add a variety of vitamins to the supplement test the supplement on mice in the laboratory develop packaging that is attractive to women test the supplement on a larger sample of women
I am hesitating between 4 options to answer the following question, which option should I choose?
Question: A dietary supplement manufacturer developed a new calcium supplement that appears to increase the bone density in middle-aged women. When tested in a small clinical trial, the supplement was shown to cause a 15% increase in bone density in 8 out of 10 women. Before the supplement is offered to the general public, which step should the manufacturer take next?
Possibilities:
- add a variety of vitamins to the supplement
- test the supplement on mice in the laboratory
- develop packaging that is attractive to women
- test the supplement on a larger sample of women

test the supplement on a larger sample of women