Recent research has shown that Pif1 directs the mo
Recent research has shown that Pif1 directs the movement of these objects, and the cancer drug Cytarabine causes destabilization of them. Enzymes which act on them are governed by RPA, and these objects were first confirmed using a pulse-chase experiment with tritium-marked substrates. Enzymes like RNAse H and FEN1 remove the RNA primers which begin these objects, and phosphodiester bonds are then formed as they are linked together by ligase. Occurring because DNA polymerase only works in the 5-prime to 3-prime direction, FTP, name these pieces of DNA formed on the lagging strand during replication, named for a Japanese husband-and-wife team.
Recent research has shown that Pif1 directs the movement of these objects, and the cancer drug Cytarabine causes destabilization of them.
{Okazaki fragments}