It comes from the pleiotropic effects of a point mutation substituting a glutamic acid for valine at position 6, causing the abnormal HbS form of hemoglobin and resulting in blockage of arteries and veins.
Vaso-occlusive crises in people with this condition can cause priapism in males, along with jaundice, paleness, fatigue, and organ damage. It comes from the pleiotropic effects of a point mutation substituting a glutamic acid for valine at position 6, causing the abnormal HbS form of hemoglobin and resulting in blockage of arteries and veins. In addition, its presence counteracts Plasmodium and the resulting effects of malaria. Found mainly in sub-Saharan Africans and their descendants, For 10 points, identify this condition which commonly causes anemia, the presence of which is marked by bent blood cells.
Vaso-occlusive crises in people with this condition can cause priapism in males, along with jaundice, paleness, fatigue, and organ damage.
{Sickle}-{cell} anemia