Enzymatic instances of this reaction are catalyzed by bacterial type II fatty acid synthesis enzymes, and by Chalcone synthase, which contain a Thiolase fold. A modification of it replaces a reactant with succinate, while a classic version of it occurs between ethyl benzoate and acetophenone, the former of which is not enolizable. It is driven by the removal of a doubly-alpha proton in the final product and the subsequent resonance stabilization of the negative charge, and its modifications include the Stobbe and crossed varieties. An intramolecular version of this reaction is used to create five- or six-member rings and is named for Dieckmann. For 10 points, name th
Enzymatic instances of this reaction are catalyzed by bacterial type II fatty acid synthesis enzymes, and by Chalcone synthase, which contain a Thiolase fold. A modification of it replaces a reactant with succinate, while a classic version of it occurs between ethyl benzoate and acetophenone, the former of which is not enolizable. It is driven by the removal of a doubly-alpha proton in the final product and the subsequent resonance stabilization of the negative charge, and its modifications include the Stobbe and crossed varieties. An intramolecular version of this reaction is used to create five- or six-member rings and is named for Dieckmann. For 10 points, name this condensation reaction that forms beta-keto-esters, the ester counterpart of the aldol condensation.
Enzymatic instances of this reaction are catalyzed by bacterial type II fatty acid synthesis enzymes, and by Chalcone synthase, which contain a Thiolase fold.
Claisen condensation