[NOTE TO MODERATOR: agalsidase is pronounced ay-GAL-suh-dase] In humans, Vitamin D upregulates hCAP18 (h-CAP-eighteen), a peptide found in this organelle of macrophages and PMNs. An X-linked disease caused by deficiency of iduronate-2-sulfatase (id-UH-roan-ate-two-SULF-uh-tace) is linked to defects in this organelle. In another disease of this orga
[NOTE TO MODERATOR: agalsidase is pronounced ay-GAL-suh-dase] In humans, Vitamin D upregulates hCAP18 (h-CAP-eighteen), a peptide found in this organelle of macrophages and PMNs. An X-linked disease caused by deficiency of iduronate-2-sulfatase (id-UH-roan-ate-two-SULF-uh-tace) is linked to defects in this organelle. In another disease of this organelle, G-b-3 accumulates in tissues. That deficient enzyme which functions in this organelle is compensated for using agalsidase alfa or agalsidase beta, and is encoded by the (*) G-L-A gene. Other related diseases of this organelle are treated by targeting a pathway involving acid hydrolase precursor proteins marked with mannose-6-phosphate. Niemann-Pick and Tay-Sachs are two of this organelle's namesake "storage diseases." For 10 points, name these digestive organelles which break down cellular wastes.
[NOTE TO MODERATOR: agalsidase is pronounced ay-GAL-suh-dase]