These proteins come in v and t varieties, which are present on vesicles and target membranes.
One component of this complex is mutated in the blind-drunk mouse. One protein found in this complex contains an H-a-b-c regulatory domain, whose "closed" conformation is stabilized by Munc18. A cytoplasmic protein that localizes to this complex is inhibited to N-methylamide; that protein is responsible for recycling elements of this complex and is called NSF. Members of this complex are cleaved by tetanospasmin and (*) botulinum toxin; those members are synaptobrevin and SNAP-25. The calcium-sensitive protein synaptotagmin is responsible for triggering a conformational change in this complex, which causes the release of neurotransmitters. These proteins come in v and t varieties, which are present on vesicles and target membranes. For 10 points, name these zipper-like proteins that are responsible for fusing membranes together in vesicular transport.
One component of this complex is mutated in the blind-drunk mouse.
SNARE [or soluble NSF attachment protein receptor]