However, in the last decade it has been documented that in some parts of the world the etiology of PUs has changed. The prevalence of H. pylori infections, and consequently H. pylori associated ulcers, has declined while the prevalence of NSAID and ASA use, and consequently associated ulcers, has increased 18.
Sin embargo, en la última década, se ha documentado que en algunas latitudes, epidemiología de los agentes etiológicos de las UPs ha cambiado conforme ha declinado la prevalencia de la infección por H. pylori y se ha incrementado la utilización de AINES y ASA 18.