In rare cases it may caused by a mutation in the A-I-R-E gene, but more commonly may be caused by HIV, tuberculosis, or metastatic cancer, or most commonly autoimmune causes.  Symptoms of this disease include salt loss and hyperpigmentation, which differentiates it from secondary causes.  Leading to atrophy of the zona fasciculata and zona reticularis, in nearly 90 percent of cases, autoantibodies attack the enzyme 21-hydroxylase, interrupting the production of aldostero
In rare cases it may caused by a mutation in the A-I-R-E gene, but more commonly may be caused by HIV, tuberculosis, or metastatic cancer, or most commonly autoimmune causes.  Symptoms of this disease include salt loss and hyperpigmentation, which differentiates it from secondary causes.  Leading to atrophy of the zona fasciculata and zona reticularis, in nearly 90 percent of cases, autoantibodies attack the enzyme 21-hydroxylase, interrupting the production of aldosterone and another hormone.  Producing profound weakness and pallor, FTP, name this disease from which John F. Kennedy suffered, an inability of the adrenal glands to produce cortisol, which is named for the British physician who first described it.
In rare cases it may caused by a mutation in the A-I-R-E gene, but more commonly may be caused by HIV, tuberculosis, or metastatic cancer, or most commonly autoimmune causes.  
Addison's Disease (accept chronic adrenal insufficiency before adrenal, and hypocortisolism before cortisol)