The E6 and E7 proteins encoded by HPV respectively degrade this protein and the very similar Rb.
A zinc atom binds to the H1 helix and L3 loop of this protein, whose oligomerization domain allows it to form a tetramer and interact with DNA. The E6 and E7 proteins encoded by HPV respectively degrade this protein and the very similar Rb. As a transcription factor, this protein upregulates the expression of Bax and PUMA, members of the Bcl-2 gene family. The serine/threonine kinase (*) ATM phosphorylates this protein to prevent it from being polyubiquitinated and degraded by Mdm2. This protein, which is essential for cell-cycle arrest at the G1 checkpoint, is mutated or deleted in over half of all human tumors. For 10 points, name this tumor suppressor gene known as the "guardian angel of the genome."
A zinc atom binds to the H1 helix and L3 loop of this protein, whose oligomerization domain allows it to form a tetramer and interact with DNA.
tumor protein p53 [or cellular tumor antigen p53; or phosphoprotein p53; or tumor suppressor p53; or antigen NY-CO-13; or transformation-related protein 53; or TRP53]