MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors in Lynch syndrome are caused by germline mutations in MLH 1, MSH 2, MSH 6, and PMS2.
Whereas, MSI tumors in Lynch Syndrome are caused by germline mutations in MLH 1, MSH 2, MSH 6 and PMS2. MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter.
MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter. Whereas, MSI tumors in Lynch Syndrome are caused by germline mutations in MLH 1, MSH 2, MSH 6 and PMS2.
MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter. Whereas, MSI tumors in Lynch Syndrome are caused by germline mutations in MLH 1, MSH 2, MSH 6 and PMS2.