Nevertheless, it is possible that during a DENV heterologous infection, only a small subpopulation of T cells are sero-crossed, and this combined with the fact that every human being has a repertoire of T cell specific receptors, could explain la great variability in the presentation of the disease after a secondary infection.
Se mantiene una activación prolongada de células T CD8+ con una producción alta en los niveles de TNF-α, IL-6 y otros factores solubles que afectan la permeabilidad vascular ver más adelante en tropismo y células endoteliales.