Â
By mimicking p-aminobenzoic acid, sulfa drugs inhibit bacterial synthesis of this compound. Â Along with vitamin B12, one derivative of this compound is required by homocysteine methyltransferase for production of methionine. Â That N-5, N-10 methylene derivative can be regenerated using serine or glycine as a carbon donor. Â Aminopterin and methotrexate block reduction of another derivative of this compound, its (*) dihydro form. Â This vitamin is absorbed in the small intestine after several glutamate residues are cleaved off by conjugase. Â A deficiency of this cofactor, which carries carries one-carbon units, typically leads to megaloblastic anemia, and this vitamin is often prescribed to pregnant women to reduce the risk of neural tube defects in fetuses. Â For 10 points, identify this vitamin also known as B9, which is usually derived from green, leafy vegetables.
By mimicking p-aminobenzoic acid, sulfa drugs inhibit bacterial synthesis of this compound.
folate or folic acid or folacin [accept vitamin B9 until mentioned; REVERSE prompt on tetrahydrofolate, dihydrofolate, THF, or DHF]