In terms of non-drug-induced analgesia, there are two possibilities: stress-induced analgesia through the action of cortisol, the most important stress hormone, that might increase the pain threshold and tolerance; however, no significant difference has been found between the two sexes.The other possibility is exercise-induced analgesia where pain thresholds and tolerance increase in women when going from a pre-exercise to a post-exercise state; however, in men, the threshold does not change between one state and the other.
La primera, que sea inducida por el estrés y su principal hormona, el cortisol, aumentando el umbral de dolor, aunque no se observa una diferencia significativa entre ambos sexos. La otra posibilidad se refiere a la analgesia inducida por el ejercicio: las mujeres aumentan el umbral de dolor y la tolerancia al pasar de un estado pre-ejercicio a un estado post-ejercicio, y en el hombre el umbral no varía de un estado a otro.