This protein contains a long alpha-helix flanked by disordered domains, and acidic and basic isoforms of it dimerize, and the dimers proceed to form tetramers which arrange in fibrils.
Dane's method is used to stain both mucin and this molecule, and this protein mediates cell polarity by binding to Albatross protein and the apical junction complex. Its aggregation is triggered by filaggrin in one organ, and this protein is prevalent in the stratum lucidum and stratum corneum of one structure. Mutations in the 5th or 14th isoforms of this protein leads to EBS, and it is attached to desmoplakin in on the one face of desmosomes. This protein contains a long alpha-helix flanked by disordered domains, and acidic and basic isoforms of it dimerize, and the dimers proceed to form tetramers which arrange in fibrils. Its structure is formed by crosslinking of cysteine , and it is the main component of type 1 intermediate filaments. For 10 points, name this structural protein that gives strength to skin, hair and nails.
Dane's method is used to stain both mucin and this molecule, and this protein mediates cell polarity by binding to Albatross protein and the apical junction complex.
Keratin