The use of NSAIDS must be avoided in the first trimester because of the risk of miscarriage, and during the second and the third trimester because of the risk of oligohydram-nios or premature closure of the ductus with an effect on fetal circulation.Dipyrone, taken out from the US market, is still available in some European and Latin-American countries.
La dipirona, retirada del mercado en Estados Unidos, persiste vigente en algunos países de Europa y Latinoamérica.