One protein associated with this disease has been shown to selectively activate Death Receptor 6 in the cells most heavily affected, and that protein is processed by PSEN1 and PSEN2. The ApoE4 allele 
One protein associated with this disease has been shown to selectively activate Death Receptor 6 in the cells most heavily affected, and that protein is processed by PSEN1 and PSEN2. The ApoE4 allele is strongly associated with this disease, and Pick's disease has a similar mechanism. Galantamine and Donepezil are used to control this disease, which is partly associated with the hyperphosphorylation of the tau protein, which creates microtubule tangles. People with down syndrome invariably develop this disease by age 40, partly because they have an extra copy of the APP gene, which is thought to form beta-amyloid plaques. Characterized by the gradual loss of longterm memory and eventual severe dementia, for 10 points, name this chronic neurological illness, named for a German.
One protein associated with this disease has been shown to selectively activate Death Receptor 6 in the cells most heavily affected, and that protein is processed by PSEN1 and PSEN2.
{Alzheimer's} Disease