Metastasized cancers of this organ can be treated with a combination of irinotecan,
Metastasized cancers of this organ can be treated with a combination of irinotecan, 5- fluorouracil, and leucovorin, a combination termed FOLFIRI. ["FOAL-fear-ee"] Oxaliplatin can also be used to treat cancer in this organ, whose staging can be described using the modified Astler-Coller or the Dukes classifications. A mutation in MSH2, MYH1, or MSH6 increases the chance of cancer in this organ; that condition can be diagnosed by finding microsatellite instability and is called Lynch syndrome. Adenomas of this organ come in serrated, tubular, villous, and tubulovillous types, depending on the shape of their polyps. This is the most common organ whose walls can form inflamed pouches, a disorder called diverticulitis. Haustral churning mixes the contents of this organ, which contains 4 regions termed sigmoid, transverse, ascending, and descending. The ileocecal valve is the entrance to, for 10 points, what digestive organ whose final section is the rectum?
Metastasized cancers of this organ can be treated with a combination of irinotecan,
large intestine [accept  colon or rectum, prompt on "bowel" or "intestine"]