Alcohols can be converted to tosylates to increase their reactivity in this kind of reaction.
The pre-equilibrium rate constant for one of these reactions is proportional to the cube of the minimum distance of the approach of the reactants times the exponential of the Coulombic potential energy of the reactants according to the Fuoss-Eigen equation. That rate constant arises from the Eigen-Wilkins mechanism, which describes this kind of reaction. In square planar complexes, the rate of this kind of reaction can be enhanced by the presence of a strong sigma donor ligand on the other side of the complex in the trans effect. This type of reaction can take place via associative or interchange mechanisms. Alcohols can be converted to tosylates to increase their reactivity in this kind of reaction. In a noted mechanism for this type of reaction, inversion of stereochemistry occurs as a nucleophile forces out a leaving group in a single step. For 10 points, name this type of reaction in which one ligand or functional group is replaced with another one.
The pre-equilibrium rate constant for one of these reactions is proportional to the cube of the minimum distance of the approach of the reactants times the exponential of the Coulombic potential energy of the reactants according to the Fuoss-Eigen equation.
ubstitution [or ligand substitution; or nucleophilic bimolecular substitution; or SN2]