The effects of this neurotransmitter are potentiated by drugs with anticonvulsant and anxiolytic effects like barbiturates, benzodiazepines, and alcohol.
Drugs blocking the synthesis of this neurotransmitter include allylglycine and thiosemicarbazide, while tiagabine selectively inhibits its Type 1 transporters. The striatum's medium spiny neurons, basket and stellate cells, and many other cortical interneurons primarily release this neurotransmitter. Its major agonist, produced from mushrooms of the genus Amanita, is muscimol, while its antagonists include picrotoxin and bicuculline, both of which can induce seizures. This compound is synthesized in a single step by glutamic acid decarboxylase, from glutamate. The effects of this neurotransmitter are potentiated by drugs with anticonvulsant and anxiolytic effects like barbiturates, benzodiazepines, and alcohol. Glycine has similar effects to this molecule, and stimulation of this neurotransmitter's type A receptors opens chloride ion channels, which hyperpolarize the neuron. For 10 points, identify this primary inhibitory neurotransmitter.
Drugs blocking the synthesis of this neurotransmitter include allylglycine and thiosemicarbazide, while tiagabine selectively inhibits its Type 1 transporters.
{GABA} [{also} accept {gamma}-{aminobutyric acid}]