Most known and nontrivial (i.e. interacting) quantum field theories in 4 dimensions are effective field theories with a cutoff scale. Since the beta-function is positive for most models, it appears that most such models have a Landau pole as it is not at all clear whether or not they have nontrivial UV fixed points. This means that if such a QFT is well-defined at all scales, as it has to be to satisfy the axioms of axiomatic quantum field theory, it would have to be trivial (i.e. a free field theory).