The pyrrolo-pyridine derivative RK-20449 inhibits Hck in these cells, after a spontaneous phenotypic switch causes them to overproduce SFKs.
The pyrrolo-pyridine derivative RK-20449 inhibits Hck in these cells, after a spontaneous phenotypic switch causes them to overproduce SFKs. The Cairns-Nowell model proposes that these cells are the ones that respond earliest to selective pressure. A conventional Aldefluor assay can detect these cells, which are killed after treatment with 3-BrOP due to inhibition of glycolysis. They turn up in a FACS assay susceptible for CD34 positive, CD38 negative cells. The potassium ionophore salinomycin selectively targets these cells. John Dick discovered these cells by xenografting NOD/SCID mice and showing that only about 4% developed (*) AML. Subclonal diversity implies that the concentration of these cells is much higher than expected. These cells are enriched in patients with minimal residual disease, which explains how they lead to remittances. These cells are further classified into sphere-forming neoplastic and culture-forming neoplastic. For 10 points, name these non-differentiated cells which turn into tumors.
The pyrrolo-pyridine derivative RK-20449 inhibits Hck in these cells, after a spontaneous phenotypic switch causes them to overproduce SFKs.
cancer stem cells [or CSCs; or tumor stem cells; or TICs; or tumor-initiating cells; prompt on stem cells; prompt on cancer or tumor cells]