Also undergoing the Pinner reaction with alcohols, they react with Grignard reagents to form imines, which can then be hydrolyzed to ketones.
Aromatic versions of these compounds can be produced from aryl halides in the Rosenmund-von Braun reaction, and a variation of the Friedel-Crafts reaction that uses one of them as a reagent is the Hoben-Hoesch reaction. Both these compounds and their iso-versions are produced in the Kolbe synthesis, while they are created form carboxylic acids in the Letts synthesis. Also undergoing the Pinner reaction with alcohols, they react with Grignard reagents to form imines, which can then be hydrolyzed to ketones. Usually created by simply reacting an unhindered alkyl halide with a cyanide ion in an SN2 reaction, these are, FTP, what organic compounds which contain a carbon triple bonded to nitrogen.
Aromatic versions of these compounds can be produced from aryl halides in the Rosenmund-von Braun reaction, and a variation of the Friedel-Crafts reaction that uses one of them as a reagent is the Hoben-Hoesch reaction.
{Nitrile}