Minecraft wiki entry for Pufferfish_(item), associated text: The consumption of pufferfish inflicting the player with Nausea and Poison is based on reality. Real pufferfish contain the dangerous tetrodotoxin within their organs, especially in the liver. Tetrodotoxin leads to quick death through respiratory paralysis. Muscle tissue and blood contain trace amounts. In East Asia, pufferfish are considered a delicacy known as fugu, as small parts of the fish are actually edible. Any chef preparing fugu must have special licensing/certification to prepare this dish.