Template:Side effects of high-dose cyproterone acetate
Frequency System Organ Class Side effect
Very common ( ≥10% ) General disorders and administration site conditions Headache Tiredness
Very common ( ≥10% ) Psychiatric disorders Decreased libido ( men ) Erectile dysfunction ( men ) Reduced ejaculate volume ( men )
Very common ( ≥10% ) Reproductive system and breast disorders Reversible inhibition of spermatogenesis ( men ) Inhibition of ovulation and reversible infertility ( women )
Very common ( ≥10% ) Hepatobiliary disorders Elevated liver enzymes
Common ( ≥1% and < 10% ) Metabolism and nutrition disorders Weight gain or loss ( can be associated with fluid retention )
Common ( ≥1% and < 10% ) Psychiatric disorders Depressed mood Restlessness
Common ( ≥1% and < 10% ) Reproductive system and breast disorders Gynecomastia ( men ) Breast pain/tenderness Irregular menstruation
Common ( ≥1% and < 10% ) General disorders and administration site conditions Fatigue Hot flashes Sweating
Common ( ≥1% and < 10% ) Respiratory , thoracic , and mediastinal disorders Shortness of breath
Common ( ≥1% and < 10% ) Gastrointestinal disorders Nausea Gastrointestinal complaints
Uncommon ( ≥0.1% and < 1% ) Psychiatric disorders Decreased libido ( women )
Uncommon ( ≥0.1% and < 1% ) Skin and subcutaneous tissue disorders Rash
Rare ( ≥0.01% and < 0.1% ) Immune system disorders Hypersensitivity reactions ( rash , itching , shortness of breath )
Rare ( ≥0.01% and < 0.1% ) Psychiatric disorders Increased libido ( women )
Very rare ( < 0.01% ) Neoplasms benign and malignant Benign and malignant liver tumors
Very rare ( < 0.01% ) Musculoskeletal and connective tissue disorders Osteoporosis
Very rare ( < 0.01% ) Cardiovascular disorders Thromboembolic events Tachycardia
Very rare ( < 0.01% ) Reproductive system and breast disorders Galactorrhea
Very rare ( < 0.01% ) General disorders and administration site conditions Sleep disturbances
Unspecified Unsorted Anemia Meningioma Hyperprolactinemia Prolactinoma Intra-abdominal hemorrhage Breast tension Menstrual spotting Low Dysmenorrhea Vaginal discharge Skin discoloration Stretch marks Rare Liver toxicity ( including jaundice , hepatitis , liver failure )
N/A