In its rate limiting step, the second carbon on the zwitterionic thiazolium ring of the TPP cofactor performs a nucleophilic attack, releasing a CO2.
The first and third isoforms of an enzyme that inactivates this complex are abundant in the heart and testes, respectively. An enzyme in this complex is arranged as twenty four subunits forming a cubic core in prokaryotes, and sixty subunits forming a dodecahedral core in eukaryotes. Most people with primary biliary cirrhosis have autoantibodies to this complex, which catalyzes a reaction called the Swanson conversion. The last enzyme in this complex, which also appears in similar complexes acting upon branched chain amino acids and alpha-ketoglutarate, produces a molecule apiece of (*) FAD and NADH. In its rate limiting step, the second carbon on the zwitterionic thiazolium ring of the TPP cofactor performs a nucleophilic attack, releasing a CO2. The E2 enzyme in this complex catalyzes the transfer of an acetyl group from a "swinging arm" of lipoate to the thiol group, forming the final product. For 10 points, name this enzyme complex that converts the end product of glycolysis into acetyl-CoA.
The first and third isoforms of an enzyme that inactivates this complex are abundant in the heart and testes, respectively.
pyruvate dehydrogenase complex [or PDC; do not accept or prompt on "pyruvate decarboxylase"]