Uttu was one of these.  
In Seneca Indian myth, an enormous one of these which kept its heart in the ground so that it could survive any attack was finally killed by Othegwendha.  In Micronesian myth, an "ancient" one created the sun, moon, and earth from a snail he found in a mussel shell.  In addition to Djien and Areop-Enap, the Sumerian goddess Uttu was one of these.  Among the Hopi, Hahai Wugti is associated with this creature, while among the Navajo people of this type established the four warnings of death,  A better known one was the son of Asase Ya and Nyame, and won his powers in a contest with the sky-god Nyankopon.  More famously, a daugher of Colophon and Idmon was changed to one of these after losing a contest with Athena.  FTP, name the type of animal associated with the Ashanti trickster god Anansi and an unfortunate weaver named Arachne.
In Seneca Indian myth, an enormous one of these which kept its heart in the ground so that it could survive any attack was finally killed by Othegwendha.  
the spider