During the acute phase of a secondary infection by an heterologous serotype, hyperactive CD8+ clones activate, which can produce an elevated concentration of pro and anti-inflammatory cytokines, like IFN-γ, TNF-α and IL-13 with low levels of IL-10.31-32 a prolonged activation of CD8+ cells is maintained with elevated production of TNF- α, IL-6 and other soluble factors that affect the vascular permeability read ahead in tropism and endothelial cells. These T cells react differently against heterologous serotypes and against homologous epitopes. Also, they lose their cytolytic capacity, which would explain the delay in the viral elimination during a secondary infection.
Durante la fase aguda de una infección secundaria por un serotipo heterólogo, se activan preferiblemente clones CD8+ hiperreactivos, los cuales pueden producir una elevada concentración de citoquinas pro y anti-inflamatorias, como IFN-γ, TNF-α e IL-13 y niveles bajos de IL-10.