In S. cerevisiae, the ARO4 gene codes for a form of DAHP synthase that is inhibited by this compound.
In S. cerevisiae, the ARO4 gene codes for a form of DAHP synthase that is inhibited by this compound. This is the second-heaviest of the three compounds that can be formed from chorismate at the end of the shikimate pathway. One protein whose functionality relies on this residue is blocked by imatinib, and another group of proteins utilizing it form a signaling pathway with STAT. This residue helps cut the DNA helix at the catalytic site of topoisomerases. The Bcr-Abl protein produced by the Philadelphia chromosome and the Janus proteins are examples of kinases named for this amino acid. An A-A-A-H synthesizes this amino acid by hydroxylating phenylalanine. For 10 points, identify this precursor to dopamine, an amino acid with a phenol side chain.
In S. cerevisiae, the ARO4 gene codes for a form of DAHP synthase that is inhibited by this compound.
tyrosine [prompt on Y]