Occcasionally it is followed by the formation of an alkene bond, and it does not work for substrates with high molecular weights or those that are highly sensitive to acid.
It is used as an intermediate step in the synthesis of the HIV-inhibiting drugs known as calanolides. Occcasionally it is followed by the formation of an alkene bond, and it does not work for substrates with high molecular weights or those that are highly sensitive to acid. Commonly used to convert the product of the Friedel-Crafts reaction to an alkyl-side chain, it is performed in the presence of a zinc and mercury catalyst, which provides an active metal surface. FTP, name this reaction similar to the Wolff-Kishner reaction, but performed in an acidic environment, which converts a carbonyl group to a methylene.
It is used as an intermediate step in the synthesis of the HIV-inhibiting drugs known as calanolides.
Clemmensen reduction