Since immunosuppressive agents were limited to corticosteroids and aziothropine other avenues were also explored; antilymphocytic globulin ALG was extensively used in kidney and liver recipients; as a matter of fact since it was injected just before surgery, and in some cases it was repeated three hours later, we found that in more than one occasion the esophageal temperature rose15 during surgery figure 11; this was at the time when malignant hyperthermia was being studied16; so we feared that it was in process in several cases, only to find out that was easily treated when we stopped warming the intravenous fluids.
Aunque los métodos inmunosupresores se limitaban a los corticosteroides y la aziotropina otros fueron explorados; la globulina antilinfocítica GAL se usó extensivamente en los receptores de riñón e hígado; como en efecto sucedía se inyectaba antes de la cirugía, y en algunos casos se repetía tres horas después. Vimos que en más de una ocasión la temperatura esofágica se elevaba durante la cirugía figura 11; por esta época se iniciaba el estudio de la hipertermia maligna, así que se temió fuera el caso en varios pacientes, sin embargo con solo parar los líquidos calientes que se administraban se controló la subida de la temperatura.