text: This interaction changes the refractive index of a thin gold film on which a molecule is immobilized with a Biacore sensor chip.
full_question: This interaction changes the refractive index of a thin gold film on which a molecule is immobilized with a Biacore sensor chip. Programs like Autodock simulate this interaction, which is screened by fragment-based lead discovery. Protein-directed dynamic combinatorial chemistry is a method used to optimize the strength of this interaction for molecules. The major uses of isothermal titration calorimetry and surface plasmon resonance are to test potential drugs for this non-enzymatic interaction, which is modeled by the MWC and Hill equations if it's cooperative. Affinity constants quantify the strength of this interaction, which is measured in saturation experiments that can be visualized on a Scatchard plot. For 10 points, name this physical interaction between a ligand and its receptor.
first_sentence: This interaction changes the refractive index of a thin gold film on which a molecule is immobilized with a Biacore sensor chip.
raw_answer: ligand binding [or binding to a receptor; prompt on protein-protein interaction or PPI or similar answers; anti-prompt on protein activation or inhibition or specific cases of binding; prompt on drug activity or related answers; do not accept "forming a bond", "bonding", or any answer about covalent bonding]