Like FAS, this molecule's receptor associates with TRADD upon ligand binding, causing either survival through derepression of NF-kappa-B or, alternatively, caspase-8-mediated apoptosis.
The dynamics of this molecule's receptors are described by the ligand-passing model, and it is cleaved by the metallopeptidase ADAM17. This molecule induces externalization of granules and surface expression of P-selectin in Weibel-Palade bodies. It was discovered as a suppressor of lipoprotein lipase and as a factor involved in triglyceridemia, leading to its alternative name of cachexin. Infliximab, a monoclonal antibody against this protein, was developed by Mark Feldmann and colleagues, who studied the signalling cascade of this protein in rheumatoid arthritis. Like FAS, this molecule's receptor associates with TRADD upon ligand binding, causing either survival through derepression of NF-kappa-B or, alternatively, caspase-8-mediated apoptosis. Systemic release of this molecule leads to intravascular blood clotting, increased vascule permeability, and other symptoms of septic shock. For 10 points, name this pro-inflammatory cytokine secreted primarily by macrophages and mast cells.
The dynamics of this molecule's receptors are described by the ligand-passing model, and it is cleaved by the metallopeptidase ADAM17.
tumor necrosis factor alpha (accept "cachexin" or "cachectin" early; do not prompt on or accept tumor necrosis factor beta or TNF-beta; don't accept TGF, which is something else altogether)