In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: In particular , a significant proportion of disease - causing mutations results in the premature termination of protein synthesis , and the majority of these mutations occur as C - - > T transitions at CpG dinucleotides ( CpGs ) .
### Output Text:
In particular , a significant proportion of disease - causing mutations results in the premature termination of protein synthesis , and the majority of these mutations occur as C - - > T transitions at CpG dinucleotides ( CpGs ) . 