In the " Death of Spider-Man " storyline, Osborn breaks him and the rest of the Six out of the Triskelion with Vulture as their latest member. After their escape, Osborn informs them that he believes that God wishes for them to kill Spider-Man. Octavius disagrees, seeking to leave the group to pursue a normal life as a scientist, happy with the knowledge that both he and Osborn created Spider-Man. Outraged, Osborn attacks and kills Octavius.