In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: These results suggest that even in a referral clinic specializing in screening women from high - risk families , the majority of tests for BRCA1 mutations will be negative and therefore uninformative . .
### Output Text:
These results suggest that even in a referral clinic specializing in screening women from high - risk families , the majority of tests for BRCA1 mutations will be negative and therefore uninformative . . 