This condition is associated with dysfunctional NFAT signalling pathways.  
This condition involves overexpression of DSCAM.  Hypothyroidism used to be considered a cause of this condition, which is sometimes caused by a Robertsonian translocation on chromosome fourteen.  This condition is associated with dysfunctional NFAT signalling pathways.  One symptom of this condition is white spots on the (*) eye, called Brushfield spots, while half of children born with this condition suffer from heart defects.  Other symptons include upward slanting eyes, flattened nose, and excess skin at the nape of the neck.  For 10 points, name this genetic disorder caused by the trisomy of chromosome twenty one.
This condition involves overexpression of DSCAM.  Hypothyroidism used to be considered a cause of this condition, which is sometimes caused by a Robertsonian translocation on chromosome fourteen.  
{Down} Syndrome [prompt on trisomy 21 until mentioned]