These proteins may bind their substrates by recognizing "destruction boxes," and they are preceded in their pathway by activating and conjugating enzymes.
These proteins are responsible for the recognition step of the N-end pathway, and Meetei et al discovered that FANCL (fank-ell), rather than BRCA1 (bra-cah-one) plays this role in the Fanconi anemia pathway. Members of the catalytic subtype of these proteins have a HECT domain and perform their namesake action directly through a thioester intermediate, while the scaffold subtype of these proteins includes SCF-type complexes and the anaphase promoting complex. U-box-containing elongation factors can further modify the targets of these proteins, and all known scaffold-type proteins of this class contain, or bind to a protein containing, a RING finger domain. These proteins may bind their substrates by recognizing "destruction boxes," and they are preceded in their pathway by activating and conjugating enzymes. For 10 points, name this class of enzymes responsible for marking target proteins for nuclear localization or proteolytic degradation by covalently attaching a 76-amino acid protein to them.
These proteins are responsible for the recognition step of the N-end pathway, and Meetei et al discovered that FANCL (fank-ell), rather than BRCA1 (bra-cah-one) plays this role in the Fanconi anemia pathway.
ubiquitin ligases [or ubiquitin E3 ligases; prompt on answers like ubiquitinylating proteins or ubiquitinating proteins that don't specify that the proteins are ligases but DO indicate that they are involved in ubiquitinylating; prompt on ligases; prompt on E3; DO NOT ACCEPT OR PROMPT ON "ubiquitin" alone; DO NOT ACCEPT OR PROMPT ON any answer containing the word "SUMO" or "sumoylation"]