Diethyl oxalate and a zinc catalyst, followed by a decarboxylation, are used to create versions of this compound in the Reissert synthesis. Three equivalents of a vinyl Grignard reagent can be used to synthesize substituted ones in the Bartoli synthesis, while a two-step reaction using Raney nickel synthesizes these compounds from o-nitro-toluenes in the Leimgruber-Batcho reaction. Buchwald modified the earliest synthesis of this compound with a palladium catalyst, and the original version of that reaction used phenyl- hydrazine and a ketone and is named for Emil Fisch
Diethyl oxalate and a zinc catalyst, followed by a decarboxylation, are used to create versions of this compound in the Reissert synthesis. Three equivalents of a vinyl Grignard reagent can be used to synthesize substituted ones in the Bartoli synthesis, while a two-step reaction using Raney nickel synthesizes these compounds from o-nitro-toluenes in the Leimgruber-Batcho reaction. Buchwald modified the earliest synthesis of this compound with a palladium catalyst, and the original version of that reaction used phenyl- hydrazine and a ketone and is named for Emil Fischer. Consisting of a benzene ring fused to pyrrole, FTP, name this compound found in the side chain of tryptophan, first formed by reacting indigo with oleum.
Diethyl oxalate and a zinc catalyst, followed by a decarboxylation, are used to create versions of this compound in the Reissert synthesis.
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