In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The set of 32 families in which no BRCA1 alterations were detected included 1 breast - ovarian cancer kindred manifesting clear linkage to the BRCA1 region and loss of the wild - type chromosome in associated tumors .
### Output Text:
The set of 32 families in which no BRCA1 alterations were detected included 1 <span class="disease">breast - ovarian cancer</span> kindred manifesting clear linkage to the BRCA1 region and loss of the wild - type chromosome in associated <span class="disease">tumors</span> . 