Jehle's research interests spanned particle physics, biophysics and astrophysics. His contributions included the first theoretical description of two-component fields with mass and charge, the prediction of particlelike singular solutions in nonlinear field theory, extension of the formalism of covariant two-component spinor fields, the association of some comets with the orbital parameters of Jupiter, new statistical methods in gravitational systems, calculation of specificity of the van der Waals' interactions between macromolecules due to coherent quantum charge fluctuations, models of DNA replication, and quark models based on the topology of singular quantized magnetic flux loops.