After the death of her Burgundian husband from typhoid, she refused to be parted from his body, and she was eventually immured in the castle of Tordesillas while her son, who defeated Francis I in the battle of Pavia, ruled Spain.  
Pierre de La Rue wrote the devotional "Gaude Virgo" for this monarch and her husband.  Her daughter Eleanor's unhappy marriage was arranged in the Ladies' Peace of Cambrai, and the War of the Communities was fought to reinstate her as queen of her country.  After the death of her Burgundian husband from typhoid, she refused to be parted from his body, and she was eventually immured in the castle of Tordesillas while her son, who defeated Francis I in the battle of Pavia, ruled Spain.  FTP, name this wife of Philip the Handsome and mother of Holy Roman Emperor Charles V, a Spanish queen known for being loco in the cabeza.
Pierre de La Rue wrote the devotional "Gaude Virgo" for this monarch and her husband.  
Juana the Mad (or Juana of Castile or Joanna the Mad or Joanna of Castile)