During the last six months of the disease, the patient experienced overt deterioration with involvement of the four limbs that prevented ambulation and required wheel chair; later the patient became bed-ridden because the severity of the spasticity prevented her from sitting down on the chair.
En los últimos 6 meses de su enfermedad la paciente presentó un franco deterioro, con compromiso de las 4 extremidades que le impide la deambulación; precisa silla de ruedas y posteriormente termina encamada dada la severidad de la espasticidad, que le impide sentarse en la silla.