In addition to the previously described evidence, two RCTs that compared Azithromycin with doxycycline which included 971 patients with Chlamydia trachomatis infection mainly urethritis and cervicitis did find differences in terms of clinical cure RR range 1.03-1.06, However, there was no significant difference in terms of clinical cure or bacteriological cure RR range 0.97-1.01 or regarding the presence of adverse events RR range 0.89-1.1 compared to patients treated with doxycycline 80, 81. It is worth noting that these trials included patients with Chlamydia trachomatis infection in general, i.e. not specifically due to strains related to venereal lymphogranuloma: serovars L1, L2 and L3 level of evidence: moderate.
Además de la evidencia ya descrita, dos ECA que incluyen 971 pacientes con infecciones por Chlamydia trachomatis mayormente uretritis y cervicitis no encontraron diferencias en términos de cura clínica RR entre 1,03 a 1,06, cura bacteriológica RR entre 0,97 a 1,01 o presencia de eventos adversos RR entre 0,89 a 1,1, en comparación con pacientes tratados con doxiciclina 80, 81.Vale la pena anotar que la calidad de la evidencia disminuye debido a que los pacientes incluidos presentan infecciones por Chlamydia trachomatis en general, no específicamente debidas a las cepas relacionadas con el linfogranuloma venéreo serotipos L1, L2 y L3Nivel de evidencia: moderado.