This protein's exon Novex-3 has been found to encode an alternative C-terminal domain, and this protein's many PEVK exons may give it its most important physical characteristic. Familial dilated cardiomyopathy has been found to result from an insertion mutation or a missense mutation in the gene coding for this protein, and abnormal isoform ratios of it have been implicated in ventricular stiffening in patients with ischemic heart disease. Upregulation of seven of its PEVK exons contributes to inflexibility in the lung 
This protein's exon Novex-3 has been found to encode an alternative C-terminal domain, and this protein's many PEVK exons may give it its most important physical characteristic. Familial dilated cardiomyopathy has been found to result from an insertion mutation or a missense mutation in the gene coding for this protein, and abnormal isoform ratios of it have been implicated in ventricular stiffening in patients with ischemic heart disease. Upregulation of seven of its PEVK exons contributes to inflexibility in the lung tissue of patients with COPD. This protein has its C-terminus in the A-band, and it interacts near the I-band with obscurin and the actin-binding protein nebulin. For 10 points, name this enormous protein that connects the M line and Z line of a sarcomere and gives muscles their passive elasticity.
This protein's exon Novex-3 has been found to encode an alternative C-terminal domain, and this protein's many PEVK exons may give it its most important physical characteristic.
{titin} [or {connectin}]