He served as vice president for both John Quincy Adams and Andrew Jackson, and late in life, he was unable to read his own speech against the Compromise of 1850.  
He first came to Washington to give a speech in the aftermath of the Chesapeake Affair, and he created the Bureau of Indian Affairs while serving as Secretary of War under Monroe.  In another role, he was replaced by Martin Van Buren after his wife Floride exacerbated the Peggy Eaton affair, and earlier he wrote an Exposition and Protest named for his home state that argued against the Tariff of Abominations. He served as vice president for both John Quincy Adams and Andrew Jackson, and late in life, he was unable to read his own speech against the Compromise of 1850.  For 10 pints, name this proponent of slavery and nullification, a senator from South Carolina.
He first came to Washington to give a speech in the aftermath of the Chesapeake Affair, and he created the Bureau of Indian Affairs while serving as Secretary of War under Monroe.  
John Caldwell Calhoun