That reaction was developed by Meldal, Tornoe, and a scientist at the Scripps Institute ? best known for his work in this field.
This theory has been applied to Activity Base Protein Profiling by a group led by Benjamin Cravatt. A notable biological application of it was developed by Carolyn Bartozzi, who used it to probe glycans on cell-surface receptors with the aid of DIFO. That route avoids the use of biologically toxic copper catalysts used in the most famous application of this idea, wherein nitriles and azides react to form oxazoles, triazaoles, or tetrazoles in a variant of a 1,3-dipolar cycloaddition reaction named for Huisgen. That reaction was developed by Meldal, Tornoe, and a scientist at the Scripps Institute ? best known for his work in this field. For 10 points, identify this paradigm wherein simple reactions are performed with cheaply available reagents in aqueous solutions, often providing high quantitative yields, pioneered by K. Barry Sharpless.
This theory has been applied to Activity Base Protein Profiling by a group led by Benjamin Cravatt.
{Click chemistry} [or {Click} reactions]