One family of these proteins is the autoantigen in (*) pemphigus foliaceus and pemphigus vulgaris.
Daschous and Fat are atypical examples of these proteins, the latter of which is an upstream regulator of the Hippo signalling pathway. A paper by Crespi et al hypothesizes that the expression of three of these proteins in the placenta is an example of an evolutionary "red queen with a green beard". Flamingo proteins have homology to both GPCRs and these proteins. An autoimmune disease that targets these proteins shows a positive Nikolsky sign. The cytoplasmic face of these proteins can bind to plakoglobin in order to influence the actin cytoskeleton or bind to beta-catenin to influence gene expression. One family of these proteins is the autoantigen in (*) pemphigus foliaceus and pemphigus vulgaris. These proteins contain a series of Ig-like domains on their extracellular face which mediate homophilic binding. This protein comes in E-, N-, and P- types, which allows "like" tissues to find each other during development. For 10 points, name these calcium binding cell adhesion molecules, some of which localize to desmosomes.
Daschous and Fat are atypical examples of these proteins, the latter of which is an upstream regulator of the Hippo signalling pathway.
cadherin [accept desmoglein before mention; prompt on “cell adhesion proteins” or anything like that, prompt on “desmosomes”]