In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Finally - and in contrast to prior predictions - atm and p53 do not appear to interact in acute radiation toxicity , suggesting a separate atm effector pathway for this DNA damage response and having implications for the prognosis and treatment of human tumours . .
### Output Text:
Finally - and in contrast to prior predictions - atm and p53 do not appear to interact in <span class="disease">acute radiation toxicity</span> , suggesting a separate atm effector pathway for this DNA damage response and having implications for the prognosis and treatment of human <span class="disease">tumours</span> . . 