This disease leads to chronic dilation and destruction of air spaces without fibrosis, leading to a great increase in compliance of the lung and shortness of breath.  
Although its panacinar form can be caused by a genetic deficiency of the enzyme alpha-1-anti-trypsin, its more common centrilobular form usually results from a far more nefarious activity. This disease leads to chronic dilation and destruction of air spaces without fibrosis, leading to a great increase in compliance of the lung and shortness of breath.  FTP, name this chronic obstructive lung disease common to smokers.
Although its panacinar form can be caused by a genetic deficiency of the enzyme alpha-1-anti-trypsin, its more common centrilobular form usually results from a far more nefarious activity.
emphysema