The gene mutated in this disease produces an functional protein that does not fold perfectly due to a delta-508 deletion; that gene is a chloride channel.
Sufferers of this disease are unable to produce hypothiocyanate, and eighty percent of patients with this disease eventually harbor P. aeruginosa by age 18. Sufferers also have congenital absence of the vas deferens, and screening for this disease involves measuring an elevated level of immunoreactive trypsinogen followed by a sweat test. The gene mutated in this disease produces an functional protein that does not fold perfectly due to a delta-508 deletion; that gene is a chloride channel. For 10 points, name this genetic disease which results in the buildup of thick mucus in the lungs.
Sufferers of this disease are unable to produce hypothiocyanate, and eighty percent of patients with this disease eventually harbor P. aeruginosa by age 18.
{cystic fibrosis} [or {CF}]