This amino acid is replaced with aspartic acid in the Hiroshima variant of hemoglobin, causing a decrease in the efficacy of the Bohr effect.
This amino acid is replaced with aspartic acid in the Hiroshima variant of hemoglobin, causing a decrease in the efficacy of the Bohr effect. Three residues of this amino acid coordinate the central zinc cation in the active site of carbonic anhydrase. This amino acid is phosphorylated by ATP in bacterial two-component regulatory systems. Mutations in bacteria that cannot synthesize this amino acid are central to the Ames test. It is not tryptophan, but this amino acid's side chain is aromatic and has a pKa of 6. Besides aspartate and their namesake, serine proteases contain this amino acid in their catalytic triad. For 10 points, name this barely-basic amino acid with an imidazole side chain.
This amino acid is replaced with aspartic acid in the Hiroshima variant of hemoglobin, causing a decrease in the efficacy of the Bohr effect.
histidine [or His]