This syndrome was first described by Rubin in a patient with severe bloody diarrhea which was resolved by eliminating cow's milk from the patient's diet. In 1960 Ikol referred to severe gastrointestinal reactions in response to rice and wheat intake which were consistent with FPIES.
Este síndrome fue descrito por primera vez por Rubin, en un paciente con diarrea sanguinolenta severa que resolvió con restricción de leche de vaca; en 1960, Ikol refiere reacciones gastrointestinales severas en respuesta a ingesta de arroz y trigo consistentes con FPIES.