Since hypogammaglobulinemia and lymphopenia are secondary to the loss of lymph 2, 9, cellular immunity may be affected by severe lymphopenia. In some cases it is considered the second most important factor for loss of T lymphocytes which have longer half-lives than do B lymphocytes. Since T lymphocytes are in peripheral circulation for longer time, they are less susceptible to gastrointestinal loss of chyle than are B lymphocytes.
Siendo la hipogamaglobulinemia y linfopenia secundarias a la pérdida de la linfa 2, 9, la inmunidad celular puede afectarse por la linfopenia grave e incluso, mantenerse en algunos casos; se considera que es secundaria a la mayor pérdida relativa de linfocitos T de vida media larga, en comparación con linfocitos B de vida media más corta y menos susceptibles a la pérdida gastrointestinal de quilo, porque permanecen mayor tiempo en la circulación periférica.