Initially introduced to account for homologous recombination in yeast, these four-stranded structural intermediates in DNA repair and recombination were proposed by a namesake British biologist in 1964.
Studies of the crystal structure of these have revealed that the ACC trinucleotide motif is crucial in their formation. RuvABC complexes have been shown to catalyze branch migration and resolution of these in E. coli, acting as a sliding collar to prevent their disruption. Their geometry is defined by a resolving plane and bisecting plane and they're located at the vertex of the interduplex angle; they come in two formations known as "Open-X" and "Stacked-X". Initially introduced to account for homologous recombination in yeast, these four-stranded structural intermediates in DNA repair and recombination were proposed by a namesake British biologist in 1964. FTP, name ► these eponymous junctions in DNA.
Studies of the crystal structure of these have revealed that the ACC trinucleotide motif is crucial in their formation.
Holliday junctions 