From approximately 10 seconds after the Big Bang, during a period known as the hadron epoch, the temperature of the universe had fallen sufficiently to allow quarks to bind together into hadrons, and the mass of the universe was dominated by hadrons. Initially, the temperature was high enough to allow the formation of hadron–anti-hadron pairs, which kept matter and antimatter in thermal equilibrium. However, as the temperature of the universe continued to fall, hadron–anti-hadron pairs were no longer produced. Most of the hadrons and anti-hadrons were then eliminated in particle–antiparticle annihilation reactions, leaving a small residual of hadrons by the time the universe was about one second old.