Its over-expression is known as Conn's syndrome and can very rarely cause hypernatremia.
It is produced by a cytochrome P450 isoenzyme with 18-hydroxylase activity. The prostaglandins PGE2 and PGI2 of the macula densa stimulate the secretion of a peptide hormone which regulates the release of this compound. The nonselective receptor antagonist to this compound, spironolactone, can control plasma levels, unlike ACE inhibitors. Its over-expression is known as Conn's syndrome and can very rarely cause hypernatremia. It is secreted by the endocrine secretory epithelium of the zona glomerulosa region of the adrenal cortex and is regulated by conversion of angiotensinogen to angiotensin I by renin. For 10 points, what is this cholesterol. derived from the steroid corticosterone, the primary regulator of water and salt balance in the body?
It is produced by a cytochrome P450 isoenzyme with 18-hydroxylase activity.
{aldosterone}