High doses of this compound can lead to a form of macular thickening, while its deficiency leads to a syndrome called Casal collar, where a erythematous rash is localized to dermatomes C3 and C4.
A green reaction for the industrial synthesis of this compound was developed by Robert Raja and uses 3-picoline as the starting material, and that reaction eliminates the nitrous oxide product usually obtained in conventional synthesis. This compound treats a condition characterized by ataxia and aminoacidurea called Hartnup disease. The biosynthesis of this compound begins with the conversion of an amino acid into kynurenine, which is then converted into (*) quinolinate. High doses of this compound can lead to a form of macular thickening, while its deficiency leads to a syndrome called Casal collar, where a erythematous rash is localized to dermatomes C3 and C4. Consisting of a pyridine ring 3-substituted with a carboxyl group, it is readily converted to its corresponding amide which acts as a coenzyme in pathways such as glycolysis. For 10 points, identify this compound whose deficiency is called pellagra, the third B vitamin.
A green reaction for the industrial synthesis of this compound was developed by Robert Raja and uses 3-picoline as the starting material, and that reaction eliminates the nitrous oxide product usually obtained in conventional synthesis.
{niacin} [or {nicotinic} acid; accept {b3} until "{third B vitamin}"]