Our first conclusion should be that the use of antibiotic prophylaxis for the handling of acute pancreatitis has shown benefit only for those cases of severe pancreatitis in which there is necrosis of 30% or more of the pancreatic tissue. Necrosis is defined according to the Atlanta classification: localized or diffuse zones of nonviable pancreatic tissue that are generally associated with peripancreatic fat cell necrosis.
Como primera conclusión tenemos que el uso de la profilaxis antibiótica en el manejo de la pancreatitis aguda, solo ha mostrado beneficio en casos de pancreatitis severa con necrosis del 30% o más del tejido pancreático, definiendo la necrosis de acuerdo a la clasificación de Atlanta como zonas localizadas o difusas de tejido pancreático no viable que, generalmente, se asocian a necrosis grasa peripancreática.