These cells are infected in Waldenstrom's macroglobulinemia.
These cells are infected in Waldenstrom's macroglobulinemia. Belimumab is used to inhibit the growth of these cells, which express TNF receptor superfamily 17 genes when mature and requires Pax5 expression for differentiation. These cells express CD20 throughout their lifetimes, and use somatic hypermutation in one important process, which also sees a recombination between V, D and J exons of a certain gene cluster. They are partitioned into plasma and memory types, and are usually activated by helper-T cells in response to an infection. Usually produced in the bone marrow, FTP, name these antibody-producing lymphocytes, the basis for humoral immunity.
These cells are infected in Waldenstrom's macroglobulinemia.
B cells