Lipo-poly- saccharide hypo-responsiveness is indicative of mutations in these proteins.
In these proteins, the conserved proline at the 712 position is known to be mutated into a histidine in C3h/HeJ mice, and  the Mal protein is an adaptor protein that associates with this class of proteins. When activated, nine out of the ten known variants of these proteins recruit MyD88, which in turn recruits a group of IRAK proteins. Lipo-poly- saccharide hypo-responsiveness is indicative of mutations in these proteins. Though they do not contain Ig-like domains, the cytoplasmic  domains of these proteins contain leucine-rich repeats. Jules (*) Hoffman was awarded a Nobel Prize in 2011 for his  discovery of these proteins. For 10 points, name this class of proteins in the innate immune response system that recognize  patterns that are unique to pathogenic microbes and are named for a Drosophila protein that is key to dorso-ventral pattern  establishment.
In these proteins, the conserved proline at the 712 position is known to be mutated into a histidine in C3h/HeJ mice, and  the Mal protein is an adaptor protein that associates with this class of proteins.
Toll-like receptors [or TLRs]  2