If both (a) and (b) are satisfied, cosmic inflation selects one patch of the Universe within which the spontaneous breaking of the PQ symmetry leads to a homogeneous value of the initial value of the axion field. In this "pre-inflationary" scenario, topological defects are inflated away and do not contribute to the axion energy density. However, other bounds that come from isocurvature modes severely constrain this scenario, which require a relatively low-energy scale of inflation to be viable.