Stimulants such as thyroxine, caffeine, and amphetamines lead to overestimation of time intervals by both humans and rats, while depressants and anesthetics such as barbiturates and nitrous oxide can have the opposite effect and lead to underestimation of time intervals. The level of activity in the brain of neurotransmitters such as dopamine and norepinephrine may be the reason for this. A research on stimulant-dependent individuals (SDI) showed several abnormal time processing characteristics including larger time differences for effective duration discrimination, and overestimating the duration of a relatively long time interval. Altered time processing and perception in SDI could explain the difficulty SDI have with delaying gratification. Another research studied the dose-dependent effect in methamphetamine dependents with short term abstinence and its effects on time perception. Results shows that motor timing but not perceptual timing, was altered in meth dependents, which persisted for at least three months of abstinence. Dose-dependent effects on time perception were only observed when short-term abstinent meth abusers processed long time intervals. The study concluded that time perception alteration in meth dependents is task specific and dose dependent.