In these cases, there is also presence of tubular defects which can reach the dentin-enamel junction. In 1991, Seeto and Seow reported that dentin of HR patients was characterized by the presence of a great number of calcospherites separated by irregular zones of inter-globular dentin.
En 1991, Seeto y Seow reportaron que la dentina de los pacientes con raquitismo hipofosfatémico RH está caracterizada por la presencia de un gran número de calcosferitas separadas por zonas irregulares de dentina interglobular.