The analgesic activity of tramadol is affected by the inhibition of CYP2D6 as its analgesic effects are produced by its metabolite M1 O-desmetiltramadol 24,26,40.
La actividad analgésica del tramadol se ve afectada, principalmente, por la inhibición de CYP2D6, pues sus efectos analgésicos resultan, en su mayor parte, de la formación del metabolito M1 O-desmetiltramadol 24,26,40.