That cofactor consists of a porphyrin ring coordinated to an atom of iron, and a Glu6Val mutation in this protein is responsible for Sickle Cell anemia.
The affinity of this protein for its substrate is decreased by 2,3-bisphospho-glycerate. The binding of substrate to one of its subunits causes a conformational change that enables the substrate to quickly bind its three other subunits. Its affinity for a competitive inhibitor is described by the Haldane effect, and delta-ALA synthase catalyzes the rate-limiting step of the biosynthesis of its metal cofactor. That cofactor consists of a porphyrin ring coordinated to an atom of iron, and a Glu6Val mutation in this protein is responsible for Sickle Cell anemia. For 10 points, identify this protein found in red blood cells that helps transport oxygen.
The affinity of this protein for its substrate is decreased by 2,3-bisphospho-glycerate.
{Hemoglobin} [accept {Hb}]