One originator of this reaction initially used it in the synthesis of Sch 38516, an antifungal compound, and one variation of this reaction was used repeatedly in the total synthesis of ciguatoxin because it can create difficult 7 or 8 member rings. One catalyst for this reaction was modified to place an isopropoxy group in place of a phosphine ligand, and said catalyst also contains an imidazolidine group. This reaction, which occurs through a metallocyclobutane intermediate, proceeds through a traditionally (*) symmetry-forbidden 2+2 addition. Catalysts for this reaction include Grubbs ruthenium and Schrock carbenes
One originator of this reaction initially used it in the synthesis of Sch 38516, an antifungal compound, and one variation of this reaction was used repeatedly in the total synthesis of ciguatoxin because it can create difficult 7 or 8 member rings. One catalyst for this reaction was modified to place an isopropoxy group in place of a phosphine ligand, and said catalyst also contains an imidazolidine group. This reaction, which occurs through a metallocyclobutane intermediate, proceeds through a traditionally (*) symmetry-forbidden 2+2 addition. Catalysts for this reaction include Grubbs ruthenium and Schrock carbenes. For 10 points, name this reaction which earned the 2005 Nobel Prize in Chemistry, in which a pair of alkenes trades the groups attached to their double bonds.
One originator of this reaction initially used it in the synthesis of Sch 38516, an antifungal compound, and one variation of this reaction was used repeatedly in the total synthesis of ciguatoxin because it can create difficult 7 or 8 member rings.
olefin metathesis