A metallocyclobutane intermediate is produced in the ring-closing form of this reaction according to the Chauvin mechanism, which was first demonstrated in complexes of carbenes.
Cook et al. used this reaction to convert an oxazoline into a seven-membered nitrogen heterocycle in a synthesis of the PKC inhibitor balanol. A green variant of this reaction can cleave plant oils like oleate esters. The efficiency of a catalyst for this reaction was increased by replacing one of its two bulky phosphine ligands with 3-bromopyridine. One experiment concerning this reaction found that it produced a statistical distribution of terminal (*) alkyl groups, providing evidence against a pairwise mechanism. This reaction can cause the polymerization of norbornene in order to relieve its ring strain. A metallocyclobutane intermediate is produced in the ring-closing form of this reaction according to the Chauvin mechanism, which was first demonstrated in complexes of carbenes. For 10 points, name this reaction catalyzed by a ruthenium complex named for Grubbs, an exchange of substituents across two double bonds.
Cook et al. used this reaction to convert an oxazoline into a seven-membered nitrogen heterocycle in a synthesis of the PKC inhibitor balanol.
olefin metathesis [accept alkene metathesis; prompt on partial answer; accept ring-opening metathesis polymerization or ROMP; accept cross-metathesis or CM; accept ethenolysis; accept Shell higher olefin process or SHOP; accept acyclic diene metathesis polymerization or ADMET; accept ring-closing metathesis or RCM before mentioned; prompt on "polymerization" or related answers]