Ayers derivation of this theory used the fact that a certain exchange reaction was endothermic, and Kornblum's rule for ambident nucleophiles follows from it.
Ayers derivation of this theory used the fact that a certain exchange reaction was endothermic, and Kornblum's rule for ambident nucleophiles follows from it. One equation related to this theory is used to find the enthalpy change in terms of electrostatic and covalent interactions, the Drago-Wayland formula. Parr's quantitative version of it sets a parameter eta equal to the second derivative of total energy over electron number, and MO theory predicts that a chemical system will seek to maximize said parameter. The Fukui function can be used to evaluate reactivity under this theory, which makes sense since this theory sorts molecules by their HOMO-LUMO gap. A test for sorting molecules under it reacts them with methylmercury ion, and this theory is used to explain why adding iodide to AgCl precipitates silver iodide and why carbon monoxide reacts with nickel over hydrogen. Sorting species in terms of polarizibility, for 10 points, identify this theory developed by Ralph Pearson, which sorts acids and bases into those that are small with high charge states and those that are big with low charge states.
Ayers derivation of this theory used the fact that a certain exchange reaction was endothermic, and Kornblum's rule for ambident nucleophiles follows from it.
Pearson’s {Hard-Soft} Acid Base or {HS}AB