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Merck Manual

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Amyloidosis in Cats


Ian Tizard



Amyloidosis is a condition that occurs when amyloid, a substance composed of abnormally folded protein, is deposited in various organs of the body. Some types of amyloidosis are hereditary in cats. Abyssinian cats are known to be at risk for hereditary amyloidosis, in which an abnormal gene causes amyloid to be produced. Other types occur as a result of infections, various cancers, or other inflammatory or immune-related conditions. However, the cause is often unknown.

Amyloid can be deposited throughout the body, or in just one specific area. The misfolded protein causes damage by displacing normal cells. The disease can become fatal if extensive amyloid is deposited into the tissue of critical organs, such as the kidneys, liver, or heart. All domestic mammals may develop amyloidosis. Senile systemic amyloidosis is the form of amyloidosis commonly seen in older animals. Aged animals commonly have minor deposits of amyloid without signs.

There are several types of amyloid, and the classification of amyloidosis is based on which amyloid protein is involved. Deposits of AA amyloid can result from chronic inflammatory diseases, chronic bacterial infections, and cancer. The amyloid is usually deposited in organs, such as the spleen or kidneys. The animal may not show any signs of illness. If AA amyloid is deposited in the kidneys, it can lead to a buildup of protein and result in kidney failure. However, kidney amyloidosis is uncommon in cats, except for Abyssinian cats, in which it is inherited. AL amyloid is another common form of amyloid protein that usually forms in animals with certain types of cancer (plasma cell tumors or myelomas). AL amyloid tends to be deposited in nerve tissue and joints.

Because of its wide distribution and hidden onset, amyloidosis is difficult to diagnose. However, your veterinarian might suspect amyloidosis if your cat has a chronic infection or inflammation and develops kidney or liver failure. No specific treatment can prevent the development of amyloidosis or promote the reabsorption of the protein deposits. Instead, efforts aim to control longterm inflammation, to minimize the production of more amyloid.

Also see professional content regarding amyloidosis.

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