Its N-methyl D version stimulates namesake receptors implicated in epilepsy.
In 1980, Steiner et al showed that E. coli mutants could convert this compound into quinolinic acid, a precursor to NAD. Biosynthesis of pyrimidines begins with carbamoylation of this amino acid, two molecules of which are contained in the catalytic site of pepsin. Interconversion between it and oxaloacetate provides the antiporter activity necessary for malate transport into mitochondrial matrix. The fibronectin motif for integrin binding consists of arginine, glycine, and this amino acid, whose side chain with pKa 3.9 makes it useful in the catalytic triad of proteases along with serine and histidine. Its N-methyl D version stimulates namesake receptors implicated in epilepsy. Possessing one less carbon than the similarly structured glutamate, for 10 points, name this amino acid symbolized D or Asp.
In 1980, Steiner et al showed that E. coli mutants could convert this compound into quinolinic acid, a precursor to NAD.
{aspartate} or {aspartic} acid [accept {D} or {Asp} before mentioned]