This molecule promotes gut homing in T-cells when it is secreted by intestinal dendritic cells. Hogan and Chen discovered that this molecule was synthesized in Hensen's node, and along with Sonic hedgehog, this molecule regul
This molecule promotes gut homing in T-cells when it is secreted by intestinal dendritic cells. Hogan and Chen discovered that this molecule was synthesized in Hensen's node, and along with Sonic hedgehog, this molecule regulates Lefty-1 expression to control the left-right axis in limb development. This molecule's deposition along the anterior-posterior axis is established in part by Cyp26, which degrades it. The most successful example of "differentiation therapy" is the treatment of acute progranulocytic leukemia with the all-trans type of this molecule. Enhancer elements that bind to this irreversibly oxidized molecule's receptor include several repeats of the sequence GGTCA and are found upstream of the 3-prime HOX genes, explaining this molecule's caudalizing effects. Defects in formation of the first and second pharyngeal arches were observed in fetal mammals exposed to its 13-cis derivative, the acne treatment Accutane. For 10 points, name this active metabolite of vitamin A.
This molecule promotes gut homing in T-cells when it is secreted by intestinal dendritic cells.
retinoic acid or RA [do not accept "vitamin A"; do not accept "retinol"; do not accept "retinal"; do not accept "retinaldehyde"]