Shugoshin protects Rec8 from degradation during this process.
Shugoshin protects Rec8 from degradation during this process. Mad proteins and Aurora B prevent entry into this process by detecting tension in syntelic (SIN-tel-ick) or merotelic (MERE-oh-tel-ick) attachments. Cdc20 binds a protein complex named for this process. This process proceeds by the proteasomal degradation of securin by the E3 ubiquitin (you-BICK-wit-en) ligase activity of APC/C. Transition to this stage involves cleavage of cohesin after the cell passes the (*) spindle assembly checkpoint. During this phase, polar microtubules lengthen and kinetochore (kin-ET-oh-core) microtubules contract to separate sister chromatids, pulling the chromosomes to opposite sides of the cell. The stage after this one is when the cleavage furrow begins to form in mitosis. For 10 points, name this stage that precedes telophase and follows metaphase.
Shugoshin protects Rec8 from degradation during this process.
anaphase [or anaphase I; or anaphase II; or metaphase-to-anaphase transition; prompt on mitosis; prompt on meiosis]