This protein is the target of a macrolide isolated from Bugula neritida; that compound is an experimental HIV and Alzheimer's drug and is called bryostatin.
Cdc42, Par6, Par3, and one form of this protein come together to form a complex which mediates epithelial cell polarity. This protein is the target of a macrolide isolated from Bugula neritida; that compound is an experimental HIV and Alzheimer's drug and is called bryostatin. MARCKS proteins are substrates of this protein. This protein contains a "pseudosubstrate" sequence which constitutively inhibits its action by binding to its catalytic domain until this protein binds to its allosteric activators. This protein comes in 15 isoforms, divided into 3 families called conventional, novel, and atypical. This protein is translocated to the plasma membrane by RACK proteins after it is activated by di∙acyl∙glycerol. For 10 points, name this family of signalling proteins, which, like a protein named for calmodulin, classically phosphorylate other proteins at serine and threonine residues in a calcium-dependent manner.
Cdc42, Par6, Par3, and one form of this protein come together to form a complex which mediates epithelial cell polarity.
protein kinase C [or PKC]