In scleroderma, Anti-SCL 70 attacks the type
Discovered at Berkeley in 1971 by James Wang, this class of enzymes is inhibited by quinolones and camptothecins to halt reproduction of bacteria and cancer cells. Without active ones, chromosomal replication forks cannot advance, because the DNA after the fork forms a plectonemic or toroidal conformation. In scleroderma, Anti-SCL 70 attacks the type I of these, which along with type II normally function to nick and re-ligate DNA strands to decrease positive supercoiling of the double helix. For ten points, name this class of enzymes which change the linking number of DNA to decrease the topological strain of the helix caused by unwinding.
Discovered at Berkeley in 1971 by James Wang, this class of enzymes is inhibited by quinolones and camptothecins to halt reproduction of bacteria and cancer cells.
DNA {topoisomerase}(s)