In humans, this enzyme is inhibited by drugs such as acetazolamide in order to treat glaucoma, hypertension, and osteoporosis.
In marine diatoms, the catalytic metal in this enzyme may be substituted with either cadmium or cobalt. In humans, this enzyme is inhibited by drugs such as acetazolamide in order to treat glaucoma, hypertension, and osteoporosis. A mutation in which alanine replaces the histidine at position 64 decreases catalysis by this enzyme, lending support to the hypothesis that that histidine deprotonates an aqua ligand to start the reaction it catalyzes. The resulting hydroxide ligand then attacks a linear triatomic substrate to generate a biologically important buffer ion. It was the first discovered enzyme to have an active site including zinc. For 10 points, name this enzyme that catalyzes the hydration of carbon dioxide to form bicarbonate.
In marine diatoms, the catalytic metal in this enzyme may be substituted with either cadmium or cobalt.
carbonic anhydrase