Using Ac-DAP to facilitate "de-blocking" in this reaction eliminates the need for an extra purifiÂcation step. Wang et al developeda "ladder" technique that alternates cycles of this reaction with mass spectrometry. Dansyl chloride is sometimes used
Using Ac-DAP to facilitate "de-blocking" in this reaction eliminates the need for an extra purifiÂcation step. Wang et al developeda "ladder" technique that alternates cycles of this reaction with mass spectrometry. Dansyl chloride is sometimes usedas a reagent in this reaction because it produces flfluorescent sulfonamides, particularly in the "subtractive" type. This reaction improves upon an earlier technique that used a benzyl alcohol to start a Curtius rearrangement. Humpback whale myoglobinwas used as a reagent in the Âfirst automation of this reaction, developed by Begg and its namesake. Following an extractioninto an organic solvent and an exposure to acidic conditions, a phenylthiohydantoin derivative is produced in this reaction,an improvement over a similar procedure named for Max Bergmann, which begins with the reaction of phenylisothiocyanatewith an uncharged terminal amino group. For 10 points, name this reaction invented by a Swedish chemist, which can synthesizeup to 30 amino acids in a peptide.
Using Ac-DAP to facilitate "de-blocking" in this reaction eliminates the need for an extra purifiÂcation step.
Edman degradation [prompt on "degradation"]