Polyestriol phosphate
Estrogen Form Major brand names EPD CIC-D Duration
Estradiol Aqueous solution - ? - < 1 day
Estradiol Oil solution Estradiol 40-60 mg - 1-2 mg ≈ 1-2 days
Estradiol Aqueous suspension Aquadiol , Diogyn , Progynon , Mego-E ? 3.5 mg 0.5-2 mg ≈ 2-7 days ; 3.5 mg ≈ > 5 days
Estradiol Microspheres Juvenum-E , Juvenum ? - 1 mg ≈ 30 days
Estradiol benzoate Oil solution Progynon-B 25-35 mg - 1.66 mg ≈ 2-3 days ; 5 mg ≈ 3-6 days
Estradiol benzoate Aqueous suspension Agofollin-Depot , Ovocyclin M 20 mg - 10 mg ≈ 16-21 days
Estradiol benzoate Emulsion Menformon-Emulsion , Di-Pro-Emulsion ? - 10 mg ≈ 14-21 days
Estradiol dipropionate Oil solution Agofollin , Di-Ovocylin , Progynon DP 25-30 mg - 5 mg ≈ 5-8 days
Estradiol valerate Oil solution Delestrogen , Progynon Depot , Mesigyna 20-30 mg 5 mg 5 mg ≈ 7-8 days ; 10 mg ≈ 10-14 days ; 40 mg ≈ 14-21 days ; 100 mg ≈ 21-28 days
Estradiol benzoate butyrate Oil solution Redimen , Soluna , Unijab ? 10 mg 10 mg ≈ 21 days
Estradiol cypionate Oil solution Depo-Estradiol , Depofemin 20-30 mg - 5 mg ≈ 11-14 days
Estradiol cypionate Aqueous suspension Cyclofem , Lunelle ? 5 mg 5 mg ≈ 14-24 days
Estradiol enanthate Oil solution Perlutal , Topasel , Yectames ? 5-10 mg 10 mg ≈ 20-30 days
Estradiol dienanthate Oil solution Climacteron , Lactimex , Lactostat ? - 7.5 mg ≈ > 40 days
Estradiol undecylate Oil solution Delestrec , Progynon Depot 100 ? - 10-20 mg ≈ 40-60 days ; 25-50 mg ≈ 60-120 days
Polyestradiol phosphate Aqueous solution Estradurin 40-60 mg - 40 mg ≈ 30 days ; 80 mg ≈ 60 days ; 160 mg ≈ 120 days
Estrone Oil solution Estrone , Kestrin , Theelin ? - 1-2 mg ≈ 2-3 days
Estrone Aqueous suspension Estrone Aq . Susp. , Kestrone , Theelin Aq ? - 0.1-2 mg ≈ 2-7 days
Estriol Oil solution - ? - 1-2 mg ≈ 1-4 days
Polyestriol phosphate Aqueous solution Gynäsan , Klimadurin , Triodurin ? - 50 mg ≈ 30 days ; 80 mg ≈ 60 days
Pharmacology
PE3P is similar to polyestradiol phosphate ( PEP ) , and is , likewise , an estrogen ester – specifically , an ester and prodrug of estriol – in the form of a polymer with phosphate linkers . [ 2 ] [ 4 ] [ 5 ] [ 9 ] When adjusted for differences in molecular weight , PE3P contains the equivalent of about 80% of the amount of estriol . [ 16 ] As such , 40 mg PE3P corresponds to about 32 mg estriol . [ 16 ] Doses of PE3P of 10 mg or more have an extended duration of action . [ 17 ] A single intramuscular injection of 80 mg PE3P has a duration of about 1 month and of 80 mg about 2 months . [ 5 ] [ 14 ] The effects of PE3P on the vagina , uterus , pregnancy , prostate gland , coagulation , and fibrinolysis , as well as on mammary and endometrial cancer risk , have been studied . [ 18 ] [ 19 ] [ 20 ] [ 21 ] [ 22 ] [ 23 ] [ 24 ] [ 25 ] [ 16 ] The endometrial proliferation dose of PE3P over 14 days in women is 40 to 60 mg by intramuscular injection . [ 14 ]
Polyestriol phosphate (PE3P, SEP), sold under the brand names Gynäsan, Klimadurin, and Triodurin, is an estrogen medication which was previously used in menopausal hormone therapy (i.e., to treat menopausal symptoms in postmenopausal women) and is no longer available.