About 20% of people with it also suffer from transient leukemia, and they have a higher incidence of ALL and AML.
Brushfield spots are more common in sufferers of this disease, many of whom also suffer from duodenal atresia. About 20% of people with it also suffer from transient leukemia, and they have a higher incidence of ALL and AML. The mechanism of this disease may partially be due to overexpression of miR-155 and miR-802 resulting in decreased MeCP2 expression and dysregulation of NFAT. The increased development of Alzheimer's in people with this disease is due to overexpression of APP and SOD1. This condition can result from a Robertsonian translocation involving chromosome 14, and sufferers have a small chin, large tongue, an extra fold in the eyelid, and an IQ in the 50s. For 10 points, name this genetic condition characterized by an extra chromosome 21.
Brushfield spots are more common in sufferers of this disease, many of whom also suffer from duodenal atresia.
{Down} syndrome [or {Trisomy 21} before "{21}" is read]