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These proteins all share a structure consisting of three alpha helices separated by two loops, comprising a namesake "fold" that interacts through a "handshake motif." Protein complexes such as Polycomb can make post-translational modifications on these proteins, which are recognized by chromodomains and bromodomains. HATs can reduce these proteins' positive charge by performing acetylation on them. A "code" named for these proteins describes modifications that can promote or repress transcription. These proteins, which form the core of a nucleosome, include H2A, H2B, H3, and H4. For 10 points, name these proteins around which eukaryotic DNA winds.
These proteins all share a structure consisting of three alpha helices separated by two loops, comprising a namesake "fold" that interacts through a "handshake motif.
histones