Though his relationship with co-workers was typically hostile, he was social enough to give a demonstration of his harness to a small group. He showed how the metal tentacles allowed him to work safely with chemicals that would normally be too dangerous for a human being to touch or be in close vicinity to. One such person impressed by this was a scientist named Mary Alice Anders, and the two soon dated. In due time, Otto proposed marriage to Mary Alice. However, when Otto joyously announced his future marriage to his mother, her feelings were not reciprocated. Believing that no woman was good enough for her son, she made him feel guilty that she was going to be pushed aside for his bride-to-be. Shocked that he hurt his mother, and to please her, Otto broke off the engagement with Mary Alice. Later, when Otto discovered that his mother had hypocritically begun dating a librarian, he finally snapped and lashed out at her, causing her to have a fatal heart attack. With the death of his mother and Mary Alice Anders out of his life, Octavius' disposition towards nearly everyone became mean-spirited, and he had become more distracted from paying attention to detail and safety precautions in his work. His co-workers often called him "Doctor Octopus" behind his back, a pun on his actual name inspired by the four-armed apparatus; he was aware of this insult, but he barely cared.