In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: We conclude that CyS2010 is essential for normal dimerization of vWF subunits through disulfide bonding of carboxyl - terminal domains and that a heterozygous mutation in the corresponding codon is responsible for defective multimer formation in type IID von Willebrand disease . .
### Output Text:
We conclude that CyS2010 is essential for normal dimerization of vWF subunits through disulfide bonding of carboxyl - terminal domains and that a heterozygous mutation in the corresponding codon is responsible for defective multimer formation in <span class="disease">type IID von Willebrand disease</span> . . 