In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Many different mutations occur in BRCA1 , including several examples of recurrent mutations , each of which accounts for a significant number of families with heritable cancer predisposition .
### Output Text:
Many different mutations occur in BRCA1 , including several examples of recurrent mutations , each of which accounts for a significant number of families with heritable <span class="disease">cancer</span> predisposition . 