Because the linking number must remain constant, its writhe must always compensate for changes in twist, and vice-versa.
At larger length scales, it can be accurately modeled with the Kratky-Porod worm-like chain, although below the persistence length the bending force becomes constant, making sharp kinks not uncommon. This bending is anisotropic, a property first discovered using molecules from the kinetoplasts of trypanosomatids. Under sufficient stresses, it can change conformation to the P-form, named for the scientist who proposed a structure for this molecule. Because the linking number must remain constant, its writhe must always compensate for changes in twist, and vice-versa. Topoisomerase relieves supercoiling in, FTP, what polymer held together by Watson-Crick hydrogen bonds?
At larger length scales, it can be accurately modeled with the Kratky-Porod worm-like chain, although below the persistence length the bending force becomes constant, making sharp kinks not uncommon.
{DNA} or {deoxyribonucleic acid}