They did not find evidence to support the theory that osmotic agents reduce CBV, arguing against the theory that they reduce ICP by creating cerebral vasoconstriction The AHA guidelines still in force show that osmotherapy is among other aggressive medical measures for the treatment of critically ill patients with malignant cerebral oedema after a large cerebral infarction.
No encontraron apoyo para la teoría de que los agentes osmóticos reducen el VSC, argumentando en contra la teoría de que reducen la PIC mediante la producción de vasoconstricción cerebral.