For 10 points, identify this pathway consisting mainly of a reversal of glycolysis, which synthesizes glucose from non-carbohydrate sources.
In this pathway, dihydroxyacetone phosphate undergoes an aldol condensation with glyceraldehyde-3-phosphate. The second step of this pathway is carried out by an enzyme requiring both magnesium and manganese ions, which first decarboxylates then phosphorylates oxaloacetate. The enzyme carrying out its rate-limiting step is activated by citrate and inhibited by high levels of cyclic AMP. The first molecule to enter this pathway may be created from the catabolism of amino acids, or from lactate after it undergoes the first half of the Cori cycle. This process occurs to a limited extent in the kidneys, although the majority happens within the liver. Its unique enzymes include fructose-1,6-bisphosphatase, pyruvate carboxylase, and PEP carboxykinase. For 10 points, identify this pathway consisting mainly of a reversal of glycolysis, which synthesizes glucose from non-carbohydrate sources.
In this pathway, dihydroxyacetone phosphate undergoes an aldol condensation with glyceraldehyde-3-phosphate.
{gluconeogenesis}