After syn-addition of the reactants, this reaction forms its product with a beta hydride elimination, before reductive elimination with base regenerates the catalyst, a cycle similar to one employed in the Wacker process.
One variation of this reaction uses the ionic liquid HEmimBF4 instead of phosphine ligands, and thallium and silver salts are used to control regioselectivity in one step. Like the Sonagashira reaction, this reaction makes use of a zero-valent organometallic catalyst. It is used commercially to couple naphthalene derivatives to ethylene, forming naproxen and this reaction is used in the Danishefsky Taxol total synthesis to close the B ring of enol triflate. After syn-addition of the reactants, this reaction forms its product with a beta hydride elimination, before reductive elimination with base regenerates the catalyst, a cycle similar to one employed in the Wacker process. FTP, name this reaction that joins an unsaturated halide to an alkene with an organo-palladium catalyst.
One variation of this reaction uses the ionic liquid HEmimBF4 instead of phosphine ligands, and thallium and silver salts are used to control regioselectivity in one step.
The {Mizoroki-Heck} reaction