The expansion history and large-scale structure of the universe is a key prediction of cosmological models, and DESI observations will permit scientists to probe diverse aspects of cosmology, from dark energy to alternatives to General Relativity to neutrino masses to the early universe. The data from DESI will be used to create three-dimensional maps of the distribution of matter covering an unprecedented volume of the universe with unparalleled detail. This will provide insight into the nature of dark energy and establish whether cosmic acceleration is due to a cosmic-scale modification of General Relativity. DESI will be transformative in the understanding of dark energy and the expansion rate of the universe at early times, one of the greatest mysteries in the understanding of the physical laws.