The NtRTI tenofovir inhibits an enzyme encoded by pol first isolated from these viruses that is also used to generate cDNA in RT-PCR.
These agents can be innately targeted by TRIM5 and APOBEC family proteins. Several X-linked SCID patients developed leukemia due to these agents during gene therapy. They can be modified into SIN vectors. These agents use a PBS region for their "second jump," which follows RNase H cleavage of tRNA and involves plus-strand transfer. The acquired protein src (sark) in a type of these agents can fuse with their gag protein to induce oncogenesis. The NtRTI tenofovir inhibits an enzyme encoded by pol first isolated from these viruses that is also used to generate cDNA in RT-PCR. A class of drugs targeting them includes AZT. For 10 points, name these viruses, such as HIV, that convert RNA to DNA with reverse transcriptase.
These agents can be innately targeted by TRIM5 and APOBEC family proteins.
retroviruses [prompt on lentivirus] &lt;Smart&gt;