Similar to von Willebrand disease, its mild "C" variety is like Tay-Sachs disease in that it is concentrated in Ashkenazi Jews. The most common version, known as "classical" or "A," involves an inversion of the F8 gene; the "B" form is associated with mutations in the F9 gen
Similar to von Willebrand disease, its mild "C" variety is like Tay-Sachs disease in that it is concentrated in Ashkenazi Jews. The most common version, known as "classical" or "A," involves an inversion of the F8 gene; the "B" form is associated with mutations in the F9 gene located further up the long arm of the X chromosome. As a result, the F8 and F9 proteins have significantly reduced or no activity, causing platelets to not be held in place at a wound site. For 10 points, name this sex-linked inherited disease in which blood fails to clot properly.
Similar to von Willebrand disease, its mild "C" variety is like Tay-Sachs disease in that it is concentrated in Ashkenazi Jews.