In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. 
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.

### Input Text: In all three siblings , we demonstrated the presence of anergic CD3 + CD4 - CD8 - ( double negative , [ DN ] ) T cells ; moreover , a chronic lymphocyte activation was found , as demonstrated by the presence of high levels of HLA - DR expression on peripheral CD3 + cells and by the presence of high levels of serum activation markers such as soluble interleukin - 2 receptor ( slL - 2R ) and soluble CD30 ( sCD30 ) . .
### Output Text:
In all three siblings , we demonstrated the presence of anergic CD3 + CD4 - CD8 - ( double negative , [ DN ] ) T cells ; moreover , a chronic lymphocyte activation was found , as demonstrated by the presence of high levels of HLA - DR expression on peripheral CD3 + cells and by the presence of high levels of serum activation markers such as soluble interleukin - 2 receptor ( slL - 2R ) and soluble CD30 ( sCD30 ) . . 