In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Ten of the possible 12 mutations in the five familial cases and five of the sporadic patients were found , all of which conformed to a functional outcome of haploinsufficiency .
### Output Text:
Ten of the possible 12 mutations in the five familial cases and five of the sporadic patients were found , all of which conformed to a functional outcome of haploinsufficiency . 