On the review aggregator website Rotten Tomatoes, the film holds an approval rating of 63% based on 154 reviews, with an average rating of 6/10. The website's critics consensus reads, " Radioactive ' s flawed script and counterproductive storytelling choices are offset by Rosamund Pike's central performance in a sincere tribute to a brilliant scientific mind." Metacritic, which uses a weighted average, assigned the film a score of 56 out of 100, based on 31 critics, indicating "mixed or average" reviews.