The treaty was in force for 51 years, until being abrogated by the Hay-Pauncefote agreement.  
Nine years after the treaty was signed, the Bay Islands were ceded to Honduras.  A year before the treaty, E G. Squier obtained Tigre Island from Nicaragua, after which the United States refused to recognize the protectorate of Mosquitia.  The treaty was in force for 51 years, until being abrogated by the Hay-Pauncefote agreement.  FTP, name this treaty in which the United States and Great Britain both guaranteed the neutrality of an eventual canal through Panama and which was signed in 1850.
Nine years after the treaty was signed, the Bay Islands were ceded to Honduras.  
Clayton-Bulwer treaty