The mechanism of action o
The mechanism of action of these compounds was deduced by John Vane. One of these compounds causes an imbalance of prostacyclins and thromboxanes; that is called Rofecoxib. These drugs, classes of which include fenamates and oxicams, work by inhibiting cyclooxygenases, and, like similar compounds that inhibit phospholipase A2, they downregulate production of (*) prostaglandins. These compounds, which include naproxen, have the same effect as synthetic corticosteroids. Patients are told to chew one of these drugs when having a heart attack. They are the second most common cause of gastrointestinal bleeding and ulcers, so many patients take acetaminophen instead. For 10 points, name this class of painkillers that reduce fever and inflammation, and include aspirin and ibuprofen.
The mechanism of action of these compounds was deduced by John Vane.
NSAIDs [or nonsteroidal anti-inflammatory drugs; also accept agents, analgesics, or medicines in place of "drugs"; prompt on "painkillers," "analgesics," or any answer about relieving pain before mentioned; prompt on "anti-inflammatory drugs" or any answer about reducing inflammation before mentioned; anti-prompt on "ibuprofen," "aspirin," "salicylates," or any other drug listed in the tossup, before mentioned]