This definition has been questioned thoroughly, because in most countries that have dengue cases and hemorrhagic dengue, the clinical symptoms and the laboratory findings do not agree with the ones defined by the WHO and also, patients present variations due to the infection of different serotypes. In the present review the factors that could play a fundamental role in the dengue pathogenesis are exposed. Also, the new clinical classification of dengue dictated by the OMS is emphatically presented.
Esta definición ha sido ampliamente cuestionada, ya que en la mayoría de los países donde hay casos de dengue y dengue hemorrágico, los síntomas clínicos y hallazgos de laboratorio no concuerdan con los definidos por la OMS y además, los pacientes presentan variabilidad ante las infecciones por los diferentes serotipos.