In his 1853 paper, Helmholtz was concerned with the electromotive properties of "physically extensive conductors", in particular, with animal tissue. He noted that earlier work by physiologist Emil du Bois-Reymond had shown that "every smallest part of a muscle that can be stimulated is capable of producing electrical currents." At this time, experiments were carried out by attaching a galvanometer at two points to a sample of animal tissue and measuring current flow through the external circuit. Since the goal of this work was to understand something about the internal properties of the tissue, Helmholtz wanted to find a way to relate those internal properties to the currents measured externally.