The Danishefsky Taxol synthesis replaces a hydroxyl group with a selenide for further reaction in the Grieco version of this, while in another variety of this reaction, a tosylhydrazone is formed from a carbonyl and then cleaved by an alkoxide in the Bamford-Stevens version.
The Danishefsky Taxol synthesis replaces a hydroxyl group with a selenide for further reaction in the Grieco version of this, while in another variety of this reaction, a tosylhydrazone is formed from a carbonyl and then cleaved by an alkoxide in the Bamford-Stevens version. Alkyllithium can also be used in the Shapiro reaction of this type, while a hydroxylamine can be generated as a side product in the (*) Cope version. More famously, methyl iodide and silver oxide can be used to remove an amine in the Hofmann version, which has selectivity opposite to Zaitsev's rule. For 10 points, name this type of reaction coming in E1 and E2 varieties, which culminates in double bond formation.
The Danishefsky Taxol synthesis replaces a hydroxyl group with a selenide for further reaction in the Grieco version of this, while in another variety of this reaction, a tosylhydrazone is formed from a carbonyl and then cleaved by an alkoxide in the Bamford-Stevens version.
{elimination}