A common assay to detect the outcome of this process is to perform an HpaII digestion followed by PCR of a series of CAG repeats in the polymorphic HUMARA locus.
A common assay to detect the outcome of this process is to perform an HpaII digestion followed by PCR of a series of CAG repeats in the polymorphic HUMARA locus. Mutations in HRPT cause results of this process to appear biased in blood due to negative selection. This process uses LINE-1 elements as "way stations" or "boosters," and Tsix (tee-six) is one important gene for controlling it. The "propagation" stage of this process requires PRC2 binding to H3K27 tri-methyl histones, results in the recruitment of macroH2A, and relies on a processed, polyadenylated non-coding RNA called XIST [ex-ist]. If this process is skewed, it can result in carriers of diseases like G6PD deficiency and factor VIII deficiency manifesting symptoms. The randomness of this process gives calico cats their tortoiseshell fur color. FTP, name this process discovered by Mary Lyon, which occurs in the nuclei of human females and results in the production of a Barr Body.
A common assay to detect the outcome of this process is to perform an HpaII digestion followed by PCR of a series of CAG repeats in the polymorphic HUMARA locus.
X-inactivation [accept equivalents like "inactivation of the X chromosome", accept Lyonization before Mary Lyon's name is said, accept Barr body formation before mention, accept X-condensation instead of inactivation]