In 1954, Talmi joined the Weizmann Institute of Science where he became Professor of Physics in 1958. Talmi was one of the founders of the Department of Nuclear Physics at the Weizmann Institute. He served as the Head of the Nuclear Physics Department (1967–1976), and the Dean of the Faculty of Physics (1970–1984). Talmi spent sabbatical years at Princeton, Stanford, Massachusetts Institute of Technology (MIT), Yale and other universities as a visiting professor.