Dependencies to this substance have been noted in patients with defective transketolase or pyruvate dehydrogenase, two enzymes that require a cofactor derived from it for their activity. One of its deficiency syndromes manifests as damage to the mamm
Dependencies to this substance have been noted in patients with defective transketolase or pyruvate dehydrogenase, two enzymes that require a cofactor derived from it for their activity. One of its deficiency syndromes manifests as damage to the mammillary bodies and is frequently found in chronic alcoholics, while another deficiency syndrome, known as Shoshin's disease, manifests as heart failure and sudden death. It is required as its pyrophosphate for decarboxylation reactions. First crystallized by Donath and Jansen from rice polishings, FTP identify this vitamin whose deficiency can manifest as wet or dry forms of beriberi.
Dependencies to this substance have been noted in patients with defective transketolase or pyruvate dehydrogenase, two enzymes that require a cofactor derived from it for their activity.