In this process, Dicer cleaves a double-stranded RNA, creating a guide strand that is incorporated into RISC, which then cleaves a complementary gene transcript.
SNALPs are used for transfection of a kind of molecule used in this process that has a phosphorylated 5' end and a hydroxylated 3' end. Analogs of this process are called quelling in fungi and cosuppression in plants. Before export from the nucleus, a precursor to one type of molecule involved in this process is cut by the "Microprocessor" complex formed from DGCR8 and (*) Drosha. One complex used in this process uses Argonaute proteins for catalysis. In this process, Dicer cleaves a double-stranded RNA, creating a guide strand that is incorporated into RISC, which then cleaves a complementary gene transcript. Andrew Fire and Craig Mello won a 2006 Nobel Prize for their work on this phenomenon in C. elegans. For 10 points, name this process in which microRNAs or siRNAs cause post-transcriptional gene silencing.
SNALPs are used for transfection of a kind of molecule used in this process that has a phosphorylated 5' end and a hydroxylated 3' end.
RNA interference [or RNAi; prompt on "gene silencing," "post-translational gene silencing," or "PTGS"]