The Bartoli synthesis uses three equivalents of them to produce indoles, and another reaction that uses them results in the production of enol lactones, the Fujimoto-Belleau reaction.
The Bartoli synthesis uses three equivalents of them to produce indoles, and another reaction that uses them results in the production of enol lactones, the Fujimoto-Belleau reaction. Their utility is limited by the Boord reaction, and they are instrumental in the production of the drugs Taximofen and Naproxen. Because they dimerize by the Schenk equilibrium, they must be coordinated to solvents like THF or diethyl ether. Also used in the ring opening of epoxides, they act as strong nucleophiles to produce alcohols from aldehydes or ketones, and as bases, they produce the corresponding alkane when dissolved in water. FTP, identify these magnesium halide organometallic reagents, named for a Frenchman.
The Bartoli synthesis uses three equivalents of them to produce indoles, and another reaction that uses them results in the production of enol lactones, the Fujimoto-Belleau reaction.
{Grignard} reagents