Perhaps the oldest theory concerning this disease is that it is caused by a shortage of acetylcholine in the brain.
The inherited form of this disease has been linked to presenilin 1 and 2 genes, as well as the apoE4 gene on chromosome 19. Hyperphosphorylation of tau proteins figures into the tau hypothesis concerning the pathogenesis of this disease. A better-known hypothesis is the amyloid beta hypothesis, which suggests that the buildup of amyloid beta plaques is responsible. Perhaps the oldest theory concerning this disease is that it is caused by a shortage of acetylcholine in the brain. For 10 points, name this neurodegenerative disease primarily affecting the elderly whose symptoms include memory loss.
The inherited form of this disease has been linked to presenilin 1 and 2 genes, as well as the apoE4 gene on chromosome 19.
Alzheimer's Disease