Substitution of serine for cysteine at position 1564 of the alpha-5 chain of that type of this protein leads to a severe form of Alport Syndrome.
Autoantibodies attack the alpha-3 chains of one type of this protein in Goodpasture's Syndrome. Substitution of serine for cysteine at position 1564 of the alpha-5 chain of that type of this protein leads to a severe form of Alport Syndrome. Along with laminins, type IV of this protein forms a two-dimensional mesh in the basal lamina. This protein primarily consists of a triple helix of Gly-X-Y repeats, where X and Y are typically proline and hydroxyproline. Type I of this protein is secreted by chondrocytes and osteoblasts, and is mineralized to form bone matrix. For 10 points, name this most abundant protein in the human body, whose high tensile strength makes it ideal in tendons and skin.
Autoantibodies attack the alpha-3 chains of one type of this protein in Goodpasture's Syndrome.
collagen