P80, or coilin, uniquely localizes to these structures.
One set of molecules that localize to these structures are targeted here by CAB box motifs and often have composite H/ACA and C/D box motifs. The localization of SMN complex to these structures is disrupted by mutations in SOD1. Telomerase RNA requires these structures for localization to telomeres, and the primary component of these structures uses its C-terminus to interact with Sm proteins. P80, or coilin, uniquely localizes to these structures. They are responsible for directing the assembly and maturation of snRNPs (snurps), which are components of the (*) splicing machinery. These structures are between one-half and one micrometer in diameter and are found in the same compartment as paraspeckles, GEMS, and PML bodies. In nondividing cells, these structures are often found near the nucleolus.  For 10 points, name these densely staining organelles found in the nucleus, which are often named for a Spanish neurologist.
One set of molecules that localize to these structures are targeted here by CAB box motifs and often have composite H/ACA and C/D box motifs.
Cajal bodies [or coiled bodies, prompt on “nuclear bodies”]