Recently, analysis of positive staining for protein S-100t has been cited to support the hypothesis that these tumors originate from epithelial neuroendocrine complexes rather than from intraepithelial endocrine cells.
Recientemente se ha dicho que estos tumores se inician de complejos neuroendocrinos epiteliales en vez de células endocrinas intraepiteliales, lo que está sustentado por la tinción positiva con proteína S-100.