In 1995 she was appointed by President Bill Clinton to serve as chairman of the US Nuclear Regulatory Commission (NRC), becoming the first woman and first African American to hold that position. At the NRC, she had "ultimate authority for all NRC functions pertaining to an emergency involving an NRC licensee". In addition, while Jackson served on the commission she assisted in the establishment of the International Nuclear Regulators Association. Dr. Jackson served as the chairperson for the International Regulators Association from 1997 to 1999. The association consisted of senior nuclear regulatory officials from countries like Canada, France, Germany and Spain.