Multiple "hits" are needed to deactivate them according to Knudson's hypothesis.
APC is one of these that controls beta-catenin, and whose inactivation is linked with FAP disease. The malfunction of another one of these named VHL leads to Von-Hippel-Lindau disease. Multiple "hits" are needed to deactivate them according to Knudson's hypothesis. A study on a rare childhood disease affecting the retina lead to the discovery of one of these known as Rb1. The inactivation of one of them leads to (*) Li-Fraumeni Syndrome. The proteins derived from these genes play a role in carrying out apoptosis, facilitating DNA repair and regulating the cell cycle, all of which are essential in preventing the onset of carcinogenesis. For 10 points, name this class of genes opposed by oncogenes, one of whose members is p53, the "guardian angel of the cell."
APC is one of these that controls beta-catenin, and whose inactivation is linked with FAP disease.
tumor suppressor genes or tumor suppressor proteins [or anti-oncogenes before oncogenes are mentioned, do not take "oncogenes," or "proto-oncogenes, which are notably the exact opposite of what we are talking about.]