This protein's repeat domain contains a series of KXGS motifs, and this This protein's six isoforms are all encoded by a single gene, and those isoforms vary by the inclusion of exons two, three, and ten.
Par-1 phosphorylation of this protein establishes an anterior-posterior gradient in Drosophila embryos. FTDP-17 is caused by mutations of this disease, and in another disease this protein is found in Pick bodies. This protein's repeat domain contains a series of KXGS motifs, and this This protein's six isoforms are all encoded by a single gene, and those isoforms vary by the inclusion of exons two, three, and ten. The disease most closely associated with this protein occurs when this protein is hyperphosphorylated and forms paired helical filaments; that disease is also associated with Hirano bodies and aberrant gamma-secretase cleavage of beta-amyloid protein. FTP, name this microtubule-associated protein which is found in neurofibrillary tangles in Alzheimer's disease.
Par-1 phosphorylation of this protein establishes an anterior-posterior gradient in Drosophila embryos.
Tau