A Trofile assay distinguishes M and T-tropism based on receptors present on these cells' surfaces.
A Trofile assay distinguishes M and T-tropism based on receptors present on these cells' surfaces. The follicular type of these cells are CXCR5 and CXCR4 positive and localize to the Peyer's patches. Upon activation by Signal 1 and Signal 2, these cells secrete interleukin-2 but not perforin. The delta-32 mutation in the CCR5 gene greatly enhances (*) survival of these cells. When mature, all of these cells express CD4, the protein targeted by gp120, on their surfaces. A disease that primarily targets them commonly presents with Kaposi's sarcoma. These cells are activated by MHC class II on professional APCs such as dendritic cells, in contrast with their "cytotoxic" counterparts. For 10 points, name these T cells that are scarce in AIDS patients.
A Trofile assay distinguishes M and T-tropism based on receptors present on these cells' surfaces.
helper T cells [or helper T lymphocytes; or CD4+ cells; prompt on T cells or T lymphocytes]