List of largest selling pharmaceutical products
Rank Drug Trade name Type Main indications Company Sales ( USD millions/year ) ∆ vs 2014
1 Adalimumab Humira Biologic Rheumatoid arthritis AbbVie Inc 14,012 1,469
2 Ledipasvir/sofosbuvir Harvoni Small molecule Hepatitis C Gilead Sciences 13,864 11,737
3 Etanercept Enbrel Biologic Rheumatoid arthritis Amgen Pfizer 8,697 4,009
4 Infliximab Remicade Biologic Crohn 's Disease Rheumatoid Arthritis Johnson & Johnson 8,355 1,487
5 Rituximab Mabthera Rituxan Biologic Lymphoma Leukemia Autoimmune disorders Roche 7,115 1,456
6 Insulin glargine Lantus Biologic Diabetes mellitus Sanofi 7,029 51
7 Bevacizumab Avastin Biologic Metastatic cancers Roche 6,751 270
8 Trastuzumab Herceptin Biologic Breast cancer Roche 6,603 265
9 Lenalidomide Revlimid Small molecule Multiple myeloma Myelodysplastic syndromes Celgene 5,801 821
10 Sofosbuvir Sovaldi Small molecule Hepatitis C Gilead Sciences 5,276 ( 5,007 )
11 Fluticasone propionate/salmeterol Seretide Advair Small molecule Asthma Chronic obstructive pulmonary disease GlaxoSmithKline 5,227 ( 778 )
12 Rosuvastatin Crestor Small molecule Cardiovascular diseases AstraZeneca 5,017 ( 495 )
Largest selling pharmaceutical products of 2015
Drugs with sales above $ 5 billion in 2015 included : [ 2 ]