The action of this is facilitated by an ylidic attack of a ketone group, resulting in a beta-alkoxide that is decarboxylated and deprotonated to form a thiamine heterocycle.
The action of this is facilitated by an ylidic attack of a ketone group, resulting in a beta-alkoxide that is decarboxylated and deprotonated to form a thiamine heterocycle. It contains a core of lysine-bound lipoic acid "arms" that make up E2 di-hydro-lipoyl trans-acetylases, whose disulfide groups serve as acyl and electron carriers. This multimer contains an E3-bound flavin adenine dinucleotide which transfers protons from reduced lipoyl-lysine to nicotinamide adenine dinucleotide. It catalyzes irreversible oxidative decarboxylation, attaching the remaining hydroxyl-ethyl group to TPP in E1 before the lipoyl-lysine of E2 carries it to coenzyme A. Similar to alpha-ketoglutarate dehydrogenase found later in the Krebs cycle, FTP name this enzyme complex that oxidizes the product of glycolysis.
The action of this is facilitated by an ylidic attack of a ketone group, resulting in a beta-alkoxide that is decarboxylated and deprotonated to form a thiamine heterocycle.
pyruvate dehydrogenase complex (prompt on "pyruvate oxidase")