Chemotherapy drugs like irinotecan and teniposide work by inhibiting this class of enzymes.
Chemotherapy drugs like irinotecan and teniposide work by inhibiting this class of enzymes. Type IIB is generally found only in archaea and some higher plants. This enzyme works by forming a covalent linkage between its catalytic tyrosine and either the 5-prime or 3-prime phosphoryl group of its target molecule. Type IIA includes the most popular variety known as gyrase. Use of this enzyme is not ATP-dependent, rather relying on the torque present in DNA to drive the uncoiling. FTP, identify this enzyme that catalyzes the unknotting of strands in DNA replication.
Chemotherapy drugs like irinotecan and teniposide work by inhibiting this class of enzymes.
{topoisomerase}