In the 1980s he and other physicists opposed the Strategic Defense Initiative missile system conceived by the Ronald Reagan administration. In 1995, at the age of 88, Bethe wrote an open letter calling on all scientists to "cease and desist" from working on any aspect of nuclear weapons development and manufacture. In 2004, he joined 47 other Nobel laureates in signing a letter endorsing John Kerry for President of the United States as someone who would "restore science to its appropriate place in government".