After oral ingestion, glycyrrhizin is first hydrolysed to 18b-glycyrrhetinic acid by intestinal bacteria, and after complete absorption from gut, 18beta-glycyrrhetinic acid is metabolised to 3beta-monoglucuronyl-18beta-glycyrrhetinic acid in the liver.
After complete absorption from the gut, β-glycyrrhetinic acid is metabolized to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver. After oral ingestion, glycyrrhizin is first hydrolyzed to 18β-glycyrrhetinic acid by intestinal bacteria.
After oral ingestion, glycyrrhizin is first hydrolyzed to 18β-glycyrrhetinic acid by intestinal bacteria. After complete absorption from the gut, β-glycyrrhetinic acid is metabolized to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver.
After oral ingestion, glycyrrhizin is first hydrolyzed to 18β-glycyrrhetinic acid by intestinal bacteria. After complete absorption from the gut, β-glycyrrhetinic acid is metabolized to 3β-monoglucuronyl-18β-glycyrrhetinic acid in the liver.