In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Only one of the two male breast cancer patients carrying a BRCA2 mutation had a family history of cancer , with one case of ovarian cancer in a first - degree relative .
### Output Text:
Only one of the two <span class="disease">male breast cancer</span> patients carrying a BRCA2 mutation had a family history of <span class="disease">cancer</span> , with one case of <span class="disease">ovarian cancer</span> in a first - degree relative . 