For ten points, identify this extracellular matrix protein that also forms the basement membrane.
The activity of this molecule on neurons relies upon its heparin-binding domain, and the human 37-kDa receptor for this protein has been shown to interact with prion protein PrPSc. The receptor for this protein on platelets is the integrin VLA-6, and this heterotrimeric protein associates with type IV collagen networks via enactin, and binds cell membranes to contribute to cell attachment. The A-chain of this protein is integral in the initiation of cell polarity in kidney cells, and splice site and nonsense mutations in the alpha-2 gene for a type of this protein has been shown to result in congenital muscular dystrophy. For ten points, identify this extracellular matrix protein that also forms the basement membrane.
The activity of this molecule on neurons relies upon its heparin-binding domain, and the human 37-kDa receptor for this protein has been shown to interact with prion protein PrPSc.
{Laminin}