A common test for the presence of this functional group involves the addition of benzene sulfonyl chloride and base; that test is named for Hinsberg.
These compounds are coupled to aromatic rings in the presence of palladium in the Buchwald-Hartwig reaction. In solid-phase peptide synthesis, a cyclic example of these in DMF is commonly used to remove Fmoc groups. A common test for the presence of this functional group involves the addition of benzene sulfonyl chloride and base; that test is named for Hinsberg. These compounds are formed form carboxylic acids, but not ketones, in a reaction involving an isocyanate intermediate, the (*) Schmidt reaction. Another synthesis of these, examples of which include piperidine and pyrrole, involves reacting an alkyl halide with potassium phthalimide, the Gabriel synthesis. Attached to benzene in the compound aniline, this is, for 10 points, what functional group containing a lone-pair on a nitrogen atom, whose primary type sees nitrogen singly bonded to carbon and two hydrogens.
These compounds are coupled to aromatic rings in the presence of palladium in the Buchwald-Hartwig reaction.
amines [accept amino group; do not accept "amide" or "imine"]