The cold-sensitive mutants brr1 and brr2 have defects in the assembly of this structure.
The cold-sensitive mutants brr1 and brr2 have defects in the assembly of this structure. Another protein required for the assembly of this structure has the Tudor domain, complexes with GEMINs and the UNRIP protein, and is named because it's deficient in spinal muscular atrophy. It co-precipitates with the DEXD/H box proteins p68 and p72. Proteins in this magnesium-dependent complex share an N-terminal alpha helix followed by five consecutive beta sheets, which is called the (*) Sm motif, and links the proteins B, D1, D2, D3, E, F, and G in a heptameric assembly. The P element in Drosophila is a silencer for this complex when it acts on DSCAM or fibronectin. The U2 component of this structure hybridizes to the branchpoint sequence and causes an adenosine to "bulge". This structure catalyzes two transesterifications marked off by the poly-pyrimidine tract. For 10 points, name this complex of snRNPs [snurps] that removes introns from pre-mRNA.
The cold-sensitive mutants brr1 and brr2 have defects in the assembly of this structure.
spliceosome [prompt on snRNPs; prompt on any alphanumeric protein beginning with U like U1, U2, U6, etc.]