Due to these reasons, microcolonies can not be established, this then demonstrates interference in early phases of biofilm development and allows for a strategy to prevent the antibiotic resistance which is related to the formation of these structures. P. gingivalys and P. intermedia reside as biofilms in subgingival plaque. Recent studies have determined that allocating bovine lactoferrin to patients afflicted with chronic periodontitis decreases the number of these bacteria in the plaque. For these reasons, biofilm formation ability of several forms of lactoferrin has been explored: human and bovine apo iron free native and holo iron saturated as well as lactoferricin LFcinB. Inhibition of biofilm formation activity has been found in low concentrations. It has also been found that use combined with antibiotics enhances the effect. For all the aforementioned reasons lactoferrin use is proposed in prevention and treatment of periodontal diseases.
P. gingivalis y Prevotella intermedia residen como biopelículas en la placa subgingival, estudios recientes han determinado que la administración de lactoferrina bovina en pacientes con periodontitis crónica disminuye el número de estas bacterias en la placa, por esta razón se ha explorado la capacidad de formación de biopelículas de varias formas de lactoferrina: apo libre de hierro, nativa y holo saturada de hierro tanto humana, bovina y lactoferricina LFcin B encontrándose actividad para la inhibición de la formación de biopelículas a bajas concentraciones y que el uso combinado con antibióticos amplifica el efecto, por lo que se propone el uso de la lactoferrina en la prevención y tratamiento de las enfermedades periodontales.