: One enzyme in this pathway has very high sequence and protein fold similarity to the lens protein delta-crystallin. In the most common disease affecting this pathway, OTC deficiency, excessive amounts of the substrate are converted to orotic acid. N-acetylglutamic acid activates the starting enzyme of this pathway, an isoform of which is also used in pyrimidine biosynthesis. 3 ATP is hydrolyzed to 2 ADP and 1 AMP in this pathway, whose penultimate step produces (*) fumarate, allowing coupling to the Krebs cycle. The c
: One enzyme in this pathway has very high sequence and protein fold similarity to the lens protein delta-crystallin. In the most common disease affecting this pathway, OTC deficiency, excessive amounts of the substrate are converted to orotic acid. N-acetylglutamic acid activates the starting enzyme of this pathway, an isoform of which is also used in pyrimidine biosynthesis. 3 ATP is hydrolyzed to 2 ADP and 1 AMP in this pathway, whose penultimate step produces (*) fumarate, allowing coupling to the Krebs cycle. The compound that enters this pathway condenses with bicarbonate via carbamoyl synthetase I. Citrulline is produced in the first step of this pathway, whose final step is a condensation reaction with arginine to yield ornithine and the namesake product. For 10 points, name this cycle that converts ammonia to the waste product excreted in urine.
: One enzyme in this pathway has very high sequence and protein fold similarity to the lens protein delta-crystallin.
urea cycle