That polyQ sequence results in cognitive degeneration and loss of muscle control.
Low levels of CREB binding protein characterize this disease, whose namesake protein is thought to be related to embryo survival and anti-apoptotic function. It sees the destruction of certain GABAergic receptors and presents atypically early in its Westphal variant. Purkinje cells in the cerebellum and striata of the (*) basal ganglia are also destroyed in this disorder, whose onset and rapidity of progression are governed by the number of CAG repeats on chromosome 4. That polyQ sequence results in cognitive degeneration and loss of muscle control. For 10 points, name this autosomal dominant illness that causes jerky movements dubbed its "chorea," known for its characteristic onset during middle age.
Low levels of CREB binding protein characterize this disease, whose namesake protein is thought to be related to embryo survival and anti-apoptotic function.
{Huntington's} disease [or {Huntington's} chorea]