Deisseroth's group switched out the intracellular domain of one of these proteins with an adrenergic receptor, creating OptoXR.
Georg Nagel isolated one of these proteins from Chlamydomonas which is linked to a nonspecific cation channel. Deisseroth's group switched out the intracellular domain of one of these proteins with an adrenergic receptor, creating OptoXR. Those proteins, known as the "channel-" type, are commonly used in optogenetics, while the "bacterio" type is used as a proton pump. This protein, when activated, decreases the concentration of cyclic GMP via the activation of transducin. Its cofactor changes into an all-trans state upon activation of this protein; that cofactor originally adopts an 11-cis confirmation and is known as retinal. For 10 points, name this transmembrane protein found in photoreceptor cells, responsible for converting light energy to cellular signals.
Georg Nagel isolated one of these proteins from Chlamydomonas which is linked to a nonspecific cation channel.
{Rhodopsin}