In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: An exception is BRCA1 , which contributes to a significant fraction of familial breast and ovarian cancer , but undergoes mutation at very low rates in sporadic breast and ovarian cancers .
### Output Text:
An exception is BRCA1 , which contributes to a significant fraction of <span class="disease">familial breast and ovarian cancer</span> , but undergoes mutation at very low rates in <span class="disease">sporadic breast and ovarian cancers</span> . 