Both types of dysplasia were completely eradicated as confirmed by normal esophageal mucosa found in follow-up examinations which once again confirms the favorability of this combined approach. R.E. Pouw's retrospective study of 169 patients with average 32 months follow up showed the superiority of combined management for resection of visible lesions associated with RFA for complete eradication of Barrett's mucosa. The study showed absence of Barrett's mucosa in the short and medium term and a low recurrence rate of 6% in cases of BE without dysplasia. The study showed a complete response in 100% of cases of carcinoma in situ 35. In addition this technique resulted in a lower frequency of complications such as perforations and stenosis than did circumferential mucosal resections. All of the above points toward taking combined therapy into consideration for multiple reasons. First, focal mucosal resection of visible lesions provides a surgical piece which is evaluable to the pathologist and which provides the security of correct oncological management. Second, it avoids complications derived from extensive circumferential mucosal resections and the complication of stenosis with respect to the submucosa.
Pouw realizó un estudio retrospectivo en 169 pacientes con un seguimiento medio de 32 meses mostrando la superioridad del manejo combinado de resección de lesiones visibles asociada a ARF para erradicación completa de la mucosa de Barrett en cuanto a la ausencia de la misma a corto y mediano plazo con una recurrencia de apenas 6% en casos de EB no displásico y una respuesta completa hasta de 100% en casos con carcinoma in situ 35, además, ha presentado una frecuencia mucho menor de complicaciones como perforación y estenosis al compararlo con procedimientos de resecciones mucosas circunferenciales.