These heavily glycosylated proteins consist of a heterodimer of an alpha and beta subunit, which bind to collagen and other extracellular matrix components.
The RGD domain of von Willebrand factor binds to one of these proteins, and the anti-angiogenic factor cilengitide binds to one of these. The receptor for adenovirus is one of these molecules. Glanzmann's Thrombasthenia is caused by a defect in one of these proteins. The anticoagulant monoclonal antibody abciximab attacks one of these proteins, which binds to fibrinogen in an ADP-dependent manner. The N-termini of their alpha-subunits bind to divalent cations. The binding of talin binds to and activates these proteins, which can trigger the activity of focal adhesion kinases. These heavily glycosylated proteins consist of a heterodimer of an alpha and beta subunit, which bind to collagen and other extracellular matrix components. For 10 points, name these cell surface proteins named for the fact that they are integral to the cell membrane.
The RGD domain of von Willebrand factor binds to one of these proteins, and the anti-angiogenic factor cilengitide binds to one of these.
{Integrins} (prompt on {glycoproteins})