The discovery of bromodomain and chromodomain-containing proteins which bind to the amino tail of these proteins was cited as evidence for a "code" associated with these according to a landmark paper by Jenuwein and Allis.
The discovery of bromodomain and chromodomain-containing proteins which bind to the amino tail of these proteins was cited as evidence for a "code" associated with these according to a landmark paper by Jenuwein and Allis. Gcn5 and the SWI/SWF complex found in yeasts modify this class of proteins, and CENP-A is homologous to one of the proteins and is found in centrosomes. Their namesake acetyltransferases add acetyl groups to lysine residuses near the amino terminus, and they contain large amounts of basic residues which facilitates their interaction with DNA. Discovered by Albrecht Kossel, for 10 points, identify these octameric proteins around which DNA binds to produce nucleosomes, which come in H2, H3 and H4 varieties.
The discovery of bromodomain and chromodomain-containing proteins which bind to the amino tail of these proteins was cited as evidence for a "code" associated with these according to a landmark paper by Jenuwein and Allis.
{histone}s