The committed step in their formation involves transfer of an ammonia group from glutamine to PRPP, eventually forming PRA.
An analog of one of these compounds, acyclovir, is used as an antiviral treatment. Besides causing uric acid buildup, the defective HGPRT in Lesch-Nyhan syndrome affects the synthesis and breakdown of these compounds. The synthesis of these compounds includes the addition of aspartate in a step immediately followed by one releasing fumarate. The committed step in their formation involves transfer of an ammonia group from glutamine to PRPP, eventually forming PRA. One key step in the synthesis of these compounds is the reaction of FGAM to AIR, forming an (*) imidazole ring. They are attached to ribose-5-phosphate during synthesis, and the first one formed is inosine monophosphate, or IMP. For 10 points, name these compounds composed of two aromatic nitrogen and carbon rings, notably including uric acid, caffeine, and the base pairs adenine and guanine.
An analog of one of these compounds, acyclovir, is used as an antiviral treatment.
Purines [prompt on nucleotides]