Schreiber's synthesis of this compound had a pipecolinal undergo an Evans-Tischenko fragment coupling, while Ley's version used a Stille coupling to stitch the final product together, and used SnCl4 to cyclize an allyl stannate. The biosynthesis of this molecule, which contains a central macrocycle surrounded by three ketone and two methoxy groups, attaches L-pipecolate to a polyketide, then cyclizes. Originally isolated from S. hygroscopicus, Kennedy and Kaberlein found that administering this compound to rats in mid-life drastically extended lifespan, and it is used instead of calcineurin inhibitors due to the latters' nephrotoxicity. This compound prevents the formation of complex contain
Schreiber's synthesis of this compound had a pipecolinal undergo an Evans-Tischenko fragment coupling, while Ley's version used a Stille coupling to stitch the final product together, and used SnCl4 to cyclize an allyl stannate. The biosynthesis of this molecule, which contains a central macrocycle surrounded by three ketone and two methoxy groups, attaches L-pipecolate to a polyketide, then cyclizes. Originally isolated from S. hygroscopicus, Kennedy and Kaberlein found that administering this compound to rats in mid-life drastically extended lifespan, and it is used instead of calcineurin inhibitors due to the latters' nephrotoxicity. This compound prevents the formation of complex containing G-beta-L, PRAS40, and Raptor, while a related complex containing the Rictor protein is unaffected by it. Marketed as an immune suppressant under the name Sirolimus, it binds to the protein FKBP12, which in turn inhibits a certain kinase. For 10 points, name this antibiotic which notably "Targets" a pathway containing the protein TOR.
Schreiber's synthesis of this compound had a pipecolinal undergo an Evans-Tischenko fragment coupling, while Ley's version used a Stille coupling to stitch the final product together, and used SnCl4 to cyclize an allyl stannate.
{Rapamycin} or {Rapamune} or {Sirolimus} before mention