This process is inhibited by the release of plasminogen, thrombospondin-1, endostatin, and the drug Avastin, and inhibition is also responsible in part for birth defects seen after use of thalidomide.
The completion of this process requires Ephrins B2 and B4 in targeting of disparate pseudopodia. Mediated by Prox-1 in lymphatic tissue and the orphan receptor COUP-TF2 in veins, patients with Von Hippel-Lindau disease are unable to repress this process due to a mutation in a gene that degrades the hypoxia induced protein HIF1. This process is inhibited by the release of plasminogen, thrombospondin-1, endostatin, and the drug Avastin, and inhibition is also responsible in part for birth defects seen after use of thalidomide. Upregulated by FGF and VEGF [veg-eff] in response to low cellular oxygen levels, FTP, name this biological process of wound healing and tumor development, the growing of new blood vessels from pre-existing vessels.
The completion of this process requires Ephrins B2 and B4 in targeting of disparate pseudopodia.
angiogenesis