Examples of them include Frizzled and Smoothened, and opsins have a structure similar to them.
Graminski and Lerner's melanophore screen is used to screen these proteins for drug targets, while other assays for that purpose include Arena pharmaceuticals' CART. Examples of them include Frizzled and Smoothened, and opsins have a structure similar to them. Axel and Buck determined that types of these proteins are responsible for sensing odorant molecules. These proteins interact with and activate Gustdusin and Transducin. Phosphorylation of these proteins leads to arrestin binding, which causes clathrin to drag them out of the cell membrane. Upon ligand binding, these proteins split their partners into the alpha and beta-gamma subunits, leading to increasing cAMP or IP3 levels. For 10 points, name these 7-pass transmembrane receptors, named their activation of G proteins.
Graminski and Lerner's melanophore screen is used to screen these proteins for drug targets, while other assays for that purpose include Arena pharmaceuticals' CART.
 GPCRs [or G-protein coupled receptors; or Serpentine receptors; accept G proteins until “Frizzled”; prompt after]