Imetelstat, a potential new cancer therapy agent, works by targeting the enzyme that repairs these structures.
Imetelstat, a potential new cancer therapy agent, works by targeting the enzyme that repairs these structures. Blackburn, Greider, and Szostak received the 2009 Nobel Prize for determining the role of these structures, which typically adopt a G-quadruplex shape. The shortening of these structures explains the Hayflick limit to cell division and is the basis for the cellular theory of aging, and that shortening of these structures can lead to cell senescence or apoptosis. Consisting of thousands of TTAGGG repeats in humans, name these end sequences of chromosomes that prevent genes from being lost during DNA replication.
Imetelstat, a potential new cancer therapy agent, works by targeting the enzyme that repairs these structures.
telomeres [prompt on chromosomes before "role"]