Its 3 and 4 forms work in tandem with XRCC1 and XRCC4, respectively, and in some cases, its major function is assisted by the Ku protein. The activity of the most common form of this molecule can be inhibited by both sodium chloride and potassium chloride, and increased by the addition of polyethylene glycol. NAD is used as a cofactor for the one derived from E. coli, but the most commonly used one requires ATP as a cofactor and is derived from the T4 bacteriophage. It functions through the form
Its 3 and 4 forms work in tandem with XRCC1 and XRCC4, respectively, and in some cases, its major function is assisted by the Ku protein. The activity of the most common form of this molecule can be inhibited by both sodium chloride and potassium chloride, and increased by the addition of polyethylene glycol. NAD is used as a cofactor for the one derived from E. coli, but the most commonly used one requires ATP as a cofactor and is derived from the T4 bacteriophage. It functions through the formation of phosphodiester bonds between the 5-prime phosphate and the 3-prime hydroxyl. FTP, identify this enzyme, responsible for joining Okazaki fragments into a single DNA strand.
Its 3 and 4 forms work in tandem with XRCC1 and XRCC4, respectively, and in some cases, its major function is assisted by the Ku protein.
DNA ligase