Defects in the NPXY sorting signal prevent this molecule's receptor from binding a clathrin/AP2 pit, leading to a disease abbreviated FH.
Defects in the NPXY sorting signal prevent this molecule's receptor from binding a clathrin/AP2 pit, leading to a disease abbreviated FH. SREBP activates transcription of this particle's receptor, a protein that Brown and Goldstein won Nobel Prizes for characterizing. This molecule's oxidized product accumulates in macrophages called foam cells. A massive 4536-residue monomer called (*) ApoB-100 is one of its components. These particles have a much lower concentration of triglycerides than do chylomicrons. A high concentration of these particles in blood vessels can lead to atherosclerosis. For 10 points, name these lipoproteins that transport cholesterol from the liver to the tissues, erroneously known as "bad cholesterol."
Defects in the NPXY sorting signal prevent this molecule's receptor from binding a clathrin/AP2 pit, leading to a disease abbreviated FH.
LDL [or low-density lipoprotein; or very low-density lipoprotein or VLDL; prompt on partial answer; prompt on cholesterol before it is read]