Initially, ESD was used only to resect mucosal lesions in the stomach which were larger than 2 cm the classical Japanese criteria. Subsequently, it was shown that outcomes and prognoses were just as good for well-differentiated adenocarcinomas under 30 mm in diameter that compromised the superficial submucosal layer sm1: up to 500 microns.
Inicialmente, la DES buscaba resecar lesiones mucosales mayores de 2 cm, en estómago; posteriormente se evidenció que el resultado y el pronóstico era igual de bueno para los adenocarcinomas bien diferenciados, pequeños menores de 30 mm de diámetro que comprometían incluso la capa submucosal superficial sm1: hasta 500 micras, e incluso algunas lesiones con ulceración 12.