The mammalian form of this enzyme consists of two transmembrane domains called M1 and M2 and two catalytic domains called C1 and C2 which are activated by a G-s-alpha subunit of a stimulatory G protein.
This enzyme is inhibited by the compounds KH7 and NKY80. The gene cyaA in Bordetella pertussis codes for a toxin which is cleaved into hemolysin and a calmodulin-dependent form of this enzyme. The only soluble isoform of this enzyme is regulated by bicarbonate and is highly expressed in sperm cells. This enzyme can be inhibited by P-site inhibitors and activated by forskolin. The mammalian form of this enzyme consists of two transmembrane domains called M1 and M2 and two catalytic domains called C1 and C2 which are activated by a G-s-alpha subunit of a stimulatory G protein. The compound produced by this enzyme is used to activate catabolite activator protein in the lac operon; that compound was discovered by Earl Sutherland and also activates protein kinase A. For 10 points, name this enzyme important in signal transduction which produces a pyrophosphate as it converts ATP to cyclic AMP.
This enzyme is inhibited by the compounds KH7 and NKY80. The gene cyaA in Bordetella pertussis codes for a toxin which is cleaved into hemolysin and a calmodulin-dependent form of this enzyme.
adenylyl cyclase [or adenylate cyclase; or AC]