The ideal hypnotic agent for administering fentanyl in continuous infusion, in surgeries over two hours long, is desfluorane or sevofluorane at concentrations between 0,8 and 1 MAC. 1. Gutstein HB, Akil H. Opioid Analgesics. En Goodman & Gilman`s. The Pharmacological Basis of Therapeutics. 11th Ed. New York. McGraw Hill; 2006. p. 547-90. 2. Coda B. Opioids. En Barash PG. Clinical Anesthesia. Fifth edition. Philadelphia: Lippincott Williams and Wilkins; 2006. p. 353-83. 3. Wang H, Li EY, Xu GW, Wang CS, Gong YL, Li P. Intravenous fentanyl is exhaled and the concentration fluctuates with time. J Int Med Res. 2009;374:1158-66. 4. Coral IS, Moore AR, Strunin L. Plasma concentrations of fentanyl in normal surgical patients with severe renal failure. Br J Anaesth. 1980; 52:101.
El hipnótico ideal para administrar el fentanilo en infusión continua, en cirugías mayores de dos horas, es el desfluorano o el sevofluorano a concentraciones entre 0,8 y 1 CAM.