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Due to the founder effect, this disease has a higher frequency among Dutch Afrikaners. It results from an error located on the short arm of chromosome 4, the trinucleotide repeat CAG, and is characterized by buildup of the protein mHTT. [*] Symptoms of this autosomal dominant genetic disorder include erratic movement known as chorea; unlike Alzheimer's, it causes subcortical dementia and usually manifests as people reach middle age. For 10 points, name this hereditary neurodegenerative disease.
Due to the founder effect, this disease has a higher frequency among Dutch Afrikaners.
{Huntington's} disease [accept {Huntington's chorea} before mention] [AF/MJ]