In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Immune defects also are evident in ATM - / - mice , including reduced numbers of B220 + CD43 - pre - B cells , thymocytes , and peripheral T cells , as well as functional impairment of T - cell - dependent immune responses .
### Output Text:
<span class="disease">Immune defects</span> also are evident in ATM - / - mice , including reduced numbers of B220 + CD43 - pre - B cells , thymocytes , and peripheral T cells , as well as functional impairment of T - cell - dependent immune responses . 