In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Defective dimerization of von Willebrand factor subunits due to a Cys - > Arg mutation in type IID von Willebrand disease .
### Output Text:
Defective dimerization of <span class="disease">von Willebrand</span> factor subunits due to a Cys - > Arg mutation in <span class="disease">type IID von Willebrand disease</span> . 