Alpha radiation is dangerous when alpha-emitting radioisotopes are ingested or inhaled (breathed or swallowed). This brings the radioisotope close enough to sensitive live tissue for the alpha radiation to damage cells. Per unit of energy, alpha particles are at least 20 times more effective at cell-damage as gamma rays and X-rays. See relative biological effectiveness for a discussion of this. Examples of highly poisonous alpha-emitters are all isotopes of radium, radon, and polonium, due to the amount of decay that occur in these short half-life materials.