Deletion of genes involved in this process was recently shown to inhibit white adipocyte differentiation and promote brown adipocyte transdifferentiation. mTOR (em-TOR) is thought to downregulate this process through phosphorylation of the ULK complex. Adaptor proteins for this process such as p62 and NBR1 commonly possess a LIR motif, which selectively binds to the Atg8 family of proteins. An ass
Deletion of genes involved in this process was recently shown to inhibit white adipocyte differentiation and promote brown adipocyte transdifferentiation. mTOR (em-TOR) is thought to downregulate this process through phosphorylation of the ULK complex. Adaptor proteins for this process such as p62 and NBR1 commonly possess a LIR motif, which selectively binds to the Atg8 family of proteins. An assay for this process can be performed by immunoblotting for LC3-II turnover during the (*) starvation-induced form of this process. The "macro" form of this process involves a formation of a double membrane around the cytoplasmic target, which can then fuse with the lysosome for degradation. For 10 points, name this process in which a cell digests its own components for energy.
Deletion of genes involved in this process was recently shown to inhibit white adipocyte differentiation and promote brown adipocyte transdifferentiation.
autophagy [or autophagocytosis, or macroautophagy or microautophagy]