This disease spreads to humans when its sylvatic form causes a mass die-off of rats, and its best known form is characterized by necrosis and gangrene at the extremities.
The bacteria responsible for this disease produces a factor called YopJ which interferes with the phosphorylation of MAPK kinases, and its YopO protein induces apoptosis in human macrophages, allowing it to resist phagocytosis. Other virulence factors produced in this disease include fibrinolytic enzymes, coagulase, and a respiratory inhibiting murine exotoxin. In Xenopsylla cheopis, this disease leads to the formation of biofilms, blocking off the gut. This causes the vector to bite additional hosts out of hunger, and to regurgitate the contents of its gut at sites where the insect bites. Its primary pneumonic form has nearly a 100% mortality rate. This disease spreads to humans when its sylvatic form causes a mass die-off of rats, and its best known form is characterized by necrosis and gangrene at the extremities. For 10 points, name this disease caused by Yersinia pestis, most notably characterized by the formation of lymph node buboes.
The bacteria responsible for this disease produces a factor called YopJ which interferes with the phosphorylation of MAPK kinases, and its YopO protein induces apoptosis in human macrophages, allowing it to resist phagocytosis.
{bubonic plague}