Stimulating T cells with ionomycin and PMA will primarily induce them to produce interferon gamma and one of these compounds.
One member of this class of proteins is fused with the monoclonal antibody tucotuzumab in a drug that targets the EpCAM surface protein on cancer cells. One member in this family of molecules stimulates bone resorption by osteoclasts following decreased estrogen activity, thereby contributing to osteoporosis. The disorder X-SCID is caused by mutations in the receptor for one type of these proteins, and those receptors generally contain a common gamma chain. The first and eighteenth one of these proteins is activated by a complex containing PYCARD and caspase-1, called the (*) inflammosome. TNF and one of these proteins can contribute to a breakdown of the blood-brain barrier during inflammation. Stimulating T cells with ionomycin and PMA will primarily induce them to produce interferon gamma and one of these compounds. For 10 points, name these cytokines which are named for their role in signaling between white blood cells.
One member of this class of proteins is fused with the monoclonal antibody tucotuzumab in a drug that targets the EpCAM surface protein on cancer cells.
interleukins [prompt on "cytokines"]