In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Six single - base changes leading to missense mutations were identified in patients from Turkey ( D114E , R168C ) , The Netherlands ( I16T ) , Germany ( G27R ) , Ireland ( C152Y ) , and Canada ( G123E ) .
### Output Text:
Six single - base changes leading to missense mutations were identified in patients from Turkey ( D114E , R168C ) , The Netherlands ( I16T ) , Germany ( G27R ) , Ireland ( C152Y ) , and Canada ( G123E ) . 