Imes died of throat cancer on September 11, 1941. His colleague Swann wrote in an obituary for the journal Science that, "his research laboratory was a mecca for those who sought an atmosphere of calm and contentment. Peacefully smoking a pipe, Imes could always be relied upon to bring to any discussion an atmosphere of philosophic soundness and levelheaded practicalness. Gifted, moreover with a poetic disposition, he was widely read in literature, and a discriminating and ardent appreciator of music."