One neoplasm of these cells produces Pautrier abscesses, and they are laden with mucopolysaccharides in Sezary syndrome.
One neoplasm of these cells produces Pautrier abscesses, and they are laden with mucopolysaccharides in Sezary syndrome. So-called gamma-delta ones are considered immature, and besides Mycosis fungoides, another cancer of these cells is caused by infection with the HTLV virus. Their expression of the CD28 marker allows them to be activated by CD80 and CD86. One subpopulation of them differentiates under the control of FoxP3. Tacrolimus inhibits the release of interleukin-2 from these cells, which trigger aggregation of phagocytes into granulomas during certain infections. Another type of them secretes perforin and granzyme to destroy virus-infected cells; that subclass expresses CD8. Most populations of these cells express CD3, and they can be differentiated by their expression of CD4 and CD8. These cells develop in the bone marrow, but mature in the thymus, where they undergo clonal selection. FTP, name these lymphocytes which are divided into regulatory, cytotoxic, and helper varieties.
One neoplasm of these cells produces Pautrier abscesses, and they are laden with mucopolysaccharides in Sezary syndrome.
{T}-{cells} or {T}-{lymphocytes} [Prompt on {white blood cells}, prompt on {lymphocytes}, accept {more specific} answers]