A Thai group discussed the synthesis of Telisatin via an annulation followed by this reaction in the presence of microwave irradiation.
A Thai group discussed the synthesis of Telisatin via an annulation followed by this reaction in the presence of microwave irradiation. Pier Gozzi developed the first enantioselective version of this reaction with ketones that used a chiral Mn-Salen catalyst; Gozzi also developed a one-pot variant of this reaction which uses an imine reagent, and showed that ethyl iodoacetate better promotes it than the corresponding bromoacetate. This reaction proceeds via an enolate intermediate formed from nucleophilic attack by an organozinc compound, which is stabilized by esters. For 10 points, identify this reaction where an alpha halo ester reacts with an aldehyde or ketone to yield a beta-hydroxy ester, and is named for a Russian chemist.
A Thai group discussed the synthesis of Telisatin via an annulation followed by this reaction in the presence of microwave irradiation.
{Reformatsky} reaction