In the MC2 alternate future series Spider-Girl, Carolyn Trainer returns to supervillainy years after Otto Octavius's death, initially reclaiming the 'Doctor Octopus' title. Intending to create mutate soldiers for the mob, she briefly turns John Jameson back into Man-Wolf, before beating Spider-Girl in a pitched battle. Later, she frees crime boss Canis from prison in the hope of uniting to take over the criminal underworld and oppose the Black Tarantula ; it is later revealed that she is in fact working for the Tarantula, setting Canis up for a fall. Spider-Girl battles Carolyn once again and finally takes her down.