This principal component of the extracellular matrix forms a triple helix structure, which is assembled outside the cell.
This protein is targeted by the drug Xiaflex, which treats Dupuytren's contracture with Clostridium-isolated enzymes that hydrolyze this protein. The N-terminal domain of this protein is cleaved by proteins such as ADAMTS-2 and ADAMTS-3. Ascorbic acid both stimulates production of this protein and regulates hydroxylation of its lysine and proline residues. This protein contains a repeated Gly-X-Y motif, where X is often proline and Y is hydroxyproline. This principal component of the extracellular matrix forms a triple helix structure, which is assembled outside the cell. For 10 points, name this most abundant protein in mammals, found in hair, skin, and the organic components of bone and cartilage.
This protein is targeted by the drug Xiaflex, which treats Dupuytren's contracture with Clostridium-isolated enzymes that hydrolyze this protein.
collagen