One enzyme that can hydrolyze a broad-spectrum class of these compounds generated controversy for implying (*) Indian hospitals were unsafe - that enzyme is NDM-1.
The MarR gene is upregulated in E coli that have the ability to resist one class of these compounds. Another class of these compounds is divided into four generations with ever increasing gram-negative properties, and the third generation of that class crosses the blood-brain barrier and is used to treat meningitis. Aztreonam is a member of a small class of these with no fused ring. One enzyme that can hydrolyze a broad-spectrum class of these compounds generated controversy for implying (*) Indian hospitals were unsafe - that enzyme is NDM-1. 2-Azetidinone may be considered the simplest example of these compounds, which are characterized by a moiety that resembles D-alanyl-D-alanine, allowing them to disrupt the synthesis of peptidoglycan in cell walls. For 10 points, name this family of compounds with antibiotic activity which include carbapenems, cephalosporins, and penicillins which are based around a cyclic amide.
The MarR gene is upregulated in E coli that have the ability to resist one class of these compounds.
beta-lactams [accept carbepenems before "generations", anti-prompt on carbepenems, monobactams, cephalosporins and penicillins]