In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The predicted PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin , a protein that interacts with actin filaments at focal adhesions .
### Output Text:
The predicted PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin , a protein that interacts with actin filaments at focal adhesions . 