Leukemia inhibitory factor and ciliary neurotrophic factor bind to gp130 and LIFR-beta receptor subunits and activate JAK tyrosine kinases that phosphorylate STAT transcription factors.
Leukemia inhibitory factor and ciliary neurotrophic factor bind to gp130 and LIFR-beta receptor subunits and activate JAK tyrosine kinases that phosphorylate STAT transcription factors. Along with cardiotrophin, these form class 6 of these cytokines that also activate plasma cells and cytotoxic T cells in the immune system.
Leukemia inhibitory factor and ciliary neurotrophic factor bind to gp130 and LIFR-beta receptor subunits and activate JAK tyrosine kinases that phosphorylate STAT transcription factors.
{interleukin}s