One of these proteins is commonly mutated in threonine-286 in endometrial carcinomas, and one of these proteins is activated by an 11 to 14 translocation commonly found in Mantle Cell lymphoma. Gamma herpesviruses encode a viral form of these proteins, which are used to inactivate Rb. Both the Retinoblastoma protein and transcription factor 2-B contain a fold named for this class of proteins. They're not securins, but the APC/C protein complex directs ubiquitination of these proteins. These proteins bind to the PSTAIRE helix of another set of protein, which causes that
One of these proteins is commonly mutated in threonine-286 in endometrial carcinomas, and one of these proteins is activated by an 11 to 14 translocation commonly found in Mantle Cell lymphoma. Gamma herpesviruses encode a viral form of these proteins, which are used to inactivate Rb. Both the Retinoblastoma protein and transcription factor 2-B contain a fold named for this class of proteins. They're not securins, but the APC/C protein complex directs ubiquitination of these proteins. These proteins bind to the PSTAIRE helix of another set of protein, which causes that partner to move its T-loop out of the way of its active site. The HIV (*) Tat protein binds to the T type of these proteins. Proteins like Wee1 and Sic1 are responsible for inhibiting complexes of these proteins and their effectors; one such complex contains one of these proteins bound to p34 and is called the MPF. These proteins have a namesake 5-helix domain, and come in types including A, B, D, and E, the last of which spikes at the G1/S boundary. For 10 points, name these proteins that regulate the progression of the cell cycle.
One of these proteins is commonly mutated in threonine-286 in endometrial carcinomas, and one of these proteins is activated by an 11 to 14 translocation commonly found in Mantle Cell lymphoma.
cyclin