This condition is also treated by drugs that prevent the binding of catecholamines to beta-adrenergic receptors.
The drug bosentan treats a form of this condition that is associated with the overproduction of endothelin-1, and that can be alleviated by prostacyclins. This condition, which is the subject of the Birmingham paradox, may be partly alleviated by a cascade wherein HMWK and LMWK are cleaved by kallikrein. One class of drugs that treats this condition are dicarboxylates, which prevent the removal of two C-terminal residues from a hormone that is converted to an active form by an aspartyl protease secreted by the juxtaglomerular apparatus. This condition is also treated by drugs that prevent the binding of catecholamines to beta-adrenergic receptors. This condition can be controlled by modulating the renin-angiotensin-aldosterone system. The primary or essential version of this condition, which is treated by ACE inhibitors and beta blockers, accounts for most cases of it. For 10 points, name this condition in which a vital sign that is measured in systolic and diastolic forms is elevated.
The drug bosentan treats a form of this condition that is associated with the overproduction of endothelin-1, and that can be alleviated by prostacyclins.
high blood pressure [or essential hypertension; accept equivalents such as elevated blood pressure; accept "pulmonary artery hypertension" until "hemorrhagic"]