To clarify and prove the rule, consider a Feynman diagram formed from vertices, terms in the Lagrangian, with Fermion fields. The full term is Bosonic, it is a commuting element of the Grassmann algebra, so the order in which the vertices appear is not important. The Fermi lines are linked into loops, and when traversing the loop, one can reorder the vertex terms one after the other as one goes around without any sign cost. The exception is when you return to the starting point, and the final half-line must be joined with the unlinked first half-line. This requires one permutation to move the last ψ to go in front of the first ψ, and this gives the sign.