The mathematics of the Yang–Mills theory is a very active field of research, yielding e.g. invariants of differentiable structures on four-dimensional manifolds via work of Simon Donaldson. Furthermore, the field of Yang–Mills theories was included in the Clay Mathematics Institute 's list of " Millennium Prize Problems ". Here the prize-problem consists, especially, in a proof of the conjecture that the lowest excitations of a pure Yang–Mills theory (i.e. without matter fields) have a finite mass-gap with regard to the vacuum state. Another open problem, connected with this conjecture, is a proof of the confinement property in the presence of additional fermions.