The most common genetic cause of this disease is mutations in the LRRK2 gene. The most commonlyused rating scale for this disease incorporates the Hoehn and Yahr staging scale. An important case study ofthis disease occurred when several people consumed MPPP, a synthetic opioid, that was contaminated withMPTP, which is metabolized by MAO-B to MPP+. That case study was documented by William Langstonin the book The Case of the Frozen Addicts. This disease is characterized by proteinaceous inclusions ofalpha-synuclein in neurons called Lewy bodies. The most common treatment for this disease isadministration of levodopa. For 10 points, identify this neurodegenerative disorder that results from thedestruction of dopamine-producing cells in the s
The most common genetic cause of this disease is mutations in the LRRK2 gene. The most commonlyused rating scale for this disease incorporates the Hoehn and Yahr staging scale. An important case study ofthis disease occurred when several people consumed MPPP, a synthetic opioid, that was contaminated withMPTP, which is metabolized by MAO-B to MPP+. That case study was documented by William Langstonin the book The Case of the Frozen Addicts. This disease is characterized by proteinaceous inclusions ofalpha-synuclein in neurons called Lewy bodies. The most common treatment for this disease isadministration of levodopa. For 10 points, identify this neurodegenerative disorder that results from thedestruction of dopamine-producing cells in the substantia nigra.
The most common genetic cause of this disease is mutations in the LRRK2 gene.
Parkinson's disease [or idiopathic parkinsonism; or primary parkinsonism; or hypokinetic rigid syndrome; or HRS; or paralysis agitans]