In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: A high prevalence of two different CETP gene mutations ( D442G , 5 . 1 % ; intron 14G A , 0 . 5 % ) , was found in 3 , 469 men of Japanese ancestry in the Honolulu Heart Program and mutations were associated with decreased CETP ( - 35 % ) and increased HDL chol levels ( + 10 % for D442G ) .
### Output Text:
A high prevalence of two different CETP gene mutations ( D442G , 5 . 1 % ; intron 14G A , 0 . 5 % ) , was found in 3 , 469 men of Japanese ancestry in the Honolulu Heart Program and mutations were associated with decreased CETP ( - 35 % ) and increased HDL chol levels ( + 10 % for D442G ) . 