During healing of a wound, this change allows some cells to become motile and invasive because they could then move into the wound site to fill in the gap.
This temporary process is triggered when MMPs from stroma cells activate latent growth factors like TGF-beta 1 from the extracellular matrix. In monolayer cultures, this process involves vimentin, fibronectin, and N-cadherin being expressed rather than the normal expression of cytokeratins and E-cadherin. Addition of metalloproteinase-3 stimulates this process to cause the regular polygonal shape of certain cells to become more fibroblastic.  During healing of a wound, this change allows some cells to become motile and invasive because they could then move into the wound site to fill in the gap. Name this change in which cells from one type of germ line lose their anchoring connections to neighboring cells so that they resemble another type of cells from mesodermal origins, a shift in contrast to MET.
This temporary process is triggered when MMPs from stroma cells activate latent growth factors like TGF-beta 1 from the extracellular matrix.
{Epithelial}-{Mesenchymal Transition} [or {EMT}]