Mediated by Prox-1 in lymphatic tissue and the orphan receptor COUP-TF2 in veins, patients with Von Hippel-Lindau disease are unable to repress this process due to a mutation in a gene that degrades the hypoxia induced protein HIF1.
The completion of this process requires Ephrins B2 and B4 in targeting of disparate pseudopodia. Mediated by Prox-1 in lymphatic tissue and the orphan receptor COUP-TF2 in veins, patients with Von Hippel-Lindau disease are unable to repress this process due to a mutation in a gene that degrades the hypoxia induced protein HIF1. This process is inhibited by the release of plasminogen, thrombospondin-1, endostatin, and the drug Avastin, and inhibition is also responsible in part for birth defects seen after use of thalidomide. Upregulated by FGF and VEGF [veg-eff] in response to low cellular oxygen levels, FTP, name this biological process of wound healing and tumor development, the growing of new blood vessels from pre-existing vessels.
The completion of this process requires Ephrins B2 and B4 in targeting of disparate pseudopodia.
angiogenesis