Proteins destined for this structure are tagged at their N-linked oligosaccharides by mannose-6-phosphate, which allow receptors to mediate vesicular 
Proteins destined for this structure are tagged at their N-linked oligosaccharides by mannose-6-phosphate, which allow receptors to mediate vesicular transport of tagged proteins. Malfunction of this process is the cause of inclusion cell disease, while the lack of a critical enzyme inside this organelle leads to diseases such as Pompe's disease and Hurler syndrome. The lack of hexos-aminidase A causing buildup of gangliosides in this organelle is the cause of Tay-Sachs disease. Proton pumps and ion channels in this organelle maintain the pH of 4.8 that is critical for enzymatic function. Discovered in 1949 by Christian de Duve, FTP, name these organelles that destroy cellular waste and aid in the breakdown of macromolecules.
Proteins destined for this structure are tagged at their N-linked oligosaccharides by mannose-6-phosphate, which allow receptors to mediate vesicular transport of tagged proteins.
lysosomes