Slotin might have been present at the start-up of Enrico Fermi 's " Chicago Pile-1 ", the first nuclear reactor, on 2 December 1942; the accounts of the event do not agree on this point. During this time, he also contributed to several papers in the field of radiobiology. His expertise on the subject garnered the attention of the United States government, and as a result he was invited to join the Manhattan Project, an effort to develop an atomic bomb. Slotin worked on the production of plutonium under future Nobel laureate Eugene Wigner at the university and later at the Oak Ridge National Laboratory in Oak Ridge, Tennessee. He moved to the Los Alamos National Laboratory in New Mexico in December 1944 to work in the bomb physics group of Robert Bacher.