It is believed that the decrease, which is now found consistently, is mainly due to increasing primary resistance of H. pylori to amoxicillin, clarithromycin and metronidazole 8-12.
La declinación en la eficacia consistentemente encontrada en la actualidad, se considera que se debe fundamentalmente al progresivo aumento de la resistencia primaria de H. pylori a la claritromicina y al metronidazol 8-12.