Aryl versions of this functional group can be synthesized with an arylboronic acid and an alcohol in Chan-Lam coupling, or via the Mitsunobu reaction using phenols.
Aryl versions of this functional group can be synthesized with an arylboronic acid and an alcohol in Chan-Lam coupling, or via the Mitsunobu reaction using phenols. Phospholipids in archaebacteria use this functional group to join fatty acids to glycerol, as this group is more resistant to oxidation than esters. Molecules with this functional group are relatively inert except under highly acidic conditions, where they undergo cleavage. Cyclical examples such as THF are often used as solvents. Two methods leading to their formation are alkoxymercuration-reduction and the reaction of an alkoxide and a haloalkane, a reaction named for its discoverer, Alexander W. Williamson. For ten points, name this functional group that consists of an oxygen attached to two carbon chains.
Aryl versions of this functional group can be synthesized with an arylboronic acid and an alcohol in Chan-Lam coupling, or via the Mitsunobu reaction using phenols.
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