It opened on Broadway at the Royale Theatre on 11 April 2000 and ran for 326 performances. Directed by Michael Blakemore, it starred Philip Bosco (Niels Bohr), Michael Cumpsty (Werner Heisenberg), and Blair Brown (Margrethe Bohr). It won the Tony Award for Best Play, Best Featured Actress in a Play, Blair Brown, and Best Direction of a Play (Michael Blakemore).