Affected cells become deformed easily, leading to an outward diffusion of potassium that makes those cells less hospitable for P. falciparum in humans who are heterozygous for hemoglobin S.
TNF-alpha may contribute to the cerebral type of this disease as a result of up-regulation of ICAM-1. Deficiency of glucose-6-phosphate dehydrogenase increases resistance to this disease, as do certain thalassemias. It causes the membranes of certain cells to become porous seconds before making them burst. Humans who are Duffy blood group negative are protected from one agent causing this disease that lacks redundancy in invasion pathways, P. vivax. Affected cells become deformed easily, leading to an outward diffusion of potassium that makes those cells less hospitable for P. falciparum in humans who are heterozygous for hemoglobin S. That heterozygosity, which also allows the spleen to preferentially destroy infected red blood cells, is sickle cell anemia. For 10 points, name this disease commonly treated with quinine which is caused by Plasmodium and transmitted by the Anopheles mosquito.
TNF-alpha may contribute to the cerebral type of this disease as a result of up-regulation of ICAM-1.
malaria