Alpha‐boranophosphates are a novel class of compounds that inhibit this protein. This proteincommonly acquires mutations at T215, M41, and K65 during therapy. The version of this enzymeencoded by M‐MLV has an error rate around one in seventeen thousand, and other versions ofthis protein have a domain that automatically degrades heteroduplexes. This enzyme, which isinhibited by efavirenz and tenofivir, is used in the laboratory to create (*) cDNA libraries. LINEelements and class I transposons with long‐terminal repeats code for a version of this protein inorder to replicate themselves. Another compound which inhibits this enzyme is activated bythymidylate kinase and acts as a chain‐terminator; that compound is a nucleoside analog called AZT
Alpha‐boranophosphates are a novel class of compounds that inhibit this protein. This proteincommonly acquires mutations at T215, M41, and K65 during therapy. The version of this enzymeencoded by M‐MLV has an error rate around one in seventeen thousand, and other versions ofthis protein have a domain that automatically degrades heteroduplexes. This enzyme, which isinhibited by efavirenz and tenofivir, is used in the laboratory to create (*) cDNA libraries. LINEelements and class I transposons with long‐terminal repeats code for a version of this protein inorder to replicate themselves. Another compound which inhibits this enzyme is activated bythymidylate kinase and acts as a chain‐terminator; that compound is a nucleoside analog called AZT.For 10 points, name this enzyme which creates DNA from RNA, used by retroviruses like HIV.
Alpha‐boranophosphates are a novel class of compounds that inhibit this protein.
reverse transcriptase