Double inversion recovery is a sequence that suppresses both cerebrospinal fluid (CSF) and white matter, and samples the remaining transverse magnetisation in fast spin echo, where the majority of the signals are from the grey matter. Thus, this sequence is useful in detecting small changes on the brain cortex such as focal cortical dysplasia and hippocampal sclerosis in those with epilepsy. These lesions are difficult to detect in other MRI sequences.