It is believed that factors liberated by osteoclasts represent the activating signals for osteoclasts while osteoblasts in turn liberate substances such as receptor activator of nuclear factor kappa-B ligand RANKL and macrophage colony-stimulating factor M-CSF which are responsible for stimulating osteoclasts.
Se cree que factores liberados por los osteoclastos representan la señal activadora de la acción de los osteoblastos.