A deficiency in one of this class of proteins caused hypersensitivity to oxazolone in a paper by Antonopoulos et al investigating its role in the migration of Langerhans cells.  
A deficiency in one of this class of proteins caused hypersensitivity to oxazolone in a paper by Antonopoulos et al investigating its role in the migration of Langerhans cells.  cFLIPL and cFLIPS interfere with activation of this class of enzymes, and they can be irreversibly inhibited by molecules containing (*) CMK or FMK functional groups.  Number 12 of this class of enzymes is found almost exclusively in the endoplasmic reticulum, while number 9 is activated by Apaf-1 upon release of cytochrome c from mitochondria.  Among their substrates are poly(ADP-ribose) polymerase, topoisomerase I, and lamins, all of which are cleaved by number 3 as part of their namesake "cascade."  Number 8 is activated at the DISC, or death-inducing signaling complex.  For 10 points, identify this class of proteases that includes ICE, all of which act as downstream signaling molecules during apoptosis.
A deficiency in one of this class of proteins caused hypersensitivity to oxazolone in a paper by Antonopoulos et al investigating its role in the migration of Langerhans cells.  
{caspase}s [or {c}ysteine(-dependent) {asp}art{ase}s] (4) [DW]