It results in the creation of a double-membraned vesicle around the targeted organelle, which then fuses with a lysosome.
This process is inhibited in culture by 3-methyladenine, and one method of activating this process occurs when galectin-8 binds to NDP52. ULK complexes are responsible for triggering this process, and it is inhibited by the action of Beclin-1 and PI3-Kinase. This process can be assayed for by immunoblotting for the conversion of LC3-I to LC3-II. It's not gluconeogenesis but during starvation, AMP kinase triggers this process, and mTOR inhibits this process when nutrients are plentiful. In yeast, this process is regulated by the (*) ATG proteins. This process is responsible for clearing out mutant htt in patients with Huntington's disease. It results in the creation of a double-membraned vesicle around the targeted organelle, which then fuses with a lysosome. For 10 points, name this process in which a cell eats its own damaged components.
This process is inhibited in culture by 3-methyladenine, and one method of activating this process occurs when galectin-8 binds to NDP52.
autophagy [accept autophagocytosis]