer of particle accelerators. Mauderli moved to the United States in May 1956 and assumed a position at the University of Arkansas. In 1960 he became the first medical physicist at the University of Florida ("UF") and retired as Professor Emeritus in 1988. He was also academically affiliated with the Departments of Nuclear Engineering Sciences and Environmental Engineering Sciences. In the 1960s Mauderli was one of the founders of the medical physics graduate program at UF and radiologic technology training programs at two regional community colleges. He supervised many graduate students in their master's and doctoral research efforts.