An area of research involving this asks why its function is extremely stably conserved while its sequence is known to evolve rapidly; that is its namesake (*) paradox.
A "neo-" version of these structures commonly appears in atypical lipomas and well-differentiated sarcomas. 60% of patients with limited systemic scleroderma have antibodies to these structures. The application of Eg5 STLC inhibitor causes these regions to orient towards a monopole.  An area of research involving this asks why its function is extremely stably conserved while its sequence is known to evolve rapidly; that is its namesake (*) paradox. A major epigenetic mark of these structures is the histone H3 variant CENP-A, and in humans it primarily consists of alpha-satellite repeats.  During mitotic and meiotic cell division, this region serves as the location where the kinetochore is assembled.  For 10 points, name this condensed region of the chromosome that joins together sister chromatids.
A "neo-" version of these structures commonly appears in atypical lipomas and well-differentiated sarcomas.
centromeres