This protein exists in "batho""meta-I" and "meta-II" states, the last of which is thought to require the clockwise outward rotation of helix III and helix VI, and like other proteins of its kind, it possesses a DRY/ERY consensus sequence at region which binds to transducin.
Oguchi's disease occurs due to a mutation in genes encoding for arrestins or for kinases which act on this protein. This protein exists in "batho""meta-I" and "meta-II" states, the last of which is thought to require the clockwise outward rotation of helix III and helix VI, and like other proteins of its kind, it possesses a DRY/ERY consensus sequence at region which binds to transducin. The E113 residue acts as a counterion and they have characteristic lysine-296 residue which has a Schiff-base linkage with its cofactor. The activation of this protein results in the downstream increase in the activity of cGMP phosphodiesterase, and it was the first G-protein coupled receptor to have its structure revealed. The isomerization of its chromophore into the all-trans form occurs when photons strike the chromophore. For 10 points, identify this protein which forms a complex with 11-cis-retinal, the primary photoreceptor protein present in rod cells.
Oguchi's disease occurs due to a mutation in genes encoding for arrestins or for kinases which act on this protein.
{rhodopsins} [prompt on {opsin} until "{transducin};" accept: {arrestins} until mentioned; accept: {rhodopsin kinase} until "{kinases}"]