Gardner, Rand, and Haynes used this reaction to synthesize docosanedioc acid.
Gardner, Rand, and Haynes used this reaction to synthesize docosanedioc acid. One modification of this reaction uses scandium trifloromethane sulfonate and BTBSH to overcome the side production of dimers and is named for Meyer, while another variation is used on alpha-beta epoxy carbonyls and is named for Wharton. Modern instances of this reaction are performed in a pot of ethylene glycol instead of the sealed tubes used in the original version, in a modification named for Huang and Minlon. Its second step relies on three equivalents of hydroxide and is driven by the evolution of nitrogen. FTP, name this alternative to the Clemmensen reduction, which uses hydrazine to reduce a carbonyl to an alkane in strongly basic conditions.
Gardner, Rand, and Haynes used this reaction to synthesize docosanedioc acid.
{Wolff-Kishner} reaction or reduction