It should be adjusted later depending on cultures. In places where it is technically difficult to obtain samples for culturing from the site of the necrosis, once other causes are ruled out and infection is still suspected, it is recommended that empirical antibiotic therapy be started using drugs that reach minimum inhibitory concentrations in the pancreas. The first choice is carbapenem. 1. Dervenis C, Johnson CD, Bassi C, et al. Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. Int J Pancreatol 1999; 25: 195-210. 2. Fritz S, Hackert T, Hartwig W, et al.
En sitios donde sea técnicamente difícil obtener muestras para cultivo del sitio de necrosis se recomienda, ante la sospecha de infección, y una vez descartados otros focos, iniciar antibioticoterapia empírica con fármacos que alcancen concentraciones inhibitorias mínimas en páncreas, siendo de primera elección los carbapenémicos.