In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Somatic mutations were not detected in any of the tumours studied , and the present data do not provide support for somatic ESR base mutations as an important mechanism for hormonal therapy resistance in estrogen receptor - positive breast carcinomas . .
### Output Text:
Somatic mutations were not detected in any of the <span class="disease">tumours</span> studied , and the present data do not provide support for somatic ESR base mutations as an important mechanism for hormonal therapy resistance in <span class="disease">estrogen receptor - positive breast carcinomas</span> . . 