Besides storing hemosiderin, they mainly act as macrophages in the sinusoids of this organ and are called Kupffer cells.
Its cells may accumulate lipofuscin when lysosomes accumulate residue over time, whereas vitamin A and fat are stored in cells that lie beneath the endothelial cells in this organ. Along with the aforementioned Ito cells found in the space of Disse, other cells in this organ are star-shaped macrophages that release cytokines and reactive oxygen species. Besides storing hemosiderin, they mainly act as macrophages in the sinusoids of this organ and are called Kupffer cells. Having cells arranged in cords, this organ can degrade estrogen and insulin along with metabolizing heme into bilirubin. Aflotoxin toxicity compounds the likelihood of disease in, for 10 points, this organ that is afflicted by cirrhosis and hepatitis.
Its cells may accumulate lipofuscin when lysosomes accumulate residue over time, whereas vitamin A and fat are stored in cells that lie beneath the endothelial cells in this organ.
liver