A calculation by Cyrus Levinthal proved that this process doesn't occur randomly.
In bacteria, this process occurs when each one of seven subunits of a dual-ringed protein is bound to a molecule of ATP, causing a conformation change so that the target is trapped in the GroEL-GroES complex. The addition of urea and beta-mercaptoethanol to species in the Anfinsen experiment showed that mistakes in this process are corrected spontaneously. A calculation by Cyrus Levinthal proved that this process doesn't occur randomly. An intermediate in this process is the molten globule, which forms after the burial of hydrophobic side chains. Assisted by chaperone proteins, this process is simulated @home on computers participating in a Stanford project. For 10 points, prions result from failures in what process that creates tertiary and quaternary structures in proteins?
In bacteria, this process occurs when each one of seven subunits of a dual-ringed protein is bound to a molecule of ATP, causing a conformation change so that the target is trapped in the GroEL-GroES complex.
protein folding