Since sufferers of this disease have increased production of a certain precursor protein, this ‬disease causes early-in-life Alzheimer's-like accumulation of Amyloid protein in neurons.
TS65Dn mice are used as a model for this disease. Like a condition that t‬his disease can lead to, this disease has increased expression of its CR1 also known as RCAN1,‭ ‬which can inhibit calcineurin mediated VGEF signaling. One method to check for this disease is looking for low PAPP-A levels. The sufferers of this disease have oblique palpebral fissures is best and are likely to have Brushfield spots. Since sufferers of this disease have increased production of a certain precursor protein, this ‬disease causes early-in-life Alzheimer's-like accumulation of Amyloid protein in neurons. Like other diseases of its type, it can be caused by a Robertsonian translocation. Symptoms of this disease include flat facial features and mental retardation. For 10 points, name this disease caused by having three copies of chromosome 21.
TS65Dn mice are used as a model for this disease. Like a condition that t‬his disease can lead to, this disease has increased expression of its CR1 also known as RCAN1,‭ ‬which can inhibit calcineurin mediated VGEF signaling.
Down's Syndrome [prompt on trisomy 21]