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The MPTP metabolite MPP+ is toxic to neurons producing this neurotransmitter in the pars compacta. Â Homovanilic acid is the major metabolite of this substance in humans, and this neurotransmitter is implicated in the incentive sensitization theory of drug addiction. Â Via its tuberohypophyseal pathway, this substance inhibits (*) prolactin synthesis by the anterior pituitary gland. Â Beta-endorphins disinhibit the release of this substance into the nucleus accumbens. It is formed from its immediate precursor by aromatic amino acid decarboxylase, and this catecholamine is converted by its namesake beta hydroxylase to norepinephrine. Â Major production of this substance occurs in the ventral tegmental area and substantia nigra. Â For 10 points, identify this neurotransmitter, whose reuptake through a presynaptic transporter is blocked by cocaine, and whose excess may lead to psychosis, as seen in schizophrenia.
The MPTP metabolite MPP+ is toxic to neurons producing this neurotransmitter in the pars compacta.
dopamine