In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: We conclude that the codon change N314D in cis with the base - pair transition 1721C - - > T produces the LA variant of galactosemia and that this nucleotide change increases GALT activity by increasing GALT protein abundance without increasing transcription or decreasing thermal lability .
### Output Text:
We conclude that the codon change N314D in cis with the base - pair transition 1721C - - > T produces the <span class="disease">LA variant of galactosemia</span> and that this nucleotide change increases GALT activity by increasing GALT protein abundance without increasing transcription or decreasing thermal lability . 