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Aunque la REM y la DES pueden ser usadas como terapia definitiva de lesiones premalignas o malignas de estadio temprano T1m-N0 del tracto digestivo, quizás algunos estadios que actualmente son indicación de cirugía se manejen en el futuro con una combinación de manejo endoscópico combinado con disección linfonodal regional laparoscópica o con procedimientos de NOTES Natural Orifice Transluminal Endoscopy Surgery que probablemente incluirán resecciones parciales de la capa muscular y sutura de las mismas 44, 45.