Estradiol dipropionate
Route/form Estrogen Dosage
Oral Estradiol 1-2 mg 3x/day
Oral Conjugated estrogens 1.25-2.5 mg 3x/day
Oral Ethinylestradiol 0.15-3 mg/day
Oral Ethinylestradiol sulfonate 1-2 mg 1x/week
Oral Diethylstilbestrol 1-3 mg/day
Oral Dienestrol 5 mg/day
Oral Hexestrol 5 mg/day
Oral Fosfestrol 100-480 mg 1-3x/day
Oral Chlorotrianisene 12-48 mg/day
Oral Quadrosilan 900 mg/day
Oral Estramustine phosphate 140-1400 mg/day
Transdermal patch Estradiol 2-6x 100 μg/day Scrotal : 1x 100 μg/day
IM or SC injection Estradiol benzoate 1.66 mg 3x/week
IM or SC injection Estradiol dipropionate 5 mg 1x/week
IM or SC injection Estradiol valerate 10-40 mg 1x/1-2 weeks
IM or SC injection Estradiol undecylate 100 mg 1x/4 weeks
IM or SC injection Polyestradiol phosphate Alone : 160-320 mg 1x/4 weeks With oral EE : 40-80 mg 1x/4 weeks
IM or SC injection Estrone 2-4 mg 2-3x/week
IV injection Fosfestrol 300-1200 mg 1-7x/week
IV injection Estramustine phosphate 240-450 mg/day
Medical uses
The medical uses of estradiol dipropionate are the same as those of estradiol and other estrogens . [ 8 ] [ 9 ] Estradiol dipropionate is used in hormone therapy for the treatment of menopausal symptoms such as hot flashes and vaginal atrophy and in the treatment of hypoestrogenism and delayed puberty due to hypogonadism or other causes in women . [ 8 ] [ 9 ] It is also used in feminizing hormone therapy for transgender women . [ 14 ] Aside from hormone therapy , estradiol dipropionate is used in the treatment of gynecological disorders such as menstrual disorders , dysfunctional uterine bleeding , and breast engorgement . [ 8 ] [ 9 ] In addition , it is used as a form of high-dose estrogen therapy in the palliative treatment of prostate cancer in men . [ 8 ] Estradiol dipropionate has typically been used at a dosage of 1 to 5 mg once or twice per week by intramuscular injection for relevant indications . [ 8 ] [ 16 ] It has been used in the treatment of menopausal symptoms at a dosage of 1 to 5 mg initially for two to three injections and 1 to 2.5 mg for maintenance once every 10 to 14 days , and in the treatment of hypoestrogenism and delayed puberty at a dosage of 2.5 to 5 mg once per week . [ 8 ] [ 21 ] As a component of feminizing hormone therapy for transgender women , estradiol dipropionate has been used at dosages of 2 to 10 mg once per week or 5 to 20 mg once every 2 weeks . [ 14 ] In the treatment of prostate cancer , estradiol dipropionate has been used at a dosage of 5 mg once per week . [ 8 ]
Estradiol dipropionate (EDP), sold under the brand names Agofollin, Di-Ovocylin, and Progynon DP among others, is an estrogen medication which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders. It has also been used in feminizing hormone therapy for transgender women and in the treatment of prostate cancer in men. Although widely used in the past, estradiol dipropionate has largely been discontinued and is mostly no longer available today. It appears to remain in use only in Japan, Macedonia, and Australia. Estradiol dipropionate is given by injection into muscle at intervals ranging from once or twice a week to once every week and a half to two weeks. Side effects of estradiol dipropionate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. Estradiol dipropionate is a synthetic estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. It is an estrogen ester and a prodrug of estradiol in the body. Because of this, it is considered to be a natural and bioidentical form of estrogen. Estradiol dipropionate was patented in 1937 and was introduced for medical use by 1940. It was one of the earliest estradiol esters to be used. Along with estradiol benzoate, estradiol dipropionate was among the most widely used esters of estradiol for many years following its introduction.