Consequently, the primary mechanism by which mannitol reduces ICP is by increasing the osmotic gradient through the BBB a structure which does not diffuse freely because of its low permeability coefficient.
O sea que el mecanismo primario del manitol para reducir la PIC es por aumento del gradiente osmótico a través de la BHE una estructura que no difunde libremente por su bajo coeficiente de permeabilidad.