Many sufferers of this disease have alpha-synuclein-containing Lewy neurites in the CA2-3 region, and all have APP that has been fragmented via proteolysis.
Many sufferers of this disease have alpha-synuclein-containing Lewy neurites in the CA2-3 region, and all have APP that has been fragmented via proteolysis. It can only be definitively diagnosed via treatment of tissue samples with Congo Red or Bielschowsky staining for a specific peptide derived from APP. Those that have the E4 allele of apolipoprotein E are at an increased risk for this condition, which causes the breakdown of microtubules in the brain due to tau protein aggregation. FTP, name the incurable  neurodegenerative disease that affects the hippocampus and results in dementia, a condition which is characterized by the formation of beta-amyloid plaques and tangles.
Many sufferers of this disease have alpha-synuclein-containing Lewy neurites in the CA2-3 region, and all have APP that has been fragmented via proteolysis.
Alzheimer’s disease