As it was originally stated, it does not apply if the product contains any elements other than carbon and hydrogen, because it does not account for inductive effects or resonance.  
As it was originally stated, it does not apply if the product contains any elements other than carbon and hydrogen, because it does not account for inductive effects or resonance.  Using a very hindered base may block the formation of the predicted product, forming the Hoffman product instead.  It requires a strong base and a tertiary alkyl halide to prevent the reaction from occurring via the SN2 mechanism.  Concerning the regioselectivity of an E2 reaction, FTP, identify this principle that states that the major product results from the elimination of hydrogen from the carbon atom originally bonded to the fewest hydrogen atoms, resulting in the alkene with the most substituted carbon-carbon double bond, an oppposite of Markovnikov's Rule.
As it was originally stated, it does not apply if the product contains any elements other than carbon and hydrogen, because it does not account for inductive effects or resonance.  
{Zaitsev's} Rule (also accept {Saytzeff's} rule)