Lesion occurs in two forms: hepatocellular ballooning and/or subsinusoidal or pericellular fibrosis. Ballooning is characterized by edema and cytoplasmic rarefaction resulting in enlarged cells with clear appearances with intracytoplasmic residual granular material located in Zone 3. In advanced stages the disease is adjacent to fibrous septa Figure 5.
La balonización se caracteriza por edema y rarefacción del citoplasma, son células agrandadas, de apariencia clara, con material residual granular intracitoplasmático; localizados en la zona 3, en etapas avanzadas de la enfermedad están adyacentes a los septos fibrosos figura 5.