Read the following paragraph and answer the question. Give ONLY the answer, no other words or explanation.

For example:

Answer: <most likely answer, as short as possible>.

Paragraph: I had a neurology appointment today . After the usual poking and prodding ( I have lost ten pounds because of the drugs ) I got to talk to my doctor and hear a phrase you never want to hear in medicine , " uh - oh . " We were talking about the fact I am having seizures daily still after trying 4 medicines . Several of these medicines have been at the safest highest dose .

Question: What might be the reason why the doctor said uh - oh ?
My treatment is not going well .
The patient is experiencing daily seizures despite trying several medicines at their safest, highest doses.