PPIs are metabolized by isoenzymes of cytochrome P450, most importantly CYP2C19 10, 14. Homozygotic mutations in the CYP2C19 gene can be found in 5% of Caucasians and in 15% of Asians.
Los IBP son metabolizados por las isoenzimas del citocromo P 450 siendo la más importante de ellas las CYP2C19 10, 14.