Using the C2C12 mybolast line, it was established that QSulf1's 6-O-endosulfatase activity is resp
Using the C2C12 mybolast line, it was established that QSulf1's 6-O-endosulfatase activity is responsible for the decreased binding activity between these proteins and heparan sulfate proteoglycans. Important inhibitors of these proteins include Cerebrus, SFRPs ("s-FRIPs"), and Dkk ("D-k-k") proteins. They bind to a receptor complex containing the LRP5/6 protein to disrupt the APC/Axin/GSK3 complex that degrades beta-catenin, which their (*) canonical pathway is dependent on. These glycoproteins bind to a cysteine-rich domain of the Frizzled receptor, creating a signal that's transduced to Dishevelled, inside a cell. For 10 points, name this important set of signaling molecules that is named for the segment polarity gene wingless and its vertebrate homolog, integrated.
Using the C2C12 mybolast line, it was established that QSulf1's 6-O-endosulfatase activity is responsible for the decreased binding activity between these proteins and heparan sulfate proteoglycans.
Wnt proteins [prompt on: Wg]