In another variant of this reaction, carbon monoxide and HCl are reacted with benzene derivatives to form benzaldehydes.
This reaction is closely related to one in which use of vinyl mercuric chloride solves stereochemical complications in synthesis of alpha, beta- unsaturated ketones from alkenes. In a recent modification of this reaction found by Allemann and Siegel, which could be used for fullerene synthesis, a tri-isopropylsilyl cation and a carborane anion are used to synthesize polyaromatic compounds from aryl fluorides. This reaction is followed by two Clemmensen reductions in a reaction using succinic anhydride to produce naphthalenes discovered by Haworth. In another variant of this reaction, carbon monoxide and HCl are reacted with benzene derivatives to form benzaldehydes. Modified by the Gattermann-Koch reaction, this reaction is often catalyzed with aluminum chloride. FTP, name this Lewis acid catalyzed reaction in which acyl or alkyl groups are added to an aromatic ring.
This reaction is closely related to one in which use of vinyl mercuric chloride solves stereochemical complications in synthesis of alpha, beta- unsaturated ketones from alkenes.
{Friedel}-{Crafts} (prompt on {Electrophilic Aromatic Substitution} or {EAS})