Proteins can interact with these structures via TOG domains. A drug that prevents their formation cannot continue to be used in patients with foot drop and is 100% fatal if it gets into the spine; that drug is vincristine, wh
Proteins can interact with these structures via TOG domains. A drug that prevents their formation cannot continue to be used in patients with foot drop and is 100% fatal if it gets into the spine; that drug is vincristine, which like vinblastine is a vinca alkaloid. A compound that prevents the growth of these structures is commonly used to treat gout, and that compound is also used to synchronize cells for karyotyping. Gamma ring complexes nucleate their growth, which alternate phases of (*) assembly and catastrophe in a process called "dynamic instability". Their monomers bind and hydrolyze GTP. Their growth is inhibited by colchicine and stabilized by taxol, and they form the mitotic spindle by connecting chromosomes to the centrosome. These structures are made of tubulin. For 10 points, name these components of the cytoskeleton that are bigger than intermediate filaments.
Proteins can interact with these structures via TOG domains.
microtubules