It can be applied to the theory of local breeding values to predict the effects of random drift on genetic architecture. Its presence in founder events, inbreeding, and bottlenecking can produce an increase in additive genetic variance. Analysis of this type using double mutants is employed to develop order-of-function maps for genes that regulate cellular pathways, and it can result in the nonpenetrance of mutant genes such as the gene for Marfan syndrome. Individuals who have a homozygous recessive mutation that blocks the addition of fucose to an H substance precursor fail to express A and B type blood groups and posses the Bombay phenotyp
It can be applied to the theory of local breeding values to predict the effects of random drift on genetic architecture. Its presence in founder events, inbreeding, and bottlenecking can produce an increase in additive genetic variance. Analysis of this type using double mutants is employed to develop order-of-function maps for genes that regulate cellular pathways, and it can result in the nonpenetrance of mutant genes such as the gene for Marfan syndrome. Individuals who have a homozygous recessive mutation that blocks the addition of fucose to an H substance precursor fail to express A and B type blood groups and posses the Bombay phenotype, an example of this effect. For 10 points, the gene for albinism is an example of what type of gene, which masks the phenotypic effects of a hypostatic gene?
It can be applied to the theory of local breeding values to predict the effects of random drift on genetic architecture.