These compounds are useful to produce drugs such as Tamoxifen by reducing ketone side groups. As an undesirable side reaction, they can convert haloethers to alkenes by the Boord olefin synthesis, and their synthesis always produces Schlenk equilibrium. Before use of these compounds, one must flush the reaction vessel with nitrogen, as they are hig
These compounds are useful to produce drugs such as Tamoxifen by reducing ketone side groups. As an undesirable side reaction, they can convert haloethers to alkenes by the Boord olefin synthesis, and their synthesis always produces Schlenk equilibrium. Before use of these compounds, one must flush the reaction vessel with nitrogen, as they are highly reactive with oxygen, and they are usually dissolved in either THF or diethyl ether. Used to form strong nucleophiles and eventually carbon-carbon bonds, they are produced by reacting an organohalide with magnesium. FTP, identify these compounds, named for the French chemist who won the 1912 Nobel Prize for their discovery.
These compounds are useful to produce drugs such as Tamoxifen by reducing ketone side groups.
Grignard reagents