The toxin streptolysin O works by binding to this compound. This compound is hydroxylated twice prior to reacting with HSD3B7 in the beginning of an "acidic pathway" which converts it to CDCA. Type C Niemann-Pick disease is typically diag- nosed by filipin staining to detect the presence of this com
The toxin streptolysin O works by binding to this compound. This compound is hydroxylated twice prior to reacting with HSD3B7 in the beginning of an "acidic pathway" which converts it to CDCA. Type C Niemann-Pick disease is typically diag- nosed by filipin staining to detect the presence of this compound. This compound and its fungal analogue can be removed from cells by nystatin, amphotericin B, or methyl-beta-cyclodextrin. The enzymes DHCR7 and CYP51 catalyze the biosynthesis of this compound, which is regulated by the transcription factor SREBP-2. Macrophages which have ingested large amounts of this compound turn into foam cells. This compound is the starting point for the synthesis of bile acids in the liver. This compound's synthesis includes intermediates such as mevalonate and squalene and is suppressed by HMG-CoA reductase inhibitors. For 10 points, name this steroid whose levels are lowered by statins, which is carried by HDL and LDL in its good and bad forms.