This disease is suggested by low serum levels of the metalloproteinase pappalysin (pap-uh-"LICE"-in).
An inhibitor of calcineurin (cal-sih-NOOR-in) named for this disease's candidate region suppresses VÂ·EÂ·GÂ·F, which is why people with this disease rarely get solid tumors. A cell adhesion molecule named for this disease in Drosophila (druh-SAHF-ih-luh) is a canonical example of alternative splicing. This disease is suggested by low serum levels of the metalloproteinase pappalysin (pap-uh-"LICE"-in). Though it's neither ALS nor Alzheimer's, this disease causes overexpression of SÂ·OÂ·DÂ·1 and the amyloid precursor protein. People with this disease o en have transverse creases on their hands or white spots on the outside of their irises. The familial form of this disease is caused by a translocation; more commonly, it is caused by a nondisjunction of the smallest chromosome. For 10 points, name this disease, the trisomy of chromosome 21.
An inhibitor of calcineurin (cal-sih-NOOR-in) named for this disease's candidate region suppresses VÂ·EÂ·GÂ·F, which is why people with this disease rarely get solid tumors.
Down syndrome [or Down's syndrome; accept DS; prompt on "trisomy 21" or other answers mentioning "trisomy" and "chromosome 21" before "trisomy"]