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Y14, MAGOH, eIF4AIII, and MLN51 form the complex central to this process in higher eukaryotes. Â In C. elegans, the proteins SMG-1, 5, 6, and 7, named for their effects as supressors of morphogenetic effects on genitalia, are all required for this pathway. Â During this process, SMG-1, eRF-1 and -3, and Upf-1 form the SURF complex, which associates with a downstream (*) EJC. Â This process is thought to occur during a pioneer round of translation, and ultimately happens due to the persistence of exon-junction complexes at locations where splicing errors have occurred. Â For 10 points, identify this process which prevents the translation of truncated proteins by recognizing premature stop codons and subsequently destroying the defective mRNA.
Y14, MAGOH, eIF4AIII, and MLN51 form the complex central to this process in higher eukaryotes.
nonsense-mediated decay