This molecule's receptor, which is degraded by PCSK9, contains three EGF-like domains sandwiched around a beta-propeller domain.
This molecule's receptor, which is degraded by PCSK9, contains three EGF-like domains sandwiched around a beta-propeller domain. The gene for that receptor is activated by the bHLH fragment of SREBP. Endocytosis of this molecule can induce macrophages to become foam cells. ASPs can inhibit a reaction in which copper ions oxidize this molecule; an important step in that reaction is the modification of apoprotein B-100. Ezitimibe is one drug that reduces the amount of this molecule in the body; however, it is much more effective when used with HMG-CoA reductase inhibitors, or statins. For 10 points, name this molecule responsible for depositing cholesterol on artery walls, sometimes referred to as the "bad" cholesterol.
This molecule's receptor, which is degraded by PCSK9, contains three EGF-like domains sandwiched around a beta-propeller domain.
LDL [or low-density lipoprotein; prompt on cholesterol until mentioned]