Can the combination of Depakote and Zoloft cause weight gain?

  • Q: I am taking Depakote and Zoloft. Can they cause weight gain?
  • A: Zoloft (sertraline) is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms. It is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Depakote (divalproex sodium) affects chemicals in the body that may be involved in causing seizures. It is used to treat various types of seizure disorders. Divalproex is sometimes used together with other seizure medications. It can also be used to treat other non-seizure related conditions like bipolar disorder, migraines, and certain types of pain. Weight gain and/or increased appetite can be common side effects of both of these medications. Sometimes, switching antidepressants can help because people react differently to different medications in the SSRI class. If the weight gain is bothersome, talk to your doctor for specific recommendations about your medications. Do not stop or change the amount of medication you take without talking to your doctor first. Suddenly stopping your medications can result in serious withdrawal side effects. Your health care provider is best able to evaluate your medical condition and guide your treatment decisions based on your specific circumstances. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications. Sarah McKenney Lewis, RPh
This question was answered on October 08, 2010.


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