This protein contains a "pseudosubstrate" sequence which constitutively inhibits its action by binding to its catalytic domain until this protein binds to its allosteric activators.
Cdc42, Par6, Par3, and one form of this protein come together to form a complex which mediates epithelial cell polarity. This protein is the target of a macrolide isolated from Bugula neritida; that compound is an experimental HIV and Alzheimer's drug and is called bryostatin. MARCKS proteins are substrates of this protein. This protein contains a "pseudosubstrate" sequence which constitutively inhibits its action by binding to its catalytic domain until this protein binds to its allosteric activators. This protein comes in 15 isoforms, divided into 3 families called conventional, novel, and atypical. This protein is translocated to the plasma membrane by RACK proteins after it is activated by di∙acyl∙glycerol. For 10 points, name this family of signalling proteins, which, like a protein named for calmodulin, classically phosphorylate other proteins at serine and threonine residues in a calcium-dependent manner.
Cdc42, Par6, Par3, and one form of this protein come together to form a complex which mediates epithelial cell polarity.
protein kinase C [or PKC]