In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Therefore , disease - causing mutations at CpGs in RB1 appear to be determined by several factors , including the constitutive presence of DNA methylation at cytosines within CpGs , the specific codon within which the methylated cytosine is located , and the particular region of the gene within which that codon resides . .
### Output Text:
Therefore , disease - causing mutations at CpGs in RB1 appear to be determined by several factors , including the constitutive presence of DNA methylation at cytosines within CpGs , the specific codon within which the methylated cytosine is located , and the particular region of the gene within which that codon resides . . 