A Robinson Annulation is a combination of this reaction with a Michael Addition that uses a weak base rather than the typical strong one.
A Robinson Annulation is a combination of this reaction with a Michael Addition that uses a weak base rather than the typical strong one. TMS enol ethers enhance its enantioselective cross variety. It begins with the removal by the hydroxide of the acidic alpha hydrogen, forming a reactive enolate that attacks the electrophilic carbonyl group in its second step. Its final step is a simple acid-base reaction in which a water molecule is deprotonated by the alkoxide, creating the beta-hydroxyaldehide product. FTP, what is this condensation reaction also used for ketones as well as its eponymous functional group?
A Robinson Annulation is a combination of this reaction with a Michael Addition that uses a weak base rather than the typical strong one.
{aldol} condensation