Mutations in HCLS are treated by giving large quantities of this substance, and a disorder in which this substance isn't appropriately recycled results in high levels in hydroxyisovalerate.
Mutations in HCLS are treated by giving large quantities of this substance, and a disorder in which this substance isn't appropriately recycled results in high levels in hydroxyisovalerate. MCC, an enzyme required for leucine breakdown, uses it as a cofactor, as does the In lymphocytes, this substance is attached to histones during the G1 phase, and may be a signal of DNA damage. It contains a thiopene ring back to back with a ureido ring, with a short carboxylic acid tail. The first bypass step in gluconeogenesis is catalyzed by an enzyme that uses this substance as a (*) cofactor, and pulldown assays often exploit this substances tight binding to streptavidin. For 10 points, name this cofactor that's used by pyruvate carboxylase and several other carboxylases, sometimes called vitamin B7 or H.
Mutations in HCLS are treated by giving large quantities of this substance, and a disorder in which this substance isn't appropriately recycled results in high levels in hydroxyisovalerate.
Biotin (accept vitamin B7 or vitamin H)