text: Enzymes that degrade this molecule can be inhibited by cilomilast and piclamilast.
full_question: Enzymes that degrade this molecule can be inhibited by cilomilast and piclamilast. This molecule activates the Rap guanine nucleotide exchange factors, which fall under the Epac family of proteins. Levels of this compound are increased by forskolin. This molecule binds to an enzyme that phosphorylates CREB, which then binds to this molecule's namesake "response element." This compound is degraded by phosphodiesterase 4. In E. coli, this molecule binds to its namesake receptor protein to regulate the lac operon. In signal transduction pathways, this molecule activates protein kinase A after the production of this molecule is catalyzed by adenylyl cyclase. For 10 points, name this "second messenger" derived from ATP.
first_sentence: Enzymes that degrade this molecule can be inhibited by cilomilast and piclamilast.
raw_answer: cyclic AMP [or cyclic adenosine monophosphate; or cAMP]