One reaction to accomplish this forms a namesake thiohydroxamic ester and either uses tert-butyl mercaptan or chloroform; that reaction is named for Barton. Another requires a
One reaction to accomplish this forms a namesake thiohydroxamic ester and either uses tert-butyl mercaptan or chloroform; that reaction is named for Barton. Another requires a beta- electron withdrawing group and generally employs lithium chloride in DMSO. That ionic reaction named for Krapcho contrasts with the believed radical pathway involved with the treatment with bromine and tetrachloromethane of silver salts, a reaction named for Hunsdiecker. This reaction is the final step in the pyridine-employing Doebner modification of the Knoevenagel reaction and of the malonic ester synthesis of cyclic carboxylic acids, where it occurs upon the addition of aqueous acid and heat. This operation turns pyruvate into acetyl-CoA in the citric acid cycle. For 10 points, name this reaction that often features the loss of carbon dioxide, wherein a COOH group departs.
One reaction to accomplish this forms a namesake thiohydroxamic ester and either uses tert-butyl mercaptan or chloroform; that reaction is named for Barton.
decarboxylation