Li and Cai have used it to synthesize peptides with tetrahedral phosphorous molecules, which have the potential to act as enzyme inhibitors.
Li and Cai have used it to synthesize peptides with tetrahedral phosphorous molecules, which have the potential to act as enzyme inhibitors. One variation of it that uses hydrophosphoryl compounds is the Kabachnick- Fields reaction, while a ring-forming variant of it is the Pictet-Spengler reaction. An asymmetric version of it uses a proline catalyst, which blocks attack from the Re face in its second step. In the first step, a primary or secondary amine attacks formaldehyde and eliminates the resulting hydroxyl group, forming a Schiff base. This is followed by the abstraction of an acidic alpha-hydrogen and formation of a carbon-carbon bond. FTP, name this organic reaction that forms a beta-amino-carbonyl, named for a German chemist.
Li and Cai have used it to synthesize peptides with tetrahedral phosphorous molecules, which have the potential to act as enzyme inhibitors.
{Mannich} reaction