The quantum theory asserts that a vacuum, even the most perfect vacuum devoid of any matter, is not really empty. Rather the quantum vacuum can be depicted as a sea of continuously appearing and disappearing [pairs of] particles that manifest themselves in the apparent jostling of particles that is quite distinct from their thermal motions. These particles are ‘virtual’, as opposed to real, particles....At any given instant, the vacuum is full of such virtual pairs, which leave their signature behind, by affecting the energy levels of atoms.