For 10 points, name these proteins important in lipid transport, which are important but only quizbowl-famous because of their E4 variant being linked to Alzheimers.
One of these proteins, which was formerly called beta-2-glycoprotein-1, is, along with cardiolipin, a common auto-antigen in APS, while a polymorphism in another is linked to both T. brucei resistance and focal segmental glomerulosclerosis. The C2 type of this protein is responsible for activating LPL, while another one has a notable Milano variant, is mutated in Tangier disease, and activates LCAT. The messenger RNA of one of these proteins is edited at residue 2153 in order to generate its "48" isoform in the (*) small intestine. One of these proteins has polymorphisms in which either Cys and Arg occur at position 112 and 158, and mutations in that protein causes orange palms and tuberoeruptive xanthomas. Chylomicrons contain their A, B, C, and E varieties, and these proteins are found in VLDL, HDL, and LDL particles. For 10 points, name these proteins important in lipid transport, which are important but only quizbowl-famous because of their E4 variant being linked to Alzheimers.
One of these proteins, which was formerly called beta-2-glycoprotein-1, is, along with cardiolipin, a common auto-antigen in APS, while a polymorphism in another is linked to both T. brucei resistance and focal segmental glomerulosclerosis.
apolipoproteins [prompt on “lipoprotein”, accept specific apolipoproteins, ie ApoA-I, ApoB, ApoE, ApoC-I, ApoC-II, ApoL1]