The presence of sclerosing hyaline necrosis is a combination of large quantities of well-formed Mallory-Denk bodies, perivenular fibrosis with type III collagen deposits, hepatocyte necrosis in zone 3 and veno-occlusive disease. This is the so called alcoholic foamy degeneration corresponding to microvacuolar steatosis in zone 3 and cholestasis. Noninvasive models have been proposed for differentiating between NASH and ALD.
La presencia de necrosis hialina esclerosante que es una combinación de cuerpos de Mallory o Mallory-Denk bien formados, en gran cantidad, fibrosis perivenular con depósito de colágeno de Tipo III y necrosis de hepatocitos localizados en la zona 3; enfermedad venooclusiva, la llamada degeneración espumosa alcohólica que corresponde a esteatosis microvacuolar en la zona 3 y colestasis.