Two of the Lipinski rules of five place constraints on the amount of these interactions in which a candidate drug can participate.
This effect explains why orthoÂ­nitrophenol has a lower melting point than meta or paraÂ­nitrophenol. In its mechanism of action, the antibiotic vancomycin forms these interactions with the sideÂ­chains of peptidoglycan cellÂ­wall precursors, preventing crossÂ­linking. Two of the Lipinski rules of five place constraints on the amount of these interactions in which a candidate drug can participate. This phenomenon explains the (*) broad absorption spectrum of alcohols in IR spectroscopy. BetaÂ­diketones exhibit an intramolecular form of this interaction. This strongest interaction of this type occurs in the bifluoride ion, where protons are fluxionally shuttled between HF and F minus. Differences in the number of these interaction account for differences in DNA melting temperatures. For 10 points, name these interactions, two of which form between A and T and three of which form between G and C.
This effect explains why orthoÂ­nitrophenol has a lower melting point than meta or paraÂ­nitrophenol.
hydrogen bonds