In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Wiskott - Aldrich syndrome protein , a novel effector for the GTPase CDC42Hs , is implicated in actin polymerization .
### Output Text:
<span class="disease">Wiskott - Aldrich syndrome</span> protein , a novel effector for the GTPase CDC42Hs , is implicated in actin polymerization . 