The Brain spawn (voiced by Maurice LaMarche) are a race of flying telepathic brains that wish to collect all of the data in the universe and kill all other intelligent beings, because the mere act of them thinking causes them great pain. They are able to use "stupefaction fields" to render all intelligent beings on a planet too stupid to resist them. This allows them to collect all knowledge on the planet and destroy it. Their main enemies are the Nibblonians, who send Nibbler on a mission to find Fry, the only being resistant to the Brain spawn. Fry lacks the delta brainwave, due to himself being his own grandfather, so he is able to repel the Brain spawn when they attack Earth. Fry later sends the Brain spawn and their space station, the Infosphere, into another dimension with a bomb given to him by the Nibblonians.