Patients with FTLD or this condition often show buildups in misfolded FUS and TDP-43 proteins.
Along with frontotemporal dementia, this condition is strongly linked to a GGGGCC repeat expansion in a noncoding region on chromosome 9. Patients with FTLD or this condition often show buildups in misfolded FUS and TDP-43 proteins. A4V and G93A are among the more than twenty missense mutations linked with this disease; those mutations, which may cause the misfolding and aggregation of superoxide dismutase, are in the (*) SOD1 gene. Sufferers of this condition may exhibit symptoms like the "pseudobulbar affect," or uncontrollable periods of laughing or crying. This condition, which is often mitigated by the drug Riluzole, is characterized by symptoms of both upper and lower motor neuron damage. In late stages of this condition, muscle atrophication prevents speaking, swallowing, or breathing. For 10 points, name this disease that causes rapid degeneration of motor neurons, which afflicts Stephen Hawking and Lou Gehrig.
Along with frontotemporal dementia, this condition is strongly linked to a GGGGCC repeat expansion in a noncoding region on chromosome 9.
amyotrophic lateral sclerosis [or  ALS; accept modifiers like "familial" or "sporadic"; accept Lou Gehrig's disease until mention; prompt on  motor neuron disease or MND]