Its coenzyme form acts as a substrate for poly(ADP-ribose) polymerase and is synthesized in the light reactions of photosynthesis along with ATP.
Deficiency of this compound can result in skin lesions known as Casal's necklaces, as well as diarrhea and dermatitis. When administered in gram quantities, it can be used as a cholesterol-lowering drug with flushing as a major side effect. It can be biosynthesized in a multi-step pathway via cleavage of the five-membered ring of tryptophan and rearrangement of the remaining six-membered ring. Its coenzyme form acts as a substrate for poly(ADP-ribose) polymerase and is synthesized in the light reactions of photosynthesis along with ATP. FTP, identify this water-soluble vitamin whose nutritional deficiency is called pellagra and was originally isolated as an oxidation product of nicotine.
Deficiency of this compound can result in skin lesions known as Casal's necklaces, as well as diarrhea and dermatitis.
niacin (or nicotinic acid or vitamin B3)