Due to therisk of hydride transfer, the Friedel-Craftfts reaction of this type suffers from poor selectivity.
As a way to circumvent the heavily regulated research use of pseudoephedrine, A.G.Myers suggested carrying out this kindof transformation with pseudoephenamine instead. Dolling, Davis, and Grabowski used a cinchona alkaloid based phasetransfer catalyst to effect this kind of transformation in the synthesis of indacrinone. The enantioselective version of theTsuji-Trost reaction is an asymmetric allylic reaction of this kind. Nitrogen mustards and nitrosoureas belong to a class ofcompounds named for their ability to effect this kind of reaction at the N-7 atom of guanine. A "unit" named for this transformationuses hydrofluoric or sulfuric acid as a catalyst and increases the octane number of the input. Along with reduction,a transformation of this kind happens to aldehydes and ketones when the simplest Grignard reagents are added. Due to therisk of hydride transfer, the Friedel-Craftfts reaction of this type suffers from poor selectivity. For 10 points, name this type ofreaction in which a carbon chain like methyl is attached to a molecule.
As a way to circumvent the heavily regulated research use of pseudoephedrine, A.G.Myers suggested carrying out this kindof transformation with pseudoephenamine instead.
alkylation [prompt on "making carbon-carbon bonds" and similar stu; reverse prompt on "methylation," "ethylation," "propylation," and "butylation"]