The translocation also tends to protect against transformation to diffuse large cell lymphoma. Transformation to diffuse large B-cell lymphoma happens in less than 10% of these patients, usually after prolonged illness. This transformation is often associated with other genetic events such as p5317p13 mutations and p169p21 deletions.
Transformación a linfoma B difuso de célula grande puede ocurrir en menos del 10% de los pacientes, usualmente en relación con un curso prolongado, asociado a otros eventos genéticos como mutaciones del p5317p13 y deleciones del p169p21; no tiene relación con enfermedad diseminada 31.