University of Cambridge astrophysics student Stephen Hawking begins a relationship with literature student Jane Wilde. Although Stephen is intelligent, his friends and professors are concerned about his lack of a thesis topic. After he and his professor Dennis Sciama attend a lecture on black holes, Stephen speculates that black holes may have been part of the creation of the universe, and decides to write his thesis on them. However, Stephen's muscles begin to fail, giving him decreasing coordination with his body. He learns he has motor neuron disease, which will eventually leave him unable to move, swallow, and even breathe. There are no treatments, and he has approximately two years to live. The doctor assures Stephen that his brain will not be affected, so his thoughts and intelligence will remain intact, but eventually, he will be unable to communicate them. As Stephen becomes reclusive, focusing on his work, Jane confesses she loves him. She tells his father she intends to stay with Stephen even as his condition worsens. They marry and have their first son, Robert.