For 10 points, name this innate immune pathway in which the membrane attack complex kills pathogens.
A protein in this pathway is named for the city of Hakata, Japan and also for the fact that it has collagen-like and fibrinogen-like regions. Porins in Neisseria gonorrhea bind an inhibitor of this process. The decay-accelerating factor speeds degradation of proteins involved in this process. This pathway is overactive in GPI-anchor deficiencies like PNH or in atypical hemolytic uremia. An effector protein for it polymerizes in a ring after a (*) proteolytic cascade of factors B, D, and P. When present together, CD59 and sialic acid block this process from occurring. This pathway initiates when a convertase cleaves an isopeptide bond to form anaphylatoxin C4a. Serum is heat-inactivated before use to destroy this pathway. Its three forms are lectin, classical, and alternative. For 10 points, name this innate immune pathway in which the membrane attack complex kills pathogens.
A protein in this pathway is named for the city of Hakata, Japan and also for the fact that it has collagen-like and fibrinogen-like regions.
complement system [or classical complement system; or alternative complement system; or lectin complement system; prompt on innate immunity]