Aquaporin-4 and P2 are targets during this process, and animal models for this process are generated by infecting rodents with Theiler's virus or with JHM virus, which causes the onset of EAE. It can be detected by excretion of proteolytic fragments of MBP. A defect in the aspartoacylase gene causes this process to occur in Canavan's disease, while it is caused by galactosylphingosine buildup in Krabbe disease. Overly rapid correction of hyponatremia can cause this process to occur in the pons, and the reversal of this process is observed in "shadow plaques". This process is most commonly seen in a disease whose diagnostic markers include optic neuritis and oligoclonal banding in the cerebrospinal fluid; that disease disproportionately affects people with the DR-2 haplotype, especially Caucasian women from northern climates. For 10 points, name this process that can be caused by the dest
Aquaporin-4 and P2 are targets during this process, and animal models for this process are generated by infecting rodents with Theiler's virus or with JHM virus, which causes the onset of EAE. It can be detected by excretion of proteolytic fragments of MBP. A defect in the aspartoacylase gene causes this process to occur in Canavan's disease, while it is caused by galactosylphingosine buildup in Krabbe disease. Overly rapid correction of hyponatremia can cause this process to occur in the pons, and the reversal of this process is observed in "shadow plaques". This process is most commonly seen in a disease whose diagnostic markers include optic neuritis and oligoclonal banding in the cerebrospinal fluid; that disease disproportionately affects people with the DR-2 haplotype, especially Caucasian women from northern climates. For 10 points, name this process that can be caused by the destruction of oligodendrocytes or Schwann cells in diseases like multiple sclerosis.
Aquaporin-4 and P2 are targets during this process, and animal models for this process are generated by infecting rodents with Theiler's virus or with JHM virus, which causes the onset of EAE.
demyelination [accept demyelinization; accept anything indicating that myelin is being destroyed or is degenerating]