One disorder involving this organelle is caused by a mutation in E325K on the NAGA gene, called Schindler disease. One method of transporting molecules to it involves an hsc70-containing chaperone complex. Another disorder results in enzyme transport to the extracellular space rather than this organelle and is called I-cell disease. Proteins are marked for this structure with mannose-6-phosphate, and proton pump activity in this organelle maintains the acidic pH necessary for its primary function. One genetic defect results in ganglioside build
One disorder involving this organelle is caused by a mutation in E325K on the NAGA gene, called Schindler disease. One method of transporting molecules to it involves an hsc70-containing chaperone complex. Another disorder results in enzyme transport to the extracellular space rather than this organelle and is called I-cell disease. Proteins are marked for this structure with mannose-6-phosphate, and proton pump activity in this organelle maintains the acidic pH necessary for its primary function. One genetic defect results in ganglioside buildup in this organelle and thus causes Tay-Sachs disease. For 10 points, identify this cellular organelle that breaks down macromolecules with the aid of acid hydrolases.
One disorder involving this organelle is caused by a mutation in E325K on the NAGA gene, called Schindler disease.
lysosome