For 10 points, name this class of enzymes that create small breaks to help to reduce coiling and supercoiling in DNA.
This enzyme was shown to be a component of the complex pol II holoenzyme, implying that this enzyme is necessary for CDC. Antibiotics like quinolones target these enzymes by forming a complex that inhibits these molecules' ligase domains but not their nuclease domains, and cancer drugs like amsacrine and camptothecins target these enzymes. Gyrase is a member of the type II class of these enzymes, which reduces linking number by two. The first one was discovered in E. coli by Wang. These enzymes are needed because of tension introduced by the function of helicase. For 10 points, name this class of enzymes that create small breaks to help to reduce coiling and supercoiling in DNA.
This enzyme was shown to be a component of the complex pol II holoenzyme, implying that this enzyme is necessary for CDC.
topoisomerases I or II