In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Nine different germ - line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47 kindreds from southern Sweden , by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein - truncation test for exon 11 , followed by direct sequencing .
### Output Text:
Nine different germ - line mutations in the BRCA1 <span class="disease">breast and ovarian cancer</span> susceptibility gene were identified in 15 of 47 kindreds from southern Sweden , by use of SSCP and heteroduplex analysis of all exons and flanking intron region and by a protein - truncation test for exon 11 , followed by direct sequencing . 