Grinberg's theoretical basis for this phenomenon relies upon the ability of an induced dipole between the directing group and the central atom to weaken the bond with the leaving group.
Grinberg's theoretical basis for this phenomenon relies upon the ability of an induced dipole between the directing group and the central atom to weaken the bond with the leaving group. Chatt-Orgell theory describes this effect in compounds like Zeise's anion, in which an ethylene substituent stabilizes the transition state by accepting pi-backbonding, allowing it to absorb some of the electron density on the central metal atom. The Kurnakov procedure uses the strength of this effect in molecules containing thiourea groups to make structural predictions. The Dhara synthesis relies on this effect because halides exhibit it more strongly than ammonium groups, allowing the second ammonium group to be added at the proper site to generate cisplatin. For 10 points, name this phenomenon that describes the effect of a coordinated ligand upon the rate of substitution at the site opposite to it.
Grinberg's theoretical basis for this phenomenon relies upon the ability of an induced dipole between the directing group and the central atom to weaken the bond with the leaving group.
trans effect