In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: The 6174delT mutation in BRCA2 was recently identified as a frequent mutation in 8 out of 107 Ashkenazi Jewish women diagnosed with breast cancer by age 50 ( ref . 8 ) , as well as in three Ashkenazi male breast cancer patients .
### Output Text:
The 6174delT mutation in BRCA2 was recently identified as a frequent mutation in 8 out of 107 Ashkenazi Jewish women diagnosed with <span class="disease">breast cancer</span> by age 50 ( ref . 8 ) , as well as in three Ashkenazi <span class="disease">male breast cancer</span> patients . 