FTP, name this reaction which results in formation of a ring in polycyclic compounds, an annulation named for a British chemist.
The antibody Ab38C2 was found to efficiently catalyze both steps of this reaction via an enamine intermediate. That antibody is also highly enantioselective, and is thus useful in synthesis of optically active versions of the Wieland-Miescher compound. One variant of this reaction uses a 1,3-dichloro-2-butenyl derivative and is named for Wichterle, while another variant using sulfones sees the second step replaced by a Dieckmann condensation and is named for Hauser. A generalized version of this reaction sees a ketone and an enone in the presence of triflic acid and methylene chloride form bridged versions of the product. Occurring favorably with methyl vinyl ketones, this reaction is defined as a Michael addition followed by an intromolecular aldol condensation. FTP, name this reaction which results in formation of a ring in polycyclic compounds, an annulation named for a British chemist.
The antibody Ab38C2 was found to efficiently catalyze both steps of this reaction via an enamine intermediate.
Robinson Annulation