In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Here , we report that a mutation predicting the substitution of Gly 230 by glutamic acid ( G230E ) between segments D3 and D4 dramatically alters the pore properties of a recombinant human muscle Cl - channel ( hCIC - 1 ) expressed in a mammalian cell line ( tsA201 ) .
### Output Text:
Here , we report that a mutation predicting the substitution of Gly 230 by glutamic acid ( G230E ) between segments D3 and D4 dramatically alters the pore properties of a recombinant human muscle Cl - channel ( hCIC - 1 ) expressed in a mammalian cell line ( tsA201 ) . 