In a recently published meta-analysis of clinical trials in patients with headache, the main adverse effects reported were blepharoptosis RR, 9.5; 95% CI, 4.7-18.9, muscle paralysis RR, 8.9; 95% CI, 2.5-30.9, neck pain RR, 4.7; 95% CI, 3.2-6.9, neck stiffness RR, 3.2; 95% CI, 1.9-5.6, paresthesias RR, 3.3; 95% CI, 1.3-7.9, and skin numbness RR, 3.6; 95% CI, 1.6-8.3.
En un metaanálisis de ensayos clínicos en pacientes con cefalea, publicado recientemente, los principales efectos adversos reportados fueron: blefaroptosis RR: 9,5; IC 95%: 4,718,9, parálisis muscular RR: 8,9; IC 95%: 2,5-30,9, cervicalgia RR: 4,7; IC 95%: 3,2-6,9, rigidez de nuca RR: 3,2; IC 95%: 1,9-5,6, parestesias RR: 3,3; IC 95%: 1,3-7,9 y entumecimiento de la piel RR: 3,6; IC 95%: 1,6-8,3.