The patients included in the study were randomized for treatment. Patients were informed of the type of treatment they would undergo in a written notification delivered in an envelope by a doctor who was not part of the study. The envelopes' contents were unknown to the investigators. At the moment a patient was informed of his/her treatment procedures, s/he was also informed of potential adverse effects and the necessity to suspend treatment in the event of severe adverse effects diarrhea, vomiting, allergies, migraines etc..
Los pacientes incluidos en el estudio se aleatorizaron para recibir la terapia correspondiente, la cual se entregó en un sobre cuyo contenido era desconocido por los investigadores y que era a su vez entregado por otro médico que no hacía parte del estudio, momento en el cual, se les explicó la forma de tomar los medicamentos y se les informó sobre los potenciales efectos adversos y la necesidad de suspender el tratamiento si estos eran severos diarrea, vómito, alergias, cefalea etc..