A mutation in the enzyme catalyzing the final step of its biosynthesis gives rise to Smith-Lemli-Opitz syndrome, while its presence in plasma is measured by the Lieberman-Burchard test.
A mutation in the enzyme catalyzing the final step of its biosynthesis gives rise to Smith-Lemli-Opitz syndrome, while its presence in plasma is measured by the Lieberman-Burchard test. The SREBP transcription factors are regulated by this molecule. One step of its biosynthesis sees the creation of a certain 2,3-epoxide, which then cyclizes, and it is sometimes stored in chylomicrons. Farnesyl pyrophosphate and squalene are intermediates in that process and that pathway begins with the condensation of three acetyl coAs to yield HMG-CoA, which is reduced to mevalonate. That step is regulated by drugs called statins. For 10 points, identify this ubiquitous steroid that can cause atherosclerosis when bound to lipoproteins.
A mutation in the enzyme catalyzing the final step of its biosynthesis gives rise to Smith-Lemli-Opitz syndrome, while its presence in plasma is measured by the Lieberman-Burchard test.
cholesterol