These proteins are activated by kindlins and talins.
X-ray crystallography of these proteins revealed that they are bent above their Calf domains at their "knees" until they are activated into an upright conformation. In metastasizing melanoma cells, the aggregation of these metazoan-specific proteins causes FAK to autophosphorylate and bind to Src (SARC). Binding to these proteins requires the recognition sequence RGD, which allows eptifibatide and abciximab to act as fibrinogen antagonists. These proteins are activated by kindlins and talins. These heterodimeric proteins include the target of the angiogenesis-inhibiting antibody Vitaxin, (*) alpha-five beta-three, and the platelet complex Glycoprotein IIb/IIIa. These proteins serve a similar function to cadherins in hemidesmosomes and focal adhesions by linking the cytoskeleton to fibronectin in the extracellular matrix. For 10 points, name these transmembrane receptors that relay "inside-out" and "outside-in" signals between cells.
X-ray crystallography of these proteins revealed that they are bent above their Calf domains at their "knees" until they are activated into an upright conformation.
integrins [antiprompt on specific integrins before mentioned]