Constance "Connie" Tucker (June Squibb in The Big Bang Theory ; guest: season 9 and Annie Potts in Young Sheldon) is Mary's mother, George Sr.'s mother-in-law, and maternal grandmother to Georgie, Sheldon, and Missy, who call her "Meemaw". Like Sheldon's other family members, she is also native to Texas and is their neighbor in the town of Medford. Sheldon sees himself as her favorite grandchild, whom she affectionately calls " Moonpie ". Sheldon, in turn, is very affectionate toward and protective of her. Meemaw is often mentioned by Sheldon but did not appear on the series until episode 14 of season nine, "The Meemaw Manifestation".