This process involves (*) strand invasion of the 3Â­prime end of a singleÂ­stranded filament, followed by extension by DNA polymerases to form a Holliday junction.
PRDM9 is a histone methyltransferase that potentiates one type of this process. SpoÂ­11 catalyzes the first step in one iteration of this process with its catalytic tyrosine residues; then, the RecAÂ­homolog DmcÂ­1 binds in the subsequent step to form long nucleoprotein filaments. For a "gene drive" to work, the double strandÂ­break induced by an endonuclease must then be repaired via this pathway, allowing the altered sequence to drive. This process involves (*) strand invasion of the 3Â­prime end of a singleÂ­stranded filament, followed by extension by DNA polymerases to form a Holliday junction. A double junction can be resolved to form a crossover in the "homologous" type of this process that occurs in meiosis. For 10 points, name this process that results in a transfer of genetic information from one DNA molecule to another, which also occurs in early B and TÂ­cell development in its VDJ form.
PRDM9 is a histone methyltransferase that potentiates one type of this process.
genetic recombination [accept homologous recombination or V(D)J recombination; prompt on "DNA repair" and "crossing over"]