An ester with this functionality condenses with a ketone or aldehyde in the presence of elemental sulfur in the Gewald reaction to give 2-amino thiophenes, and the Letts synthesis forms these from aryl carboxylic acids.
An ester with this functionality condenses with a ketone or aldehyde in the presence of elemental sulfur in the Gewald reaction to give 2-amino thiophenes, and the Letts synthesis forms these from aryl carboxylic acids. Esters form organozinc reagents and attack these compounds to give, after hydrolysis, beta-ketoesters in the Blaise reaction, and aryl halides give this functionality in the Rosenmund-von Braun reaction. The Strecker synthesis gives as an intermediate the alpha-amino variety of these compounds before hydrolyzing to the amino acid. The simplest organic example of these compounds saw a major shortage from late 2008 to early 2009; that example is a popular medium-polarity solvent for TLC. FTP, name these compounds which contain a carbon-nitrogen triple bond.
An ester with this functionality condenses with a ketone or aldehyde in the presence of elemental sulfur in the Gewald reaction to give 2-amino thiophenes, and the Letts synthesis forms these from aryl carboxylic acids.
{nitriles}