Sufferers of this disease often develop clubbing in the extremities, and male patients are often infertile because of blockage or failed development of the vas deferens.  Hypothesized to have a high prevalence due to conferring a heterozygote advantage against cholera and salmonella, the most common mutation causing this disease is the deletion of phenylalanine-508 in its namesake ABC transporter, which is coded on chromosome 7.  Diagnosed by the
Sufferers of this disease often develop clubbing in the extremities, and male patients are often infertile because of blockage or failed development of the vas deferens.  Hypothesized to have a high prevalence due to conferring a heterozygote advantage against cholera and salmonella, the most common mutation causing this disease is the deletion of phenylalanine-508 in its namesake ABC transporter, which is coded on chromosome 7.  Diagnosed by the sweat test, FTP, name this chloride channelopathy that causes a massive buildup of mucus in many epithelial tissues, most notably the lungs.
Sufferers of this disease often develop clubbing in the extremities, and male patients are often infertile because of blockage or failed development of the vas deferens.  
Cystic Fibrosis or CF