Similar to von Willebrand disease, its mild "C" variety is like Tay-Sachs disease in that it is concentrated in Ashkenazi Jews. The most common version, known as "classical" or "A," involves an inversion of the F8 gene; the "B" form is associated with mutations in the F9 gene located further up the long arm of the X chromosome. As a result, the F8 and F9 proteins have significantly reduced or no activity, causing platelets to not be held in place
Similar to von Willebrand disease, its mild "C" variety is like Tay-Sachs disease in that it is concentrated in Ashkenazi Jews. The most common version, known as "classical" or "A," involves an inversion of the F8 gene; the "B" form is associated with mutations in the F9 gene located further up the long arm of the X chromosome. As a result, the F8 and F9 proteins have significantly reduced or no activity, causing platelets to not be held in place at a wound site. For 10 points, name this sex-linked inherited disease in which blood fails to clot properly.
Similar to von Willebrand disease, its mild "C" variety is like Tay-Sachs disease in that it is concentrated in Ashkenazi Jews.