The drug cromolyn serves as a "stabilizer" of these cells, which store many compounds also stored by (*) basophils.
An aspartate to valine mutation at position 816 of the KIT gene is strongly associated with an overabundance of these cells. The "cutaneous" overabundance of these cells can lead to red or brown lesions on the skin in a condition called urticaria pigmentosa. These cells are classified as either "T" or "TC" depending on whether they store and secrete just tryptase, or both tryptase and chymase. The drug cromolyn serves as a "stabilizer" of these cells, which store many compounds also stored by (*) basophils. These cells contain Fc-epsilon-RI receptors which bind to IgE antibodies, triggering a degranulation cascade which releases compounds such as eicosanoids, leukotrienes, and histamine, which all contribute to inflammation. For 10 points, name these leukocytes which play a major role in mediating allergic reactions.
An aspartate to valine mutation at position 816 of the KIT gene is strongly associated with an overabundance of these cells.
mast cells