The A subunit binds to a specific G protein and permanently activates it, causing constant secretion of electrolyte-rich solution into the gut.
Mutations causing cystic fibrosis may have been retained in human populations because of the resistance shown by heterozygotes to this disease. This disease's vector produces a protein toxin that consists of B subunits that bind to ganglioside receptors in intestinal microvilli and create a hydrophilic channel that allows the A subunit into the cell. The A subunit binds to a specific G protein and permanently activates it, causing constant secretion of electrolyte-rich solution into the gut. Caused by bacteria of genus Vibrio, for ten points, name this infectious disease resulting in up to 30 liters of diarrhea per day.
Mutations causing cystic fibrosis may have been retained in human populations because of the resistance shown by heterozygotes to this disease.
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