Administration of hydroxyurea eases symptoms by somehow increasing the expression of a particular gamma chain rather than a beta chain, but complications still include so-called crises, which can result in extreme pain and necrosis.
Splenic sequestration results in most sufferers of this disease not having a working spleen by the time they reach puberty. Administration of hydroxyurea eases symptoms by somehow increasing the expression of a particular gamma chain rather than a beta chain, but complications still include so-called crises, which can result in extreme pain and necrosis. Carriers of this genetic disorder suffer no symptoms, but they are more resistant to malaria, making this disease far more common among those of African descent. Caused when a glutamate is replaced by valine in the beta chain of hemoglobin, FTP name this disorder that causes deformed red blood cells.
Splenic sequestration results in most sufferers of this disease not having a working spleen by the time they reach puberty.
Sickle Cell Disease or Anemia