In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: Eleven of the 15 kindreds manifesting BRCA1 mutations were breast - ovarian cancer families , several of them with a predominant ovarian cancer phenotype .
### Output Text:
Eleven of the 15 kindreds manifesting BRCA1 mutations were <span class="disease">breast - ovarian cancer</span> families , several of them with a predominant <span class="disease">ovarian cancer</span> phenotype . 