This functional group can be created from alkyl aryl ketones and ammonium polysulfide in the Willgerodt rearrangement, and they can also be synthesized using Grignard reagents in the Bodroux reaction.
This functional group can be created from alkyl aryl ketones and ammonium polysulfide in the Willgerodt rearrangement, and they can also be synthesized using Grignard reagents in the Bodroux reaction. A multicomponent method used to synthesize these relies on an irreversible Mumm rearrangement, called the Ugi reaction. One reaction involving these compounds evolves carbon dioxide after reacting them with bromide and sodium hydroxide, creating a product that retains stereochemistry. Cyclic ones are called lactams, and SDS-PAGE gels are created by crosslinking the acryl version of this functional group. These compounds are transformed into an amine by the aforementioned Hoffman rearrangement, and lithium aluminum hydride reduces them to amines. For 10 points, name these compounds that contain a carbonyl bound to an NH2 unit.
This functional group can be created from alkyl aryl ketones and ammonium polysulfide in the Willgerodt rearrangement, and they can also be synthesized using Grignard reagents in the Bodroux reaction.
{Amides}