Recently another type of metaplasia has been recognized in experimental models infected with Helicobacter felis. This type of metaplasia has been called spasmolytic polypeptide-expressing metaplasia SPEM. It expresses spasmolytic peptide, which apparently comes from transdifferentiation of mature chief cells when there is loss of parietal cells associated with chronic inflammation 24, 25.
Recientemente se ha reconocido otra metaplasia en modelos experimentales infectados con Helicobacter felis, denominada metaplasia que expresa el péptido espamolítico, la cual al parecer proviene de transdiferenciación de células principales maduras cuando hay pérdida de células parietales asociada a inflamación crónica 24, 25.