Its maturation requires sequential binding of calnexin and calreticulin, and a complex of Erp57 and the TAP1/TAP2 heterodimer is used to load this complex.
A protein that complexes with this complex is the causative agent of hemodialysis-associated amyloidosis. The gene mutated in hemochromatosis is tightly linked to its A locus, while its B27 polymorphism is associated with ankylosing spondylitis. Its maturation requires sequential binding of calnexin and calreticulin, and a complex of Erp57 and the TAP1/TAP2 heterodimer is used to load this complex. Claus Wedekind found that this protein mediates mate selection by smell in an experiment involving sweaty T-shirts. This protein, which binds to CD8 on cytotoxic T-cells, is found on all cell types and is responsible for (*) presenting viral peptides from the cytoplasm. This heavily glycosylated polymorphic protein has to be matched between graft and host in organ donation. For 10 points, name this surface protein used to distinguish self from non-self.
A protein that complexes with this complex is the causative agent of hemodialysis-associated amyloidosis.
MHC Class I [accept MHC or Major Histocompatibility Complex, do not accept "MHC class II"; accept HLA or Human Leukocyte Antigen]