Naive cells can become either plasma or this type of cell upon exposure to an antigen.
In mice, a population of self-renewing, anti-tumor cells mediating this phenomenon can be generated by Wnt3A ["wint 3 A"] activation and GSK3-beta inhibition. In non-human primates, the panel for this phenotype consists of the markers CD95, CD28, IFN-gamma, CD8, and CD4. Differential expression of markers such as CCR7 and L-selectin, also known as CD62L, allows cells mediating this property to be subclassified into (*) "stem," "central," and "effector" populations. This phenomenon is mediated by the longer-lived cells formed during germinal center differentiation. Preferential reliance on this phenomenon can lead to "original antigenic sin." Naive cells can become either plasma or this type of cell upon exposure to an antigen. For 10 points, name this phenomenon, the hallmark of adaptive immunity, in which namesake T and B cells are primed to deal with pathogens the body has encountered before.
In mice, a population of self-renewing, anti-tumor cells mediating this phenomenon can be generated by Wnt3A ["wint 3
immunological memory [prompt on adaptive immunity before mentioned] 