FTP, name this reaction used to form polycyclic molecules, which consists of a Michael addition followed by an intra-molecular aldol condensation.
One variant of this reaction replaces a key ingredient with 1,3-dichloro- cis-2-butene, and is named for Wichterle, while an alternative to it replaces that same ingredient with a sulfoxide that has an ortho-ester attached. That reaction, named for Hauser, also replaces this reaction's second step with a Dieckmann reaction. The Wieland-Mischer and Hajos-Parrish ketones can be formed when methyl vinyl ketone is used as the alpha, beta unsaturated ketone reactant in its first step, which also requires a nucleophilic donor like an enamine or beta keto ester. FTP, name this reaction used to form polycyclic molecules, which consists of a Michael addition followed by an intra-molecular aldol condensation.
One variant of this reaction replaces a key ingredient with 1,3-dichloro- cis-2-butene, and is named for Wichterle, while an alternative to it replaces that same ingredient with a sulfoxide that has an ortho-ester attached.
{Robinson annulation}