Production of this molecule is increased by London and Arctic mutations and is diminished by an allele found in some Icelanders.
Production of this molecule is increased by London and Arctic mutations and is diminished by an allele found in some Icelanders. Site-specific levels of this molecule were integral to the now- discounted "peripheral sink" hypothesis. This molecule can be imaged with PET using Pittsburgh compound B. Its degradation is lowered in people with the ApoE epsilon 4 allele. A protein triplicated in Down syndrome is processed into C99 before being refined into this molecule. This 40- to 42-residue peptide is generated by PSEN1 in the gamma secretase complex following BACE-1 cleavage of the precursor protein APP. Cortical deposition of it accelerates tau propagation and formation of neurofibrillary tangles. For 10 points, name this peptide that comprises the insoluble plaques seen in Alzheimer's disease.
Production of this molecule is increased by London and Arctic mutations and is diminished by an allele found in some Icelanders.
amyloid beta [or beta-amyloid; prompt on plaque; prompt on amyloid precursor protein or APP until "peripheral" is read]