In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The characteristic Duarte isoform is also associated with a variant called the " Los Angeles ( LA ) phenotype , " which has increased GALT enzyme activity .
### Output Text:
The characteristic Duarte isoform is also associated with a variant called the " Los Angeles ( LA ) phenotype , " which has increased GALT enzyme activity . 