Nevertheless, severe potential adverse effects of ligature such as perforation and bleeding ulcers were not explained to patients in the study, nor were patients offered the option of changing to ligature in cases of intolerance to beta blockers 25.
Sin embargo, no se explicó a estos los efectos adversos severos como perforación o sangrados por úlceras, ni se ofreció la opción de cambio a ligadura en caso de intolerancia a los betabloqueadores 25.