In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Subsequent molecular biology , biosynthetic , and immunofluorescence studies demonstrated that C2 secretion is impaired in Type II C2 deficiency because of different missense mutations at highly conserved residues in each of the C2Q0 alleles .
### Output Text:
Subsequent molecular biology , biosynthetic , and immunofluorescence studies demonstrated that C2 secretion is impaired in <span class="disease">Type II C2 deficiency</span> because of different missense mutations at highly conserved residues in each of the C2Q0 alleles . 