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Yamaguchi developed a "cold" variant of this technique which is useful for studying unstable molecules like triplex and quadruplex DNA. Theta glass emitters are used to achieve very small flow rates in the "nano" variant of this technique. Graham Cooks developed a form of surface analysis based on a variant of this technique which, like direct analysis in real time, is classified as "ambient." One phenomenon generated by both this technique and a conceptually similar "spinning" technique occurs at an angle equal to the zero of the Legendre polynomial of order 1/2, which is around 49.3°. In this technique, when the surface tension holding droplets together is exceeded by electrostatic repulsion, the droplets break up in a Coulombic explosion. Multiply-charged analytes are produced by this technique, making it useful for studying large molecules like proteins. For 10 points, name this "soft" ionization technique used in mass spectrometry, which is contrasted with MALDI.
Yamaguchi developed a "cold" variant of this technique which is useful for studying unstable molecules like triplex and quadruplex DNA.
electrospray ionization [or ESI; accept cold-spray ionization or desorptive electrospray ionization or DESI; prompt on ionization; prompt on mass spectrometry]