PALB2 binds to a protein coded for by one of these genes. That protein regulates localization and DNA binding in RAD51.
PALB2 binds to a protein coded for by one of these genes. That protein regulates localization and DNA binding in RAD51. Phosphatase and tensin homolog is one of these genes that functions by removing membrane localization factors for Akt. One hypothesis about these genes states that mutations in them are recessive, and thus both need to be mutated for loss of function. That (*) "two-hit hypothesis" was proposed by Alfred Knudson after his work on RB1. In addition to the BRCA genes, another of this type of gene leads to LiFraumeni syndrome when mutated and is sometimes called the guardian of the cell; that gene is TP53. For 10 points, identify this class of genes that prevent cancerous cell behavior, and when mutated can lead to cancer.
PALB2 binds to a protein coded for by one of these genes. That protein regulates localization and DNA binding in RAD51.
tumor-suppressor gene (accept anti-oncogene)