The levels of PIKK complexes in this process are upregulated by RUVBL1 and RUVBL2 binding to the protein kinase SMG-1.  UPF1, 2, and 3 are key to triggering this process, whic
The levels of PIKK complexes in this process are upregulated by RUVBL1 and RUVBL2 binding to the protein kinase SMG-1.  UPF1, 2, and 3 are key to triggering this process, which is facilitated by a complex containing Y14, RNPS1 and Magoh. It's not ubiqutination, but this pathway has been shown to modulate the phenotypic severity of Von Hippel-Lindau disease by allowing some frameshifts to escape but others to remain stable, and evolutionarily it facilitates intron gain by correcting some forms of weak splicing. Ribosomal stalling leads to recruitment of eRF1 and 3 in this process, which is facilitated by the exon junction complex, leading to the formation of the SURF complex and eventual degredation of the substrate. For 10 points, name this form of mRNA surveillance that triggers RNA degradation in the presence of premature stop codons.
The levels of PIKK complexes in this process are upregulated by RUVBL1 and RUVBL2 binding to the protein kinase SMG-1.  
{Nonsense}-{Mediated Decay} [or {NMD}; prompt on {mRNA surveillance}]