Epstein and Steinberg discovered the first of these using multiplicity reactivation experiments.
Epstein and Steinberg discovered the first of these using multiplicity reactivation experiments. Some of these entities were discovered by Sydney Brenner by looking at suppressors of mutations in the head protein of the T4 phage. The accidental incorporation of these things results in the persistence of EJCs and the activation of UPF1 as part of the NMD pathway. Their function can be modified by nearby PYLIS and SECIS elements. They were originally dubbed amber, ochre, and opal, and in eukaryotes they bind to (*) releasing factor and direct the incorporation of a water molecule on the C-terminus. They occur prematurely in nonsense mutations, and they usually consist of UAA, UGA, and UAG. For 10 points, name these codons that terminate protein synthesis.
Epstein and Steinberg discovered the first of these using multiplicity reactivation experiments.
stop codons [prompt on codons; accept nonsense mutations before mention, but do NOT accept "missense"]