The drug PRIMA-1 binds to mutant forms of this protein, and ATM kinase phosphorylates this protein. This protein's N-terminus is intrinsically disordered and contains TAD1 and TAD2 subdomains; that N-terminus is a transactivator that binds to CBP. This protein upregulates the expression of PUMA and it is ubiquitinated by Mdm2. This protein tetramerizes and binds to (*) DNA in order to trigger p21 expression, which inhibits the G1 to S transition. This protein is up-regul
The drug PRIMA-1 binds to mutant forms of this protein, and ATM kinase phosphorylates this protein. This protein's N-terminus is intrinsically disordered and contains TAD1 and TAD2 subdomains; that N-terminus is a transactivator that binds to CBP. This protein upregulates the expression of PUMA and it is ubiquitinated by Mdm2. This protein tetramerizes and binds to (*) DNA in order to trigger p21 expression, which inhibits the G1 to S transition. This protein is up-regulated in response to UV light and free-radical damage, which allows it to arrest the cell cycle or trigger apoptosis. For 10 points, name this tumor suppressor called the "guardian angel" of the genome, named for its weight.
The drug PRIMA-1 binds to mutant forms of this protein, and ATM kinase phosphorylates this protein.
p53