This organism's virulence is primarily based on two glucosyltransferase proteins which inactivate Rac, Rho, and other small GTPases; those proteins are its namesake A and B toxins.
Two proteins found in this organism share a large degree of homology within their C-termini--those regions are called "combined repetitive oligopeptides." In October 2016, the FDA approved the drug bezlotoxumab to treat infections by this pathogen. This organism's virulence is primarily based on two glucosyltransferase proteins which inactivate Rac, Rho, and other small GTPases; those proteins are its namesake A and B toxins. The drug fidaxomicin treats infections by this organism, which are more commonly treated with orally-administered vancomycin or metronidazole. Because this opportunistic pathogen infects patients with a disrupted microbiome, it can be treated using a fecal transplant to restore normal gut flora. For 10 points, name this spore-forming and colon-infecting bacterium, the leading cause of antibiotic-associated diarrhea.
Two proteins found in this organism share a large degree of homology within their C-termini--those regions are called "combined repetitive oligopeptides."
Clostridium difficile [do not accept or prompt on partial answers]