80% of the heme group comes from hemoglobin released by senescent erythrocytes and ineffective erythropoiesis. The other 20% is related to enzymatic non-erythroid sources 11, 12.
El 80% del grupo hem proviene de la hemoglobina liberada de los eritrocitos senescentes y de la eritropoyesis ineficaz y el 20% restante corresponde a las fuentes enzimáticas no eritroides mencionadas 11, 12.