In the " Sinister War " storyline, Doctor Octopus coerces Dr. Curt Connors into using the Isotope Particle Accelerator on himself which separates Lizard from Dr. Connors. While in the Osborn Graveyard, Doctor Octopus demands that Kindred gives him the answers he seeks. Kindred states to Doctor Octopus that he'll get the answers soon as he adds Mysterio to the latest incarnation to the Sinister Six. In truth, Doctor Octopus secretly prepares a sonic transducer to destroy Kindred's centipedes, at cost of knocking the rest of Spider-Man's past foes, while saving them as well from hunting Spider-Man before the centipedes devoured their brains. To do so, Otto took a centipede from an undead Sin-Eater's brain and used it on his transducer to both knock out and save Spider-Man's past foes, barring Spider-Man and himself, while Boomerang was killed by Morlun when trying to save Spider-Man. Before splitting up, Otto urges Peter to make himself scarce and continue to fight Kindred safely before the surviving factions could recover, as most of them would still want to kill him.