In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Administration of drugs that inhibit adenine phosphoribosyltransferase ( APRT ) in HPRT - deficient mice has produced the suggestion that deficiency of APRT in combination with HPRT - deficiency in mice may lead to self - mutilation behavior [ C . L . Wu and D . W . Melton ( 1993 ) Nature Genet . 3 , 235 - 240 ] .
### Output Text:
Administration of drugs that inhibit adenine phosphoribosyltransferase ( APRT ) in <span class="disease">HPRT - deficient</span> mice has produced the suggestion that <span class="disease">deficiency of APRT</span> in combination with <span class="disease">HPRT - deficiency</span> in mice may lead to self - mutilation behavior [ C . L . Wu and D . W . Melton ( 1993 ) Nature Genet . 3 , 235 - 240 ] . 