I, which is inhibited by many anti-hypertensive drugs to lower blood pressure.
The man who discovered this protein, Leonard Skeggs, also invented the AutoAnalyzer. A competitive inhibitor for this proteinÂ—basically, the dipeptide proline-alanine, but with a sulfhydryl groupÂ—was one of the first pharmaceuticals designed using QSAR. A homolog of this protein is the receptor targeted by the SARS virus. This enzyme catalyzes the formation of Abeta-40 from Abeta-42, which explains why its inhibitors like (*) captopril increase susceptibility to Alzheimer's disease. This enzyme synthesizes an octapeptide by cleaving off a histidine and a leucine residue from its substrate's C terminus. It also breaks down bradykinin. This protease, which localizes mostly to the lungs, acts in combination with renin in the RAAS system. For 10 points, name this protein that forms angiotensin II from angiotensin I, which is inhibited by many anti-hypertensive drugs to lower blood pressure.
The man who discovered this protein, Leonard Skeggs, also invented the AutoAnalyzer.
angiotensin-converting enzyme [or ACE; do not accept or prompt on "angintensin I" or "angiotensin II" or "angiotensin"] 