In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: When these data were combined with the results of our previous investigations , mutations were identified in a total of 99 ( 83 % ) of 119 patients .
### Output Text:
When these data were combined with the results of our previous investigations , mutations were identified in a total of 99 ( 83 % ) of 119 patients . 