This condition can result from upregulation of the Ras pathway, and the onset of this condition is described by Alfred Knudson's two-hit hypothesis. This disease's byproducts are suppressed by the proteins pRb and p53; histological grading can determine how anaplastic, or poorly differentiated, those byproducts are on a scale from 1 to 4. Cells affected by this can produce excess telomerase. Associated with the mutation of proto-oncogenes, and spread via metastasis [accent on "ta" as in "tap"], 
This condition can result from upregulation of the Ras pathway, and the onset of this condition is described by Alfred Knudson's two-hit hypothesis. This disease's byproducts are suppressed by the proteins pRb and p53; histological grading can determine how anaplastic, or poorly differentiated, those byproducts are on a scale from 1 to 4. Cells affected by this can produce excess telomerase. Associated with the mutation of proto-oncogenes, and spread via metastasis [accent on "ta" as in "tap"], for 10 points, name this malignant disease state where excessive cell growth causes the formation of tumors after exposure to carcinogens.
This condition can result from upregulation of the Ras pathway, and the onset of this condition is described by Alfred Knudson's two-hit hypothesis.
cancer [accept cancerous or malignant neoplasm; prompt "carcinoma," "sarcoma," "blastoma," or "tumor" formation]