For 10 points, name this neurodegenerative disease caused by an autosomal dominant mutation, which normally manifests itself in middle age.
The most famous symptom of this disease also appears in the rheumatic fever-associated gravidarum and Sydenham's diseases. In Drosophila, the intrabody C4 sFv has been shown to delay the symptoms of this disease. The GTP-binding protein Rhes induces sumoylation in and therefore increases cytotoxicity of a protein modified in this disease. It involves an increase in the number of glutamines beyond 36 in the polyQ region on chromosome 4. It's not Tourette syndrome, but tetrabenazine was the first drug to be FDA-approved to treat the involuntary, irregular muscle contractions called chorea that is characteristic of this disease.  For 10 points, name this neurodegenerative disease caused by an autosomal dominant mutation, which normally manifests itself in middle age.
The most famous symptom of this disease also appears in the rheumatic fever-associated gravidarum and Sydenham's diseases.
Huntington's disease