The currently largest PAC laboratory in the world is located at ISOLDE in CERN with about 10 PAC instruments, that receives its major funding form BMBF. Radioactive ion beams are produced at the ISOLDE by bombarding protons from the booster onto target materials (uranium carbide, liquid tin, etc.) and evaporating the spallation products at high temperatures (up to 2000 °C), then ionizing them and then accelerating them. With the subsequent mass separation usually very pure isotope beams can be produced, which can be implanted in PAC samples. Of particular interest to the PAC are short-lived isomeric probes such as: Cd, Hg, Pb, and various rare earth probes.