Signal transduction through this molecule is mediated by dimerization and binding to an unusual tetramerized tyrosine kinase receptor whose activity is inhibited in part by PTP-1B and enhanced by IRS-1.
Signal transduction through this molecule is mediated by dimerization and binding to an unusual tetramerized tyrosine kinase receptor whose activity is inhibited in part by PTP-1B and enhanced by IRS-1. This molecule is activated upon excision of an internal 33-residue segment called the C peptide, levels of which can be assayed in the serum. This enzyme also stimulates dephosphorylation of Acetyl-CoA carboxylase during fatty acid synthesis, promoting formation of active polymer, and is also capable of stimulating glucose uptake into all cells except those of the liver and brain. Critical for stimulation of synthesis and inhibition of breakdown of metabolic fuels, FTP, name this enzyme produced by pancreatic beta cells, functions of which are opposed by glucagon, and whose functions are deficient in diabetes mellitus.
Signal transduction through this molecule is mediated by dimerization and binding to an unusual tetramerized tyrosine kinase receptor whose activity is inhibited in part by PTP-1B and enhanced by IRS-1.
insulin