This biological pathway, which is inhibited by the adenoviral protein Gam1, was discovered in the mid-90s through work on the stable modified protein RanGAP1, which is protected from deconjugation by its association with the pore complex protein RanBP2.
This biological pathway, which is inhibited by the adenoviral protein Gam1, was discovered in the mid-90s through work on the stable modified protein RanGAP1, which is protected from deconjugation by its association with the pore complex protein RanBP2. It targets proteins involved in formation of PML nuclear bodies and DAXX, and creates changes in activity of transcription factors like c-Myc and the localization of topoisomerase I in the nucleus. The namesake protein is transferred to the E2 conjugating enzyme Ubc-9 and then to the terminal amino group of a lysine side chain in its target, after it's been activated through adenylation by the enzyme complex SAE1 or SAE2. FTP, name this post-translational modification pathway which gets its name from ►a family of "small ubiquitin-like" proteins.  
This biological pathway, which is inhibited by the adenoviral protein Gam1, was discovered in the mid-90s through work on the stable modified protein RanGAP1, which is protected from deconjugation by its association with the pore complex protein RanBP2.
sumoylation or just SUMO pathway