In 1948, Skaggs accepted a faculty appointment as assistant professor of radiology at the University of Chicago. In 1949, he took the promotion to associate professor with the responsibility for the development of radiation therapy equipment and facilities at Argonne Cancer Research Hospital (ACRH). The Atomic Energy Commission program, titled " Atoms for Peace " funded the facilities at ACRH. In 1953, the ACRH was among the initial list of hospitals dedicated to radiation therapy for cancer treatment.