A mutation in a protein of this family labelled with the number "0" causes congenital cataracts.
Plant NIPs are analogous to these proteins. They can be experimentally inhibited in the lab with mercuric chloride. A mutation in a protein of this family labelled with the number "0" causes congenital cataracts. The bacterial GlpF protein is a member of this family. Nephrogenic diabetes insipidus is caused by a defect in one of these proteins. Two conserved asparagine residues in these proteins control their selectivity, forming the NPA and aromatic/arginine motifs. The most common type of them is a tetramer of six alpha helices surrounding an hourglass-shaped channel. Vasopressin stimulates their activity in the collecting duct of the kidney to regulate urine concentration. They allow in glycerol, but not charged species like protons. For 10 points, name these membrane proteins that transport water.
Plant NIPs are analogous to these proteins. They can be experimentally inhibited in the lab with mercuric chloride.
{aquaporins} [prompt on major intrinsic proteins; don't accept or prompt on "membrane proteins" or "channel proteins"]