Drugs against this  disease include (*) Rimantadine.
The causative agent of this disease possesses the NS1 protein, which inhibits the ubiquitination of RIG-I by TRIM and  suppresses the production of interferon in host cells. One protein used by its causative agent to cause this disease includes  a 130 loop, a 190 loop, and a 220 loop. Some strains of this disease are treated by compounds that inhibit the M2 ion  channel. Thomas Francis proposed his doctrine of "original antigenic sin" while studying this disease. Drugs against this  disease include (*) Rimantadine. The binding and release of the causative agent of this disease occurs at sialic acid residues on  the host cell membrane. Ferrets are used as animal models for the transmission and pathogenicity of this disease, which is often  treated with olestamivir, a neuraminidase inhibitor. For 10 points, name this disease caused by an orthomyxovirus that comes in  "Spanish," "Avian," and "Swine" types.
The causative agent of this disease possesses the NS1 protein, which inhibits the ubiquitination of RIG-I by TRIM and  suppresses the production of interferon in host cells.
influenza [or flu]