Double therapy with acetylsalicylic acid and clopidogrel has become common practice for secondary prevention for patients previously afflicted with atherosclerotic diseases associated to thrombi formation such as cerebrovascular incidents, stent placement operations and for patients resistant to acetylsalicylic acid.
Las interacciones generalmente se observan con otros fármacos que alteren la hemostasia como lo son anticoagulantes orales, otros antiagregantes plaquetarios, agentes trombolíticos y AINE's.