In 2006, Castro was granted the Goddard Space Flight Center Exceptional Service Award. In 2007, 2008, and 2009, she received the NASA Exceptional Achievement Medal. She is also a recipient of the Austronauts' Manned Flight Program Launch Honoree, Astronauts’ Manned Flight “Snoopy” Award, Flight Project's “Mission Impossible” award, GSFC Exceptional Performance Award, and NASA Honor Group Achievement Award for the Constellation Mission Operations Working Group.