In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Similarly , while the cumulative data revealed a predominance of missense mutations among the WASP gene lesions observed in boys with isolated thrombocytopenia , missense mutations were not exclusively associated with milder WAS phenotypes , but also comprised a substantial portion ( 38 % ) of the WASP gene defects found in patients with severe disease .
### Output Text:
Similarly , while the cumulative data revealed a predominance of missense mutations among the WASP gene lesions observed in boys with <span class="disease">isolated thrombocytopenia</span> , missense mutations were not exclusively associated with milder <span class="disease">WAS</span> phenotypes , but also comprised a substantial portion ( 38 % ) of the WASP gene defects found in patients with severe disease . 