This is the most well-known virus to contain the protein Vif, which induces APOBEC3G degradation bythe ubiquitination-dependent proteasomal pathway.
This is the most well-known virus to contain the protein Vif, which induces APOBEC3G degradation bythe ubiquitination-dependent proteasomal pathway. The LTR of this virus contains the TAR element, whichis bound to by tat to cancel its effect. A 32-base pair deletion in a gene encoding a coreceptor of this virusconfers partial resistance to it. Important antigens of this virus include p24, p51 and gp41. One model forstudying this disease is the SCID mouse-human lymphoid cell chimera. This virus requires the coreceptorsCXCR4, in some cases, or CCR5 to infect cells. The most effective treatment for this disease is HAART.The glycoprotein gp120 on the envelope of this lentivirus binds to cells with CD4 on their surface. For 10points, identify this retrovirus that does, in fact, cause AIDS.
This is the most well-known virus to contain the protein Vif, which induces APOBEC3G degradation bythe ubiquitination-dependent proteasomal pathway.
HIV [or human immunodeficiency virus]