In examining a yeast analogue of the first enzyme in this pathway, T. A. Steiz, et al. found some of thefirst direct evidence for the induced fit hypothesis. It features a rare example of a feedforward activator in amolecule sometimes called a Harden-Young ester. Mutations in the GALT gene, which encodes auridylyltransferase, prevents one molecule from being degraded and entering this pathway. That moleculeis degraded by the Leloir pathway. The tracer 18F-FDG is metabolized by this pathway, which allows thedetection of cancer cells with PET. The enzyme aldolase in this
In examining a yeast analogue of the first enzyme in this pathway, T. A. Steiz, et al. found some of thefirst direct evidence for the induced fit hypothesis. It features a rare example of a feedforward activator in amolecule sometimes called a Harden-Young ester. Mutations in the GALT gene, which encodes auridylyltransferase, prevents one molecule from being degraded and entering this pathway. That moleculeis degraded by the Leloir pathway. The tracer 18F-FDG is metabolized by this pathway, which allows thedetection of cancer cells with PET. The enzyme aldolase in this pathway produces both DHAP and G3P. Itis part of a well-known futile cycle, controlled by fructose 2,6-bisphosphate, with gluconeogenesis. Thefirst enzyme in this pathway is hexokinase I, and it yields two net ATP, two NADH and two pyruvate. For10 points, identify this ten step pathway for the breaking down of glucose.
In examining a yeast analogue of the first enzyme in this pathway, T. A. Steiz, et al. found some of thefirst direct evidence for the induced fit hypothesis.
glycolysis [or EMP pathway; or Embden-Meyerhof-Parnas pathway; or Entner-Doudoroff pathway]