As part of the All-New, All-Different Marvel event, Otto Octavius is still dead but a copy of his consciousness is shown to be inside the Living Brain where he is still in love with Anna Maria Marconi. Following the events of Spider-Verse, Otto Octavius had backed up his consciousness in one of his gauntlets (the Superior Spider-Man's web-shooters) that slept for 100 days using the technology he acquired from 2099. The gauntlet housed a copy of Octavius's consciousness up to the point of Spider-Verse (without the memories of learning about power and responsibility for his act of self-sacrifice in Goblin Nation, as this copy would remain asleep during this time). After transforming the gauntlet into a version of an Octobot, he backed himself up in the Living Brain while waiting for the next opportunity to take over Parker's body again, planning to act at a time when Parker's spider-sense would be taxed so that he would miss the relevant signals.