Caused by an inflammation of the GI tract, most often the small intestine, for 10 points, name this disease characterized by bloody diarrhea and weight loss, named for an American.
One suspected causative agent of this disease is Mycobacterium avium paratuberculosis, which causes a similar disease in livestock. The autophagy-controlling gene ATG16L1 is linked to this disease. This disease is strongly linked to mutations in a protein that recognizes muramyl dipeptide moieties and contains two caspase recruitment domains, known as NOD2. The TNF-alpha inhibitor infliximab was originally approved to treat it, and it is associated with a Th17 response. Its complications include a seronegative spondylarthropathies, fissures, and fistulae. Unlike ulcerative colitis this disease shows discontinuous, or "skip" lesions, which are usually seen on colonoscopy. Caused by an inflammation of the GI tract, most often the small intestine, for 10 points, name this disease characterized by bloody diarrhea and weight loss, named for an American.
One suspected causative agent of this disease is Mycobacterium avium paratuberculosis, which causes a similar disease in livestock.
{Crohn's} Disease