Her research focuses on theoretical spectroscopy and the development of first-principles methods for electronic excitations based on (time-dependent) density functional theory and many-body perturbation theory. She edited the book "First Principles Approaches to Spectroscopic Properties of Complex Materials". She is an associate editor of npj Computational Materials. Botti was part of an international research collaboration on a silicon-based direct bandgap light emitter, which was announced to be the "Breakthrough of the Year" by Physics World in 2020.