These proteins are homologs of a drosophila protein that binds to delta and serrate ligands, while in humans they bind to JAG proteins.
Bicuspid aortic valves are associated with a mutation in one of these proteins, while mutation in a protein protein that activates one of these proteins results in a condition in which there is a paucity of bile ducts, known as Allagile syndrome. Familial hemiplegic migraine is caused by a mutation in the third of these proteins. Another mutation in these causes the most common hereditary stroke disorder, known as CADASIL syndrome. Their extracellular EGF-like repeats are variably glycosylated by Lunatic Fringe, Radical Fringe, and Manic Fringe, which alters their signaling properties.  These proteins activate the CSL transcription factor. Like TNF-alpha, one domain of these proteins is cleaved by ADAMTS17, while their intracellular domains are cleaved by gamma-secretase. These proteins are homologs of a drosophila protein that binds to delta and serrate ligands, while in humans they bind to JAG proteins. FTP, name these proteins, who get their name from their drosophila homolog whose mutation caused indentations to appear on the wings.
Bicuspid aortic valves are associated with a mutation in one of these proteins, while mutation in a protein protein that activates one of these proteins results in a condition in which there is a paucity of bile ducts, known as Allagile syndrome.
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