As well as an effect on monoamines, TCAs exert a powerful anti-muscarinic effect which may be of relevance; this effect is shared with the SSRI paroxetine 45.If, as is assumed, gut muscle "spasm" is a major factor in the genesis of pain in IBS, these anti-muscarinic effects will be of benefit.
Así como es un efecto de las monoaminas, los ADT ejercen un potente efecto antimuscarínico, que puede ser de relevancia; este efecto es compartido con el IRSS, paroxetina 45.