One variant of this reaction replaces a key ingredient with 1,3-dichloro- cis-2-butene, and is named for Wichterle, while an alternative to it replaces that same ingredient with a sulfoxide that has an ortho-ester attached. That reaction, named for Hauser, also replaces this reaction's second step with a Dieckmann reaction. The Wieland-Mischer and Hajos-Parrish ketones can be formed when methyl vinyl ketone is used as the alpha, beta unsaturated ketone reactant in its first step, which also requ
One variant of this reaction replaces a key ingredient with 1,3-dichloro- cis-2-butene, and is named for Wichterle, while an alternative to it replaces that same ingredient with a sulfoxide that has an ortho-ester attached. That reaction, named for Hauser, also replaces this reaction's second step with a Dieckmann reaction. The Wieland-Mischer and Hajos-Parrish ketones can be formed when methyl vinyl ketone is used as the alpha, beta unsaturated ketone reactant in its first step, which also requires a nucleophilic donor like an enamine or beta keto ester. FTP, name this reaction used to form polycyclic molecules, which consists of a Michael addition followed by an intra-molecular aldol condensation.
One variant of this reaction replaces a key ingredient with 1,3-dichloro- cis-2-butene, and is named for Wichterle, while an alternative to it replaces that same ingredient with a sulfoxide that has an ortho-ester attached.
{Robinson annulation}