The binding protein Pasha allows for the proper functioning of Drosha, whose products are exported to the cytoplasm for continuation of this pathway.
This pathway has been implicated in the transcription and maintenance of heterochromatin, and this pathway has been exploited to create transgenic livestock resistant to transmissible spongiform encephalopathies. It is completely absent in S. cerevisiae. The binding protein Pasha allows for the proper functioning of Drosha, whose products are exported to the cytoplasm for continuation of this pathway. GW bodies are the cytoplasmic localization sites of (*) argonaute, which along with Dicer catalyzes the activity of the RISC complex in this pathway. That complex targets key mRNAs for degradation in this pathway, which was observed first in C. elegans by Mello and Fire. For 10 points, name this process by which a gene's expression is inhibited through cleavage of double-stranded RNA.
This pathway has been implicated in the transcription and maintenance of heterochromatin, and this pathway has been exploited to create transgenic livestock resistant to transmissible spongiform encephalopathies.
{RNA interference} [or {RNAi}]