Agnathans, which have a region of gill basket epithelia that expresses DLL-B, are the most basal organisms to possess an analogous structure to this organ. The expression of the AIRE transcription factor in medullar epithelial cells of these organs leads to the production of various proteins, including insulin and myelin basic protein. Concentric rings of epithelial cells in this organ are known as Hassall corpuscles. People with DiGeorge syndrome completely lack this organ. SCID or "nude" mice lack this organ and thus are incapable of rejectin
Agnathans, which have a region of gill basket epithelia that expresses DLL-B, are the most basal organisms to possess an analogous structure to this organ. The expression of the AIRE transcription factor in medullar epithelial cells of these organs leads to the production of various proteins, including insulin and myelin basic protein. Concentric rings of epithelial cells in this organ are known as Hassall corpuscles. People with DiGeorge syndrome completely lack this organ. SCID or "nude" mice lack this organ and thus are incapable of rejecting tissue transplants due to compromised humoral immunity. In this tissue, cells expressing CD4 and/or CD8 that bind to self antigens are destroyed through negative selection. For 10 points, name this immunologically important organ located near the heart, the site of T-cell maturation.
Agnathans, which have a region of gill basket epithelia that expresses DLL-B, are the most basal organisms to possess an analogous structure to this organ.
thymus