From 1917, he worked a few years with Niels Bohr in the University of Copenhagen and received his doctoral degree at the University College of Stockholm (now Stockholm University) in 1921. In 1923, he received a professorship at University of Michigan in Ann Arbor and moved there with his recently wedded wife, Gerda Koch from Denmark. Klein returned to Copenhagen in 1925, spent some time with Paul Ehrenfest in Leiden, then became docent at Lund University in 1926 and in 1930 accepted the offer of the professorial chair in physics at the Stockholm University College, which had previously been held by Erik Ivar Fredholm until his death in 1927. Klein was awarded the Max Planck Medal in 1959. He retired as professor emeritus in 1962.