These are the most common cells that possess LFA-1 [L-F-A-one], a protein involved in forming a specialized type of synapse with APCs [A-P-C's].
A subset of these cells includes an "off switch" protein targeted by the melanoma drug ipilimumab. Cyclosporine inhibits calcineurin [CAL-sih-NEUR-in], which normally dephosphorylates a transcription factor named for these cells, called NFAT [N-fat]. These are the most common cells that possess LFA-1 [L-F-A-one], a protein involved in forming a specialized type of synapse with APCs [A-P-C's]. These cells have a namesake receptor that interacts with the co-receptor CD3. These cells mature in an organ that (*) atrophies in adulthood. Two major classes of these cells are defined by having the proteins CD4 or CD8, making them "helper" or "killer" ones respectively. For 10 points, what immune cells are named for developing in the thymus?
A subset of these cells includes an "off switch" protein targeted by the melanoma drug ipilimumab.
T cells [or T lymphocytes; accept specific types of T cells such as: helper or CD4-positive, killer or cytotoxic or CD8-positive, or naive] &lt;RY, Biology&gt;