This compound is metabolized by an enzyme containing an oxygen holding “peroxo hole”, and that oxidase oddly does not require a metal ion or cofactor to function. Lesinurad inhibits a transporter of this molecule. This compound and glucose are transported by the protein coded by the SL2A9 gene and it is also transported by ABCG2. Unlike most mammals, primates lack an enzyme that oxidizes this compound into the more soluble allantoin. This compound builds up as a result of a defective HPRT gene, which causes most of the symptoms of Lesch-Nyhan syndrome. Serum levels of this compound are lowered by febuxostat and allopurinol, both of which act as xanthine oxidase inhibitors. The ball of the foot is a common location for the deposition of tophi consisting of crystals of this product of purine metabolism. For 10 points, name this compound whose crystallization causes gout, and which birds and reptiles excrete as waste.
This compound is metabolized by an enzyme containing an oxygen holding “peroxo hole”, and that oxidase oddly does not require a metal ion or cofactor to function. Lesinurad inhibits a transporter of this molecule. This compound and glucose are transported by the protein coded by the SL2A9 gene and it is also transported by ABCG2. Unlike most mammals, primates lack an enzyme that oxidizes this compound into the more soluble allantoin. This compound builds up as a result of a defective HPRT gene, which causes most of the symptoms of Lesch-Nyhan syndrome. Serum levels of this compound are lowered by febuxostat and allopurinol, both of which act as xanthine oxidase inhibitors. The ball of the foot is a common location for the deposition of tophi consisting of crystals of this product of purine metabolism. For 10 points, name this compound whose crystallization causes gout, and which birds and reptiles excrete as waste.
This compound is metabolized by an enzyme containing an oxygen holding “peroxo hole”, and that oxidase oddly does not require a metal ion or cofactor to function.