The central atom of this enzyme coordinates three histidine residues and polarizes an O-H bond enough to deprotonate water.
In bacteria, cyanate induces the expression of this enzyme, which participates in a feedback loop with cyanase. The first drug in human therapy generated from structure-based rational drug design, Dorzolamide, inhibits this enzyme to treat glaucoma. In parietal cells and in osteoclasts, the AE1 protein antiports chloride and the product of the reaction catalyzed by this enzyme. It normally operates under diffusion control. The central atom of this enzyme coordinates three histidine residues and polarizes an O-H bond enough to deprotonate water. This metalloenzyme has a zinc ion at its center. It decreases the blood's pH near the lungs. For 10 points, name this enzyme vital for buffering blood, which catalyzes the conversion of carbon dioxide and water to bicarbonate ions.
In bacteria, cyanate induces the expression of this enzyme, which participates in a feedback loop with cyanase.
carbonic anhydrase [or CA]