Markers used for these cells include HNK-1, and before activation these cells strongly express the slug transcription factor.
Markers used for these cells include HNK-1, and before activation these cells strongly express the slug transcription factor. In Treacher-Collins syndrome, mutations in the treacle protein cause depletion of these cells, leading to characteristic skull abnormalities. The function of this tissue was originally discovered by Le Douarin using quail-chick embryo chimeras. Mutations in the RET tyrosine kinase cause aberrant functions in several derivatives of these cells, including multiple endocrine neoplasia type 2A and 2B. Another disease associated with abnormal migration of these cells characteristically causes aganglionic megacolon, and these cells also differentiate into melanocytes and large portions of the autonomic nervous system. DiGeorge's syndrome, Hirschsprung's disease, and cleft lip can all be caused by abnormal migration of this embryonic tissue. This tissue is formed from ectoderm in the border between the neural plate and the future epidermis, and pinches off after the formation of the neural tube. FTP, name this multipotent embryonic tissue that migrates throughout the body, which despite its name forms much more than just nervous system components.
Markers used for these cells include HNK-1, and before activation these cells strongly express the slug transcription factor.
{Neural crest}