That cofactor, also found in pyruvate dehydrogenase, is its namesake pyrophosphate.
Deficiency of this compound decreases cerebral glucose utilization, causing damage to the diencephalon which may lead to memory impairments in Wernicke encephalopathy. Levels of this compound in the body directly affect the activity of transketolase in red blood cells. In the Krebs cycle, a cofactor containing this compound is necessary for the formation of succinyl CoA by (*) alpha-ketoglutarate dehydrogenase. That cofactor, also found in pyruvate dehydrogenase, is its namesake pyrophosphate. Heavy consumption of betel nuts and tea, along with low dietary intake of this compound, can lead to a disorder with a wet form featuring tachycardia, edema, and congestive heart failure, and a dry form characterized by peripheral neuropathy. For 10 points, the deficiency of which nutrient most commonly leads to beriberi?
Deficiency of this compound decreases cerebral glucose utilization, causing damage to the diencephalon which may lead to memory impairments in Wernicke encephalopathy.
{thiamine} [accept {vitamin B1}]