This protein has been shown to inhibit the mitochondrial pathway of apoptosis by increasing the degradation rate of the BH3-only protein Bik, and this protein is an activator of the FAK-paxillin- p130-Crk-associated substrate cascade.
During cotranslational modification, this protein's N-terminal methionine is removed and the resulting N-terminal glycine is myristoylated by myristoyl-coA. This protein plays a role in synaptic plasticity by enhancing the activity of the NMDA receptor. This protein has been shown to inhibit the mitochondrial pathway of apoptosis by increasing the degradation rate of the BH3-only protein Bik, and this protein is an activator of the FAK-paxillin- p130-Crk-associated substrate cascade. The activation of this protein requires the removal of an inhibitory phosphate group from Tyrosine (*) 527 near the C-terminus and the phosphorylation of Tyrosine 416 in the activation loop. Due to the loss of the C-terminal residues, its viral equivalent is no longer regulated by intramolecular interactions and becomes constitutively active; that viral equivalent was discovered to cause cancer in chickens by Peyton Rous. For 10 points, name this non-receptor tyrosine kinase encoded for by a namesake proto-oncogene.
During cotranslational modification, this protein's N-terminal methionine is removed and the resulting N-terminal glycine is myristoylated by myristoyl-coA.
Src tyrosine kinase (or "sarc"; accept c-Src or Src family kinase; prompt on "SFKs")