In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Two male breast cancer patients ( 4 % of the total ) were found to carry novel truncating mutations in the BRCA2 gene .
### Output Text:
Two <span class="disease">male breast cancer</span> patients ( 4 % of the total ) were found to carry novel truncating mutations in the BRCA2 gene . 