Even though different studies with electroencephalography and positron emission images under the effect of sedation and hypnosis have demonstrated an overall decrease in cerebral consumption of glucose, this has mainly been observed in the aforementioned regions.33-34 Benzodiazepine action is related to GABA receptor α1, α2, α3, α5 and ß2 subunits, having different affinities according to the benzondiazepine used, thereby bestowing different powers; this has led to new benzodiazepines i.e. bretazenil and imidazenil being developed according to their affinity for subunits.7-8
La acción de las benzodiacepinas se relaciona con las subunidades a1, a2, a3, a5 y ß2 del receptor GABA, con diferentes afinidades de acuerdo con la benzondiacepina empleada otorgando diferentes potencias, lo cual ha permitido el desarrollo de nuevas benzodiacepinas según su afinidad por las subunidades como el bretazenil e imidazenil.7-8