In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Finally , this report provides a widely applicable strategy which ensures fast and effective screening for intronic defects that underlie differential gene expression . .
### Output Text:
Finally , this report provides a widely applicable strategy which ensures fast and effective screening for intronic defects that underlie differential gene expression . . 