This disease causes cleavage of chemokine receptor CXCR1 on neutrophils, which disables their antibacterial activity.
This disease causes cleavage of chemokine receptor CXCR1 on neutrophils, which disables their antibacterial activity. A common test for this disease in newborns screens for elevated rates of immunoreactive trypsinogen. The mutation causing this disease confers a heterozygote advantage on its carriers in the form of increased resistance to tuberculosis and increased survival of cholera and typhoid. The most common mutation that causes this disease is (*) delta-F508, which is a deletion of phenylalanine on a certain transmembrane conductance regulator. That protein is a chloride channel, which is why a common symptom of this disorder is salty sweat. For 10 points, name this disorder characterized by thick mucus buildup in the lungs.
This disease causes cleavage of chemokine receptor CXCR1 on neutrophils, which disables their antibacterial activity.
cystic fibrosis (or CF)