FTP, name these enzymes of the DNA replication complex which change the supercoiling, and therefore the topology, of DNA.
One of the causes of systemic sclerosis involves production of anti-Scl 70 antibody which attacks class I of this enzyme. The mechanism of quinolone antibiotic action depends on inhibition of the bacterial class IV version of this enzyme, while in humans, the chemotherapeutic agent teniposide and doxorubicin have their effects in part to inducing double stranded DNA breaks by inhibiting class II of this enzyme. Necessary because of tangling, class II enzymes break both strands where two chromosomes cross, while class I enzymes break single phosphodiester bonds transiently in order to decrease torsionals force due to the movement of the replication fork. FTP, name these enzymes of the DNA replication complex which change the supercoiling, and therefore the topology, of DNA.
One of the causes of systemic sclerosis involves production of anti-Scl 70 antibody which attacks class I of this enzyme.
DNA topoisomerases (do not accept gyrases, which are exclusively prokaryotic)