Consequently, it is less effective in prophylaxis after neurosurgery and encephalocranial trauma. Most frequently reported adverse effects include headaches, dizziness, diarrhea, nausea and constipation.
A pesar de aumentar la dosis no inhibe la secreción ácida vagalmente mediada, por tanto es menos eficaz en profilaxis luego de neurocirugía y trauma encefalocraneano.