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Generic Name: linaclotide (LIN a KLOE tide)
Brand Name: Linzess

What is linaclotide?




What is the most important information I should know about linaclotide?

You should not use linaclotide if you have a blockage in your intestines.

Linaclotide should not be given to a child younger than 6 years old. Linaclotide can cause severe dehydration in a child.

What should I discuss with my healthcare provider before taking linaclotide?


  • a blockage in your intestines.

Linaclotide can cause severe dehydration in a child. Linaclotide should not be given to a child younger than 6 years old. Do not give this medicine to any child or teenager without the advice of a doctor.



How should I take linaclotide?



Do not crush, chew, or break a linaclotide capsule. Swallow it whole.

If you cannot swallow the linaclotide capsule whole, you may open the capsule and sprinkle the medicine into a spoonful of applesauce or bottled water. Swallow the mixture right away without chewing. Do not save it for later use.

Even if you have taken this medicine with applesauce, wait at least 30 minutes before eating a full meal.

If needed, medicine from the linaclotide capsule may be given through a nasogastric (NG) or gastronomy tube.

Read all patient information, medication guides, and instruction sheets provided to you. Carefully follow instructions for mixing medicine from the capsule with applesauce or water, or giving the medicine through a feeding tube. Ask your doctor or pharmacist if you have any questions.


Store at room temperature away from moisture and heat. Keep this medicine out of the reach of children. Linaclotide can cause severe diarrhea and dehydration in a child who accidentally swallows this medicine. Seek emergency medical attention if this happens.


What happens if I miss a dose?


What happens if I overdose?


What should I avoid while taking linaclotide?


Linaclotide side effects



  • severe or ongoing diarrhea;

  • diarrhea with dizziness or a light-headed feeling (like you might pass out);

  • signs of an electrolyte imbalance--increased thirst or urination, leg cramps, mood changes, confusion, feeling unsteady, irregular heartbeats, fluttering in your chest, muscle weakness or limp feeling;

  • severe stomach pain; or

  • black, bloody, or tarry stools.

Common side effects may include:

  • diarrhea;

  • stomach pain;

  • gas; or

  • bloating or full feeling in your stomach.


See also: Side effects (in more detail)

Linaclotide dosing information

Usual Adult Dose for Irritable Bowel Syndrome:

290 mcg orally once a day

-Take on an empty stomach, at least 30 minutes prior to the first meal of the day
-Swallow capsules whole; do not break apart or chew

Use: Irritable bowel syndrome with constipation

Usual Adult Dose for Constipation:

145 mcg orally once a day

-Swallow capsules whole; do not break apart or chew

Use: Chronic idiopathic constipation

What other drugs will affect linaclotide?


Where can I get more information?

  • Your pharmacist can provide more information about linaclotide.


Date modified: June 01, 2017
Last reviewed: March 13, 2017