Â Their cytoskeleton consists mainly of spectrin, which is anchored by both Band 4.1 and ankyrin to the membrane-bound proteins glycophorin and Band 3, an anion exchanger.
One form of hereditary spherocytosis occurs due to genetic defects in these cells' Band 4.2 proteins. Â Their cytoskeleton consists mainly of spectrin, which is anchored by both Band 4.1 and ankyrin to the membrane-bound proteins glycophorin and Band 3, an anion exchanger. When immature, these cells are called (*) reticulocytes, and when mature, older and less flexible ones are filtered out as they move from the cords of Billroth into the splenic sinuses. Â These cells may be destroyed via phagocytosis by Kupffer cells. Â A hereditary lack of the H substance leads to the Bombay phenotype in these non-nucleated cells, which lose their characteristic biconcave shape in the presence of a certain mutation that substitutes a valine for glutamate. Â These cells have a lifespan of around 120 days, and their development is stimulated by erythropoetin. Â For 10 points, identify these cells which can express the Rh factor, as well as A and B antigens.
One form of hereditary spherocytosis occurs due to genetic defects in these cells' Band 4.2 proteins.
erythrocytes or red blood cells or RBCs