The biosynthetic enzyme thiolase I catalyzes this reaction in the biosynthesis of molecules such as polyketides and fatty acids.
The biosynthetic enzyme thiolase I catalyzes this reaction in the biosynthesis of molecules such as polyketides and fatty acids. This reaction is drawn to completion by deprotonation of the active methylene (*) in the product by the ethoxide. Generally conducted by strong basic reagents such as NaOR, LDA, or MHMDS, its intermolecular version is called Dieckmann condensation. The key to this reaction is an enolate reacting with another molecule of the ester, forming an alkoxide intermediate which subsequently undergoes elimination to form a ketone carbonyl group and eventually, a beta- ketoester. FTP, name this nucleophilic acyl substitution reaction that is the ester analogue of Aldol condensation.
The biosynthetic enzyme thiolase I catalyzes this reaction in the biosynthesis of molecules such as polyketides and fatty acids.
{Claisen} condensation