In particle physics, the most important hierarchy problem is the question that asks why the weak force is 10 times as strong as gravity. Both of these forces involve constants of nature, the Fermi constant for the weak force and the Newtonian constant of gravitation for gravity. Furthermore, if the Standard Model is used to calculate the quantum corrections to Fermi's constant, it appears that Fermi's constant is surprisingly large and is expected to be closer to Newton's constant unless there is a delicate cancellation between the bare value of Fermi's constant and the quantum corrections to it.