Cold has numerous physiological and pathological effects on the human body, as well as on other organisms. Cold environments may promote certain psychological traits, as well as having direct effects on the ability to move. Shivering is one of the first physiological responses to cold. Even at low temperatures, the cold can massively disrupt blood circulation. Extracellular water freezes and tissue is destroyed. It affects fingers, toes, nose, ears and cheeks particularly often. They discolor, swell, blister, and bleed. Local frostbite leads to so-called chilblains or even to the death of entire body parts. Only temporary cold reactions of the skin are without consequences. As blood vessels contract, they become cool and pale, with less oxygen getting into the tissue. Warmth stimulates blood circulation again and is painful but harmless. Comprehensive protection against the cold is particularly important for children and for sports. Extreme cold temperatures may lead to frostbite, sepsis, and hypothermia, which in turn may result in death.