For 10 points, name these linear polymers of disaccharides that are components of proteoglycans, examples of which include hyaluronan and heparin.
Kobayashi used a transition state analogue to synthesize an artificial one of these structures, which is the namesake of a cofactor encoded by the SERPIND-1 gene, and activates the clotting inhibitor antithrombin. Hurler syndrome and Sanfilippo syndrome are caused by the inability to break down these structures, and their concentration can be estimated by using alcian blue dye. The receptor CD44 is associated with the largest one of these structures, which can contain more than 25,000 repeating units. These structures bear negatively charged carboxylate and sulfate groups, and are composed of a sugar acid, such as uronic acid, and an amino sugar, such as N-acetylglucosamine. For 10 points, name these linear polymers of disaccharides that are components of proteoglycans, examples of which include hyaluronan and heparin.
Kobayashi used a transition state analogue to synthesize an artificial one of these structures, which is the namesake of a cofactor encoded by the SERPIND-1 gene, and activates the clotting inhibitor antithrombin.
{glycosaminoglycan}s [also accept {GAG}s]