These compounds were first isolated from electrolysis reactions in E. coli where they exhibited bacteriocidal activity in specific geometric isomers of their plus 2 and plus 4 oxidation states.
These compounds were first isolated from electrolysis reactions in E. coli where they exhibited bacteriocidal activity in specific geometric isomers of their plus 2 and plus 4 oxidation states. They can inhibit enzymatic activity in the proximal tubule leading to nephrotoxicity, but their principle mode of action is to produce 1,2-intrastrand (*) cross-linking of DNA which leads to apoptosis. Increasing doses can trigger resistance to these complexes in tumor cells. For 10 points, name these platinum based cancer drugs possessing chlorine and ammonia ligands in a specific orientation.
These compounds were first isolated from electrolysis reactions in E. coli where they exhibited bacteriocidal activity in specific geometric isomers of their plus 2 and plus 4 oxidation states.
{cisplatin} (or {cisplatinum}, or {cis}-{diamminedichlorido}({II}){platinum})