Even so, 45% of healthy people taking esomeprazole in two daily doses present escape phenomenon or nocturnal acid rebound defined as a Ph drop below 4.0 for at least one continuous hour 6-9, During episodes of dropping pH, reflux can develop in 15% of patients with gastroesophageal reflux disorder, in 50% of patients with Barretts esophagus and in up to 70% of patients with scleroderma 8, 10, 14.
Aun así, hasta el 45% de personas sanas tomando esomeprazole en dos dosis diarias pueden presentar fenómeno de escape o rebote nocturno definido como la caída del pH por debajo de 4 al menos por una hora continua 6-9.