The ability of this enzyme to access its substrate can be regulated by a complex wherein the TIN2 protein tethers the TPP1/POT1 proteins to the TRF1/TRF2 proteins; that complex is called the shelterin complex.
ITAS is a semi-quantitative assay used to study the activity of this enzyme; that assay improves upon the PCR based TRAP assay which is used to detect the activity of this enzyme. The ability of this enzyme to access its substrate can be regulated by a complex wherein the TIN2 protein tethers the TPP1/POT1 proteins to the TRF1/TRF2 proteins; that complex is called the shelterin complex. Compounds that stabilize the formation of a G-Tetrad help inhibit the activity of this enzyme. Much like DNA polymerase, it possesses thumb, palm, and finger domains, and expression of this enzymes makes cells immortal and helps them bypass the Hayflick limit. For 10 points, identify this enzyme whose discovery resolved the end-replication problem, and which lengthens namesake regions of DNA found at the ends of chromosomes.
ITAS is a semi-quantitative assay used to study the activity of this enzyme; that assay improves upon the PCR based TRAP assay which is used to detect the activity of this enzyme.
{telomerase} [or {telomerase reverse transcriptase}; or {hTERT}]