A defect in one of these proteins causes Glanzman's thrombasthenia. Mutations in the CD18 subunit of another of these pro- teins causes a disease known as LAD-1. These proteins are the targets of drugs such as abciximab, eptifibatide, and natalizumab. These proteins frequently bind to the acidic RGD or LDV sequences of their ligands. The kinase FAK mediates the signaling performed by these proteins, which bind to filamin and talin at their cytoplasmic faces. The alpha-A domain of one of these proteins is homologous to the A-domain of von Willenbrand factor. The binding of divalent cations to these heterodimeric proteins allows them to bind to ligands such as VCAMs and ICAMs. One of these proteins designated "alpha-6 beta-1" binds to laminin while one designated "alpha-5 beta-1" binds to fibronectin. They are similar to selectins and cadherins. For 10 points, name these transmembrane receptors and cell adhesion molecules which mediate interactions between cells and the extracellular matrix.
A defect in one of these proteins causes Glanzman's thrombasthenia. Mutations in the CD18 subunit of another of these pro- teins causes a disease known as LAD-1. These proteins are the targets of drugs such as abciximab, eptifibatide, and natalizumab. These proteins frequently bind to the acidic RGD or LDV sequences of their ligands. The kinase FAK mediates the signaling performed by these proteins, which bind to filamin and talin at their cytoplasmic faces. The alpha-A domain of one of these proteins is homologous to the A-domain of von Willenbrand factor. The binding of divalent cations to these heterodimeric proteins allows them to bind to ligands such as VCAMs and ICAMs. One of these proteins designated "alpha-6 beta-1" binds to laminin while one designated "alpha-5 beta-1" binds to fibronectin. They are similar to selectins and cadherins. For 10 points, name these transmembrane receptors and cell adhesion molecules which mediate interactions between cells and the extracellular matrix.
A defect in one of these proteins causes Glanzman's thrombasthenia.
ntegrins [or glycoprotein 2b/3a until "RGD" is read; prompt on "CDs" or "clusters of differentiation" until "CD18" is read; prompt on "glycoproteins" until "RGD" is read]