This molecule activates the soluble isoform of guanylyl cyclase, leading to increased cyclic GMP the relaxation of smooth muscle cells.
DAF-2 diacetate can be used to visualize this molecule, whose synthesis is inhibited by NPA. The enzyme that synthesizes this molecule contains both a heme and a tetrahydrobiopterin cofactor, and its two domains are brought together in a calmodulin-dependent manner. That enzyme comes in an inducible form, a neuronal form with an extra PDZ domain that anchors to dystrophin, and an endothelial isoform. This molecule's release is triggered by shear stress upon endothelial cells and is synthesized from L-arginine. This molecule activates the soluble isoform of guanylyl cyclase, leading to increased cyclic GMP the relaxation of smooth muscle cells. Viagra increases the levels of this molecule, which is one of the few gaseous, small signaling molecules. For 10 points, name this signaling molecule responsible for vasodilation, which is paramagnetic and diatomic with formula NO.
DAF-2 diacetate can be used to visualize this molecule, whose synthesis is inhibited by NPA.
{Nitric Oxide} or NO