Along with semaphorin F and delta-catenin, this protein is deleted in Cri-du-chat syndrome, and this molecule is targeted by Geron's GRN163 compound. The ELISA-based TRAPEZE assay is used to detect the activity of this protei
Along with semaphorin F and delta-catenin, this protein is deleted in Cri-du-chat syndrome, and this molecule is targeted by Geron's GRN163 compound. The ELISA-based TRAPEZE assay is used to detect the activity of this protein, which can also be done using the TRAP assay. POT1 and TPP1 prime this enzyme's attachment after detaching from the (*) shelterin complex, and the DSB-associated MRE11-RAD50-NBS1 complex is required for the ALT pathway, whose action is parallel to the action of this enzyme. Factors that bind to G-quadruplexes also inhibit this protein, and this protein was originally discovered in cell-free extracts of Tetrahymena by Greider and Blackburn. Like a related protein, this protein contains a Finger, Palm, and Thumb domain, and its aberrant activation leads to abrogation of the Hayflick limit. Consisting of the TERT protein and a built-in RNA template, for 10 points, name this protein that is responsible for lengthening the ends of chromosomes.
Along with semaphorin F and delta-catenin, this protein is deleted in Cri-du-chat syndrome, and this molecule is targeted by Geron's GRN163 compound.
{Telomerase Reverse Transcriptase} [accept {TERT} or {hTERT} until mention]