In Spider-Man: Reign, as conceived by Kaare Andrews, in which many superheroes had grown old and retired, Octavius appeared to save Spider-Man from death at the hands of an older version of the Sinner Six. While he originally appeared to merely be world-weary, relying on his 'four sons' (his tentacles) to keep him alive, he revealed via monologue that he had in fact been dead for months, and had left the tentacles a program that would force them into action to find Spider-Man. Furthermore, the tentacles were used to play the tape on which his monologue is recorded, and take him to the graveyard where his loved ones lay. The hope is to use Spider-Man to reignite the age of the super powered beings, as both Doctor Octopus and Spider-Man were born from nuclear accidents.