For 10 points, name this potentially fatal disease caused by a superantigen secreted by Staphylococcus aureus, an outbreak of which was associated with the overuse of super-absorbent tampons.
The protein that causes this condition appears to be restricted to binding to the V-beta variable chain and has immunogenic properties independent from its lethality according to experiments conducted on its "ovine" mutant. One criteria for this disease is the desquamation of the palms and soles after 1-2 weeks. The rash characteristic of this condition is fine, red, papular, and is often described as sunburn-like. The protein responsible for triggering this condition binds to both MHC class II and TCR, resulting in the activation of up to 20% of the patient's (*) T-cells and massive release of TNF-alpha and IL-2. This condition causes a cytokine storm and multiple organ failure. For 10 points, name this potentially fatal disease caused by a superantigen secreted by Staphylococcus aureus, an outbreak of which was associated with the overuse of super-absorbent tampons.
The protein that causes this condition appears to be restricted to binding to the V-beta variable chain and has immunogenic properties independent from its lethality according to experiments conducted on its "ovine" mutant.
toxic shock syndrome [or TSS]