It has been found that administration of gamma-interferon in vitro is linked to the oncogenesis of pancreatic cells through this pathway, which may play a role in the renewal of hematopoietic stem cells.
It has been found that administration of gamma-interferon in vitro is linked to the oncogenesis of pancreatic cells through this pathway, which may play a role in the renewal of hematopoietic stem cells. Steps in this pathway include the activation of the TCF/LEF family of transcription factors, using a "destruction complex" that includes the proteins APC and axin. The membrane portion of this pathway is stabilized by LRP, and that portion contains a trimeric G protein connecting the dishevelled and frizzled proteins. This pathway's effects hinge on its ability to control cytosolic levels of beta-catenin. Working in tandem with sonic hedgehog homolog to define an organism's dorsal-ventral axis is, for 10 points, this cellular signaling pathway, whose name is a portmanteau of a Drosophila gene and a mouse gene.
It has been found that administration of gamma-interferon in vitro is linked to the oncogenesis of pancreatic cells through this pathway, which may play a role in the renewal of hematopoietic stem cells.
{wnt} signaling pathway