This disease is genetically associated with the presence of deleterious intron variants of or the underexpression of SORL1. Low blood progranulin and elevated Dkk-3 are two of approximately 18 blood protein level signifiers t
This disease is genetically associated with the presence of deleterious intron variants of or the underexpression of SORL1. Low blood progranulin and elevated Dkk-3 are two of approximately 18 blood protein level signifiers that could be used for diagnosis of this disease. A recently discovered more effective treatment for it involves combining memantine and the more traditional donepezil. Hyperinsulinemia might contribute to this disease, the late onset of which correlates with the presence of two alleles of the Apo variant E4, by promoting the hyperphosphorylation of microtubule-stabilizing proteins that form damaging tangles. Clinical trials on a common drug for this disease, rivastigmine, show that butyrylcholinesterase may play a role in this disease in addition to a more commonly implicated neurotransmitter esterase. For 10 points, what is this disease marked by a shortage of acetylcholine, the most common form of dementia?
This disease is genetically associated with the presence of deleterious intron variants of or the underexpression of SORL1.
{Alzheimer's} disease