Wip-1 reduces the activity of this protein by dephosphorylating MAP kinase.
Substitutions of an alanine at position 143 or a histidine at position 175 allow this protein to bind to hsp70. Its L2 loop binds to an ankyrin repeat of a protein homologous to ASPP1. Wip-1 reduces the activity of this protein by dephosphorylating MAP kinase. The C-terminal RING finger motif of one protein promotes ubiquitination of this protein, while the N-terminal domain of that MDM-2 protein binds to it. Inheritance of only one copy of the gene coding for it leads to Li-Fraumeni syndrome. Human cancers typically involve mutations in either the retinoblastoma pathway or the pathway involving this protein. For 10 points, name this tumor suppressor, the "guardian angel of the genome."
Substitutions of an alanine at position 143 or a histidine at position 175 allow this protein to bind to hsp70.
p53