A technique in this 㻈eld starts with the introduction of the unnatural amino acid AÂ·HÂ·A into a protein.
A technique in this 㻈eld starts with the introduction of the unnatural amino acid AÂ·HÂ·A into a protein. SPANC ("spank") reactions, where 1,3 nitrones and DIBO combine to generate N-alkylÂ·ated isoxÂ·azoÂ·lines, is a popular approach in this 㻈eld. A strain-promoted version of a reaction in this paradigm was 㻈rst developed as a faster alternative to the Staudinger ligation. The anti-Markovnikov thiolÂ·ene and thiolÂ·yne reactions have experienced a recent revival for their applicability this 㻈eld. Carolyn Bertozzi pioneered the use of cycloÂ·octyne in the "copper-free" segment of this 㻈eld. BioÂ·orthogonal reactions utilize techniques from this paradigm within living systems. This paradigm is exempli㻈ed by the copper-one-catalyzed three-plus-two cycloÂ·addition between an alkyne and an azide; that reaction is named for Rolf Huisgen (HOY-jen). For 10 points, name this chemical paradigm that emphasizes modular units and bioÂ·mimetic reactions and is championed by K. Barry Sharpless.
A technique in this 㻈eld starts with the introduction of the unnatural amino acid AÂ·HÂ·A into a protein.
click chemistry [or bio-orthogonal chemistry]