The hormone EPO regulates the production of these cells, which can be produced in an "extramedullary" manner in the spleen and liver.
The colony-forming unit CFU-E is central to the differentiation of these cells. As these cells differentiate, they switch from staining basophilic to staining acidophilic. A protein found in these cells is switched by the transcription factor GATA1 from an infant to an adult form. The hormone EPO regulates the production of these cells, which can be produced in an "extramedullary" manner in the spleen and liver. These biconcave cells lack a nucleus. For 10 points, name these that can be "sickle" shaped in a type of anemia, and carry oxygen using hemoglobin.
The colony-forming unit CFU-E is central to the differentiation of these cells.
red {blood} cells [accept {RBCs}; or {erythrocytes}; or {erythroid cells}; or {haematids}]