This protein complex has catalytic subunits with trypsin-like, chymotrypsin-like and PHGH-like activities, and proteins are unfolded within its central barrel in an ATP-independent fashion.
Salinosporamide A is a potent inhibitor of this complex, and Gankyrin is a component of one of its subunits. Another inhibitor of this complex is used to treat relapses of multiple myeloma and causes peripheral neuropathy; that drug is bortezomib. An 11S regulatory particle attaches to this structure when it is used to generate antigens for presentation on MHC complexes. Ciechanover, Hershko, and Rose won the 2004 Nobel for characterizing this complex. Its most common form has a 20S core particle and two 19S caps, and its structure is very similar to that of chaperonins. This protein complex has catalytic subunits with trypsin-like, chymotrypsin-like and PHGH-like activities, and proteins are unfolded within its central barrel in an ATP-independent fashion. Proteins are targeted here after being ubiquitinated repeatedly. FTP, name this protein complex responsible for degrading a variety of other proteins into small peptides.
Salinosporamide A is a potent inhibitor of this complex, and Gankyrin is a component of one of its subunits.
{Proteasome}