They are characterized in part by their resistance to digestion by proteases and by their insolubility, and their secondary structures are dominated by beta sheets rather than alpha helices.
One of the disorders caused by them is associated with a homozygous polymorphism at position 129, while another known as CPEB is found in the nervous system and stimulates mRNA translation. In yeast, they can be formed from Sup35p and Ure2p, and eliminated through increased chaperone activity. They are characterized in part by their resistance to digestion by proteases and by their insolubility, and their secondary structures are dominated by beta sheets rather than alpha helices. Discovered by Stanley Pruisner to be malformed proteins, for ten points, identify these infectious agents, the causes of such diseases as fatal familial insomnia, kuru, Creutzfeld-Jacobs, and mad cow disease.
One of the disorders caused by them is associated with a homozygous polymorphism at position 129, while another known as CPEB is found in the nervous system and stimulates mRNA translation.
{prion}s