One possible diagnostic tool for this disease is Pittsburgh Compound B, a thioflavin derivative.
One possible diagnostic tool for this disease is Pittsburgh Compound B, a thioflavin derivative.Tissue from sufferers of this disease shows apple-green birefringence under polarized light afterCongo Red staining. Genetic forms of it are linked to mutations in the gamma-secretase complex, andit is also linked to the ApoE4 allele. One protein important in its pathogenesis is cleaved from APPand forms peptides between 39 and 42 amino acids long. Another key protein in this disease binds tomicrotubules and is named tau. Beta-amyloid (*) plaques are characteristic of this disease. It begins withloss of executive functions and loss of motor skill and memory is inevitable. For 10 points, name thisneurodegenerative disease named for a Frenchman.
One possible diagnostic tool for this disease is Pittsburgh Compound B, a thioflavin derivative.
Alzheimer's disease