Criticism of the Drake equation is varied. Firstly, many of the terms in the equation are largely or entirely based on conjecture. Star formation rates are well-known, and the incidence of planets has a sound theoretical and observational basis, but the other terms in the equation become very speculative. The uncertainties revolve around the present day understanding of the evolution of life, intelligence, and civilization, not physics. No statistical estimates are possible for some of the parameters, where only one example is known. The net result is that the equation cannot be used to draw firm conclusions of any kind, and the resulting margin of error is huge, far beyond what some consider acceptable or meaningful.