Symptoms of this disease include focal areas of stromal hyperplasia in the eyes known as Brushfield spots, and having a single (*) palmar crease.
This disorder is indicated when high levels of Inhibin A are found on a Quad Screen, or when AFP and UE3 are low but hCG is high on a triple screen. Symptoms of this disease include focal areas of stromal hyperplasia in the eyes known as Brushfield spots, and having a single (*) palmar crease. Patients with this disease develop an Alzheimer-like syndrome by the age of 40 because they have an extra copy of the amyloid precursor protein, and one variant of this disease that runs in families is caused by a Robertsonian translocation, though most instances are caused by nondisjunction. For 10 points, name this cause of mental retardation, which is caused by an extra copy of chromosome 21.
This disorder is indicated when high levels of Inhibin A are found on a Quad Screen, or when AFP and UE3 are low but hCG is high on a triple screen.
Down's syndrome [or Trisomy 21 before "21" is mentioned; prompt on DS]