An ester with this functionality condenses with a ketone or aldehyde in the presence of elemental sulfur in the Gewald reaction to give 2-amino thiophenes, and the Letts synthesis forms these from aryl carboxylic acids. Esters form organozinc reagents and attack these compounds to give, after hydrol
An ester with this functionality condenses with a ketone or aldehyde in the presence of elemental sulfur in the Gewald reaction to give 2-amino thiophenes, and the Letts synthesis forms these from aryl carboxylic acids. Esters form organozinc reagents and attack these compounds to give, after hydrolysis, beta-ketoesters in the Blaise reaction, and aryl halides give this functionality in the Rosenmund-von Braun reaction. The Strecker synthesis gives as an intermediate the alpha-amino variety of these compounds before hydrolyzing to the amino acid. The simplest organic example of these compounds saw a major shortage from late 2008 to early 2009; that example is a popular medium-polarity solvent for TLC. FTP, name these compounds which contain a carbon-nitrogen triple bond.
An ester with this functionality condenses with a ketone or aldehyde in the presence of elemental sulfur in the Gewald reaction to give 2-amino thiophenes, and the Letts synthesis forms these from aryl carboxylic acids.
{nitriles}