Caused by autoimmune destruction of collagen II-containing membranes, it results in disruption of the synovium of small joints and associated swelling.
Tests to diagnose this disease include the anti-cyclic citrullinated peptide test and the anti-mutated vimentin assay. DMARDs are a class of drugs used primarily to treat this disease, also treated by the TNF inhibitor infliximab. This disease's namesake factor is an IgM antibody against the constant region of human IgG, which is also present in Sjogren's syndrome and (*) lupus. High cytokine activity contributes to the progression of this disease, which can induce the swan's neck and Z-thumb deformities. Caused by autoimmune destruction of collagen II-containing membranes, it results in disruption of the synovium of small joints and associated swelling. For 10 points, name this inflammatory disorder that causes joint pain.
Tests to diagnose this disease include the anti-cyclic citrullinated peptide test and the anti-mutated vimentin assay.
rheumatoid {arthritis}