We should always take a biopsy of the overlying mucosa unless we suspect a vascular or cystic origin, because many of these lesions may have an origin in the lamina propria or muscularis mucosa. In these cases they can be reached by forceps and a precise diagnosis can be made. If biopsies are normal, this is where we must define whether we should stop or continue the study. Once the endoscopy has been performed and a subepithelial lesion has been detected, we can immediately to evaluate it.
Siempre deberíamos tomar una biopsia de la mucosa suprayacente excepto si sospechamos un origen vascular o quístico, ya que muchas de estas lesiones pueden originarse en la lámina propia o la muscular de la mucosa y están al alcance de la pinza, caso en el cual haríamos un diagnóstico preciso, pero, si las biopsias son normales, es aquí donde debemos definir si nos detenemos o seguimos el estudio.