Generic Name: Tiludronate

  • What is this medication and its most common uses?

    Skelid is a medicine used to treat Paget's disease of the bone.


    How does this medication work?

    Skelid works by stopping a type of bone cell from breaking down bones.


    What: Skelid has been shown to suppress a protein in your body involved in bone disease. By suppressing this protein, Skelid may improve your condition.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Skelid exactly as your healthcare provider has prescribed.

    How do I know it is working?


  • What are the possible side effects of this medication?


    More common side effects may include: nausea, diarrhea, heartburn.

    Less common side effects may include:

    Esophagus (the tube that connects your mouth and stomach) problems (such as irritation, swelling, or ulcers), with symptoms such as chest pain, new or worsening heartburn, or trouble or pain when you swallow.

    Skelid may also cause severe jaw bone problems or bone, joint, or muscle pain.

  • Who should not take this medication?

    Do not take Skelid if you are allergic to it or any of its ingredients.

    Do not take Skelid if you cannot stand or sit upright for at least 30 minutes.


    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Skelid. Also, talk to your healthcare provider about your complete medical history, especially if you have problems swallowing; kidney, stomach, or digestive problems; low blood calcium levels; if you plan to have dental surgery or your teeth removed; or if you have been told you have trouble absorbing minerals in your stomach or intestines.

  • What is the usual dosage?


    Adults: The recommended dose is 400 milligrams once a day for 3 months.

  • How should I take this medication?

    Take Skelid exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Skelid without first talking to your healthcare provider.

    Take Skelid with a full glass of plain water only.

    If you are taking calcium supplements, aspirin, or indomethacin, take them at least 2 hours before or 2 hours after Skelid.

    If you are taking antacids containing aluminum or magnesium, take them at least 2 hours after Skelid.

    Your healthcare provider may prescribe calcium and vitamin D to help prevent low blood calcium levels while you are taking Skelid. Take these as directed by your healthcare provider.

  • What should I avoid while taking this medication?

    Do not lie down for at least 30 minutes after you take Skelid.

    Do not take Skelid within 2 hours of food.


    If Skelid is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Skelid with the following: antacids that contain aluminum or magnesium, aspirin, calcium, or indomethacin.


    The effects of Skelid during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.



  • How should I store this medication?

    Store at room temperature.