In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: However , in the 229 female controls in whom family history of cancer was known , one of two who had a sister with breast cancer was carrying the variant allele .
### Output Text:
However , in the 229 female controls in whom family history of <span class="disease">cancer</span> was known , one of two who had a sister with <span class="disease">breast cancer</span> was carrying the variant allele . 