In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: In the four polymorphic variants that have two point mutations , one of the mutations is always 376 A - - > G ( 126 Asn - - > Asp ) , which on its own gives rise to the nondeficient polymorphic variant , G6PD A .
### Output Text:
In the four polymorphic variants that have two point mutations , one of the mutations is always 376 A - - > G ( 126 Asn - - > Asp ) , which on its own gives rise to the nondeficient polymorphic variant , G6PD A . 