Doctor Octopus and his Superior Four make plans to obtain the intellect of Doctor Octopus' counterparts throughout the Multiverse using a synthetic blood-parasite from Earth-5069 like they did on Spider-Ock of Earth-2902. When it comes to Earth-7214, the Superior Four attack its Atlantis and are confronted by Supreme Octopus. Doctor Octopus is then teleported to the Savage Land on Earth-8969 where he is ensnared by Supreme Octopus who considers himself superior to Doctor Octopus where he mentioned that he liquefied Shuma-Gorath, made Dormammu grovel, and burned Knull to ashes. The rest of the Superior Four are brought to Earth-8969 where neither of them want to follow Supreme Octopus. Despite what the Superior do, they are unable to beat Supreme Octopus. Hulk of Earth-8816, Ghost Rider of Earth-1666, and Wolverine of Earth-9712 turn against Doctor Octopus and help Supreme Octopus to rip off Doctor Octopus' tentacles. Doctor Octopus is then locked up with a skeleton and carnivorous plants in Supreme Octopus' mobile base called the Supreme Sanctorum. Upon being saved by a Man-Thing variant of himself from Earth-5069, Doctor Octopus defeated Supreme Octopus and took the rest of the Superior Four back to Earth-616 while planning to help them out. He did send Man-Thing of Earth-5067 to Earth-2902 where it shapeshifted into the new Spider-Ock.