It is triggered by Lesch-Nyhan syndrome, which increases purine  production, resulting in an abnormally high concentration of uric  acid. The uric acid causes a buildup of crystal deposits in the  joints, and the first noticeable symptom is usually a painful  swelling in the big toe. FTP, name this metabolic disorder that  
It is triggered by Lesch-Nyhan syndrome, which increases purine  production, resulting in an abnormally high concentration of uric  acid. The uric acid causes a buildup of crystal deposits in the  joints, and the first noticeable symptom is usually a painful  swelling in the big toe. FTP, name this metabolic disorder that  mostly affects middle-aged males, and which was traditionally known  as the "rich man's disease."
It is triggered by Lesch-Nyhan syndrome, which increases purine  production, resulting in an abnormally high concentration of uric  acid.
{gout}