R. This compound triggers the phosphorylation of eIF2, which in turn stops translation.
One type of these molecules is induced by STING acting on TBK1, which in turn activates IRF3. The release of this protein is assayed for in a test in which whole blood is mixed with the peptides EST-6 and CFP-10; that assay is a test for tuberculosis. This protein mediates downstream effects by activating protein kinase R. This compound triggers the phosphorylation of eIF2, which in turn stops translation. A SNP near the gene coding for the "lambda-3" one of these proteins is associated with treatment response to hepatitis C, which is treated with ribavirin and this other (*) compound. The alpha-2a and alpha-2b forms of this compound are conjugated to polyethylene glycol in pharmaceutical formulations. The secretion of these compounds is triggered by activation of TLRs in response to foreign double-stranded RNA, and these signaling molecules up-regulate the presentation of peptides on MHC I and II, which in turn activates helper and cytotoxic T cells. For 10 points, name these glycoproteins secreted by infected host cells, that get their name from their ability to slow down viral replication.
One type of these molecules is induced by STING acting on TBK1, which in turn activates IRF3.
Interferon [prompt on “cytokines” and “interleukins”]