The Hawking radiation for an astrophysical black hole is predicted to be very weak and would thus be exceedingly difficult to detect from Earth. A possible exception, however, is the burst of gamma rays emitted in the last stage of the evaporation of primordial black holes. Searches for such flashes have proven unsuccessful and provide stringent limits on the possibility of existence of low mass primordial black holes. NASA's Fermi Gamma-ray Space Telescope launched in 2008 will continue the search for these flashes.