These proteins bind to the PSTAIRE helix of another set of protein, which causes that partner to move its T-loop out of the way of its active site.
One of these proteins is commonly mutated in threonine-286 in endometrial carcinomas, and one of these proteins is activated by an 11 to 14 translocation commonly found in Mantle Cell lymphoma. Gamma herpesviruses encode a viral form of these proteins, which are used to inactivate Rb. Both the Retinoblastoma protein and transcription factor 2-B contain a fold named for this class of proteins. They're not securins, but the APC/C protein complex directs ubiquitination of these proteins. These proteins bind to the PSTAIRE helix of another set of protein, which causes that partner to move its T-loop out of the way of its active site. The HIV (*) Tat protein binds to the T type of these proteins. Proteins like Wee1 and Sic1 are responsible for inhibiting complexes of these proteins and their effectors; one such complex contains one of these proteins bound to p34 and is called the MPF. These proteins have a namesake 5-helix domain, and come in types including A, B, D, and E, the last of which spikes at the G1/S boundary. For 10 points, name these proteins that regulate the progression of the cell cycle.
One of these proteins is commonly mutated in threonine-286 in endometrial carcinomas, and one of these proteins is activated by an 11 to 14 translocation commonly found in Mantle Cell lymphoma.
cyclin