In 1995 HR gene was finally cloned, and the product of this gene, called PHEX gene phosphate regulating gene with homologies with endopeptidases of the X chromosome was an enzyme of unknown substrate. Nevertheless it is known that it expresses in osteoblasts and causes phosphate loss.
En 1995 logró clonarse el gen de RH y el producto de este gen, denominado gen PHEX phosphate regulating gene with homologies with endopeptidases on the X chromosome fue una enzima cuyo sustrato es desconocido pero que se sabe que se expresa en los osteoblastos y que conduce a la pérdida de fosfato.