In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: 43 in men with mutations ( P < . 05 ) ; after adjustment for CHD risk factors , the RR was 1 .
### Output Text:
43 in men with mutations ( P < . 05 ) ; after adjustment for <span class="disease">CHD</span> risk factors , the RR was 1 . 