In the House of M continuity, Doom is still the ruler of Latveria, his mother is still alive, he is married to Valeria, and he has adopted Kristoff. Reed Richards's test flight still encounters cosmic radiation, but rather than empowering Reed, Sue and John Jameson, who went up instead of Johnny Storm, the three of them are killed by the cosmic radiation. Ben Grimm survives, but his intelligence is reduced. This inspires Doom to create the Fearsome Four, consisting of himself, the It(Grimm), the Invincible Woman (Valeria), and the Inhuman Torch (Kristoff). Due to Doom's arrogance and his brutality towards Grimm, the It betrays the team; Valeria and Kristoff are killed, his mother is kidnapped, and Doom is left broken, but preparing his revenge. He genetically mutates himself to study and advance technologies and mysticism to better himself to be perfect, and transforms his skin into liquid metal and can form weapons from his hands.