While humans have around 500 of them, their highly conserved structures were thought to make them poor drug targets.
While humans have around 500 of them, their highly conserved structures were thought to make them poor drug targets. However, imatinib successfully inhibits the activity of Bcr-Abl, one of these that is formed by the Philadelphia chromosome. Another well-studied one is activated by mitogen, and functions in diverse pathways such as osmoregulation and the mating response in yeast. PFK-1 is an important allosteric regulator of glycolysis, and they are also important in signal transduction, where they often function in cascades. These enzymes target serine, threonine, or tyrosine residues, and are opposed by phosphatases. FTP, name this class of enzymes that transfers the gamma phosphate from ATP onto a substrate.
While humans have around 500 of them, their highly conserved structures were thought to make them poor drug targets.
{kinase}