With Cobb, the namesake of this reaction characterized the reaction of quinone and hydrochloric acid, and cyclopentenone undergoes this reaction with thiols and GSH in biological systems. Ochiai and Tada developed a tandem version of it with a carben
With Cobb, the namesake of this reaction characterized the reaction of quinone and hydrochloric acid, and cyclopentenone undergoes this reaction with thiols and GSH in biological systems. Ochiai and Tada developed a tandem version of it with a carbene rearrangement, and a more famous variation uses a silyl enol ether and is named for Mukaiyama. Chiral ammonium salts are used to force the reaction to favor the "Syn" product produced by this reaction, known as its asymmetric version. This reaction is combined with an intramolecular aldol reaction to create a six-membered ring in the Robinson annulation. FTP, name this reaction which adds a namesake donor to an alpha-beta unsaturated ketone, named for an American.
With Cobb, the namesake of this reaction characterized the reaction of quinone and hydrochloric acid, and cyclopentenone undergoes this reaction with thiols and GSH in biological systems.
Michael addition