He has appeared numerous times on The Daily Show with Jon Stewart. He has made appearances on Late Night with Conan O'Brien, The Tonight Show with Jay Leno, Late Night with Jimmy Fallon, and The Rachel Maddow Show. He served as one of the central interviewees on the various episodes of the History Channel science program, The Universe. Tyson participated on the NPR radio quiz program Wait Wait... Don't Tell Me! in 2007 and 2015. He appeared several times on Real Time with Bill Maher and he was also featured on an episode of Who Wants to Be a Millionaire? as the ask-the-expert lifeline. He has spoken numerous times on the Philadelphia morning show, Preston and Steve, on 93.3 WMMR, as well as on SiriusXM's Ron and Fez and The Opie and Anthony Show.