In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Furthermore , the complemented hybrids undergo programmed cell death in vitro via a mechanism that does not require nuclear localization of p53 .
### Output Text:
Furthermore , the complemented hybrids undergo programmed cell death in vitro via a mechanism that does not require nuclear localization of p53 . 