A dicarboxylic compound of this type can be synthesized by combining ammonia, an aldehyde, and a tartaric acid derivativein the Maquenne synthesis. Tosylmethyl isocyanide is added in a "three-component" synthesis of this compound devisedby Van Leusen. Electron donor groups on this functionality coordinate to transition metals in a form of immobilized metalanitychromatography used to purify compounds with a short affinity tag. The drug with trade name Flagyl, which is commonlyused against C. difficile infection, contains a nitro-derivative of this functional group. Myoglobin is protected fromcarbon monoxide poisoning because the heme is close to two of these sterically-hindered groups, whose positively-chargedsalts are stabilized by resonance. An atom in this functional group abstracts a proton from serine in the catalytic triad. Thisfunctionality is a Âfive-membered ring heterocycle with two double bonds and 
A dicarboxylic compound of this type can be synthesized by combining ammonia, an aldehyde, and a tartaric acid derivativein the Maquenne synthesis. Tosylmethyl isocyanide is added in a "three-component" synthesis of this compound devisedby Van Leusen. Electron donor groups on this functionality coordinate to transition metals in a form of immobilized metalanitychromatography used to purify compounds with a short affinity tag. The drug with trade name Flagyl, which is commonlyused against C. difficile infection, contains a nitro-derivative of this functional group. Myoglobin is protected fromcarbon monoxide poisoning because the heme is close to two of these sterically-hindered groups, whose positively-chargedsalts are stabilized by resonance. An atom in this functional group abstracts a proton from serine in the catalytic triad. Thisfunctionality is a Âfive-membered ring heterocycle with two double bonds and two nitrogen atoms. For 10 points, name thisaromatic functional group present in the side chain of histidine.
A dicarboxylic compound of this type can be synthesized by combining ammonia, an aldehyde, and a tartaric acid derivativein the Maquenne synthesis.
imidazoles [accept imidazolides, imidazolates, and imidazoliums]