The Grewe cyclization is central to Kenner Rice’s total synthesis of this compound, considered the only one remotely close to being synthetically viable. Robert Robinson’s proposed structure for this compound was confirmed after its 1952 total synthesis by Marshall Gates. That synthesis of this compound saw an early synthetic use of the Diels-Alder reaction to form this compound’s C-ring. This compound’s biosynthesis begins from the benzylisoquinolone reticuline, whose R-isomer is converted to to salutaridine, then thebaine, which can be used to produce thebacon. The diacetylated derivative of this compound easily crosses the blood-brain barrier before being converted to 6-MAM and this compound. Rearranging this compound results in the compound found in Dilaudid. Pyridine can be used to demethylate codeine, resulting in this compound. For 10 points, name this potent analgesic, the primary component of opium.
The Grewe cyclization is central to Kenner Rice’s total synthesis of this compound, considered the only one remotely close to being synthetically viable. Robert Robinson’s proposed structure for this compound was confirmed after its 1952 total synthesis by Marshall Gates. That synthesis of this compound saw an early synthetic use of the Diels-Alder reaction to form this compound’s C-ring. This compound’s biosynthesis begins from the benzylisoquinolone reticuline, whose R-isomer is converted to to salutaridine, then thebaine, which can be used to produce thebacon. The diacetylated derivative of this compound easily crosses the blood-brain barrier before being converted to 6-MAM and this compound. Rearranging this compound results in the compound found in Dilaudid. Pyridine can be used to demethylate codeine, resulting in this compound. For 10 points, name this potent analgesic, the primary component of opium.
The Grewe cyclization is central to Kenner Rice’s total synthesis of this compound, considered the only one remotely close to being synthetically viable.