The first immediate-early gene to be found to be fully dependent on this family's namesake's best known pathway is sometimes used in a neuroscience assay called catFISH; that element is the plasticity factor Arc.
The first immediate-early gene to be found to be fully dependent on this family's namesake's best known pathway is sometimes used in a neuroscience assay called catFISH; that element is the plasticity factor Arc. Three unusual exemplars of this family contain SEG motifs in their activation loops. Like survival motor neuron protein, one example of this protein interacts with the activator of the far upstream element of c-myc. The p38 family of these is involved in differentiation and apoptosis, and another family of these proteins is involved in the inflammation response mediated by proteins like RANTES and is often called stress-activated; that family is the c-Jun N-terminal ones, while their classical subset includes RAF, which is activated by Ras. For 10 points, name this family of serine/threonine kinases that respond to mitogen stimulus.
The first immediate-early gene to be found to be fully dependent on this family's namesake's best known pathway is sometimes used in a neuroscience assay called catFISH; that element is the plasticity factor Arc.
{MAPK} [or {mitogen}-{activated} protein kinases; or {MAP} kinases]