Carbamates formed with its N-terminal amino acids can regulate binding by this molecule whose non-protein component requires the synthesis of delta-aminolevulinic acid in reticulocytes.  
The genetic disease hydrops fetalis is characterized by formation of the Bart type of this molecule.  Perutz proposed that it consists of two stable conformational states.  Carbamates formed with its N-terminal amino acids can regulate binding by this molecule whose non-protein component requires the synthesis of delta-aminolevulinic acid in reticulocytes.  Thalassemias result from decreased or absent synthesis of one its four chains, while one of its most common disease-causing mutations is a glutamate to valine mutation at position 6 of the beta chain.  Regulated by levels of BPG and the Bohr effect, FTP identify this oxygen-carrying protein in red blood cells that is mutated in sickle cell anemia patients.
The genetic disease hydrops fetalis is characterized by formation of the Bart type of this molecule.  
hemoglobin