The disruption of trkA signalling early in this disease leads to denervation of the cerebral microvascular system and the degradation of efferent projections from the basal forebrain.
The disruption of trkA signalling early in this disease leads to denervation of the cerebral microvascular system and the degradation of efferent projections from the basal forebrain. One form of this disease has been linked to mutations in the presenilin-1 gene. Other genetic risk factors include the ApoE4 allele. Hyperphosphorylation of a protein that normally stabilizes microtubules, (*) tau, leads to the development of neurofibrillary tangles in this disease, which is also characterized by the accumulation of beta-amyloid plaques. It is frequently treated with the acetylcholinesterase-inhibitor donepezil. Mild cognitive impairment is associated with an increased risk of, for 10 points, which neurodegenerative disease with both early- and late-onset forms?
The disruption of trkA signalling early in this disease leads to denervation of the cerebral microvascular system and the degradation of efferent projections from the basal forebrain.
{Alzheimer's} disease [prompt on “{AD}”]