A synthesis of withasomnine makes use of a variant of this reaction to cleave bicyclic pyrazole rings.
A synthesis of withasomnine makes use of a variant of this reaction to cleave bicyclic pyrazole rings. Parquet and Lin report the time taken by this reaction may be reduced by use of a microwave oven, and it requires the use of a polar, high-boiling solvent like ethylene glycol. One modification of this reaction puts all of the reagents in one pot; that one is named for Huang-Minlon. In its third step, a resonance-stabilized carbocation reacts with water to form a diazene, which is then deprotonated. After that step, the production of nitrogen gas keeps the reaction from reversing. Its first step involves the conversion of the primary reagent to a hydrazone by reaction with hydrazine. For 10 points, name this reaction that reduces ketones and aldehydes to alkanes, the basic analogue of the Clemmensen reduction.
A synthesis of withasomnine makes use of a variant of this reaction to cleave bicyclic pyrazole rings.
{Wolff}-{Kishner} reduction [or reaction]