There is no doubt that extensive randomized tests of higher quality are needed to clarify the crucial question: does a reduction of the infected necrosis reduce mortality? To demonstrate a significant reduction of 10% in the rate of infections among patients with pancreatic necrosis between 240 and 400 patients would have to be included in the study. In order to really demonstrate that a reduction of infected necroses diminishes the mortality rate from 20% to 10%, at least 3000 patients would have to be included in the study 12.
No hay duda de que se necesitan ensayos extensos aleatorizados de calidad superior para clarificar la pregunta crucial ¿una reducción de la necrosis infectada reduce la mortalidad?; para demostrar una disminución significativa de la infección de la necrosis pancreática del 10% hace falta incluir entre 240-400 pacientes en ese ensayo, y para demostrar realmente que disminuye la mortalidad del 20% al 10%, hace falta reunir a más de 3.000 pacientes 12.