The main representatives of this category are gabapentin and pregabalin. Their mechanism of action is based on their binding to the α2-δ subunit of the voltage-dependent calcium channels, reducing the release of glutamate, norepinephrine and substance P 35.
Sus principales representantes son gabapentin y pregabalina; su mecanismo de acción se basa en su unión a la subunidad α2-δ de los canales de calcio voltaje dependientes, disminuyendo la liberación de glutamato, norepinefrina y sustancia P 35.