Excised tissue biopsy is essential for differential diagnosis. Other possible diagnoses which must be discarded include squamous tongue cancer, smoking, histoplasmosis in endemic areas 10, syphilis, traumatic lesions, aphthous ulcers 14, lymphomas and various bacterial infections 16.
La biopsia excisional es fundamental en el diagnóstico diferencial del cáncer escamoso de la lengua en fumadores y de la histoplasmosis en áreas endémicas 10, sífilis, lesiones traumáticas y úlceras aftosas 14, así como de linfomas e infecciones bacterianas diversas 16.