Molecular approaches to treating this disorder have recently focused on inhibiting the RANK/RANKL/OPG triad pathway.
Molecular approaches to treating this disorder have recently focused on inhibiting the RANK/RANKL/OPG triad pathway. The breast cancer drug raloxifene, a selective estrogen receptor modulator, was initially developed to treat this disease, which is also treated with bisphosphonates. Unlike Paget's disease, which is more localized, this disease affects its entire target system, though of the types of tissue affected by this disease, the tissue that is lost most rapidly is the trabecular, or spongy, variety. Late stages of this disease are characterized by dorsal kyphosis, or curvature of the spine, and its progress can be slowed by calcitonin, which inhibits osteoclast activity. For 10 points, name this disease common in older women in which a decrease in bone mass results in an increased likelihood of fractures.
Molecular approaches to treating this disorder have recently focused on inhibiting the RANK/RANKL/OPG triad pathway.
osteoporosis