In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Recent studies suggest that vascular endothelial growth factor ( VEGF ) mRNA is upregulated in RCC - and von Hippel - Lindau disease - associated tumors .
### Output Text:
Recent studies suggest that vascular endothelial growth factor ( VEGF ) mRNA is upregulated in <span class="disease">RCC - and von Hippel - Lindau disease - associated tumors</span> . 