Hydroxybenzotriazole is added in one part of this process to increase stereospecificity in a step which forms an O-acylisourea using a carbodiimide, such as DCC or DIC.
Hydroxybenzotriazole is added in one part of this process to increase stereospecificity in a step which forms an O-acylisourea using a carbodiimide, such as DCC or DIC. Another step of this process creates a dibenzofulvene intermediate after beta elimination activated by a weak base, typically piperidine. This process is terminated with the cleavage of an ester bond with trifluoroacetic acid. This procedure, developed by Robert Bruce (*) Merrifield, is characterized by repeated couplings of amines to carboxylic acids and deprotection of either t-BOC or Fmoc. This procedure begins by attaching a carboxylic acid to an insoluble bead, often polystyrene resin. For 10 points, name this procedure which assembles biological polymers by attaching amino acids onto a non-liquid support.
Hydroxybenzotriazole is added in one part of this process to increase stereospecificity in a step which forms an O-acylisourea using a carbodiimide, such as DCC or DIC.
solid-phase peptide synthesis (prompt on "SPPS")