In 1973 Ihler et al reported the first use of these structures in enzyme replacement therapy.  Howell-Jolly bodies are the remains of one process performed during the maturation of these objects.  Heinz bodies in these struct
In 1973 Ihler et al reported the first use of these structures in enzyme replacement therapy.  Howell-Jolly bodies are the remains of one process performed during the maturation of these objects.  Heinz bodies in these structures can form as a reaction to some antibiotics and other oxidizing drugs, and show up as "bumps" in a Romanowsky stain.  (*) Kupffer cells destroy these structures, which can aggregate to form rouleaux.  If they are abnormally shaped, they are known as poikilocytes or schistocytes, while polycythemia refers to an abnormally high concentration of these cells.  Immature forms of these cells are called reticulocytes.  A genetic disorder whose heterozygote form confers some resistance to malaria causes these cells to take on the shape of a sickle instead of their usual biconcave form.  For 10 points, name these notably enucleated cells that use hemoglobin to transport oxygen in the blood.
In 1973 Ihler et al reported the first use of these structures in enzyme replacement therapy.  
{erythrocyte}s [accept {red blood cell}s; prompt on {blood cell}s] (1)