Taking the size effect into account is essential for safe prediction of strength of large concrete bridges, nuclear containments, roof shells, tall buildings, tunnel linings, large load-bearing parts of aircraft, spacecraft and ships made of fiber-polymer composites, wind turbines, large geotechnical excavations, earth and rock slopes, floating sea ice carrying loads, oil platforms under ice forces, etc. Their design depends on the material properties measured on much smaller laboratory specimens. These properties must be extrapolated to sizes greater by one or two orders of magnitude. Even if an expensive full-scale failure test, for example a failure test of the rudder of a very large aircraft, can be carried out, it is financially prohibitive to repeat it thousand times to obtain the statistical distribution of load capacity. Such statistical information, underlying the safety factors, is obtainable only by proper extrapolation of laboratory tests.