Its release can be blocked by ruthenium red and facilitated by cyclic ADP-ribose via cyclic GMP increase, both acting on ryanodine receptors, allowing oscillations of it to propagate in dendrites.
Its release can be blocked by ruthenium red and facilitated by cyclic ADP-ribose via cyclic GMP increase, both acting on ryanodine receptors, allowing oscillations of it to propagate in dendrites. It enters the cell as inwardly rectifying CRAC currents via trp [TRIP] channels when its intracellular levels are depleted by IP3-mediated release from smooth ER. It can activate nitric oxide synthase and CaM kinase II upon binding to calmodulin, and binds to its sensor synaptotagmin to mediate vesicle fusion at the synapse. FTP name this +2 ion whose influx causes the release of neurotransmitters.
Its release can be blocked by ruthenium red and facilitated by cyclic ADP-ribose via cyclic GMP increase, both acting on ryanodine receptors, allowing oscillations of it to propagate in dendrites.
{calcium}