In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Although the doubly - deficient mice excrete adenine and its highly insoluble derivative , 2 , 8 - dihydroxyadenine , which are also associated with human APRT deficiency , additional abnormalities or any self - injurious behavior were not detected .
### Output Text:
Although the doubly - deficient mice excrete adenine and its highly insoluble derivative , 2 , 8 - dihydroxyadenine , which are also associated with human <span class="disease">APRT deficiency</span> , additional abnormalities or any self - injurious behavior were not detected . 