A type of antiÂ­nuclear antibodies that targets SclÂ­70, a member of this group of enzymes, is implicated in the diffuse systemic type of scleroderma.
A type of antiÂ­nuclear antibodies that targets SclÂ­70, a member of this group of enzymes, is implicated in the diffuse systemic type of scleroderma. Many of these enzymes function by first binding to a GÂ­segment of DNA and forming a doubleÂ­strand break in that GÂ­segment using a pair of catalytic tyrosine residues; then, the TÂ­segment is transported through the CÂ­terminal gate and the break is resealed. That is the twoÂ­gate model of these enzymes. These enzymes are responsible for the resolution of catenanes and hemiÂ­catenanes. The quinolone family of antibiotics target this group of enzymes. Compounds isolated from the genus Camptotheca, like irinotecan and (*) topotecan, inhibit the Type I form of these enzymes in eukaryotes. The function of that subgroup is to change the DNA linking number by units of plus or minus 1. DNA gyrase is a prokaryotic type II form of these enzymes. For 10 points, name these enzymes that regulate DNA supercoiling and overall topology.
A type of antiÂ­nuclear antibodies that targets SclÂ­70, a member of this group of enzymes, is implicated in the diffuse systemic type of scleroderma.
topoisomerases