The "reverse" form of this effect results in loss of stromal ca·ve·olin-1 and autophagy of neighboring  broblasts.
The "reverse" form of this effect results in loss of stromal ca·ve·olin-1 and autophagy of neighboring  broblasts. In one type of tissue this effect occurs when the E·3 ligase von Hippel-Lindau protein can no longer interact with hypoxia-inducible factor one-alpha. Lloyd Demetrius attributed the age-dependent acceleration of brain dysfunction in Alzheimer's and Parkinson's to the the "inverse" form of this effect. Di·chloro·acetic acid inhibits this effect by inhibiting mono·carboxylate transporters. It is o ten accompanied by an increase in the PK-M2 isoform of pyruvate kinase. This effect is the reverse of the Pasteur effect. The idea for this effect was based on the observation that certain types of tumors produce lactate even in the presence of oxygen. For 10 points, give this effect named for a German doctor who observed that cancer cells rely mostly on glycolysis.
The "reverse" form of this effect results in loss of stromal ca·ve·olin-1 and autophagy of neighboring  broblasts.
Warburg effect