Provide your best answer for the following question. Give ONLY the answer, no other words or explanation.
For example:

Answer: <most likely answer, as short as possible; not a complete sentence, just the answer!>.

The question is: Of the examples listed, which event is thought by scientists to have led to the greatest extinction?
whalers of the 17th, 18th, and 19th centuries
The end-Permian extinction.