Disappearing totally during mitosis, this structure is the location of 75% of the polymerase activity in the cell, primarily through the transcription of rDNA through RNA polymerase I.
Noncanonical functions for this structure are regulation of telomerase, modification of microRNAs, interaction with viral proteins, and sequestration of proteins important for tumor suppression and the cell cycle. Consisting of fibrillar centers, dense fibrillar components, and granular components, it is surrounded by a layer of condensed chromatin. Disappearing totally during mitosis, this structure is the location of 75% of the polymerase activity in the cell, primarily through the transcription of rDNA through RNA polymerase I. Also the location of synthesis of tRNAs and signal recognition particles, FTP, name this cellular organelle that is the primary site of ribosome synthesis, a subcomponent of the nucleus.
Noncanonical functions for this structure are regulation of telomerase, modification of microRNAs, interaction with viral proteins, and sequestration of proteins important for tumor suppression and the cell cycle.
nucleolus