Amino acid derived imidazolidinones named for MacMillan are a common organocatalyst used for this reaction, which is responsible for the synthesis of betanones.
This reaction can be used to prepare the Vince Lactam from chlorosulfonyl isocyanate. Amino acid derived imidazolidinones named for MacMillan are a common organocatalyst used for this reaction, which is responsible for the synthesis of betanones. The photo-catalyzed version of this reaction is the mechanism by which UV light forms thymidine dimers in DNA. Groups on one reactant tend to form 1,2 or 1,4-adducts in this reaction, whose transition state usually contains one reactant underneath the other with its electron-withdrawing groups pointed inward in order to maximize interaction between the HOMO and the LUMO. This reaction forms cyclohexenes and preferentially forms the endo product. For 10 points, name this cycloaddition in which a diene and a dienophile react.
This reaction can be used to prepare the Vince Lactam from chlorosulfonyl isocyanate.
Diels-Alder reaction