Strickland studied for her graduate degree in The Institute of Optics, receiving a Doctor of Philosophy degree from the University of Rochester in 1989. She conducted her doctoral research at the associated Laboratory for Laser Energetics, supervised by Gérard Mourou. Strickland and Mourou worked to develop an experimental setup that could raise the peak power of laser pulses, to overcome a limitation, that when the maximal intensity of laser pulses reached gigawatts per square centimetre, self-focusing of the pulses severely damaged the amplifying part of the laser. Their 1985 technique of chirped pulse amplification stretched out each laser pulse both spectrally and in time before amplifying it, then compressed each pulse back to its original duration, generating ultrashort optical pulses of terawatt to petawatt intensity. Using chirped pulse amplification allowed smaller high-power laser systems to be built on a typical laboratory optical table, as "table-top terawatt lasers". The work received the 2018 Nobel Prize in Physics.