These metabotropic receptors associated with the G inhibitory protein Gi/o reduce cyclic adenosine monophosphate AMP through adenyl cyclase inhibition, and induce an increase in potassium 14 by enhanced permeability of inflow and outflow channels, hyperpolarizing the postsynaptic neuron.
Estos receptores metabotrópicos asociados a la proteína G inhibitoria Gi/o disminuyen el adenosin monofosfato cíclico AMP a través de la inhibición de la adenilatociclasa e inducen el aumento de potasio 14 por aumento en la permeabilidad de canales de salida y entrada, hiperpolarizando la neurona postsináptica.