The chemical composition of comets should reflect both the conditions in the outer solar nebula some 4.5 × 10 ayr, and the nature of the natal interstellar cloud from which the Solar System was formed. While comets retain a strong signature of their ultimate interstellar origins, significant processing must have occurred in the protosolar nebula. Early models of coma chemistry showed that reactions can occur rapidly in the inner coma, where the most important reactions are proton transfer reactions. Such reactions can potentially cycle deuterium between the different coma molecules, altering the initial D/H ratios released from the nuclear ice, and necessitating the construction of accurate models of cometary deuterium chemistry, so that gas-phase coma observations can be safely extrapolated to give nuclear D/H ratios.