2008-2019 Kalender's research was focused on the development of an efficient breast-CT system to improve the early detection of breast cancer. The scanner and in particular the development of its high-resolution photon-counting detector design allow scanning the breast with a dose similar to that of digital mammography, but with much higher resolution and clarity than mammography due to superposition-free fully 3D-resolution of breast-CT. The introduction into clinical practice was performed in 2018 at the University Spital Zurich (Swiss).