This chemist was the first to discover a reaction in which thermal or photochemical degradation ofprotonated aliphatic N-haloamines yields pyrrolidine or piperidine derivatives; that reaction is also usuallynamed with LÃ¶ffler and Freytag. The produc
This chemist was the first to discover a reaction in which thermal or photochemical degradation ofprotonated aliphatic N-haloamines yields pyrrolidine or piperidine derivatives; that reaction is also usuallynamed with LÃ¶ffler and Freytag. The products of another reaction due to this chemist are used in thePasserini and Ugi reactions. That reaction uses primary amines and chloroform in the presence of alkali tosynthesize isonitriles. Because another reaction named for this chemist occurs by an E1cB-like E2mechanism, the highest yield is of the least substituted alkene, which is the opposite of Zaitsev's rule. Thatreaction is an elimination in which a primary amine is treated with methyl iodide and aqueous silver oxide.Although not Curtius, a rearrangement named for this chemist uses a basic hypohalite and occurs via anisocyanate intermediate. That rearrangement is used to convert carboxylic amides into primary amines withone less carbon atom. For 10 points, identify this German chemist whose rearrangement is usually calledhis degradation.
This chemist was the first to discover a reaction in which thermal or photochemical degradation ofprotonated aliphatic N-haloamines yields pyrrolidine or piperidine derivatives; that reaction is also usuallynamed with LÃ¶ffler and Freytag.
August Wilhelm von Hofmann