Corey and Yamamoto used this reaction to selectively synthesize allylic alcohols, and the Corey-Chaykovsky reaction replaces the reagent in this reaction with one containing sulfur in order to synthesize epoxides.
Corey and Yamamoto used this reaction to selectively synthesize allylic alcohols, and the Corey-Chaykovsky reaction replaces the reagent in this reaction with one containing sulfur in order to synthesize epoxides. An ester version of it was developed by Wadsworth, Emmons, and Horner while the Schlosser modification switches the stereochemistry of the products from Z to E. Its final step proceeds through a four-member ring, which comes immediately after a nucleophillic attack creates a betaine. Its reagent is prepared by reacting an alkyl halide with triphenylphosphine and deprotonating the product with n-butyllithium, creating a ylide. FTP, name this reaction named for a German chemist that creates an alkene from a carbonyl compound.
Corey and Yamamoto used this reaction to selectively synthesize allylic alcohols, and the Corey-Chaykovsky reaction replaces the reagent in this reaction with one containing sulfur in order to synthesize epoxides.
{Wittig} Reaction