The symptoms of this disease include dystonia and chorea.  
Recent research has shown that the protein central to this disease is sumoylated by Rhes, leading to increased cytotoxicity. One drug approved for treating this disease is tetrabenazine.  Like Parkinson's disease, this disease sees atrophy and neuron death in the striatum. The genetic basis of this disease is an increase in the polyQ track of a gene located on chromosome four, causing more CAG repeats. The symptoms of this disease include dystonia and chorea.  For 10 points, name this neurodegenerative disease caused by an autosomal dominant mutation which usually does not manifest until the victim is forty years old.
Recent research has shown that the protein central to this disease is sumoylated by Rhes, leading to increased cytotoxicity.
Huntington's Disease