In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: We identified a frameshift mutation in the 3 part of exon 15 , resulting in a stop codon at 1862 , in a large Dutch kindred with AAPC .
### Output Text:
We identified a frameshift mutation in the 3 part of exon 15 , resulting in a stop codon at 1862 , in a large Dutch kindred with <span class="disease">AAPC</span> . 