One protein found in this pathway is mutated in both Gardner's syndrome and Turcot's syndrome.
One ligand in this pathway is retained in the ER in porcupine mutants, which have a defective acetyltransferase. One protein found in this pathway is mutated in both Gardner's syndrome and Turcot's syndrome. Coreceptors in one version of this pathway include Knypek and Ror2, and that version of the pathway activates CamKII and PKC. A transcription factor important in one version of this pathway contains a series of armadillo repeats and is triggered for degradation by a complex containing Axin. This pathway's namesake protein triggers the dimerization of LRP and (*) disheveled receptor, which in turn inhibits GSK3 and allows the displacement of the Groucho transcription factor from LEF/TCF by beta-catenin. This pathway's namesake protein binds to Frizzled and is secreted from the Nieuwkoop center to activate the development of dorsal structures. For 10 points, name this signaling pathway important in development, which gets its name partly from a mutation in Drosophila that inhibits wing formation.
One ligand in this pathway is retained in the ER in porcupine mutants, which have a defective acetyltransferase.
Wnt pathway