In 2003, the pyridol-pyrimidine class of these molecule's inhibitors were shown to have a previously unseen degree of specificity for the alpha isoform of one class of this molecule, which is activated by lipopolysaccharide.
The pyridyl nitrogen of one inhibitor of this class of molecules forms a hydrogen bond with the main chain amido nitrogen of residue 109, which is found in the ATP pocket. That inhibitor is pyridine-imidazole, and these enzymes are activated by dual phosphorylation of conserved threonine and tyrosine residues in the activation loop. In 2003, the pyridol-pyrimidine class of these molecule's inhibitors were shown to have a previously unseen degree of specificity for the alpha isoform of one class of this molecule, which is activated by lipopolysaccharide. For 10 points, name this enzyme whose JNK and p38 classes respond to stress stimuli, and which has a namesake cascade.
The pyridyl nitrogen of one inhibitor of this class of molecules forms a hydrogen bond with the main chain amido nitrogen of residue 109, which is found in the ATP pocket.
{MAP Kinases} [or {Mitogen}-{Activated Protein Kinases}]