Most members of this family have an alpha-helical coiled-coil stalk domain attached to a light chain with a TPR domain, which remains unfolded until its bound to cargo.
Mutations in the 5A member of this protein family causes type 10 hereditary spastic paraplegia, and Erg-5 is a double-headed version of this protein involved in mitosis. Block et al pioneered the use of optical trap technology to study this protein, which attaches one part of it to a 70 nm bead to show that it has an 8 nm step size. This molecule's two heads follow the "hand-over-hand" model, in which bind and hydrolyze ATP in a strongly cooperative manner, such that when one head is bound the other one is free. Most members of this family have an alpha-helical coiled-coil stalk domain attached to a light chain with a TPR domain, which remains unfolded until its bound to cargo. These proteins work in the opposite manner as dyenins, as they cargo towards the positive end of a microtubule. For 10 points, name these motor proteins, one of whose functions is to carry vesicular cargo down an axon to the synapse.
Mutations in the 5A member of this protein family causes type 10 hereditary spastic paraplegia, and Erg-5 is a double-headed version of this protein involved in mitosis.
kinesin