When this reaction occurs in tandem with an aldol condensation, the sequence is called a Robinson annulation.
The first published reaction of this kind was conducted soon after its namesake obtained a cyclopropane derivative by using 2-bromacrylic acid ethylester, and involved an ethyl ester of cinnamic acid mixed with ethanol for four days. Glutathione pacifies carcinogens which undergo this reaction with DNA. This reaction only occurs in very high pressure conditions between bicyclic ketones and dimethyl methylmalonate. 4-hydroxycoumarin undergoes this reaction in the last step of the succinct synthesis of Warfarin. The (*) Stork enamine alkylation is analogous to this reaction. The end product of the Knoevenagel condensation commonly undergoes this reaction, which happens when Mannich bases are heated up in the presence of ketones. When this reaction occurs in tandem with an aldol condensation, the sequence is called a Robinson annulation. For 10 points, name this common reaction which joins an enolate to an alpha, beta unsaturated carbonyl compound, a 1,4- addition
The first published reaction of this kind was conducted soon after its namesake obtained a cyclopropane derivative by using 2-bromacrylic acid ethylester, and involved an ethyl ester of cinnamic acid mixed with ethanol for four days.
Michael addition