Leukemia inhibitory factor and ciliary neurotrophic factor bind to gp130 and LIFR-beta receptor subunits and activate JAK tyrosine kinases that phosphorylate STAT transcription factors. Along with cardiotrophin, these form cl
Leukemia inhibitory factor and ciliary neurotrophic factor bind to gp130 and LIFR-beta receptor subunits and activate JAK tyrosine kinases that phosphorylate STAT transcription factors. Along with cardiotrophin, these form class 6 of these cytokines that also activate plasma cells and cytotoxic T cells in the immune system.
Leukemia inhibitory factor and ciliary neurotrophic factor bind to gp130 and LIFR-beta receptor subunits and activate JAK tyrosine kinases that phosphorylate STAT transcription factors.
{interleukin}s