One protein found on the membrane of this structure is Ire1, whose dimeric form is an endonuclease that splices Hac1 mRNA. Hereditary emphysema is caused by the aggregation of alpha-one-antitrypsin in this structure. Proteins destined for this structure typically contain a hydrophobic N-terminal signal sequence. Pro-alpha-six-integrin may be retained in this structure due to the lectin calnexin, a type I transmembrane protein. Protein disulfide isomerase catalyzes spontaneous disulfide bond formation in this structure, 
One protein found on the membrane of this structure is Ire1, whose dimeric form is an endonuclease that splices Hac1 mRNA. Hereditary emphysema is caused by the aggregation of alpha-one-antitrypsin in this structure. Proteins destined for this structure typically contain a hydrophobic N-terminal signal sequence. Pro-alpha-six-integrin may be retained in this structure due to the lectin calnexin, a type I transmembrane protein. Protein disulfide isomerase catalyzes spontaneous disulfide bond formation in this structure, the only eukaryotic cell structure in which it can happen. Like the Golgi body, it may consist of a series of flattened disks known as cisternae. For 10 points, name this organelle that synthesizes phospholipids and fats in its "smooth" variety and proteins in the ribosomes attached to its "rough" variety.
One protein found on the membrane of this structure is Ire1, whose dimeric form is an endonuclease that splices Hac1 mRNA.
{endoplasmic reticulum} [or {ER}]