In Alzheimer's disease, m
In Alzheimer's disease, mutations of either one of two of these residues in presenilin-1 eliminates the protein's ability to interact with Notch. The condensation of this compound and carbamoyl phosphate is the first committed step of pyrimidine biosynthesis. P-type ATPases all catalyze the phosphorylation of this amino acid, whose namesake protease is encoded for by HIV's pol gene. The N-methyl derivative of this amino acid is the selective agonist for an ionotropic receptor blocked in a voltage-dependent fashion by magnesium. This compound hydrogen bonds to a histidine to form part of the catalytic triad of chymotrypsin. A cytosolic (*) transaminase converts this amino acid to oxaloacetate in a shuttle named for this malate and this compound. The methyl ester of the dipeptide that this amino acid forms with phenylalanine is the active ingredient of a namesake artificial sweetener. For 10 points, name this amino acid that like glutamate has an acidic side chain.
In Alzheimer's disease, mutations of either one of two of these residues in presenilin-1 eliminates the protein's ability to interact with Notch.
aspartate [or aspartic acid; or Asp; or D]