Onuchic and Wolynes borrow the formulation of "minimal frustration" from th
Onuchic and Wolynes borrow the formulation of "minimal frustration" from the statistical mechanics of spin glasses to describe this process. Richards used Voronoi polyhedra to examine the packing density predicted by one model of this problem. One subproblem of this process is resolved by the Complimentary Twist Model of Chothia and Janin. A namesake "funnel" model of this process features a "molten globule" state, and this process may be studied via circular dichroism spectroscopy. Statistical mechanical models of this process include studies of self-avoiding walks. Early theories of this process were supported by an experiment that featured the addition, then removal, of two equivalents of 2-mercaptoethanol and of urea; the dogma thus supported, which was a response to Levinthal's paradox, assumed a kinetically accessible free energy minimum and is named for Anfinsen. Since then, it appears that primary structure is not the sole determining factor. For 10 points, name this process by which polypeptides acquire tertiary structure.
Onuchic and Wolynes borrow the formulation of "minimal frustration" from the statistical mechanics of spin glasses to describe this process.
{protein folding} [prompt on {denaturing} or anything that has to do with tertiary {structure changing}; prompt on polymer {folding} by saying “what kind of polymer”]