For 10 points, name these cells that take on a curved shape in sickle-cell anemia, which are responsible for carrying oxygen and giving blood its color.
One disease in which the precursors of these cells are multinucleated is caused by mutation in the SEC23B gene. Another disease called "M6" in the FAB classification is caused by overproliferation of their precursors. They take on unusual morphologies in poikilocytosis and dacrocytosis, the latter of which is caused by myelofibrosis. They form stacks called rouleaux in response to inflammation, and mutations in their cytoskeletal components cause elliptocytosis or (*) spherocytosis. These cells develop from the differentiation of reticulocytes. Another disease of these cells causes splenic auto-infarction and is most commonly caused by a glutamic acid to valine mutation in the beta-chain of hemoglobin; that disease causes these cells to lose their biconcave shape. For 10 points, name these cells that take on a curved shape in sickle-cell anemia, which are responsible for carrying oxygen and giving blood its color.
One disease in which the precursors of these cells are multinucleated is caused by mutation in the SEC23B gene.
erythrocytes [or red blood cells; or RBCs; prompt on "blood cells"]