Clofibrate and salicilic acid increase levels of this compound in rats, a result attributed to their agonistic effect on PPAR alpha. This compound is a cofactor in the uncoupling protein used in fatty acid-dependent proton transport, and it is a cosubstrate of the enzyme that effects de novo pyrimidine synthesis, DHOD. A synthetic analogue of this compound sometimes used to treat Friedrich's ataxia is idebenone, which is being tested as a treatment for Leber's hereditary optic neuropathy, which arises from mutations in the genes for the ND4, ND1 and ND6 subunits. One name for this compound comes in part from its ten isoprene repeats. A less energetic reaction this co
Clofibrate and salicilic acid increase levels of this compound in rats, a result attributed to their agonistic effect on PPAR alpha. This compound is a cofactor in the uncoupling protein used in fatty acid-dependent proton transport, and it is a cosubstrate of the enzyme that effects de novo pyrimidine synthesis, DHOD. A synthetic analogue of this compound sometimes used to treat Friedrich's ataxia is idebenone, which is being tested as a treatment for Leber's hereditary optic neuropathy, which arises from mutations in the genes for the ND4, ND1 and ND6 subunits. One name for this compound comes in part from its ten isoprene repeats. A less energetic reaction this compound participates in is the oxidation of succinate to fumarate, and its reduction by NADH generates four cytosolic protons in its reduction by NADH in complex I. For 10 points, name this component of the electron transport chain, a quinone derivative which passes electrons to cytochrome c.
Clofibrate and salicilic acid increase levels of this compound in rats, a result attributed to their agonistic effect on PPAR alpha.
{coenzyme Q10} [or {ubiquinone}; or {ubidecarenone}]