In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: G6PD Malaga is associated with enzyme deficiency ( class III ) , and the enzymic properties of G6PD Malaga and G6PD Santamaria are quite similar , indicating that in this case the effects of the two mutations are additive rather than synergistic .
### Output Text:
G6PD Malaga is associated with <span class="disease">enzyme deficiency</span> ( class III ) , and the enzymic properties of G6PD Malaga and G6PD Santamaria are quite similar , indicating that in this case the effects of the two mutations are additive rather than synergistic . 