Induced in response to interferons alpha and beta and macrophages, they are the only cytotoxic cells to act early in infection, primarily through the production of interferon gamma.
These cells are responsible for providing immunity in mice lacking the RAG-1 or RAG-2 recombinase, while the lack of these in humans is the cause of Chediak-Higashi syndrome. Discovered by accident in the 1970s, these cells display the CD16 receptor and C-type lectins for MHC class I-mediated inhibition, but do not display the CD3 receptor or standard surface immunoglobulins. Induced in response to interferons alpha and beta and macrophages, they are the only cytotoxic cells to act early in infection, primarily through the production of interferon gamma. Characterized by their ability to kill cells which lack "self" markers even without activation, these are, FTP, what cytotoxic lymphocytes that participate in innate immunity against tumors and virally infected cells?
These cells are responsible for providing immunity in mice lacking the RAG-1 or RAG-2 recombinase, while the lack of these in humans is the cause of Chediak-Higashi syndrome.
NK lymphocytes or cells or natural killer cells