In 2001, Hugot and Omura separately published their discoveries that the NOD2 gene within the IBD1 locus on chromosome 16 is a marker for susceptibility to CD. Afterwards the gene's pathogenic role was discovered.
En 2001, Hugot y Omura, por separado, publicaron el descubrimiento del gen NOD2 dentro del locus IBD1 del cromosoma 16 como marcador de susceptibilidad para EC, al que posteriormente se le encontró un papel patogénico.