Vedeneyeva was with Parnok and Tsuberbiller when Parnok died in 1933 and she fell into a depression. Traveling alone in the summer of 1934 to Armenia, she sought to restore herself, but the depression returned in 1936 and she took a retreat at the beginning of 1936 to sanatorium near Moscow and then in the summer another solo trip to Sudak. Returning to Moscow, Vedeneyeva completed her doctorate in Physical and Mathematical Sciences in 1937 and moved to the Institute of Geological Sciences of the National Academy of Sciences of the USSR to head the optical section in 1941. Working with the Red Army Engineering Unit, she developed a method of spectrophotometry to be used in the field which dealt with the problem of color masking due to crystallographic defects. When the war ended, in 1945, Vedeneyeva became the supervisor of the Crystal Optics Laboratory at the Institute of Crystallography. That same year, she was awarded the Order of the Badge of Honour.