Chairlike transition states were posited to determine E/Z selectivity in the formation of these molecules in the Ireland model.
Chairlike transition states were posited to determine E/Z selectivity in the formation of these molecules in the Ireland model. In the the alkylation of these nucleophilic molecules, clustered ones tend to react at the softer reaction center, resulting in C-alklyation. Strong bases, such as LDA, catalyze the formation of kinetic ones, while weaker bases promote the formation of thermodynamic ones, and sufficiently weak bases can allow this charged intermediate to react with the compound from which it is generated--this reaction is called a crossed aldol reaction. This compound is generated when a strong base abstracts an alpha hydrogen in the first step of the Michael addition. For 10 points, name this class of reactive compounds, the conjugate bases of carbonyl compounds, which can be formed by deprotonating the tautomer of a keto compound.
Chairlike transition states were posited to determine E/Z selectivity in the formation of these molecules in the Ireland model.
enolates [do not prompt on or accept "enols"]