Phosphatidylinositol 3-kinase-related kinase
Gene Protein Function
ATM ataxia-telangiectasia mutated response to DNA damage
ATR ataxia- and Rad3-related
PRKDC DNA-dependent protein kinase catalytic subunit ( DNA-PKcs )
MTOR mammalian target of rapamycin ( mTOR ) nutrient-regulated kinase that controls metabolism and cell growth
SMG1 suppressor of morphogenesis in genitalia regulates nonsense-mediated mRNA decay
TRRAP transformation/transcription domain-associated protein transcription factor co-activator
Members
The human PIKK family includes six members :
Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).