This house took the throne when John of Gaunt's son, Henry Bolingbroke, deposed Richard II.
The first ruler from this house was said to have been struck with leprosy after executing Archbishop Scrope. That ruler from this house was targeted in the Epiphany Rising plot and by the Welsh rebel Owen Glendower. Its final ruler married Margaret of Anjou and had his son die at the battle of Tewkesbury. That final ruler of this house faced an uprising led by Jack Cade and was imprisoned by his cousin, Edward IV. Another of its rulers contended with a rebellion by "Hotspur" Percy, while another defeated the French at the battle of Agincourt. This house took the throne when John of Gaunt's son, Henry Bolingbroke, deposed Richard II. For 10 points, name this royal house of Henry IV, Henry V, and Henry VI, which fought the Wars of the Roses with the House of York.
The first ruler from this house was said to have been struck with leprosy after executing Archbishop Scrope.
House of Lancaster [accept word forms, accept Bolingbroke until mentioned, prompt on House of Plantagenet]