This procedure was first published with Claparede in 1881 in two forms, the second for a hydroxyl-substituted benzene. As performed today, it usually requires an initial acylation but, even with this, the relevant methanoate derivatives are notably unable to carry out the self- form of this reaction. One of the reactants contains a hydrogen alpha to a carbonyl; a deprotonation occurs at this site in the first step and the resulting conjugated system attacks the other reactant, an ester. It requires a strong base catalysis, so the relevant alkoxide is often added to the
This procedure was first published with Claparede in 1881 in two forms, the second for a hydroxyl-substituted benzene. As performed today, it usually requires an initial acylation but, even with this, the relevant methanoate derivatives are notably unable to carry out the self- form of this reaction. One of the reactants contains a hydrogen alpha to a carbonyl; a deprotonation occurs at this site in the first step and the resulting conjugated system attacks the other reactant, an ester. It requires a strong base catalysis, so the relevant alkoxide is often added to the system. FTP, name this reaction of two esters to yield a beta-keto ester; a condensation named for a German chemist.
This procedure was first published with Claparede in 1881 in two forms, the second for a hydroxyl-substituted benzene.
Claisen condensation (or Claisen reaction)