For 10 points, identify this process in which the variable, diverse, and joining gene segments are randomly rearranged, helping generate the variety of T-cell receptors and antibodies needed to combat foreign antigens.
The ARTEMIS protein is involved in the nicking of hairpin loops during this process. P-nucleotides are palindromic segments which may be added during this process, while the addition of N-nucleotides by TdT enhances the outcome of this process. Segments which undergo this process have highly conserved heptamer/nonamer motifs separated by 12 or 23 base pair spacer sequences, and RAG-1 and RAG-2 proteins perform this process. This process occurs via the formation of double (*) stranded breaks that are repaired by non-homologous end joining, and its products are found in the light and heavy chains of certain structures. For 10 points, identify this process in which the variable, diverse, and joining gene segments are randomly rearranged, helping generate the variety of T-cell receptors and antibodies needed to combat foreign antigens.
The ARTEMIS protein is involved in the nicking of hairpin loops during this process.
{V}({D}){J Recombination} [accept {VJ Recombination} or {somatic recombination}]