The angiogenesis inhibitor endostatin is derived from the breakdown of this protein. The coppercontaining enzyme lysyl oxidase catalyzes the formation
The angiogenesis inhibitor endostatin is derived from the breakdown of this protein. The coppercontaining enzyme lysyl oxidase catalyzes the formation of aldehydes from the epsilon-amino group of lysines, allowing cross-linking of this protein. A form of this protein is defective in a disease that presents with blue sclera. Defects in it can result in EhlersDanlos syndrome, osteogenesis imperfecta, and (*) Alport's syndrome. The pro form of this protein is assembled in the ER, and peptidases cleave propetides at the ends of that pro form after secretion. It contains many glycine-proline-X and glycine-X-hydroxyproline motifs. Ascorbic acid is a cofactor in the synthesis of this protein, which possesses a triple-helix structure. For 10 points, name this fibrous protein that comprises most of the extracellular matrix.
The angiogenesis inhibitor endostatin is derived from the breakdown of this protein.
collagen