The ESRF site forms part of the " Polygone Scientifique ", lying at the confluence of the rivers Drac and Isère about 1.5 km from the centre of Grenoble. It is served by Grenoble tramway system and local bus lines of Semitag (C6, 22 and 54). It is served by Grenoble–Isère Airport and Lyon–Saint-Exupéry Airport.