Doom Supreme later witnessed the fight between the Prehistoric Avengers and a younger Thanos. After watching that battle, Doom Supreme is approached by Mephisto who advised him to put together a variation of the Masters of Evil from the evilest villains throughout the Multiverse and to conquer it while saving Earth-616 for last. Doom Supreme was able to do that by gathering Black Skull, Dark Phoenix and her Berserkers, Ghost Goblin, Kid Thanos, and King Killmonger. They attacked the Prehistoric Avengers of different Earths, slew them, and took over their worlds. Though they violated the order to save Earth-616 for last and arrived there where Doom Supreme slew Orb, broke the Watcher's eye in his possession, and sent some of his Multiversal Masters of Evil to fight the different members of the Avengers. Doom Supreme and Kid Thanos attacked Avengers Mountain where they fought Black Panther, Namor, and Valkyrie before Avengers Mountain exploded. After a talk with Mephisto's dog form and Iron Inquisitor, Doom Supreme puts the unburned fragment of the Watcher's eye into his own eye and leaves with Kid Thanos so that the Multiversal Masters of Evil can get back to work.