Its namesake first proposed it at the same university that Irvin R. Hentzel made shattering discoveries concerning Monopoly.
Applied to protein folding by Matouschek and Fersht, this principle has been expanded upon by a group who are known by the acronym Bema Hapothle. The quaternization of reduced heterocyclic bases with triethyloxonium fluoroborate is an example of a failure of this principle. Its namesake first proposed it at the same university that Irvin R. Hentzel made shattering discoveries concerning Monopoly. The Bronsted coefficient has been used to quantify this principal, which is used in the creation of More O'Ferrall-Jencks plots, and has a corollary stated by Melander that concerns increased exothermicities. Occasionally named for Florida State professor John Leffler, it can be applied to SN1 reactions to state that the rate-determining step is the formation of the carbocation. For 10 points, name this postulate used to deduce the approximate structure of a transition state.
Applied to protein folding by Matouschek and Fersht, this principle has been expanded upon by a group who are known by the acronym Bema Hapothle.
{Hammond}'s postulate [also accept {Hammond-Leffler} postulate or vice-versa]