PRMD1, also known as Blimp-1, is necessary for the differentiation of these cells.
Recent research has revealed that, though these cells are differentiated in response to XBP-1 splicing, the process is surprisingly not driven by unfolded protein response in the ER. PRMD1, also known as Blimp-1, is necessary for the differentiation of these cells. Bortemozib is a protease inhibitor that can effectively deplete the "long-lived" versions of these cells, which can cause SLE in mice. Flow cytometry can detect these cells because they express high levels of CD138 on their surface, and these cells notably do not express (*) CD20. The cancer of these cells is called multiple myeloma. In somatic hypermutation, the differentiation of these cells is driven by their high affinity for a given antigen. These cells are differentiated from their counterparts because they secrete antibodies immediately in response to infection. Those longer-lasting counterparts of these cells secrete antibodies in response to reinfection. For 10 points, identify this type of B cell that isn't a memory cell.
Recent research has revealed that, though these cells are differentiated in response to XBP-1 splicing, the process is surprisingly not driven by unfolded protein response in the ER.
plasma cell [prompt on  B cell]