FAM63B
Post-translational Modification Site ( s ) Impact on Protein
Acetylation Ser3 Stability , localization , metabolism , apoptosis , ribosome recognition for synthesis
Lysine Glycation Lys88 , Lys251 , Lys280 , Lys282 , Lys332 , Lys393 , Lys398 , Lys454 , Lys547 Impaired function , changed characteristics
Phosphorylation Ser7 , Ser21 , Ser25 , Ser26 , Ser62 , Ser66 , Ser68 , Ser72 , Ser90 , Ser94 , Ser111 , Ser148 , Ser153 , Ser158 , Ser160 , Ser165 , Ser170 , Ser175 , Ser188 , Ser193 , Ser233 , Ser396 , Ser440 , Ser499 , Ser541 , Ser558 , Ser587 , Ser589 , Ser590 , Ser594 , Ser597 , Thr48 , Thr255 , Thr344 , Thr453 , Tyr505 Conformation change , turn enzymatic activity on/off
Picornaviral Cleavage Glu195 , Gln535 Cleavage of polyprotein , degradation
O-GlcNAc Ser3 , Ser21 , Ser49 , Ser62 , Ser66 , Ser68 , Ser80 , Ser152 , Ser153 , Ser158 , Ser170 , Ser499 , Ser575 , Ser587 , Ser589 , Ser590 , Thr144 , Thr576 Nucleocytoplasmic location
Protein -- Post-translational Modifications
Post-translational modifications of the FAM63B protein . [ 9 ]
FAM63B is a protein which in humans is encoded by the gene FAM63B. This gene is highly expressed in humans. The FAM63B gene is also highly conserved throughout evolutionary history. The discovered function of FAM63B is an interaction with the kinesin-1 light chain and the transportation of vaccinia virus from the nucleus to the cell periphery.