In our case, apart from surgery, a daily dose of 400 mg of Gleevec was used for six months, from the day following the surgery to the present moment. The patient has been found to be free of symptomatology or metastasis through frequent analytical and imaging check-ups required by the adverse reactions of the medicine. 1. DeMatteo RP, Lewis JJ, Leung D, El-Rifai W. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 2000; 231: 51-58. 2. Mukherjee S, Talavera F, Williams N, Mechaber AJ, Katz J, editors. Gastrointestinal Stromal Tumors [monograph on the Internet]. New York: www.emedicine.com; 2008 [last Updated 2008 March 4]. Available from: http://www.emedicine.com/med/topic1179.htm 4. Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor GIPACT: gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998; 1525: 1259-69. 6. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998; 2795350: 577-80. 7. DAmato R, Steinert DM, McAuliffe JC, Trent J. Update on the biology and therapy of gastrointestinal stromal tumors. Cancer Control 2005; 12: 44-56. 8. Kindblom L-G, Meis-Kindblom, Bümming P. Incidence, prevalence, phenotype and biologic spectrum of gastrointestinal stromal cell tumors GIST: a population based study of 600 cases. Ann Oncol 2002; 13Suppl 5: 157. 10. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002; 335: 459-65. 11. Dematteo RP, Heinrich MC, El-Rifai WM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol 2002; 335: 466-77. 12. Trupiano J, Stewart R, Misick C. Gastric stromal tumors: a clinicopathologic study of 97 cases with correlation of features with nonaggressive and aggressive clinical behaviours. Am J Surg Pathol 2002; 26: 705-14. 13. González R, Araya J, Madila T. Diferenciación inmunohistoquímica con CD117 en tumores estromales gastrointestinales. Madrid: Congreso Virtual Hispoanomericano de Anatomía Patológica. 2004. 15. Miettinnen M, Majidi M, Lasota J. Pathology and diagnostic criteria of Gastrointestinal Stromal Tumors GIST: a review. Europ J of Cancer 2002; 38Suppl 5: S37-S51. 16. Goss G, Merrian P, Manola J. Clinical and pathological characteristics of gastrointestinal stromal tumors GIST. Proc Am Soc Clin Oncol 2000; 19: 559-65 [Abstract]. 17. Eisenberg B, Judson I. Surgery and Imatinib in the management of GIST: Emerging approaches to adjuvant and neoadjuvant therapy. Ann Surg Oncol 2004; 11: 465-475. 19. Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Brief report: effect of the tyrosine kinase inhibitor STI-571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001; 344: 1052-1056.
En nuestro caso, además de la cirugía se empleó el Glivec, con dosis de 400 mg diarios, durante seis meses desde el día posterior a la operación hasta el momento actual, y nuestro paciente se encuentra libre de sintomatología y metástasis, con controles analíticos e imagenológicos frecuentes debido a las reacciones adversas del medicamento.