The reduction in its effectiveness has been essentially attributed to the development of resistance to clarithromycin and metronidazole 1,14. In Colombia this resistance is over 15% for clarithromycin and 80% for metronidazole 18-20.
El descenso en la eficacia ha sido atribuido fundamentalmente a la resistencia a la claritromicina y al metronidazol 1, 14, que en nuestro medio están por encima del 15% y del 80% respectivamente 18-20.