Trimethoprim and pyrimethamine both inhibit a reductase important in the sy
Trimethoprim and pyrimethamine both inhibit a reductase important in the synthesis of this compound, in bacteria and protists respectively. Along with cyanocobalamin, this compound participates in many one carbon transfers, such as the remethylation of homocysteine to methionine, or the methylation of dUMP to dTMP. Because of that step in DNA synthesis, lack of this compound or vitamin B12 leads to megaloblastic anemia. In the diet, this compound is most commonly found with multiple glutamate moieties. Most famously neural tube defects can result from its deficiency in pregnant women. For 10 points, name this water soluble vitamin found in leafy green vegetable and enriched grains, also known as B9.
Trimethoprim and pyrimethamine both inhibit a reductase important in the synthesis of this compound, in bacteria and protists respectively.
Folic Acid [or Folate; or Folacin, orVitamin B9; or Vitamin B9 before mentioned]