Mutations in parC and parE can confer resistance to this class of compounds, as can mutations in the QRDR region of another protein. These compounds are contraindicated in pregnancy because they can cause cartilage damage in the fetus, and in elderly people taking prednisone, these compounds can cause rupture of the Achilles tendon. Nalidixic acid was the first of these compounds on the market, and these compounds have a 
Mutations in parC and parE can confer resistance to this class of compounds, as can mutations in the QRDR region of another protein. These compounds are contraindicated in pregnancy because they can cause cartilage damage in the fetus, and in elderly people taking prednisone, these compounds can cause rupture of the Achilles tendon. Nalidixic acid was the first of these compounds on the market, and these compounds have a piperazine group ortho to the heteroatom that gives them part of their name. They are often given to CF patients as (*) empirical treatment against Pseudomonas, and like macrolides, these antibiotics can cause prolongation of the QT interval. This class of compounds targets DNA gyrase and topoisomerase IV, and are commonly used to treat anthrax and urinary tract infections. For 10 points, name this class of antibiotics that include moxlifloxacin, ciprofloxacin, and levofloxacin.
Mutations in parC and parE can confer resistance to this class of compounds, as can mutations in the QRDR region of another protein.
fluoroquinolones