This protein is activated by phosphorylation of its N terminal domain and upon activation, this protein's half-life increases and it undergoes a conformational change that allows it to act as a transcription regulator.
EBNA1 can compete with this protein to bind with USP7, an enzyme that stabilizes this protein. This protein is activated by phosphorylation of its N terminal domain and upon activation, this protein's half-life increases and it undergoes a conformational change that allows it to act as a transcription regulator. In unstressed cells, Mdm2 binds to this protein and transports it to the cytosol, where it causes this protein to be marked for degradation. An autosomal dominant disease caused by mutations in this gene, Li-Fraumeni syndrome, leads to an increased susceptibility to cancer. In cells affected by stressors such as membrane damage or oxidative stress, this protein upregulates DNA repair proteins through p21 or, in unrepairable cases, causes the cell to undergo apoptosis. For 10 points, name this "guardian of the genome" that is instrumental in preventing cancer.
EBNA1 can compete with this protein to bind with USP7, an enzyme that stabilizes this protein.
{p53}