Similarly, the use of antiangiogenic chemotherapy significantly increases the risk of perforation. This is probably because it weakens the colon wall. This might explain the high incidence of perforations presented by some publications 34.
De igual forma el uso de quimioterápicos antiangiogénicos dispara el riesgo de perforación al debilitar probablemente la pared del colon, lo que podría explicar la alta incidencia de perforaciones presentada por algunas series 34.