The bimolecular collision frequency related to many reactions including protein coagulation/aggregation is initially described by Smoluchowski coagulation equation proposed by Marian Smoluchowski in a seminal 1916 publication, derived from Brownian motion and Fick's laws of diffusion. Under an idealized reaction condition for A + B → product in a diluted solution, Smoluchovski suggested that the molecular flux at the infinite time limit can be calculated from Fick's laws of diffusion yielding a fixed/stable concentration gradient from the target molecule, e.g. B is the target molecule holding fixed relatively, and A is the moving molecule that creates a concentration gradient near the target molecule B due to the coagulation reaction between A and B. Smoluchowski calculated the collision frequency between A and B in the solution with unit #/s/m :