Leptophos
Organism Test Type Route Reported Dose Source
Cat LDLo Skin 2250 mg/kg National Technical Information Service . Vol . OTS0543229 ,
Chicken LD Intravenous > 30 mg/kg Environmental Health and Preventive Medicine
Chicken LD50 Oral 4700 mg/kg Experientia . Vol . 30 , Pg . 63 , 1974
Mammal ( species unspecified ) LD50 Skin 50 mg/kg Gigiena Truda i Professional'nye Zabolevaniya . Labor Hygiene and Occupational Diseases . Vol . 21 ( 7 ) , Pg . 34 , 1977
Mouse LD50 Oral 65 mg/kg
Mouse LD50 Subcutaneous 120 mg/kg Oyo Yakuri . Pharmacometrics . Vol . 3 , Pg . 74 , 1969
Rabbit LD50 Oral 124 mg/kg Journal Europeen de Toxicologie . Vol . 6 , Pg . 70 , 1973
Rabbit LD50 Skin 800 mg/kg Journal Europeen de Toxicologie . Vol . 6 , Pg . 70 , 1973
Rat LD50 Intravenous 135 mg/kg Oyo Yakuri . Pharmacometrics . Vol . 22 , Pg . 373 , 1981
Rat LD50 Oral 19 mg/kg Fundamental and Applied Toxicology . Vol . 7 , Pg . 299 , 1986
Rat LD50 Skin 44 mg/kg Fundamental and Applied Toxicology . Vol . 7 , Pg . 299 , 1986
Toxicity
Due to the severe toxicity of leptophos , the lethal doses ( LD ) are determined in animal tests . Toxicity differs between species and between exposure through the skin , inhalation and the gastrointestinal track ( table ) . [ 14 ]
Leptophos (O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate) belongs to the organophosphates and at room temperature it is a stable white solid. It is also known as Phosvel, Abar and Vcs 506. Leptophos was primarily used as a pesticide and fungicide. for rice, cotton, fruit and vegetables until its use was discontinued in 1975 in USA, but still sold in Sout-Eastern Asia in 1981. Leptophos was first discovered to be toxic in 1974 when more than 1000 water buffaloes died after exposure to leptophos in Egypt. In response to this event, the effect of leptophos was investigated on chickens, mice and sheep.