Present in an octomeric form known as a nucleosome, for 10 points, name these highly positively charged proteins, which are responsible for binding to DNA.
The presence of these proteins in apoptotic blebs may be responsible for the development of autoantibodies in Lupus, and variants of them include CenpA and 2AX, the later of which is an indication of repair. In Drosophila the Suppressor of Variegation proteins are partly responsible for modifying these proteins, and the Polycomb and Trithorax proteins have opposing effects on the clustering of these proteins. The PRMN4 pathway also acts on these proteins, and Jenuwen and Allis postulated the idea of a code of them, in which a combinatorial set of modification of them is an indication of gene expression in particular regions. They can be palmitoylated, phosphorylated, ubiquitinated, but more often they are acetylated and methylated in order to form open and closed chromatin, respectively. Present in an octomeric form known as a nucleosome, for 10 points, name these highly positively charged proteins, which are responsible for binding to DNA.
The presence of these proteins in apoptotic blebs may be responsible for the development of autoantibodies in Lupus, and variants of them include CenpA and 2AX, the later of which is an indication of repair.
{Histones}