Set weeks after a highly infectious pathogen has turned the majority of the Earth's population into homicidal cannibals, Dr. Doom arrives during the Avengers last stand against the growing number of infected and assists in repelling the attackers. Knowing of the Pathogen's unpredictable nature of transforming anyone who is infected at any point in time, Doom offers the heroes a solution to prevent anyone else from succumbing to the pathogen in the form of Doom Stones that he claims stalls the pathogen from transforming anyone who potentially carries it. However, Doom refuses to give them the Doom Stones unless they swear absolute loyalty to him.