This phenomenon is due to increased endogenous release of histamine antagonists which compete for these receptors. It usually occurs within 48 hours and can not be controlled with increased dosages since this treatment does not inhibit vagally mediated acid secretion.
Este fenómeno de tolerancia se debe al aumento de la liberación endógena de histamina para competir con estos antagonistas por los receptores, y ello suele ocurrir en las primeras 48 horas.