The crystal structure of this protein reveals that upon binding to its receptor, its C-epsilon-2 dom
The crystal structure of this protein reveals that upon binding to its receptor, its C-epsilon-2 domain must change confirmation because this protein is oddly bent. Mutations in STAT3 cause a disease characterized by high levels of this protein in the blood, known as "Hyper"-this protein-"syndrome", and its levels also inversely correlate with Th-17 cell counts. The monoclonal antibody omalizumab, or Xolair, targets these proteins. These proteins, which bind to F-c-epsilon-RI or CD23 receptors, are created by IL-4-induced class-switching resulting in incorporation of the epsilon heavy chain. These proteins, which are important in the defense against certain parasites and in the pathogenesis of asthma, achieve their most notable function during Type I hypersensitivity reactions. They bind to mast cells, resulting in degranulation and histamine release. For 10 points, name this isotype of immunoglobulin important in allergic reactions.
The crystal structure of this protein reveals that upon binding to its receptor, its C-epsilon-2 domain must change confirmation because this protein is oddly bent.