12. Based on summary measurements of the four studies, despite the finding of heterogeneity, it is suggested that significant contrast was observed for mean pain differences, as follows: first hour: -0.9 95% CI -1.07 and -0.72 p < 0.00001; 3h: -3.26 95% CI -4.01 and -2.51 p < 0.00001 and final time point -3.47 95% CI -4.29 and -2.65 p < 0.00001.
12. Con base en las medidas resumen de los 4 estudios, a pesar de encontrar heterogeneidad, se sugiere que se observaron contrastes significativos para la diferencia media del dolor. Así: hora 1: -0,9 IC 95%: -1,07 a -0,72; p < 0,00001; hora 3: -3,26 IC 95%: -4,01 a -2,51; p < 0,00001 y hora final -3,47 IC 95%: -4,29 a -2,65; p < 0,00001.