The Class I type often undergoes posttranslational modification of its N-glycan region en route to the cell surface; it is similar to the Class II type in that both are dimers of homologous proteins, but the former interacts with cytotoxic T cells by displaying signal peptides bound in the ER, while the latter binds its peptides outside the cell, works with helper T cells concerned with extracellular pathogens. It is one of the most diverse genetic loci in humans, averaging hundreds of alleles, and is conjectured to play a rule on mate selection through the use of odor to encourage heterogeneity. For 10 points, name t
The Class I type often undergoes posttranslational modification of its N-glycan region en route to the cell surface; it is similar to the Class II type in that both are dimers of homologous proteins, but the former interacts with cytotoxic T cells by displaying signal peptides bound in the ER, while the latter binds its peptides outside the cell, works with helper T cells concerned with extracellular pathogens. It is one of the most diverse genetic loci in humans, averaging hundreds of alleles, and is conjectured to play a rule on mate selection through the use of odor to encourage heterogeneity. For 10 points, name this protein, part of the immune system's signaling network.
The Class I type often undergoes posttranslational modification of its N-glycan region en route to the cell surface; it is similar to the Class II type in that both are dimers of homologous proteins, but the former interacts with cytotoxic T cells by displaying signal peptides bound in the ER, while the latter binds its peptides outside the cell, works with helper T cells concerned with extracellular pathogens.
{MHC} or {major histocompatibility complex}