This protein is fused to IL-2 in the chemotherapeutic drug Ontak.
Descriptive answer acceptable. This protein's unusual catalytic domain is an antiparallel beta sheet surrounded by three alpha helices that binds the dinucleotide inhibitor ApUp. This protein is fused to IL-2 in the chemotherapeutic drug Ontak. It targets a noncanonical histidine residue substituted by a quaternary ammonium amide. Cross-reacting material 197, derived from this protein, is a vaccine scaffold that binds heparin receptors. This protein's gene, the first moron discovered, is only transcribed under iron starvation in cells lysogenized by the beta (*) phage. It catalyzes the transfer of ribosylated ADP from NAD+ to elongation factor 2. This protein is injected in the Schick test. Emil von Behring won the first Nobel Prize in Physiology for discovering this protein, which inhibits translation. It makes up 5% of the cell weight of its disease-causing Corynebacterium. For 10 points, name this toxin included in a vaccine with toxoids for pertussis and tetanus.
Descriptive answer acceptable. This protein's unusual catalytic domain is an antiparallel beta sheet surrounded by three alpha helices that binds the dinucleotide inhibitor ApUp.
diphtheria toxin [or diphtheria exotoxin; or diphtheria toxoid; anything mentioning diphtheria is fine]