In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Mutations in ASPA that lead to loss of enzymatic activity have been identified , and E285A and Y231X are the two predominant mutations that account for 97 % of the mutant chromosomes in Ashkenazi Jewish patients .
### Output Text:
Mutations in ASPA that lead to loss of enzymatic activity have been identified , and E285A and Y231X are the two predominant mutations that account for 97 % of the mutant chromosomes in Ashkenazi Jewish patients . 