Drugs derived from these compounds include carbapenems and cephalosporins, which work by inhibiting peptidoglycan synthesis.
These compounds can be produced from alkynes and nitrones using a copper catalyst in the Kinugasa reaction. One of these compounds reacts with an alcohol in the tail addition step of the Nicolau total synthesis of Taxol. These compounds can be produced from ketenes in the Staudinger synthesis, and one example of them was first synthesized by John C. Sheehan. A class of enzymes which breaks down one type of these compounds can be inhibited by clavulanate and is exemplified by NDM-1, which is named after New Delhi. These compounds can be synthesized from oximes via an acid-catalyzed Beckmann rearrangement or from hydrazoic acid and a cyclic ketone via a Schmidt reaction. Drugs derived from these compounds include carbapenems and cephalosporins, which work by inhibiting peptidoglycan synthesis. For 10 points, identify these cyclic amides whose "beta" variety names a class of antibiotics that includes penicillin.
These compounds can be produced from alkynes and nitrones using a copper catalyst in the Kinugasa reaction.
lactams [or beta-lactams; or gamma-lactams; prompt on "cyclic amides"]