In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The high frequencies of disease - associated alleles in the general population suggest that IDDM2 locus is not responsible for the low incidence of IDDM in Japanese .
### Output Text:
The high frequencies of disease - associated alleles in the general population suggest that IDDM2 locus is not responsible for the low incidence of <span class="disease">IDDM</span> in Japanese . 