These compounds are often synthesized in a nitrogen atmosphere to avoid water and oxygen, and ethers are some of the few organic molecules these substances will not react with.
Methadone and Tamoxifen are among the pharmaceuticals produced using these substances, which must be prepared in aprotic solvents. These compounds are often synthesized in a nitrogen atmosphere to avoid water and oxygen, and ethers are some of the few organic molecules these substances will not react with. It took more than fifty years to successfully make one of these substances with fluorine, and their chemical mechanism is based on the reversed polarity of a carbon bond. Consisting of an alkyl or aryl group, a magnesium atom, and a halide, these are commonly used to reduce ketones or aldehydes to alcohols. Added to carbonyl groups to create carbon-carbon bonds, name this class of reagents.
Methadone and Tamoxifen are among the pharmaceuticals produced using these substances, which must be prepared in aprotic solvents.
Grignard (GRIN-yard) reagent