In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Both BRCA1 and the granins localize to secretory vesicles , are secreted by a regulated pathway , are post - translationally glycosylated and are responsive to hormones .
### Output Text:
Both BRCA1 and the granins localize to secretory vesicles , are secreted by a regulated pathway , are post - translationally glycosylated and are responsive to hormones . 