Although the physiopathology of FPIES is poorly understood, it is believed that there are specific antigens against T cells, humoral responses to specific antibodies, and inflammatory cytokines that modify the permeability of the intestinal barrier involved.
La fisiopatología es pobremente entendida, se cree que existen antígenos específicos contra células T, respuesta humoral de anticuerpos específicos y citoquinas inflamatorias que modifican la permeabilidad de la barrera intestinal involucrada.