A test for this condition actually targets the neighboring SNRPN gene.
In this condition, a buildup of Arc protein reduces the surface expression of GluR1 and other components of AMPA receptors due to a lack of E6-associated ubiquitin ligase. A connection between this condition and fear conditioning in the mouse model is suggested by its effects on long-term synaptic plasticity in the CA1 region of the hippocampus. A test for this condition actually targets the neighboring SNRPN gene. This condition usually results from loss of expression of one copy of the Ube3A gene, typically through loss or improper imprinting of the maternal copy of a region on chromosome 15 that is also implicated in Prader-Willi syndrome. For 10 points, name this disorder characterized by an unusual gait, hand-flapping and a happy, laughing demeanor.
In this condition, a buildup of Arc protein reduces the surface expression of GluR1 and other components of AMPA receptors due to a lack of E6-associated ubiquitin ligase.
{Angelman's} syndrome [prompt on {happy puppet syndrome} from {eugenicists}]