text: This process is made more efficient by a sliding clamp protein that prevents its central enzyme from dissociating from its substrate.
full_question: This process is made more efficient by a sliding clamp protein that prevents its central enzyme from dissociating from its substrate. In prokaryotes this process begins at ori sites. The mechanism of this process was determined by growing E. coli in a nitrogen-15 medium. This process was shown to be semiconservative by Meselson and Stahl and cannot occur without a primer. Okazaki fragments form on the lagging strand during this process since it only occurs in the "5-prime" to "3-prime" direction. This process that occurs during the S phase requires enzymes like ligase, helicase and DNA polymerase. For 10 points, name this process which creates a copy of the genome.
first_sentence: This process is made more efficient by a sliding clamp protein that prevents its central enzyme from dissociating from its substrate.