When this mutation occurs, it induces incorrect folding in the normal protein, resulting in accumulation and subsequent brain cell destruction.
Suggested to be evolutionarily advantageous for the fungus Podospora anserine, typical examples of these molecules in yeast contain a high number of glutamine and asparagine residues. These molecules have no known genetic material associated with them, and they are produced by a mutation to a gene that codes for a normal PrP protein. When this mutation occurs, it induces incorrect folding in the normal protein, resulting in accumulation and subsequent brain cell destruction. Transmissible by injection or ingestion of infected tissue, these objects are responsible for fatal familial insomnia, kuru, and Creutzfeldt-Jakob disease. FTP, name these abnormal proteins discovered and named by Stanley B. Prusiner, a portmanteau for "proteinaceous infectious particle".
Suggested to be evolutionarily advantageous for the fungus Podospora anserine, typical examples of these molecules in yeast contain a high number of glutamine and asparagine residues.
prions (accept proteinaceous infectious particles on early buzz)