Deactivated rings like phenols cannot undergo this reaction.
Reaction of naphthalenes with succinic anhydride to form phenanthrenes proceeds via this reaction followed by two reductions, a cyclization, and a dehydrogenation in the Haworth [HAY-worth] synthesis. Carbon monoxide and hydrochloric acid generate a reactive acyl chloride to formylate benzene in a variant of this reaction named for Gattermann and Koch. Possible rearrangements in one form of this reaction are avoided by using the (*) Clemmensen reduction to reduce the acyl products of its other form. Deactivated rings like phenols cannot undergo this reaction. This reaction generally uses a Lewis acid catalyst like aluminum trichloride to alkylate or acylate aromatic compounds. For 10 points name this electrophilic aromatic substitution reaction named for a French and an American chemist.
Reaction of naphthalenes with succinic anhydride to form phenanthrenes proceeds via this reaction followed by two reductions, a cyclization, and a dehydrogenation in the Haworth [HAY-worth] synthesis.
Friedel–Crafts reaction [or Friedel–Crafts alkylation; or Friedel–Crafts acylation; accept Haworth synthesis until read; prompt on electrophilic aromatic substitution until read; prompt on alkylation or acylation] &lt;JL, Chem&gt;