However, various factors are related to DENV pathogenesis: 1 viral factors, such as virulence and viral transmissibility, and 2 host factors, such as immune response, immunologic conditions and its genetic characteristics. During mid 70´s the World Health Organization WHO proposed a dengue severity classification with the purpose of aiding the diagnosis, patient management and monitoring of the disease. The following concepts were defined:
No obstante, varios factores se relacionan con la patogénesis de DENV: 1 factores virales, tales como la virulencia y la transmisibilidad del virus, y 2 factores del hospedero, tales como la respuesta inmune, su condición inmunológica y sus características genéticas.