A glutamine-to-leucine mutation in the P-loop of these proteins can cause type 2A Charcot- Marie-Tooth disease.
A glutamine-to-leucine mutation in the P-loop of these proteins can cause type 2A Charcot- Marie-Tooth disease. One class of these proteins contains a KVD finger in its loop 2 domain. Whether the critical functional domain of these proteins is in the middle or the end of their amino acid sequence determines whether they are C, N, or M-type. A "bipolar" one of these proteins called Eg5 is critical for the splitting of sister chromatids. The "conventional" type of these proteins contains an alpha-helical coiled-coil "stalk" domain bound to two light chains, whose TPR domains are important in cargo binding. These proteins utilize ATP hydrolysis to move in the anterograde direction, such as down the axon toward the synapse. For 10 points, name this class of two-footed motor proteins which carry proteins toward the plus ends of microtubules, in the opposite direction to dyneins.
A glutamine-to-leucine mutation in the P-loop of these proteins can cause type 2A Charcot- Marie-Tooth disease.
 kinesins