This molecule initially binds to the hydrophobic N-terminus (*) of some growing peptide and moves them to the rough endoplasmic reticulum.
In polymyositis, in addition to anti-Jo-1 and anti-Mi-2 antibodies, antibodies to this molecule are often found and tend to herald cardiac manifestations of the disease. The prokaryotic version of this molecule contains the F-f-h polypeptide, which binds to the FtsY receptor.Walter and Bloebel characterized the 7S RNA component of this molecule which contains a GNAR tetraloop and is probably the origin of the Alu repeats found in the human genome. Upon binding to its receptor in the translocon, this particle catalyzes the handover of its substrate via cleavage of GTP. This molecule initially binds to the hydrophobic N-terminus (*) of some growing peptide and moves them to the rough endoplasmic reticulum. For 10 points, name this particle that guides ribosomes to the ER so that their protein products can be exported, named for the fact that it recognizes targeting sequences on the peptide.
In polymyositis, in addition to anti-Jo-1 and anti-Mi-2 antibodies, antibodies to this molecule are often found and tend to herald cardiac manifestations of the disease.
Signal recognition particle [or SRP]