Yoneyama et. al unearthed that RIG-1 and MDA5, both cytosolic helicases, can trigger production of t
Yoneyama et. al unearthed that RIG-1 and MDA5, both cytosolic helicases, can trigger production of these proteins. Theyupregulate the MX1 and MX2 GTPases, which experience increased activity in Down's syndrome. Thrombocytopenia is amajor adverse effect of one of these proteins when it is administered to control the progression of hepatitis C. The fiÂrst synthetic orally-active inducer of these proteins was tilorone. A "gene factor 3" complex named for these proteins works by activatingnamesake "stimulated response elements." This term was coined by Jean Lindemann and Alick Isaacs, who were workingwith heat-inactivated influenza viruses and chicken eggs, though these proteins were fiÂrst noticed by two Japanese virologistsworking on a new smallpox vaccine. In vertebrates, these proteins activate protein kinase R after themselves being inducedupon exposure to double-stranded RNA. For 10 points, name these cytokines best-known for messing with viral replicationin infected host cells.
Yoneyama et. al unearthed that RIG-1 and MDA5, both cytosolic helicases, can trigger production of these proteins.
interferons [prompt on cytokines]