Goldstein, cited by Canguilhem 1991, p.185, says that: "Pathological phenomena are the expression of the fact that normal relationships between organism and environment have been transformed through a change of the organism, and that thereby many things which had been adequate for the normal organism are no longer adequate for the modified organism.
Dice Goldstein, citado por Canguilhem 1971, p.140: "Los síntomas patológicos son la expresión del hecho de que las relaciones entre organismo y medio ambiente que responden a la norma han sido transformadas por el cambio del organismo y de que muchas cosas que eran normales para el organismo normal ya no lo son para el organismo modificado.