In asthma and COPD, the p38 enzymes of this type are more active.
Thomas Sturgill and his postdoc Bryan Ray discovered the first of these proteins after stimulating it with insulin. These proteins interact with their targets by recognizing the "docking", or "D", motifs. Ste5 (S T E 5) and KSR are scaffold proteins that enable the activation of these enzymes. c-Raf serves as a gatekeeper in the best-known pathway involving these enzymes. In asthma and COPD, the p38 enzymes of this type are more active. The classical example of these enzymes, which must be phosphorylated (*) twice before they can phosphorylate stuff, appear in the ERK 1/2 pathway. JNKs (junks) belong to this family of enzymes. For 10 points, name this family of serine/threonine kinases that appear in many cell signaling cascades, including those activated in mitosis.
Thomas Sturgill and his postdoc Bryan Ray discovered the first of these proteins after stimulating it with insulin.
MAP kinase [or mitogen-activated protein kinase; or MAPKKK (up to 3 "K"); or MAP2K; or MAP3K; or MAP kinase kinase kinase (up to 3 "kinase"); prompt on "(serine-threonine) kinases"]