Garedew et al. showed that this complex regulates OPA1 and TFAM, which are important in the biogenesis of mitochondria.
Garedew et al. showed that this complex regulates OPA1 and TFAM, which are important in the biogenesis of mitochondria. Experiments by Almeida et al. and Colombo et al. have shown that this complex regulates PFKFB3 ["P-F-K-F-B-3"] and GLS1, which suggests that this complex has tight control over glycolysis and glutaminolysis. This complex is inactive when its activators are localized by Mad and Bub proteins. Like SCF, this complex has substrates with consensus sequences like the D-box and the KEN-box. Activators of this complex that help it bind to those substrates are the cdc20 and cdh1 proteins. This complex has 13 subunits, and is best known for its E3 ubiquitin ligase activity. One substrate of this complex undergoes degradation to release separase, which cleaves cohesin to dissociate sister chromatids and allow them to move towards opposite poles of the cell. For 10 points, name this protein complex that helps move the cell cycle along from metaphase to its namesake phase.
Garedew et al. showed that this complex regulates OPA1 and TFAM, which are important in the biogenesis of mitochondria.
anaphase promoting complex [or anaphase promoting cyclosome; or anaphase promoting complex/cyclosome; or APC/C; accept SCF complex or Skp, Cullin, F-box containing complex until "SCF"]