In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Thus , APRT - HPRT - deficient mice , which are devoid of any purine salvage pathways , show no novel phenotype and are not a model for the behavioral abnormalities associated with the Lesch - Nyhan syndrome as previously suggested
### Output Text:
Thus , <span class="disease">APRT - HPRT - deficient</span> mice , which are devoid of any purine salvage pathways , show no novel phenotype and are not a model for the <span class="disease">behavioral abnormalities</span> associated with the <span class="disease">Lesch - Nyhan syndrome</span> as previously suggested 