Smith-Lemli-Opitz syndrome can cause an interruption in delivery of cholesterol leading to impaired steriodogenesis, a possible cause of this disease. Another cause, dysgenesis of the affected gland, can be brought about by mutations in the SF1 transcription factor or DAX-1 gene mutation. It was first described by its British namesake in 1855's On 
Smith-Lemli-Opitz syndrome can cause an interruption in delivery of cholesterol leading to impaired steriodogenesis, a possible cause of this disease. Another cause, dysgenesis of the affected gland, can be brought about by mutations in the SF1 transcription factor or DAX-1 gene mutation. It was first described by its British namesake in 1855's On the Constitutional and Local Effects of Disease of the Suprarenal Capsules. Lawrence Wright in The Looming Tower  suggests that Osama Bin Laden likely has this disease as he shows many of the common symptoms, which include fatigue, weight loss, hyperpigmentation of the skin and a craving for salty foods.  For 10 points, name this rare endocrine disorder known to have been suffered by John F. Kennedy.
Smith-Lemli-Opitz syndrome can cause an interruption in delivery of cholesterol leading to impaired steriodogenesis, a possible cause of this disease.
Addison's Disease