In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Five were splice site mutations ( one in the donor site of intron 4 , two in the donor site of intron 6 , one in each of the acceptor sites of introns 8 and 9 ) and five were nonsense mutations in exons 8 , 9 , 10 , 11 , and 12 .
### Output Text:
Five were splice site mutations ( one in the donor site of intron 4 , two in the donor site of intron 6 , one in each of the acceptor sites of introns 8 and 9 ) and five were nonsense mutations in exons 8 , 9 , 10 , 11 , and 12 . 