During DNA replication in eukaryotes, flap endonucleases remove RNA nucleotides extended by DNA polymerase III. In eukaryotes they are generally between 100 to 200 nucleotides long, while they are between 1,000 to 2,000 nucleotides long in E. coli. Due to the antiparallel nature of DNA strands, only one continuous strand of DNA can be synthesised at the 3' end of the leading strand. In order to compensate, these sequences of nucleotides appear in the lagging strand of DNA. FTP, name these fragments of DNA joined together by ligase first discove
During DNA replication in eukaryotes, flap endonucleases remove RNA nucleotides extended by DNA polymerase III. In eukaryotes they are generally between 100 to 200 nucleotides long, while they are between 1,000 to 2,000 nucleotides long in E. coli. Due to the antiparallel nature of DNA strands, only one continuous strand of DNA can be synthesised at the 3' end of the leading strand. In order to compensate, these sequences of nucleotides appear in the lagging strand of DNA. FTP, name these fragments of DNA joined together by ligase first discovered by two namesake Japanese biologists.
During DNA replication in eukaryotes, flap endonucleases remove RNA nucleotides extended by DNA polymerase III.
{Okazaki} fragments