In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: A cell line has been established from the tumour of the proband and cytogenetic and molecular studies carried out , providing an extensive analysis in this family . .
### Output Text:
A cell line has been established from the <span class="disease">tumour</span> of the proband and cytogenetic and molecular studies carried out , providing an extensive analysis in this family . . 