One of the two widely studied forms of this process is attributable to the action of Vif proteins, which cause this reaction in response to APOBEC expression. That form of this mechanism was discovered first in spleen necrosis virus and was then in other lentiviridae. Another form of this biological process requires in its aftermath uracil-DNA glycosylase to undertake gene-specific high-fidelity repair to suppress the creation of lymphomas. That second form of this process is initiated by AID complexes, which induce it in proliferating plasma c
One of the two widely studied forms of this process is attributable to the action of Vif proteins, which cause this reaction in response to APOBEC expression. That form of this mechanism was discovered first in spleen necrosis virus and was then in other lentiviridae. Another form of this biological process requires in its aftermath uracil-DNA glycosylase to undertake gene-specific high-fidelity repair to suppress the creation of lymphomas. That second form of this process is initiated by AID complexes, which induce it in proliferating plasma cell candidates after an encounter with a novel antigen; it is known as the "somatic" form and is the mechanism through which B cells acquire specificity. For 10 points, name this biological mechanism, the first form of which results in a high frequency of guanine-to-adenine changes and is used by HIV to evade detection.
One of the two widely studied forms of this process is attributable to the action of Vif proteins, which cause this reaction in response to APOBEC expression.
hypermutation [accept somatic hypermutation; accept SHM; prompt on mutation; prompt on clear-knowledge equivalents like fast mutation]