In 1935, the first scientific work devoted to the thermodynamics of biological systems was published - the book of the Hungarian-Russian theoretical biologist Erwin S. Bauer (1890-1938) "Theoretical Biology". E. Bauer formulated the "Universal Law of Biology" in the following edition: "All and only living systems are never in equilibrium and perform constant work at the expense of their free energy against the equilibrium required by the laws of physics and chemistry under existing external conditions". This law can be considered the 1st law of thermodynamics of biological systems.