The association between aortic stenosis and angiodysplasia of the colon, known as Heyde's syndrome, is due to increased break
The association between aortic stenosis and angiodysplasia of the colon, known as Heyde's syndrome, is due to increased breakdown of this protein. The protease ADAMTS13 is responsible for breaking down this protein, and mutation of that protease causes TTP. When this protein is mutated, the ristocetin cofactor activity is low. Along with P-selectin, this protein is found in Weibel-Palade bodies, and desmopressin can increase expression of this protein. Cryoprecipitate notably contains this protein, which contains an RGD domain for binding to integrin IIb-3. Bernard-Soulier syndrome results when the glycoprotein receptor for this protein is mutated, and this protein clings to Factor VIII in the blood until thrombin separates them. The disease named for this protein is the most common coagulation disorder in the world. For 10 points, name this glycoprotein whose mutation causes a hemophilia-like syndrome, named for a Finnish guy.
The association between aortic stenosis and angiodysplasia of the colon, known as Heyde's syndrome, is due to increased breakdown of this protein.
von Willebrand Factor or vWF