According to Georgiana, the title feature "has been ... often called a charm," though Aylmer cannot stand its resemblance to a crimson hand or its mere presence.  
This story is set at a time when "it was not unusual for the love of science to rival the love of woman."  The protagonist's "slender figure, and pale, intellectual face" are contrasted with the "smoky aspect, and ... indescribable earthiness" of his assistant, Aminadab.  The protagonist's wife she agrees to risk anything rather than be "the object of [her husband's] horror and disgust."  According to Georgiana, the title feature "has been ... often called a charm," though Aylmer cannot stand its resemblance to a crimson hand or its mere presence.  FTP name this Hawthorne short story in which Georgiana dies after an operation to remove the titular blemish from her face.
This story is set at a time when "it was not unusual for the love of science to rival the love of woman."  
"The Birth-mark"