In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Rapid detection of regionally clustered germ - line BRCA1 mutations by multiplex heteroduplex analysis .
### Output Text:
Rapid detection of regionally clustered germ - line BRCA1 mutations by multiplex heteroduplex analysis . 