During the " Devil's Reign " storyline, Doctor Octopus becomes part of Mayor Wilson Fisk's Thunderbolts unit. He accompanied the NYPD and Homeland Security to the Baxter Building to do a full investigation on the weapons of mass destruction that might be located there. Before Reed and Susan can retaliate, Doctor Octopus appears and places power dampener collars on them. He and Mayor Fisk persuaded the government that Reed worked for the work to look the other way and states that they now must come with them as a Thunderbolts unit shows up. Susan manages to get a Code X7 out to Human Torch, Ben Grimm, Franklin Richards, and Valeria Richards causing them to evacuate and get to Alicia Masters and the kids with her. Doctor Octopus later contacts Mayor Fisk about the inventions that he found in Reed Richards' lab. In the sub-basement of City Hall, Mayor Fisk meets with Doctor Octopus as they reference the time when Doctor Doom used Purple Man to control the world as it shows Purple Man's body in a diamond-shaped container. Doctor Octopus' invention would help coerce the people of New York. Mayor Fisk states that he'll handle the rest. With the special Neuro Blockers to keep him safe from the Purple Man's influence, Doctor Octopus states that his part of the job is done. Doctor Octopus later makes use of Reed Richards' inter-dimensional gate where he brings over version of himself like Hulk from Earth-8816 who has two sets of arms growing from his back, a version of Ghost Rider from Earth-1666 with chain-tentacles coming out of his back, and a version of Wolverine from Earth-9712 with immensely sharp blades on the tentacles coming out of his back. Doctor Octopus then considers his plans "Superior". Doctor Octopus is contacted by Mayor Fisk about the Purple Children as Doctor Octopus states that he is occupied at Reed Richards' laboratory, but can work on modifying Purple Man's confinement when they have been found. After the call, Doctor Octopus tells Hulk of Earth-8816, Ghost Rider of Earth-1666, and Wolverine of Earth-9712 that they will see some action soon. Later that night, the superheroes arrive at City Hall where they are attacked by Doctor Octopus' Superior Four as Mayor Fisk watches from the window. Captain America discovers that Iron Man is actually Chameleon in disguise who Doctor Octopus was going to use to take part in the mayoral election on his behalf. Two weeks later, Doctor Octopus has released thousands of his Octobots to enforce Mayor Wilson Fisk's zero-tolerance policy, effectively wiping out all crime in the city. He and Wolverine of Earth-9712 visit Mayor Fisk as Doctor Octopus informs him that Butch Pharris has been arrested for his criminal activities.