One form of hereditary spherocytosis occurs due to genetic defects in these cells' Band 4.2 proteins.
One form of hereditary spherocytosis occurs due to genetic defects in these cells' Band 4.2 proteins. Â Their cytoskeleton consists mainly of spectrin, which is anchored by both Band 4.1 and ankyrin to the membrane-bound proteins glycophorin and Band 3, an anion exchanger. When immature, these cells are called (*) reticulocytes, and when mature, older and less flexible ones are filtered out as they move from the cords of Billroth into the splenic sinuses. Â These cells may be destroyed via phagocytosis by Kupffer cells. Â A hereditary lack of the H substance leads to the Bombay phenotype in these non-nucleated cells, which lose their characteristic biconcave shape in the presence of a certain mutation that substitutes a valine for glutamate. Â These cells have a lifespan of around 120 days, and their development is stimulated by erythropoetin. Â For 10 points, identify these cells which can express the Rh factor, as well as A and B antigens.
One form of hereditary spherocytosis occurs due to genetic defects in these cells' Band 4.2 proteins.
erythrocytes or red blood cells or RBCs