Infection by this virus is limited to basal cells of stratified epithelium.
Patients with mutations in EVER1 or EVER2 are unusually susceptible to this virus. The evolution of this virus is thought to have split into five branches along with human ethnicities; the 16 type is classified into European and Non-European. This virus can cause koilocytic atypia as part of its cytopathic effect, and can cause HSIL and LSIL lesions. Its E-six-associated protein ubiquitinates (*) p53 while E-seven inactivates retinoblastoma protein by competing for its binding. Types of this virus are classified as "high risk" when they cause intraepithelial neoplasia in the affected areas. Infection by this virus is limited to basal cells of stratified epithelium. Ras oncogene must be activated to immortalize cells infected by this virus, which was used to develop HeLa (HEE-luh) cells. Testing for this virus is part of a Pap smear. For 10 points, name this virus vaccinated against by Gardasil, the leading cause of cervical cancer.
Patients with mutations in EVER1 or EVER2 are unusually susceptible to this virus.
human papillomavirus [or HPV]