Sufferers of this disease are less responsive to GIP and have decreased levels of GIP secretion.
One treatment of this disease targets a nuclear receptor that forms a heterodimer with retinoid X receptor, influencing the transcription of genes involved in angiogenesis, adipocyte differentiation, inflammation, and other functions; that nuclear receptor is PPARÂ­gamma. Sufferers of this disease are less responsive to GIP and have decreased levels of GIP secretion. Thus, this disease can be treated with inhibitors of dipeptidylÂ­peptidaseÂ­4, which cleaves and inactivates incretins; (*) sitagliptin is one such drug. Another drug used for the treatment of this disease has a biguanide moiety, downregulates hepatic gluconeogenesis, and increases GLUT4 receptor expression in peripheral tissues; that is metformin. Approximately 60 percent of this disease's sufferers have its namesake retinopathy, which causes progressive blindness. It can be diagnosed by looking atserum levels of hemoglobin A1c. Obesity and a sedentary lifestyle are two risk factors for this disease. For 10 points, name this often adultÂ­onset disease characterized by insulin resistance.
One treatment of this disease targets a nuclear receptor that forms a heterodimer with retinoid X receptor, influencing the transcription of genes involved in angiogenesis, adipocyte differentiation, inflammation, and other functions; that nuclear receptor is PPARÂ­gamma.
type 2 diabetes mellitus [accept adultÂ­onset diabetes mellitus until read; or type 2 DM or DM2; prompt on partial answers]