This method has been used to show the role of calcium calodulin kinase II in memory and neocortical plasticity.
This method has been used to show the role of calcium calodulin kinase II in memory and neocortical plasticity. Using this method's "Swedish mutation" has helped to understand the role of amyloid precursor protein in Alzheimers patients. It has also been used to generate multiple CAG codon repeats while studying Huntington's disorder. Capecchi, Evans and Smithies were the first to perform this technique on mice, and mice are still the most commonly used organism, although extensive methylation and the use of stem cells not from Strain 129 often result in failure. FTP, identify this technique in genetic engineering where a gene or gene sequence is rendered inoperative in order to determine its function.
This method has been used to show the role of calcium calodulin kinase II in memory and neocortical plasticity.
Gene {knockout} (do not accept gene {knockdown})