Its inheritance was first demonstrated by Neel and Beet. Pedigree analysis revealed three genotypes and phenotypes controlled by a single pair of alleles, A and S. Affected individuals could arise from both homozygous genotypes.
Its inheritance was first demonstrated by Neel and Beet. Pedigree analysis revealed three genotypes and phenotypes controlled by a single pair of alleles, A and S. Affected individuals could arise from both homozygous genotypes. Linus Pauling and his colleagues provided the molecular basis for this disease by showing changes in migration after a gel electrophoresis in two different hemoglobins but were unaware of the valine-glutamine substitution error. FTP, identify this disease, named for the shape of the affected red blood cells.
Its inheritance was first demonstrated by Neel and Beet. Pedigree analysis revealed three genotypes and phenotypes controlled by a single pair of alleles, A and S. Affected individuals could arise from both homozygous genotypes.
{sickle-cell anemia}