This disease's symptoms don't usually appear until the age of 30, which is why it propagates despite being fatal and autosomal dominant.
In 2001, Steffan et al found that the protein affected by this disease possessed acetyltransferase activity, which allowed binding to CREB and p300 proteins. That affected protein has 36 to 155 glutamine residues as opposed to the usual 35, often manifesting from (*) poly-CAG repeats. It is characterized by (*) astrogliosis due to loss of spiny neurons, though the most prominent nerve cell loss occurs in the striatum. This disease's symptoms don't usually appear until the age of 30, which is why it propagates despite being fatal and autosomal dominant. For 10 points, name this degenerative genetic disorder associated with its namesake chorea.
In 2001, Steffan et al found that the protein affected by this disease possessed acetyltransferase activity, which allowed binding to CREB and p300 proteins.
{Huntington}’s disease