This compound is often delivered in Cremophor EL and ethanol, or it is bound to albumin and sold as Albraxane.
One synthesis of this compound uses a Corey-Chaykovsky reaction followed by epoxide opening to give the oxirane D ring and begins with the Wieland-Miescher ketone; that synthesis is by Danishefsky. Essential to one route to this compound is a pinacol coupling and a Shapiro reaction, which form the eight-membered B ring; that route relies on a convergent synthesis that links an amide tail to the A and C rings and was developed by Nicolaou. This compound is often delivered in Cremophor EL and ethanol, or it is bound to albumin and sold as Albraxane. This compound's commercial semisynthesis adds the Ojima lactam to the starting material from an early route to this compound, 10-deacetylbaccatin; that route was developed by Potier and quickly improved upon by Robert Holton. First isolated from the Pacific yew tree, for 10 points, name this inhibitor of microtubule assembly used in chemotherapy.
One synthesis of this compound uses a Corey-Chaykovsky reaction followed by epoxide opening to give the oxirane D ring and begins with the Wieland-Miescher ketone; that synthesis is by Danishefsky.
{Taxol} [or {paclitaxel}]