As a consequence of this activity the cytoskeleton becomes disorganized causing changes in cellular morphology including opening the epithelial GAP junctions responsible for maintaining tissue integrity 6, 15.
Como consecuencia, el citoesqueleto se desorganiza, causando alteraciones morfológicas celulares y la apertura de las uniones GAP del epitelio, que son responsables de mantener la integridad del tejido 6, 15.