In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: wt - VHL protein inhibited VEGF promoter activity in a dose - dependent manner up to 5 - to 10 - fold .
### Output Text:
wt - VHL protein inhibited VEGF promoter activity in a dose - dependent manner up to 5 - to 10 - fold . 