Like type 1 diabetes, this disease is associated with the 0201 allele of HLA-DQB1.
Jabri et al. discovered that mice with this disease can be treated by blocking IL-15 signaling. Poorly managed cases of this disease can lead to a form of T-cell lymphoma called EATL, and this disease also has a connection to the single itchiest condition known to man, dermatitis herpetiformis. Pathologic findings in this disease include crypt hyperplasia and lymphocyte invasion of the lamina propria. Like type 1 diabetes, this disease is associated with the 0201 allele of HLA-DQB1. This disease, which is diagnosed by finding antibodies to tissue transglutaminase, is triggered by antibodies to gliadin peptides and causes villous blunting. For 10 points, name this disease that manifests as gluten intolerance.
Jabri et al. discovered that mice with this disease can be treated by blocking IL-15 signaling.
celiac disease [prompt on "gluten intolerance" until it is read]