In the Marvel 1602 universe, a version of Dr. Octopus appears in the Spider-Man 1602 miniseries. Baron Victor Octavius is an Italian nobleman living in France. His attempts to use the blood of octopuses to cure himself of the bubonic plague have resulted in his becoming a deformed octopus-like monster, he is also associated with fellow Dr. Curtis Connors, transforming him into the Lizard. A potion derived from the blood of Hal McCoy by the natural philosopher Henri le Pym keeps him human, but is growing steadily less effective. He believes that the blood of Peter Parquagh might be the basis of a more effective potion. He is later killed by a transformed le Pym's giant foot.