P75 and p53 are initiators of this process, which is useful for getting rid of diseased cells so that the affliction does not spread to nearby cells.  
Akt mediated release of NF-kappa-B leads to its inhibition, which begins with SHC adaptor activation of PI-3 kinase.  It can lead to formation of the Apaf-1 complex and activation of SMAC proteins, and is mediated by Bim and JNKs (junks).  It is effected by the release of inhibition on Bcl-2, which allows Bax to move to the mitochondria, releasing cytochrome C, which induces caspase activity.  P75 and p53 are initiators of this process, which is useful for getting rid of diseased cells so that the affliction does not spread to nearby cells.  An alternative to necrosis, FTP identify this process of programmed cell death.
Akt mediated release of NF-kappa-B leads to its inhibition, which begins with SHC adaptor activation of PI-3 kinase.  
{apoptosis}