This protein's R31D mutation has an increased affinity for its receptor and was used to crystallize it. One drug used to inhi
This protein's R31D mutation has an increased affinity for its receptor and was used to crystallize it. One drug used to inhibit this protein is commonly given alongside methotrexate to decrease the formation of HACA antibodies. This protein is cleaved from its membrane-bound form to a 51 kilodalton soluble heterotrimer by a convertase called ADAM17. People taking inhibitors of this protein must have less than 5 millimeters of induration on the Mantoux skin test, because inhibition of this protein can cause reactivation of TB. It's not the fas ligand, but the binding of this protein to its receptor causes the interaction between (*) TRADD and FADD proteins, and leads to the activation of NF-kappa-B and caspase 8. Enteracept is a soluble decoy receptor for this protein, which is directly inhibited by the monoclonal antibodies adalimumab and infliximab; those drugs are used to treat ulcerative colitis and rheumatoid arthritis. For 10 points, name this pro-inflammatory cytokine secreted by macrophages, that got its name from its ability to kill cancer cells.
This protein's R31D mutation has an increased affinity for its receptor and was used to crystallize it.
TNF-alpha or [tumor necrosis factor alpha, or cachectin or cachexin]