A domain present in these proteins and primases has a structure similar to a Rossman fold. Anti-cancer drugs such as anthracyclines and acridines are thought to stabilize the complex formed by this protein and its substrate, while a more popular inhibitor of these enzymes is the alkaloid camptothecin. One type of these, which exhibits ATPase activity, initially binds to the Gate segment, after which the T segment (*) moves through the central cavity while the substrate is rigidly held, while type I of these enzymes allow for rotation and re-lig
A domain present in these proteins and primases has a structure similar to a Rossman fold. Anti-cancer drugs such as anthracyclines and acridines are thought to stabilize the complex formed by this protein and its substrate, while a more popular inhibitor of these enzymes is the alkaloid camptothecin. One type of these, which exhibits ATPase activity, initially binds to the Gate segment, after which the T segment (*) moves through the central cavity while the substrate is rigidly held, while type I of these enzymes allow for rotation and re-ligation after proceeding through a phospho-tyrosine intermediate. The first example of it was discovered in E. Coli and was called gyrase. For 10 points, identify these enzymes which change their substrate's linking number, one of which relieves positive and negative supercoiling by cutting and reconnecting DNA.
A domain present in these proteins and primases has a structure similar to a Rossman fold.
{topoisomerases}