This protein is secreted by the zone of polarizing activity during limb formation, and mutations in it cause a condition in which the brain fails to divide into hemispheres, known as holoprosencephaly.
A cis-acting regulator of this gene is found in an intron of LMBR1 and is mutated in preaxial polydactyly. Its pathway is often overactive in medulloblastomas, where it requires Bmi1 to drive proliferation. This protein is secreted by the zone of polarizing activity during limb formation, and mutations in it cause a condition in which the brain fails to divide into hemispheres, known as holoprosencephaly. In drosophila, this protein's binding to its receptors protects (*) cubitus interruptus from being cleaved, while in vertebrates it results in the activation of Gli transcription factors and oxysterol being removed from the Smoothened protein. It binds to the receptor Patched, and it is secreted by the notochord to specify the floor plate in the neural tube. For 10 points, name this important morphogen, which is named for a video game character.
A cis-acting regulator of this gene is found in an intron of LMBR1 and is mutated in preaxial polydactyly.
Sonic Hedgehog Homolog [accept shh]