For 10 points, name this process, which tumors hijack to feed themselves by generating a "leaky" vasculature.
Bergers and Benjamin argue that the "switch" named for this process is mediated on the one hand by lyso∙phospha∙tidic acid, and on the other hand by can∙statin and tum∙statin. A key protein that activates this pathway is alternatively spliced into the 121 and 165 isoforms. The EPR effect is explained by an abnormally high rate of this process. If HIF1 has not been post-translationally modified by prolyl hydroxylase, then it activates this process by up∙regulating Tie2. Hanahan and Weinberg identified the "sustained ability" for cells to activate this pathway as one of six key "hallmarks." ECM degradation by matrix metallo∙protein∙ases is the first step of the "sprouting" form of process, which is inhibited when the mono∙clonal antibody Avastin binds to the signalling molecule VEGF. For 10 points, name this process, which tumors hijack to feed themselves by generating a "leaky" vasculature.
Bergers and Benjamin argue that the "switch" named for this process is mediated on the one hand by lyso∙phospha∙tidic acid, and on the other hand by can∙statin and tum∙statin.
angiogenesis [or word forms; prompt on vasculogenesis; prompt on blood vessel formation or more specific answers like forming capillaries; prompt on tumorigenesis or tumor growth]