After multiple discussions around the methodology, it was decided not to use opiods across the board in this study because of the issue of masking of events directly associated with the dose of HLBP such as post-operative pain and the sensitivity to TES, and because they would increase the incidence of adverse events such as itching and post-operative nausea and vomiting.
Luego de múltiples discusiones metodológicas, se decidió no utilizar de manera uniforme opioides en este estudio, ya que se podrían enmascarar eventos directamente dependientes de la dosis utilizada de LBPH, como el dolor postoperatorio y la sensibilidad a la EET, al tiempo que incrementarían la incidencia de eventos adversos, como el prurito y la náusea y vómito postoperatorios.