Minecraft wiki entry for Combat, associated text: Splash potions can be a lot of help to hinder their foe or dealing damage, but use them sparingly. Remember that there is a big difference between throwing a splash potion of damage at one mob than at a group of mobs. Another good strategy is to know some potions. Splash potions of Healing or Regeneration can let you get closer to zombies or zombie pigmen and receive the Healing or Regeneration boost while damaging your target. Splash potions that have increased time make for hit and run tactics, a good strategy if the player are low on health. If they are being chased by a group of hostile mobs and you have a splash potion of Instant damage, remember that you still take damage from splash potions. Use the Knockback from the potion to take shortcuts or get over walls two blocks high.