Babin and Whitaker introduced chiraphite as ligand for enantioselective versions of this reaction.
Babin and Whitaker introduced chiraphite as ligand for enantioselective versions of this reaction. The biggest industrial application of this reaction uses a highly water-soluble sulfonated triphenylphosphine salt that complexes with rhodium. Vinyl-arenes undergo this reaction followed by an oxidation in the industrial synthesis of NSAIDS like ibuprofen. It has two separate CO elimination steps: one that occurs with the reductive elimination of the desired product, and another that occurs in its last step to allow an alkene to coordinate with the HRh(CO) complex. Like the Wacker process, it is a prominent example of homogenous catalysis. The accepted mechanism for this reaction was elucidated by David Breslow and Richard Heck. It was discovered by Otto Roelen when experimenting with products from the Fischer- Tropsch process, and it uses an alkene, carbon monoxide, and hydrogen as reagents. For 10 points, name this reaction that results in the net addition of a CHO group across an alkene to form an aldehyde.
Babin and Whitaker introduced chiraphite as ligand for enantioselective versions of this reaction.
hydroformylation [accept word forms; accept oxo reaction or oxo synthesis; prompt on "carbonylation"]