The strong nuclear force is responsible for hadronic and nuclear binding. It is mediated by gluons, which couple to color charge. Since gluons themselves have color charge, the strong force exhibits confinement and asymptotic freedom. Confinement means that only color-neutral particles can exist in isolation, therefore quarks can only exist in hadrons and never in isolation, at low energies. Asymptotic freedom means that the strong force becomes weaker, as the energy scale increases. The strong force overpowers the electrostatic repulsion of protons and quarks in nuclei and hadrons respectively, at their respective scales.