The relationship between the BCS and the use of oral contraceptives has been studied since the 1980s. A case-control study published in 1986 by Valla et al. showed that patients who had recently taken oral contraceptives had a 2.37 times higher risk of developing thrombosis of the hepatic veins than did those who had not taken these medicines 26.
La relación entre el SBC y el uso de ACO ha sido estudiada desde la década de 1980: un estudio de casos y controles publicado en 1986 por Valla, et al demostró que las pacientes con uso reciente de ACO presentaban un riesgo 2,37 veces mayor de trombosis de las venas hepáticas con respecto a aquellas que no estaban expuestas a estos medicamentos 17.