Patients having signs of systemic inflammatory response when the study began were also not included; this was defined by two or more of the following criteria: a < 4 000/mm or > 12 000/mm leukocytes, b < 35 °C or > 38 °C temperature, c > 20 x´ respiratory frequency d > 90 x´ cardiac frequency.
Tampoco se incluyeron pacientes con signos de respuesta inflamatoria sistêmica al momento del inicio del estudio definida por dos o más de los siguientes criterios: a Leucocitos < 4 000/ mm o > 12 000/mm, b Temperatura < 35 °C o > 38 °C, c Frecuencia respiratoria > 20 x´ d Frecuencia cardiaca > 90 x´.