After myristate anchors ARF to the Golgi, the binding of this molecule to ARF allows that protein to insert its N-terminal domain into the bilayer, which is a vital step in COPI ["cop one"] and clathrin assembly.
After myristate anchors ARF to the Golgi, the binding of this molecule to ARF allows that protein to insert its N-terminal domain into the bilayer, which is a vital step in COPI ["cop one"] and clathrin assembly. The Sec12 exchange factor plugs this molecule into Sar1, which allows Sec23/Sec24 coat proteins to form the COPII coat. It is used by eIF2 and eIF5 in translation, while Rho uses it to regulate actin polymerization, and it also caps stable microtubules. The nuclear transport protein Ran and the MAP kinase activator Ras are active when bound to it, and it is generated by succinyl-CoA synthetase in the Krebs cycle. GAP hydrolyzes it, and GEF allows its exchange, especially in the regulation of certain namesake hetero-trimeric proteins. FTP, name this molecule containing a purine bound to 3 phosphoryl groups, similar to ATP.
After myristate anchors ARF to the Golgi, the binding of this molecule to ARF allows that protein to insert its N-terminal domain into the bilayer, which is a vital step in COPI ["cop one"] and clathrin assembly.
{GTP} [or {G}uanidine {T}ri{p}hosphate; or {G}uanosine