Initially there is a depressor effect on the inhibitory pathways mediated by the GABA receptors 22, and a stimulating effect over the NMDA receptors 22, with clinical manifestations such as agitation, dizziness, myoclonic responses, nistag-mus, disartria, muscle contractures, perioral parestesias, taste disorders metallic taste, hearing disorders tinnitus, poor response to verbal instructions, speech disorders and finally, tonic-clonic seizures 22,23.
Inicialmente, se observa efecto depresor sobre las vías inhibitorias mediadas por receptores GABA 22, y efecto estimulante sobre receptores NMDA 22, clínicamente dado por agitación, mareo, mioclonías, nistagmos, disartria, contracturas musculares, parestesias periorales, alteración de la percepción de sabores sabor metálico, sonidos tinnitus, falta de respuesta a órdenes verbales, trastornos del habla y por último, convulsiones tónico-clónicas 22,23.