In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The family does not appear to be remarkable in the spectrum of tumours , and there is loss of the wild - type allele in a leiomyosarcoma from the proband .
### Output Text:
The family does not appear to be remarkable in the spectrum of <span class="disease">tumours</span> , and there is loss of the wild - type allele in a <span class="disease">leiomyosarcoma</span> from the proband . 