The use of these compounds can lead to the HAMA or HACA response, and one method of growingthese compounds involves collecting ascites fluid from mice. Medarex developed the UltiMab platform forcreati
The use of these compounds can lead to the HAMA or HACA response, and one method of growingthese compounds involves collecting ascites fluid from mice. Medarex developed the UltiMab platform forcreating fully humanized ones. Using the substem -zu- indicates that these compounds are humanized.These compounds are created using cells that can't express HGPRT, making them susceptible to theaminopterin present in HAT medium; those cells are immortalized myeloma cells fused to candidateB-cells to create a hybridoma. These drugs include Rituximab, which targets B-cells, and Herceptin, whichtargets the HER2/neu receptor responsible for some breast cancers. For 10 points, name theseartificially-created antibodies that target a single epitope.
The use of these compounds can lead to the HAMA or HACA response, and one method of growingthese compounds involves collecting ascites fluid from mice.
 monoclonal antibodies [prompt on "antibodies"]