It has been postulated that viral infections such as reovirus type 3, rotavirus and cytomegalovirus or genetic factors may play roles in this type of cholestasis, but these hypotheses have not been confirmed.
Se han postulado sin poder corroborarlo, el papel de algunas infecciones virales como reovirus 3, rotavirus y citomegalovirus, o formas genéticas dado el aumento del riesgo encontrado en algunas familias 3, 10.