MPMC is optimized for the study of nanoscale interfaces. MPMC supports simulation of Coulomb and Lennard-Jones systems, many-body polarization, coupled-dipole van der Waals, quantum rotational statistics, semi-classical quantum effects, advanced importance sampling methods relevant to fluids, and numerous tools for the development of intermolecular potentials. The code is designed to efficiently run on high-performance computing resources, including the network of some of the most powerful supercomputers in the world made available through the National Science Foundation supported project Extreme Science and Engineering Discovery Environment (XSEDE).