BAPTA-AM is used to differentiate between functions of this class of proteins and LPS.  Hip binds to the ATPase domain of this class of proteins through its tetratricopeptide repeat domain; the newly formed complex then binds to Hop.  Its fourteen amino acid TKD sequence is thought to be a (*) tumor-specific recognition str
BAPTA-AM is used to differentiate between functions of this class of proteins and LPS.  Hip binds to the ATPase domain of this class of proteins through its tetratricopeptide repeat domain; the newly formed complex then binds to Hop.  Its fourteen amino acid TKD sequence is thought to be a (*) tumor-specific recognition structure for natural killer cells, as that sequence is extracellular in tumor but not normal cells.  In E. coli, this class is represented by DnaK, and in mitochondria it is necessary for production of proteins containing iron sulfide clusters.  This protein is needed for the inactivation of HRI, an eIF2α kinase; thus, low levels of this protein are possibly a cause of reduced protein translation.  For 10 points, name this best-known eukaryotic chaperone protein.
BAPTA-AM is used to differentiate between functions of this class of proteins and LPS.  
{heat shock protein 70} [or {hsp70}; prompt on {hsp} or {heat shock protein}] (6) [DW]