Among the pathophysiological mechanisms, inflammatory and neuro immunological processes are considered, as there are increases in different interleukins, tumoral necrosis factor, and the peptide related to the calcitonin gene in the compromised limb 29,30.
Dentro de los mecanismos fisiopatológicos se postulan procesos inflamatorios y neuroinmunológicos, debido al incremento de diferentes interleuquinas, factor de necrosis tumoral y el péptido relacionado con el gen de la calcitonina, presentes en la extremidad afectada 29,30.