MTHFR catalyzes a reaction of this type that uses a folate derivative as a co-substrate to convert homocysteine to methionine as part of the (*) "one-carbon" cycle.
This reaction is catalyzed by many enzymes with a seven-strand twisted beta-sheet binding motif. Enzymes that catalyze this reaction are released by beta elimination after their conserved cysteine residues are deprotonated to form nucleophilic thiolates that attack in a conjugate addition. Azacitidine can reverse this reaction, which was the first known to proceed via base flipping. MTHFR catalyzes a reaction of this type that uses a folate derivative as a co-substrate to convert homocysteine to methionine as part of the (*) "one-carbon" cycle. Many enzymes that catalyze this reaction attack at the C6 position in order to activate the C5 carbon of pyrimidine derivatives and employ the donor S-adenosylmethionine. Molecules that have undergone this reaction are not converted to uracil in bisulfite sequencing. For 10 points, name this reaction that occurs at CpG sites and entails the transfer of a CH3 group.
This reaction is catalyzed by many enzymes with a seven-strand twisted beta-sheet binding motif.
transmethylation [or DNA methylation; or adding a methyl group; prompt on "alkylation"; antiprompt for the overall reaction on conjugate "addition" or beta "elimination" before mentioned]