He was a presidential candidate several times, but lost to James K. Polk and Andrew Jackson, while his fourth place finish in the election of 1824 allowed him to possibly create a corrupt bargain with John Quincy Adams.  
An argument over whether soldiers in his state should wear patriotic clothing led to a duel between Humphrey Marshall and this man.  Although his Omnibus Bill failed, he was able to get the Compromise of 1850 to pass.  He was a presidential candidate several times, but lost to James K. Polk and Andrew Jackson, while his fourth place finish in the election of 1824 allowed him to possibly create a corrupt bargain with John Quincy Adams.  For 10 points, name this senatorial giant from Kentucky who proposed the American System and was known as the Great Compromiser.
An argument over whether soldiers in his state should wear patriotic clothing led to a duel between Humphrey Marshall and this man.  
Henry {Clay}