Denaturation is similar to the opposite of this process, and flaws in it are a common feature of prion diseases.
The energy landscape of this process is funnel-shaped according to a Peter Wolynes model. This process in E. coli is aided by the GroEL/GroES system. An intermediate in this process is called the molten globule state. Hsp70 is an example of a molecular chaperone that assists this process, which is the subject of Levinthal's paradox. Denaturation is similar to the opposite of this process, and flaws in it are a common feature of prion diseases. This process might begin with the formation of secondary structures, such as alpha helices or beta sheets. For 10 points, name this process in which a linear polypeptide is transformed into its three-dimensional conformation.
The energy landscape of this process is funnel-shaped according to a Peter Wolynes model.
protein folding [accept reasonable equivalents] 