In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The hereditary breast and ovarian cancer gene , BRCA1 , encodes a large polypeptide that contains the cysteine - rich RING motif , a zinc - binding domain found in a variety of regulatory proteins .
### Output Text:
The <span class="disease">hereditary breast and ovarian cancer</span> gene , BRCA1 , encodes a large polypeptide that contains the cysteine - rich RING motif , a zinc - binding domain found in a variety of regulatory proteins . 