A mutation in CFTR, yet another member ofthis family, causes cystic fibrosis.
A member of this protein family crystallized by Kaspar Locher, Allen Lee, and Douglas Rees was the first member to have its crystal structure determined and is the E. coli protein BtuCD. The glycoprotein tapasin mediates the interaction between another member of this family and MHC I molecules; that member is TAP. The B1, C1, and G2 members of this protein family are responsible for the vast majority of multidrug resistant tumor cells. Important motifs in this family include the P-loop, Walker B motif, Q-loop, H-motif, and their namesake signature motif. Mutations in another member of this family that transfers fatty acids to peroxisomes causes adrenoleukodystrophy. A mutation in CFTR, yet another member ofthis family, causes cystic fibrosis. For 10 points, identify this largest family of transmembrane proteins that use the energy from binding and hydrolyzing ATP to transport molecules.
A member of this protein family crystallized by Kaspar Locher, Allen Lee, and Douglas Rees was the first member to have its crystal structure determined and is the E. coli protein BtuCD.
ABC transporter [or ATP-binding cassette transporter; or obvious equivalents for "transporter", such as "protein" or "transmembrane protein"; prompt on intracellular ligand-gated ion channels]