Consisting of three polypeptide chains arranged in a triple helix, it is related to elastin.
The biosynthesis of one type of it involves binding by the chaperone protein Hsp47, and it stains blue in Masson's trichrome stain. Auto-antibodies bind to the alpha-three chains of the type four of it, and mutations that alter the C-terminal globular domain of certain type-IV-alpha chains can lead to Alport's syndrome. Possessing an unusually high percentage of the amino acids glycine and proline, it can be denatured to form gelatin. Consisting of three polypeptide chains arranged in a triple helix, it is related to elastin. For 10 points, name this protein that is a major component of connective tissues, including tendons and cartilage.
The biosynthesis of one type of it involves binding by the chaperone protein Hsp47, and it stains blue in Masson's trichrome stain.
{collagen}