In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: These data functionally define a novel genetic locus , designated PAC1 , for prostate adenocarcinoma 1 , involved in tumor suppression of human prostate carcinoma and furthermore strongly suggest that the cell death pathway can be functionally restored in prostatic adenocarcinoma . .
### Output Text:
These data functionally define a novel genetic locus , designated PAC1 , for prostate adenocarcinoma 1 , involved in tumor suppression of human <span class="disease">prostate carcinoma</span> and furthermore strongly suggest that the cell death pathway can be functionally restored in <span class="disease">prostatic adenocarcinoma</span> . . 