The drug denosumab mimics a protein produced in this material that acts as a decoy receptor for RANKL (RANK-kull), and its formation is accompanied by increased expression of alkaline phosphatases.
The drug denosumab mimics a protein produced in this material that acts as a decoy receptor for RANKL (RANK-kull), and its formation is accompanied by increased expression of alkaline phosphatases. A class of critical TGF-beta growth factors are named for this substance's morphogenesis. Polynucleated cells with ruffled borders, found in depressions called Howship's (*) lacunae (lah-COO-nay), resorb this substance to increase blood calcium. Biomineralization to form this substance requires hydroxyapatite to be deposited in an organic matrix. Calcitonin is administered to treat a condition of this tissue named osteoporosis. For 10 points, name this hard connective tissue created by osteoblasts which makes up the skeleton.
The drug denosumab mimics a protein produced in this material that acts as a decoy receptor for RANKL (RANK-kull), and its formation is accompanied by increased expression of alkaline phosphatases.
bone tissue [or bone marrow]