Its class II region contains the LMP and the TAP genes, which produce parts or protein-cleaving proteosomes.
Its class II region contains the LMP and the TAP genes, which produce parts or protein-cleaving proteosomes. Discovered in the 1940s by George Snell, its function was not elucidated until 1975, when Zinkernagel and Doherty (*) found that the molecules assocated with it interacted with immune cells. Most notably, its class I region codes for molecules that present peptide chains to cytotoxic T-cells, allowing them to recognize what to attack. Known as H-2 in mice, where it is located on chromosome 17, and Human Leukocyte A in humans, it contains the most polymorphic loci found in humans. FTP, name this set of genes which control immunological self and non-self recognition, thus invoking rapid rejection of foreign tissues.
Its class II region contains the LMP and the TAP genes, which produce parts or protein-cleaving proteosomes.
{M}ajor {H}istocompatibility {C}omplex (prompt on {H-2} or {H}uman {L}eukocyte {A} before mentioned)