The story behind the discovery of these proteins was related in the article "How to Chase a Red Herring and Come up with a Smallmouth Bass." Mice lacking the STAT-1 protein pr
The story behind the discovery of these proteins was related in the article "How to Chase a Red Herring and Come up with a Smallmouth Bass." Mice lacking the STAT-1 protein produce roughly half as many of this type of protein as wild type mice. PLSCR-1 amplifies expression of genes whose transcription is induced by them. RIG-1 activates TBK1 and IKKe, which induce transcription of one type of them. Another transcription pathway for them is induced by Toll-like receptor 3. Plasmocytoid dendritic cells are specialized producers of these proteins, discovered by Alick Isaacs and Jean Lindenmann. The most recently discovered class of them is type III, or Type I?. Type Ia is typically produced by leukocytes, while Type I?is often produced by fibroblasts and epithelial cells and Type I?, or Type II, is produced by activated T cells. They promote expression of MHC Class I molecules and activate natural killer cells. For 10 points, name these cytokines produced in response to viral infection, which inhibit viral protein synthesis.
The story behind the discovery of these proteins was related in the article "How to Chase a Red Herring and Come up with a Smallmouth Bass.
interferons [or IFNs]