Other factors that imply poor prognoses include transmural involvement including the biliary gallbladder, adenosquamous carcinomas which are more aggressive than papillary histologic carcinomas, male gender men have shorter life expectancies in these cases, preoperative albumin levels lower than 3 gr/ dl and bilirubin levels over 10 mg/dl.
Otros factores que implican un mal pronóstico son que el compromiso transmural involucre la vesícula biliar, la variedad histológica papilar es menos agresiva que el adenoescamoso, en el hombre la sobrevida es menor, unas cifras preoperatorias de albúmina menor de 3 gr/dl y una bilirrubina mayor de 10 mg/dl.