This transmembrane protein dephosphorylates an ATP to move three ions out of the cell and two ions in against their concentration gradients.
Overdose of a drug that inhibits this protein is treated using fab fragments specific to it. A protein of the FXYD family associates with this protein to provide tissue-specific regulation. Ouabain and rubidium are often used to measure the activity of these proteins. Cardiac glycosides like digitalis inhibit this structure, which in turn inhibits NCX, creating increased calcium stores for more powerful heart contraction. This protein was discovered by Jens Christian Skou and has (*) high affinity for certain ions before it is phosphorylated, but releases them afterwards. This transmembrane protein dephosphorylates an ATP to move three ions out of the cell and two ions in against their concentration gradients. For 10 points, name this active transporter which maintains resting cell potential by moving Na+ and K+.
Overdose of a drug that inhibits this protein is treated using fab fragments specific to it.
Anne