Sulfur-containing analogues of these compounds are particularly toxic in people with TPMTdeficiency.
Sulfur-containing analogues of these compounds are particularly toxic in people with TPMTdeficiency. Their synthesis of these compounds is inhibited by the chemotherapeutic cladirabine andthe immunosuppressant mycophenolate. The synthesis of these compounds requires GAR andAICAR transformylase, which have a folate cofactor. The salvage of these compounds requires theenzyme HGPRT, which is mutated in Lesch-Nyhan syndrome. Inosine and hypoxanthine fall into this(*) class of compounds. Uric acid is a common byproduct of their metabolism, which causes gout. Thesecompounds contain a six-membered ring fused to a five-membered ring. For 10 points, name theseheterocyclic compounds that include guanine and adenine, which along with pyrimidines make up DNA.
Sulfur-containing analogues of these compounds are particularly toxic in people with TPMTdeficiency.
purines [prompt on "nucleotides" or "nucleosides" or "nitrogenous bases" or "bases"]