This electrophilic aromatic substitution adds moieties to aromatic rings using a Lewis acid catalyst like aluminum chloride.
In a March 2012 paper, Shu-Li You and coworkers used a chiral N-triflyl phosphoramide catalyst with this reaction to enantioselectively synthesize fluorene (with an e) derivatives. A book on the chemistry of this reaction was written by George Olah. This name reaction is part of a class of reactions that creates a Wheland intermediate. Due to it's slow rate, it almost always fails when one of its reactants has a strong electron-withdrawing group, like a sulfonyl or nitro group. One modification of this reaction formylates an arene by passing a mixture of carbon monoxide and hydrochloric acid gases over it, is used to produce benzaldehydes, and is the Gatterman-Koch reaction. This electrophilic aromatic substitution adds moieties to aromatic rings using a Lewis acid catalyst like aluminum chloride. For 10 points, identify this doubly-eponymous reaction that includes an acylation and alkylation.
In a March 2012 paper, Shu-Li You and coworkers used a chiral N-triflyl phosphoramide catalyst with this reaction to enantioselectively synthesize fluorene (with an e) derivatives.
Friedel-Crafts reaction [or Friedel-Crafts acylation before \"acylation\" is read; or Friedel-Crafts alkylation before \"alkylation\" is read]