db/db mice are homozygous for a mutation in this hormone's receptor, and it is the product of the Ob gene.
Although not EPO, when this protein binds to the b, or long, isoform of its receptor, JAK2 is activated and phosphorylates said receptor at Tyr985 and Tyr1138, leading to the recruitment of STAT3. Minokoshi, et al. found that this protein activates AMPK, leading to the inhibition of acetyl-CoA carboxylase, reduction of malonyl-CoA levels, and an increase in fatty acid oxidation. Homozygous mutant Zucker rats       feature a mutation in this protein's receptor. Of the neurons that project from the arcuate nucleus into the lateral hypothalamic area, this hormone increases the number of neurons that secrete proopiomelanocortin and decreases the number of neurons that secrete neuropeptide Y by regulating expression of Fos and SOCS-3. db/db mice are homozygous for a mutation in this hormone's receptor, and it is the product of the Ob gene. For 10 points, identify this hormone released from adipose tissue that reduces appetite and regulates hunger along with ghrelin.
Although not EPO, when this protein binds to the b, or long, isoform of its receptor, JAK2 is activated and phosphorylates said receptor at Tyr985 and Tyr1138, leading to the recruitment of STAT3.
leptin [or ob protein until "Ob" is read]