The effect of proteins like OXA-18 on these agents can be mitigated by the co-administration of clavulanic acid, which counteracts resistance to these chemicals.  
The effect of proteins like OXA-18 on these agents can be mitigated by the co-administration of clavulanic acid, which counteracts resistance to these chemicals.  Another mechanism of resistance to these agents is mutation of serine 403 in the enzyme they target.  Members of this class are structural analogues of the NAG/NAM peptide of the protein whose transpeptidation they inhibit.  The variable binding of PBP subtypes to members of this class of drugs, which includes the cephalosporins, affects the relative abilities of these drugs to inhibit the crosslinking of the bacterial cell wall component peptidoglycan.  For 10 points, name this class of antibiotics with a namesake central ring structure, a class that includes penicillin.
The effect of proteins like OXA-18 on these agents can be mitigated by the co-administration of clavulanic acid, which counteracts resistance to these chemicals.  
beta-lactams