Two classes of these molecules that can produce a namesake "storm" are secreted by leukocytes and virally infected cells and are termed interleukins and interferons, respectively.
A 1992 paper by Dantzer and Kelley reported sickness-related behavior in mice that had these chemicals administered directly to the brain. The transforming growth factor beta superfamily belongs to the group of cysteine-knot variety of these chemicals. Their receptors are linked to JAK kinases, which activate STAT transcription factors. The drug TGN1412 caused a fatal positive feedback loop involving them; an earlier instance of the same killed many in the 1918 flu pandemic. Two classes of these molecules that can produce a namesake "storm" are secreted by leukocytes and virally infected cells and are termed interleukins and interferons, respectively. They are associated with clonal selection and activation of lymphocytes. For 10 points, name this diverse class of signaling molecules used by immune cells.
A 1992 paper by Dantzer and Kelley reported sickness-related behavior in mice that had these chemicals administered directly to the brain.
{cytokines}