Defects in formation of the first and second pharyngeal arches were observed in fetal mammals exposed to its 13-cis derivative, the acne treatment Accutane.
This molecule promotes gut homing in T-cells when it is secreted by intestinal dendritic cells. Hogan and Chen discovered that this molecule was synthesized in Hensen's node, and along with Sonic hedgehog, this molecule regulates Lefty-1 expression to control the left-right axis in limb development. This molecule's deposition along the anterior-posterior axis is established in part by Cyp26, which degrades it. The most successful example of "differentiation therapy" is the treatment of acute progranulocytic leukemia with the all-trans type of this molecule. Enhancer elements that bind to this irreversibly oxidized molecule's receptor include several repeats of the sequence GGTCA and are found upstream of the 3-prime HOX genes, explaining this molecule's caudalizing effects. Defects in formation of the first and second pharyngeal arches were observed in fetal mammals exposed to its 13-cis derivative, the acne treatment Accutane. For 10 points, name this active metabolite of vitamin A.
This molecule promotes gut homing in T-cells when it is secreted by intestinal dendritic cells.
retinoic acid or RA [do not accept "vitamin A"; do not accept "retinol"; do not accept "retinal"; do not accept "retinaldehyde"]